{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:56:10Z","timestamp":1789250170712,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pharmacol Toxicol"],"DOI":"10.1186\/s40360-025-00908-0","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T13:09:54Z","timestamp":1744117794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Kaempferol inhibits cardiomyocyte pyroptosis via promoting O-GlcNAcylation of GSDME and improved acute myocardial infarction"],"prefix":"10.1186","volume":"26","author":[{"given":"Jie","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunjin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"issue":"10065","key":"908_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","volume":"389","author":"GW Reed","year":"2017","unstructured":"Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. Lancet. 2017;389(10065):197\u2013210.","journal-title":"Lancet"},{"issue":"1","key":"908_CR2","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/JCI62874","volume":"123","author":"DJ Hausenloy","year":"2013","unstructured":"Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: A neglected therapeutic target. J Clin Invest. 2013;123(1):92\u2013100.","journal-title":"J Clin Invest"},{"issue":"2","key":"908_CR3","doi-asserted-by":"publisher","first-page":"489","DOI":"10.31083\/j.rcm2202056","volume":"22","author":"F Caruntu","year":"2021","unstructured":"Caruntu F, Bordejevic DA, Buz B, Gheorghiu A, Tomescu MC. Independent predictors of in-hospital and 1-year mortality rates in octogenarians with acute myocardial infarction. Rev Cardiovasc Med. 2021;22(2):489\u201397.","journal-title":"Rev Cardiovasc Med"},{"issue":"14","key":"908_CR4","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1161\/CIRCULATIONAHA.113.004046","volume":"129","author":"AE Moran","year":"2014","unstructured":"Moran AE, Forouzanfar MH, Roth GA, Mensah GA, Ezzati M, Flaxman A, et al. The global burden of ischemic heart disease in 1990 and 2010: The global burden of disease 2010 study. Circulation. 2014;129(14):1493\u2013501.","journal-title":"Circulation"},{"issue":"1","key":"908_CR5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/2048872613514015","volume":"3","author":"T Raskovalova","year":"2014","unstructured":"Raskovalova T, Twerenbold R, Collinson PO, Keller T, Bouvaist H, Folli C, et al. Diagnostic accuracy of combined cardiac troponin and copeptin assessment for early rule-out of myocardial infarction: A systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care. 2014;3(1):18\u201327.","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"36","key":"908_CR6","doi-asserted-by":"publisher","first-page":"3786","DOI":"10.2174\/1381612827666210610114029","volume":"27","author":"D Macut","year":"2021","unstructured":"Macut D, Ognjanovic S, Asanin M, Krljanac G, Milenkovic T. Metabolic syndrome and myocardial infarction in women. Curr Pharm Des. 2021;27(36):3786\u201394.","journal-title":"Curr Pharm Des"},{"key":"908_CR7","doi-asserted-by":"crossref","unstructured":"Sun W, Gholizadeh L, Perry L, Kang K. Predicting return to work following myocardial infarction: A prospective longitudinal cohort study. Int J Environ Res Public Health. 2022;19(13).","DOI":"10.3390\/ijerph19138032"},{"issue":"1","key":"908_CR8","doi-asserted-by":"publisher","first-page":"710604678","DOI":"10.1177\/1559325820913786","volume":"18","author":"J Yang","year":"2020","unstructured":"Yang J, Yang XS, Zhang Q, Zhuang X, Dong XK, Jiang YH, et al. Downregulated LINC01614 ameliorates hypoxia\/reoxygenation-stimulated myocardial injury by directly sponging microRNA-138-5p. Dose Response. 2020;18(1):710604678.","journal-title":"Dose Response"},{"key":"908_CR9","doi-asserted-by":"crossref","unstructured":"Sharifi-Rad M, Fokou P, Sharopov F, Martorell M, Ademiluyi AO, Rajkovic J, et al. Antiulcer agents: From plant extracts to phytochemicals in healing promotion. Molecules. 