{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:05:50Z","timestamp":1791831950261,"version":"4.3.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pharmacol Toxicol"],"DOI":"10.1186\/s40360-025-00895-2","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T08:16:07Z","timestamp":1742372167000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oxidative stress and anti-oxidant status in children with sepsis"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-2524","authenticated-orcid":false,"given":"Hatice Feray","family":"Ar\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-7050","authenticated-orcid":false,"given":"Murat","family":"Ar\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-7249","authenticated-orcid":false,"given":"Serdal","family":"Ogut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"issue":"1","key":"895_CR1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.4161\/viru.27045","volume":"5","author":"AG -Randolph","year":"2014","unstructured":"Randolph AG, McCulloh RJ. Pediatric sepsis: important considerations for diagnosing and managing severe infections in infants, children, and adolescents. Virulence. 2014;5(1):179\u201389.","journal-title":"Virulence"},{"issue":"8 Suppl 1","key":"895_CR2","first-page":"5266","volume":"17","author":"DS -Wheeler","year":"2016","unstructured":"Wheeler DS, Wong HR. Sepsis in pediatric cardiac intensive care. Pediatr Crit Care Med. 2016;17(8 Suppl 1):5266\u201371.","journal-title":"Pediatr Crit Care Med"},{"issue":"Suppl 1","key":"895_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/SHK.0000000000000699","volume":"47","author":"DC -De Souza","year":"2017","unstructured":"De Souza DC, Barreira ER, Faria LS. The epidemiology of sepsis in childhood. Shock. 2017;47(Suppl 1):2\u20135.","journal-title":"Shock"},{"issue":"3","key":"895_CR4","first-page":"143","volume":"117","author":"G -Ayar","year":"2019","unstructured":"Ayar G, Sahin S, Men Atmaca Y, Uysal Yazici M, Erel O. Thiol-disulphide homeostasis is an oxidative stress indicator in critically ill children with sepsis. Arch Argent Pediatr. 2019;117(3):143\u20138.","journal-title":"Arch Argent Pediatr"},{"issue":"2","key":"895_CR5","doi-asserted-by":"publisher","first-page":"e52","DOI":"10.1097\/PCC.0000000000002198","volume":"21","author":"SL -Weiss","year":"2020","unstructured":"Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med. 2020;21(2):e52.","journal-title":"Pediatr Crit Care Med"},{"key":"895_CR6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jcrc.2018.06.025","volume":"47","author":"L -Lorente","year":"2018","unstructured":"Lorente L, Mart\u00edn MM, P\u00e9rez-Cejas A, Abreu-Gonz\u00e1lez P, Lopez RO, Ferreres J, et al. Serum total antioxidant capacity during the first week of sepsis and mortality. J Crit Care. 2018;47:139\u201344.","journal-title":"J Crit Care"},{"issue":"2","key":"895_CR7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/ACO.0b013e328328d1cc","volume":"22","author":"A -Harrois","year":"2009","unstructured":"Harrois A, Huet O, Duranteau J. Alterations of mitochondrial function in sepsis and critical illness. Curr Opin Anaesthesiol. 2009;22(2):143\u20139.","journal-title":"Curr Opin Anaesthesiol"},{"issue":"4","key":"895_CR8","doi-asserted-by":"publisher","first-page":"e12653","DOI":"10.1111\/sji.12653","volume":"87","author":"S -Kumar","year":"2018","unstructured":"Kumar S, Gupta E, Kaushik S, Kumar Srivastava V, Mehta SK, Jyoti A. Evaluation of oxidative stress and antioxidant status: correlation with the severity of sepsis. Scand J Immunol. 2018;87(4):e12653.","journal-title":"Scand J Immunol"},{"issue":"4\u20135","key":"895_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/15216540051081010","volume":"50","author":"KJ -Davies","year":"2000","unstructured":"Davies KJ. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life. 2000;50(4\u20135):279\u201389.","journal-title":"IUBMB Life"},{"issue":"18","key":"895_CR10","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.clinbiochem.2014.09.026","volume":"47","author":"O -Erel","year":"2014","unstructured":"Erel O, Neselioglu S. A novel and automated assay for thiol\/disulphide homeostasis. Clin Biochem. 2014;47(18):326\u201332.","journal-title":"Clin Biochem"},{"key":"895_CR11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jcrc.2017.09.035","volume":"43","author":"I -Bahar","year":"2018","unstructured":"Bahar I, Elay G, Baskol G, Sungur M, Donmez-Altuntas H. Increased DNA damage and increased apoptosis and necrosis in patients with severe sepsis and septic shock. J Crit Care. 2018;43:271\u20135.","journal-title":"J Crit Care"},{"issue":"3","key":"895_CR12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.clinbiochem.2007.11.018","volume":"41","author":"S -Selek","year":"2008","unstructured":"Selek S, Cosar N, Kocyigit A, Erel O, Aksoy N, Gencer M, et al. PON1 activity and total oxidant status in patients with active pulmonary tuberculosis. Clin Biochem. 2008;41(3):140\u20134.","journal-title":"Clin Biochem"},{"key":"895_CR13","doi-asserted-by":"crossref","unstructured":"Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38:1103-11","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"895_CR14","doi-asserted-by":"crossref","unstructured":"Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generationmore stable ABTS radical cation. Clin Biochem. 2004;37:277\u2013\u200985.","DOI":"10.1016\/j.clinbiochem.2003.11.015"},{"key":"895_CR15","doi-asserted-by":"publisher","first-page":"110470","DOI":"10.1016\/j.vetimm.2022.110470","volume":"251","author":"E -G\u00f6k\u00e7e","year":"2022","unstructured":"G\u00f6k\u00e7e E, Cihan P, Ataki\u015fi O, Kirmizig\u00fcl AH, Erdo\u011fan HM. Oxidative stress in neonatal lambs and its relation to health status and passive colostral immunity. Vet Immunol Immunopathol. 