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Characterization performed by carbon nuclear magnetic resonance spectroscopy proved that all values are in the expected ranges of the new compound. Gastroprotective activity of DTN was evaluated through<jats:italic>in-silico,<\/jats:italic>anti-<jats:italic>H. pylori,<\/jats:italic>in-vitro<jats:italic>,<\/jats:italic>in-vivo, and ex-vivo proteomic analysis.<jats:italic>In-silico<\/jats:italic>analysis shows that DTN possess stable binding with protein targets involved in gastric ulcer pathophysiology. DTN exhibited an inhibitory effect against 2,2-diphenyl-1-picrylhydrazyl,<jats:italic>H. pylori<\/jats:italic>and hydrogen potassium ATPase (H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase). The antiulcer activity was performed using an ethanol-induced gastric ulcer model in rats. Anti-oxidant profile of DTN showed a significant increase in glutathione-S-transferase, glutathione and catalase levels whereas lipid peroxidation levels were reduced. Histopathological findings confirmed that DTN protected the gastric mucosa of rats. Inflammatory markers tumor necrosis factor-alpha, nuclear factor kappa B, cyclooxygenase-2, interleukin 6 and interleukin-1\u03b2 were reduced and prostaglandin-E<jats:sub>2<\/jats:sub>restored expression of these cytokines in DTN pretreated animals when analyzed by using immunohistochemistry, enzyme-linked immunosorbent assay and western blot techniques. In real-time polymerase chain reaction technique, the expression of H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase was downregulated in DTN pretreated group. DTN did not cause any mortality up to 400\u2009mg\/Kg. This study indicates that the newly synthesized compound DTN, possess stable binding against selected targets. DTN exhibits a gastro-protective effect, mediated via anti-<jats:italic>H. pylori,<\/jats:italic>H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase inhibition, anti-oxidant and anti-inflammatory pathways, exploring its therapeutic potential in gastric ulcer management.<\/jats:p>","DOI":"10.1186\/s40360-022-00596-0","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T11:04:48Z","timestamp":1659092688000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pharmacological evaluation of newly synthesized organotin IV complex for antiulcer potential"],"prefix":"10.1186","volume":"23","author":[{"given":"Syed","family":"Azmatullah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif-ullah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam Gul","family":"Qazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humaira","family":"Nadeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadeem","family":"Irshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"issue":"10094","key":"596_CR1","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S0140-6736(16)32404-7","volume":"390","author":"A Lanas","year":"2017","unstructured":"Lanas A, Chan FKL. 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No. REC\/RIPS\/2021\/018) along with the guidelines of \u201cPrinciples of Laboratory Animal care \u201c. Informed consent (verbal) was obtained from all subjects and\/or their legal guardian(s). As samples were obtained from the biopsy of the gastric ulcer patients, voluntarily at care endoscopy clinics and labs (Rawalpindi, Pakistan) therefore we have just taken verbal consent and does not sign any written form. Experimental protocols were approved by an institutional committee (REC\/RIPS).We confirm that our study was performed in accordance with the ARRIVE guidelines. All the methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"N\/A","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We all declare that there is no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"58"}}