2018;23(7).","DOI":"10.3390\/molecules23071751"},{"issue":"4","key":"908_CR10","doi-asserted-by":"publisher","first-page":"298","DOI":"10.2174\/138955711795305335","volume":"11","author":"JM Calderon-Montano","year":"2011","unstructured":"Calderon-Montano JM, Burgos-Moron E, Perez-Guerrero C, Lopez-Lazaro M. A review on the dietary flavonoid Kaempferol. Mini Rev Med Chem. 2011;11(4):298\u2013344.","journal-title":"Mini Rev Med Chem"},{"key":"908_CR11","doi-asserted-by":"crossref","unstructured":"Imran M, Salehi B, Sharifi-Rad J, Aslam GT, Saeed F, Imran A, et al. Kaempferol: A key emphasis to its anticancer potential. Molecules. 2019;24(12).","DOI":"10.3390\/molecules24122277"},{"issue":"4","key":"908_CR12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s12012-018-9443-5","volume":"18","author":"A Vishwakarma","year":"2018","unstructured":"Vishwakarma A, Singh TU, Rungsung S, Kumar T, Kandasamy A, Parida S, et al. Effect of Kaempferol pretreatment on myocardial injury in rats. Cardiovasc Toxicol. 2018;18(4):312\u201328.","journal-title":"Cardiovasc Toxicol"},{"key":"908_CR13","doi-asserted-by":"publisher","first-page":"481405","DOI":"10.1155\/2015\/481405","volume":"2015","author":"M Zhou","year":"2015","unstructured":"Zhou M, Ren H, Han J, Wang W, Zheng Q, Wang D. Protective effects of Kaempferol against myocardial ischemia\/reperfusion injury in isolated rat heart via antioxidant activity and inhibition of glycogen synthase Kinase-3beta. Oxid Med Cell Longev. 2015;2015:481405.","journal-title":"Oxid Med Cell Longev"},{"key":"908_CR14","doi-asserted-by":"crossref","unstructured":"Kamisah Y, Jalil J, Yunos NM, Zainalabidin S. Cardioprotective properties of Kaempferol: A review. Plants (Basel). 2023;12(11).","DOI":"10.3390\/plants12112096"},{"issue":"2","key":"908_CR15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","volume":"7","author":"T Bergsbaken","year":"2009","unstructured":"Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: Host cell death and inflammation. Nat Rev Microbiol. 2009;7(2):99\u2013109.","journal-title":"Nat Rev Microbiol"},{"issue":"9","key":"908_CR16","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1038\/cdd.2008.91","volume":"15","author":"K Labbe","year":"2008","unstructured":"Labbe K, Saleh M. Cell death in the host response to infection. Cell Death Differ. 2008;15(9):1339\u201349.","journal-title":"Cell Death Differ"},{"issue":"2","key":"908_CR17","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1177\/1753425913484374","volume":"20","author":"G Sollberger","year":"2014","unstructured":"Sollberger G, Strittmatter GE, Garstkiewicz M, Sand J, Beer HD. Caspase-1: The inflammasome and beyond. Innate Immun. 2014;20(2):115\u201325.","journal-title":"Innate Immun"},{"issue":"11","key":"908_CR18","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.it.2019.09.005","volume":"40","author":"Y Xue","year":"2019","unstructured":"Xue Y, Enosi TD, Tan WH, Kay C, Man SM. Emerging activators and regulators of inflammasomes and pyroptosis. Trends Immunol. 2019;40(11):1035\u201352.","journal-title":"Trends Immunol"},{"issue":"6","key":"908_CR19","doi-asserted-by":"publisher","first-page":"H1553","DOI":"10.1152\/ajpheart.00158.2018","volume":"315","author":"S Toldo","year":"2018","unstructured":"Toldo S, Mauro AG, Cutter Z, Abbate A. Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2018;315(6):H1553\u201368.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"908_CR20","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","volume":"15","author":"S Toldo","year":"2018","unstructured":"Toldo S, Abbate A. The NLRP3 inflammasome in acute myocardial infarction. Nat Rev Cardiol. 2018;15(4):203\u201314.","journal-title":"Nat Rev Cardiol"},{"issue":"10","key":"908_CR21","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41419-021-04143-3","volume":"12","author":"W Liu","year":"2021","unstructured":"Liu W, Shen J, Li Y, Wu J, Luo X, Yu Y, et al. Pyroptosis inhibition improves the symptom of acute myocardial infarction. Cell Death Dis. 2021;12(10):852.","journal-title":"Cell Death Dis"},{"key":"908_CR22","doi-asserted-by":"publisher","first-page":"614419","DOI":"10.3389\/fbioe.2020.614419","volume":"8","author":"S Chen","year":"2020","unstructured":"Chen S, Ma J, Yang L, Teng M, Lai ZQ, Chen X, et al. Anti-glioblastoma activity of Kaempferol via programmed cell death induction: Involvement of autophagy and pyroptosis. Front Bioeng Biotechnol. 