{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:11:09Z","timestamp":1788793869442,"version":"build-2803163510"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pharmacol Toxicol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Adverse drug reactions (ADRs) caused by opioid drugs show individual differences. Our objective was to explore the association between gene polymorphism and ADRs induced by opioid drugs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Evidence-based medical data analysis was conducted for genes related to ADRs induced by opioid drugs to select target genes. Sixty patients with cancer pain who had ADRs after taking opioid drugs (morphine, codeine, oxycodone) and 60 patients without ADRs after taking opioid drugs were used as the experimental group and control group, respectively. Then, we used polymerase chain reaction (PCR) or in situ hybridization to detect target genes. By combining with clinical data such as age, sex, dosage and duration of medication, the effect of gene polymorphism on the ADR of patients after taking opioid drugs was statistically analysed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Based on a database search and evidence-based medical data, we identified <jats:italic>CYP2D6*10, CYP3A5*3, ABCB1,<\/jats:italic> and <jats:italic>OPRM1<\/jats:italic> as target genes for detection. The results of statistical analysis showed no significant difference in genotype distribution between the experimental group and the control group (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). However, if 32 patients with ADRs after taking oxycodone and 32 controls were selected for comparison, the SPSS22.0 and SNPStats genetic models showed that the <jats:italic>ABCB1<\/jats:italic> (062rs1045642) CT and TT genotypes correlated with the occurrence of ADRs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05): the total number of CT\u2009+\u2009TT genotypes in the experimental group was 29 (90.62%), with 11 (34.37%) CT\u2009+\u2009TT genotypes types in the control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Polymorphism of <jats:italic>ABCB1<\/jats:italic> (062rs1045642) is related to ADRs caused by oxycodone, and the incidence of ADRs is higher with the allele T. Polymorphism of <jats:italic>ABCB1<\/jats:italic> is expected to become a clinical predictor of ADRs to oxycodone, and attention should be given to the occurrence of serious ADRs in patients with <jats:italic>ABCB1<\/jats:italic> (062rs1045642) CT and TT genotypes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40360-023-00708-4","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T06:02:42Z","timestamp":1700546562000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Study on the association between adverse drug reactions to opioids and gene polymorphisms: a case-case\u2013control study"],"prefix":"10.1186","volume":"24","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-zi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun-fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-yao","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"issue":"1","key":"708_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"R Siegel","year":"2017","unstructured":"Siegel R, Miller KD, Jemal A. Cancer statistics:2017. CA Cancer J Clin. 2017;67(1):7\u201330.","journal-title":"CA Cancer J Clin."},{"issue":"3","key":"708_CR2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/cpt.910","volume":"103","author":"A Gaedigk","year":"2018","unstructured":"Gaedigk A, Ingelman-Sundberg M, Miller NA, et al. The pharmacogene variation (PharmVar) consortium: incorporation of the human cytochrome P450 (CYP) allele nomenclature database. Clin Pharmacol Ther. 2018;103(3):399\u2013401.","journal-title":"Clin Pharmacol Ther."},{"issue":"4","key":"708_CR3","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/cpt.2149","volume":"10","author":"KR Crews","year":"2021","unstructured":"Crews KR, Monte AA, Huddart R, et al. Clinical pharmacogenetics implementation consortium guideline for CYP2D6, OPRM1, and COMT genotypes and select opioid therapy. 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Clin J Pain. 2019;35(1):31\u20136.","journal-title":"Clin J Pain."},{"issue":"2","key":"708_CR8","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1177\/1099800416680474","volume":"19","author":"H Khalil","year":"2016","unstructured":"Khalil H, Sereika SM, Dai F, et al. OPRM1 and COMT gene-gene interaction is associated with postoperative pain and opioid consumption after orthopedic trauma. Biol Res Nurs. 2016;19(2):170\u20139.","journal-title":"Biol Res Nurs."},{"issue":"4","key":"708_CR9","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3390\/ijms18040669","volume":"18","author":"H Aline","year":"2017","unstructured":"Aline H, Lucine H, Nada O, et al. OPRM1 c.118A>G polymorphism and duration of morphine treatment associated with morphine doses and quality-of-life in palliative Cancer pain settings. 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The study was performed in accordance with relevant guidelines and was approved by the Ethics Committee of Shandong Provincial Third Hospital (KYLL-20211115).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"64"}}