2022;251:110470.","journal-title":"Vet Immunol Immunopathol"},{"issue":"5","key":"895_CR16","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1164\/rccm.201211-1983OC","volume":"187","author":"O -Takasu","year":"2013","unstructured":"Takasu O, Gaut JP, Watanabe E, To K, Fagley RE, Sato B, et al. Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med. 2013;187(5):509\u201317.","journal-title":"Am J Respir Crit Care Med"},{"issue":"22","key":"895_CR17","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.3109\/14767058.2016.1141885","volume":"29","author":"S -Ozler","year":"2016","unstructured":"Ozler S, Oztas E, Caglar AT, Uygur D, Ergin M, Erel O, et al. Thiol\/disulfide homeostasis in predicting adverse perinatal outcomes at 24\u201328 weeks of pregnancy in gestational diabetes. J Matern Fetal Neonatal Med. 2016;29(22):3699\u2013704.","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"11","key":"895_CR18","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.ajem.2015.06.016","volume":"33","author":"H -Kundi","year":"2015","unstructured":"Kundi H, Ates I, Kiziltunc E, Cetin M, Cicekcioglu H, Neselioglu S, et al. A novel oxidative stress marker in acute myocardial infarction; thiol\/disulphide homeostasis. Am J Emerg Med. 2015;33(11):1567\u201371.","journal-title":"Am J Emerg Med"},{"issue":"2","key":"895_CR19","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jash.2015.12.008","volume":"10","author":"I -Ates","year":"2016","unstructured":"Ates I, Ozkayar N, Inan B, Yilmaz FM, Topcuoglu C, Neselioglu S, et al. Dynamic thiol\/disulphide homeostasis in patients with newly diagnosed primary hypertension. J Am Soc Hypertens. 2016;10(2):159\u201366.","journal-title":"J Am Soc Hypertens"},{"issue":"1","key":"895_CR20","doi-asserted-by":"publisher","first-page":"e2177","DOI":"10.1016\/j.jcrc.2014.09.012","volume":"30","author":"L -Lorente","year":"2015","unstructured":"Lorente L, Mart\u00edn MM, Almeida T, Abreu-Gonz\u00e1lez P, Ferreres J, Sol\u00e9-Viol\u00e1n J, et al. Association between serum total antioxidant capacity and mortality in severe septic patients. J Crit Care. 2015;30(1):e2177\u201312.","journal-title":"J Crit Care"},{"key":"895_CR21","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3906\/sag-1905-148","volume":"50","author":"H -Yildiz","year":"2020","unstructured":"Yildiz H. Thiol\/disulphide homeostasis in intensive care unit patients with sepsis and septic shock. Turk J Med Sci. 2020;50:811\u20136.","journal-title":"Turk J Med Sci"},{"key":"895_CR22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.fct.2013.03.026","volume":"61","author":"M -Karapetsa","year":"2013","unstructured":"Karapetsa M, Pitsika M, Goutzourelas N, Stagos D, Becker AT, Zakynthinos E. Oxidative status in ICU patients with septic shock. Food Chem Toxicol. 2013;61:106\u201311.","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"895_CR23","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1080\/13510002.2016.1239866","volume":"22","author":"V -Molina","year":"2017","unstructured":"Molina V, von Dessauer B, Rodrigo R, Carvajal C. Oxidative stress biomarkers in pediatric sepsis: a prospective observational pilot study. Redox Rep. 2017;22(6):330\u20137.","journal-title":"Redox Rep"},{"issue":"7\u20138","key":"895_CR24","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.clinbiochem.2016.12.013","volume":"50","author":"G -Ayar","year":"2017","unstructured":"Ayar G, Atmaca YM, Al\u0131\u015f\u0131k M, Erel \u00d6. Effects of paraoxonase, arylesterase, ceruloplasmin, catalase, and myeloperoxidase activities on prognosis in pediatric patients with sepsis. Clin Biochem. 2017;50(7\u20138):414\u20137.","journal-title":"Clin Biochem"},{"issue":"1","key":"895_CR25","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1001\/jama.2014.5804","volume":"312","author":"V -Liu","year":"2014","unstructured":"Liu V, Escobar GJ, Greene JD, Soule J, Whippy A, Angus DC, et al. Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA. 2014;312(1):90\u20132.","journal-title":"JAMA"},{"issue":"2","key":"895_CR26","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ccc.2017.12.004","volume":"34","author":"T -Ju","year":"2018","unstructured":"Ju T, Al-Mashat M, Rivas L, Sarani B. Sepsis rapid response teams. Crit Care Clin. 2018;34(2):253\u20138.","journal-title":"Crit Care Clin"},{"key":"895_CR27","doi-asserted-by":"crossref","unstructured":"Levy B. Lactate and shock State: the metabolic view. Curr Opin Crit Care. 2006;12.","DOI":"10.1097\/01.ccx.0000235208.77450.15"}],"container-title":["BMC Pharmacology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-025-00895-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40360-025-00895-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-025-00895-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T08:16:12Z","timestamp":1742372172000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpharmacoltoxicol.biomedcentral.com\/articles\/10.1186\/s40360-025-00895-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["895"],"URL":"https:\/\/doi.org\/10.1186\/s40360-025-00895-2","relation":{},"ISSN":["2050-6511"],"issn-type":[{"value":"2050-6511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"18 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Harran University Clinical Research Ethics Committee (HR\u00dc\/22.21.16) approval was obtained by before the study began for the study. A signed informed consent form was obtained from the families or legal guardians of all patients included in the study. In addition, consent was obtained from the patients themselves over the age of 16.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"64"}}