2020;8:614419.","journal-title":"Front Bioeng Biotechnol"},{"key":"908_CR23","doi-asserted-by":"publisher","first-page":"105221","DOI":"10.1016\/j.neuint.2021.105221","volume":"152","author":"M Cai","year":"2022","unstructured":"Cai M, Zhuang W, Lv E, Liu Z, Wang Y, Zhang W, et al. Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson\u2019s disease via inhibiting p38MAPK\/NF-kappaB signaling pathway. Neurochem Int. 2022;152:105221.","journal-title":"Neurochem Int"},{"key":"908_CR24","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.freeradbiomed.2021.03.037","volume":"168","author":"Z Liu","year":"2021","unstructured":"Liu Z, Yao X, Sun B, Jiang W, Liao C, Dai X, et al. Pretreatment with Kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs-NF-kappaB signaling pathway and pyroptosis after secondary spinal cord injury. Free Radic Biol Med. 2021;168:142\u201354.","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"908_CR25","doi-asserted-by":"publisher","first-page":"e14305","DOI":"10.1111\/jfbc.14305","volume":"46","author":"F Hua","year":"2022","unstructured":"Hua F, Li JY, Zhang M, Zhou P, Wang L, Ling TJ, et al. Kaempferol-3-O-rutinoside exerts cardioprotective effects through NF-kappaB\/NLRP3\/Caspase-1 pathway in ventricular remodeling after acute myocardial infarction. J Food Biochem. 2022;46(10):e14305.","journal-title":"J Food Biochem"},{"key":"908_CR26","doi-asserted-by":"publisher","first-page":"823591","DOI":"10.3389\/fcvm.2022.823591","volume":"9","author":"M Ma","year":"2022","unstructured":"Ma M, Liang SC, Diao KY, Wang Q, He Y. Mitofilin mitigates myocardial damage in acute myocardial infarction by regulating pyroptosis of cardiomyocytes. Front Cardiovasc Med. 2022;9:823591.","journal-title":"Front Cardiovasc Med"},{"key":"908_CR27","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.3389\/fphar.2019.01635","volume":"10","author":"C Yang","year":"2019","unstructured":"Yang C, Yang W, He Z, He H, Yang X, Lu Y, et al. Kaempferol improves lung Ischemia-Reperfusion injury via antiinflammation and antioxidative stress regulated by SIRT1\/HMGB1\/NF-kappaB axis. Front Pharmacol. 2019;10:1635.","journal-title":"Front Pharmacol"},{"issue":"1","key":"908_CR28","doi-asserted-by":"publisher","first-page":"18455","DOI":"10.1038\/s41598-019-54963-9","volume":"9","author":"S Panda","year":"2019","unstructured":"Panda S, Pradhan N, Chatterjee S, Morla S, Saha A, Roy A, et al. 4,5-Disubstituted 1,2,3-triazoles: Effective inhibition of indoleamine 2,3-Dioxygenase 1 enzyme regulates T cell activity and mitigates tumor growth. Sci Rep. 2019;9(1):18455.","journal-title":"Sci Rep"},{"issue":"21","key":"908_CR29","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1056\/NEJMra1606915","volume":"376","author":"JL Anderson","year":"2017","unstructured":"Anderson JL, Morrow DA. Acute myocardial infarction. N Engl J Med. 2017;376(21):2053\u201364.","journal-title":"N Engl J Med"},{"issue":"4","key":"908_CR30","first-page":"e29","volume":"131","author":"D Mozaffarian","year":"2015","unstructured":"Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics\u20132015 update: A report from the American heart association. Circulation. 2015;131(4):e29\u2013322.","journal-title":"Circulation"},{"key":"908_CR31","doi-asserted-by":"publisher","first-page":"4973","DOI":"10.2147\/DDDT.S333372","volume":"15","author":"BH Zhang","year":"2021","unstructured":"Zhang BH, Liu H, Yuan Y, Weng XD, Du Y, Chen H, et al. Knockdown of TRIM8 protects HK-2 cells against hypoxia\/reoxygenation-induced injury by inhibiting oxidative stress-mediated apoptosis and pyroptosis via PI3K\/Akt signal pathway. Drug Des Devel Ther. 2021;15:4973\u201383.","journal-title":"Drug Des Devel Ther"},{"issue":"7","key":"908_CR32","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.cell.2016.11.047","volume":"167","author":"J Yuan","year":"2016","unstructured":"Yuan J, Najafov A, Py BF. Roles of caspases in necrotic cell death. Cell. 2016;167(7):1693\u2013704.","journal-title":"Cell"},{"issue":"6","key":"908_CR33","doi-asserted-by":"publisher","first-page":"375","DOI":"10.7555\/JBR.36.20220123","volume":"36","author":"NV