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Fourier-transform infrared spectroscopy (FTIR) confirmed successful CMGO synthesis through the presence of characteristic peaks at 1567.93 and 1639.29\u00a0cm<jats:sup>\u22121<\/jats:sup> (COONa vibrations) and increased CH<jats:sub>2<\/jats:sub> intensity compared to unmodified graphene oxide (GO). Furthermore, CMGO derived from sugarcane residues demonstrated potential in mitigating the side effects of toxic materials like carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). Treatment with CMGO partially reduced elevated levels of liver enzymes (ALT and AST) and nitrogenous waste products (urea and uric acid) in CCl<jats:sub>4<\/jats:sub>-induced liver damage models, suggesting an improvement in liver function despite ongoing cellular damage.This work paves the way for a sustainable and economical approach to produce functionalized graphene oxide with promising biomedical applications in alleviating toxin-induced liver injury.<\/jats:p>\n                <jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>","DOI":"10.1186\/s40360-024-00768-0","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T09:02:20Z","timestamp":1723539740000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Novel microwave assisted carboxymethyl-graphene oxide and its hepatoprotective activity"],"prefix":"10.1186","volume":"25","author":[{"given":"Hebat-Allah S.","family":"Tohamy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma El-Zahraa S.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"El-Sakhawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"768_CR1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1515\/tjb-2022-0208","volume":"48","author":"AB Uyumlu","year":"2023","unstructured":"Uyumlu AB, \u00c7a\u011flar Y\u0131lmaz H, Sat\u0131lm\u0131\u015f B, Erdemo\u011flu S. 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