Naryzhnaya","year":"2022","unstructured":"Naryzhnaya NV, Maslov LN, Popov SV, Mukhomezyanov AV, Ryabov VV, Kurbatov BK, et al. Pyroptosis is a drug target for prevention of adverse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy. J Biomed Res. 2022;36(6):375\u201389.","journal-title":"J Biomed Res"},{"key":"908_CR34","doi-asserted-by":"publisher","first-page":"8151836","DOI":"10.1155\/2019\/8151836","volume":"2019","author":"Z Qiu","year":"2019","unstructured":"Qiu Z, He Y, Ming H, Lei S, Leng Y, Xia ZY. Lipopolysaccharide (LPS) aggravates high glucose- and hypoxia\/reoxygenation-induced injury through activating ROS-Dependent NLRP3 inflammasome-mediated pyroptosis in H9C2 cardiomyocytes. J Diabetes Res. 2019;2019:8151836.","journal-title":"J Diabetes Res"},{"key":"908_CR35","doi-asserted-by":"publisher","first-page":"974896","DOI":"10.3389\/fnut.2022.974896","volume":"9","author":"X Huang","year":"2022","unstructured":"Huang X, Wang Y, Yang W, Dong J, Li L. Regulation of dietary polyphenols on cancer cell pyroptosis and the tumor immune microenvironment. Front Nutr. 2022;9:974896.","journal-title":"Front Nutr"},{"issue":"5","key":"908_CR36","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1080\/08923973.2019.1666405","volume":"41","author":"C He","year":"2019","unstructured":"He C, Yang J, Jiang X, Liang X, Yin L, Yin Z, et al. Kaempferol alleviates LPS-ATP mediated inflammatory injury in splenic lymphocytes via regulation of the pyroptosis pathway in mice. Immunopharmacol Immunotoxicol. 2019;41(5):538\u201348.","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"14","key":"908_CR37","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1042\/BCJ20170111","volume":"474","author":"NG Jayaprakash","year":"2017","unstructured":"Jayaprakash NG, Surolia A. Role of glycosylation in nucleating protein folding and stability. Biochem J. 2017;474(14):2333\u201347.","journal-title":"Biochem J"},{"issue":"7","key":"908_CR38","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/nrm.2017.22","volume":"18","author":"X Yang","year":"2017","unstructured":"Yang X, Qian K. Protein O-GlcNAcylation: Emerging mechanisms and functions. Nat Rev Mol Cell Biol. 2017;18(7):452\u201365.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"908_CR39","doi-asserted-by":"publisher","first-page":"1308692","DOI":"10.1155\/2017\/1308692","volume":"2017","author":"V Fisi","year":"2017","unstructured":"Fisi V, Miseta A, Nagy T. The role of stress-induced O-GlcNAc protein modification in the regulation of membrane transport. Oxid Med Cell Longev. 2017;2017:1308692.","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"908_CR40","doi-asserted-by":"publisher","first-page":"5937","DOI":"10.1111\/jcmm.15180","volume":"24","author":"CJ Zuurbier","year":"2020","unstructured":"Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, et al. Cardiac metabolism as a driver and therapeutic target of myocardial infarction. J Cell Mol Med. 2020;24(11):5937\u201354.","journal-title":"J Cell Mol Med"},{"issue":"3","key":"908_CR41","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.jacbts.2018.01.005","volume":"3","author":"D Wang","year":"2018","unstructured":"Wang D, Hu X, Lee SH, Chen F, Jiang K, Tu Z, et al. Diabetes exacerbates myocardial ischemia\/reperfusion injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation. JACC Basic Transl Sci. 2018;3(3):350\u201362.","journal-title":"JACC Basic Transl Sci"},{"issue":"8","key":"908_CR42","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1007\/s12033-023-00846-4","volume":"66","author":"H Yang","year":"2024","unstructured":"Yang H, Xiao L, Wu D, Zhang T, Ge P. O-GlcNAcylation of NLRP3 contributes to lipopolysaccharide-induced pyroptosis of human gingival fibroblasts. Mol Biotechnol. 2024;66(8):2023\u201331.","journal-title":"Mol Biotechnol"},{"issue":"10","key":"908_CR43","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1093\/jnen\/nlac055","volume":"81","author":"C She","year":"2022","unstructured":"She C, Zhu J, Liu A, Xu Y, Jiang Z, Peng Y. Dexmedetomidine inhibits NF-kappaB-Transcriptional activity in neurons undergoing ischemia-reperfusion by regulating O-GlcNAcylation of SNW1. J Neuropathol Exp Neurol. 2022;81(10):836\u201349.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"908_CR44","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"J Shi","year":"2017","unstructured":"Shi J, Gao W, Shao F, Pyroptosis. Gasdermin-Mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245\u201354.","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"908_CR45","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1161\/CIRCRESAHA.120.318629","volume":"129","author":"H Shi","year":"2021","unstructured":"Shi H, Gao Y, Dong Z, Yang J, Gao R, Li X, et al. GSDMD-mediated cardiomyocyte pyroptosis promotes myocardial I\/R injury. Circ Res. 2021;129(3):383\u201396.","journal-title":"Circ Res"},{"issue":"1","key":"908_CR46","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s10020-024-01048-7","volume":"30","author":"Y Li","year":"2024","unstructured":"Li Y, Wang X, Meng X, Xia C, Yang C, Wang J, et al. Aerobic exercise inhibits GSDME-dependent myocardial cell pyroptosis to protect ischemia-reperfusion injury. Mol Med. 2024;30(1):273.","journal-title":"Mol Med"},{"issue":"8","key":"908_CR47","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19(8):477\u201389.","journal-title":"Nat Rev Immunol"},{"issue":"312","key":"908_CR48","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1126\/stke.3122005re13","volume":"2005","author":"DC Love","year":"2005","unstructured":"Love DC, Hanover JA. The hexosamine signaling pathway: Deciphering the O-GlcNAc code. Sci STKE. 2005;2005(312):e13.","journal-title":"Sci STKE"},{"issue":"12","key":"908_CR49","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1016\/j.febslet.2010.04.044","volume":"584","author":"P Hu","year":"2010","unstructured":"Hu P, Shimoji S, Hart GW. Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation. FEBS Lett. 2010;584(12):2526\u201338.","journal-title":"FEBS Lett"},{"issue":"23","key":"908_CR50","doi-asserted-by":"publisher","first-page":"12003","DOI":"10.1074\/jbc.M116.728717","volume":"291","author":"PS Kakade","year":"2016","unstructured":"Kakade PS, Budnar S, Kalraiya RD, Vaidya MM. Functional implications of O-GlcNAcylation-dependent phosphorylation at a proximal site on keratin 18. J Biol Chem. 2016;291(23):12003\u201313.","journal-title":"J Biol Chem"},{"issue":"12","key":"908_CR51","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/s41422-023-00848-6","volume":"33","author":"YL Ai","year":"2023","unstructured":"Ai YL, Wang WJ, Liu FJ, Fang W, Chen HZ, Wu LZ, et al. Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P. Cell Res. 2023;33(12):904\u201322.","journal-title":"Cell Res"},{"issue":"Pt 2","key":"908_CR52","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1113\/jphysiol.1994.sp020252","volume":"478","author":"R Mejia-Alvarez","year":"1994","unstructured":"Mejia-Alvarez R, Tomaselli GF, Marban E. Simultaneous expression of cardiac and skeletal muscle isoforms of the L-type Ca2\u2009+\u2009channel in a rat heart muscle cell line. J Physiol. 1994;478(Pt 2):315\u201329.","journal-title":"J Physiol"}],"container-title":["BMC Pharmacology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-025-00908-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40360-025-00908-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-025-00908-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T17:21:51Z","timestamp":1744219311000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpharmacoltoxicol.biomedcentral.com\/articles\/10.1186\/s40360-025-00908-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,8]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["908"],"URL":"https:\/\/doi.org\/10.1186\/s40360-025-00908-0","relation":{},"ISSN":["2050-6511"],"issn-type":[{"value":"2050-6511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,8]]},"assertion":[{"value":"26 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Huzhou Third Municipal Hospital. All animal experiments should comply with the ARRIVE guidelines. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"76"}}