{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:19:54Z","timestamp":1790997594536,"version":"4.1.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Youth Fund of Southwest Medical University","award":["2017-ZRQN-007"],"award-info":[{"award-number":["2017-ZRQN-007"]}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["No.15197"],"award-info":[{"award-number":["No.15197"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Doctoral Research Initiation Fund of Affiliated Hospital of Southwest Medical University","award":["No.19078"],"award-info":[{"award-number":["No.19078"]}]},{"name":"Science and Technology Strategic Cooperation Programs of Luzhou Municipal People's Government and Southwest Medical University","award":["No.2024LZXNYDJ048"],"award-info":[{"award-number":["No.2024LZXNYDJ048"]}]},{"name":"Strategic Cooperation Program of Southwest Medical University","award":["No. 2024SNXNYD04"],"award-info":[{"award-number":["No. 2024SNXNYD04"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pharmacol Toxicol"],"DOI":"10.1186\/s40360-025-01033-8","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:33:21Z","timestamp":1764329601000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the impact of endocrine-disrupting chemicals on erectile dysfunction through network toxicology and machine learning"],"prefix":"10.1186","volume":"26","author":[{"given":"Zhiyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"1033_CR1","doi-asserted-by":"publisher","unstructured":"Olowosoke CB, et al. Integrative study of phytochemicals for anti-fibroid agent: a perspective on protein networks, molecular docking, ADMET, simulation, DFT and bioactivity. Chem Phys Impact. 2024\/06\/01;8:100412. https:\/\/doi.org\/10.1016\/j.chphi.2023.100412.","DOI":"10.1016\/j.chphi.2023.100412"},{"key":"1033_CR2","doi-asserted-by":"publisher","unstructured":"Olowosoke CB, et al. Deciphering the in silico molecular mechanism of coumestrol activity for uterine fibroids remedy: a promising estrogenic target drug candidate, (in eng). J Biomol Struct Dyn. 2025 Apr 17;1\u201326. https:\/\/doi.org\/10.1080\/07391102.2025.2487191.","DOI":"10.1080\/07391102.2025.2487191"},{"key":"1033_CR3","doi-asserted-by":"publisher","unstructured":"Zheng X, et al. Global burden of polycystic ovary syndrome in women of reproductive age, 1990\u20132021: analysis of the global burden of disease study 2021 with projections to 2050, (in eng). PLoS One. 2025;20(10):e0333000. https:\/\/doi.org\/10.1371\/journal.pone.0333000.","DOI":"10.1371\/journal.pone.0333000"},{"issue":"1","key":"1033_CR4","doi-asserted-by":"publisher","first-page":"vbaf132","DOI":"10.1093\/bioadv\/vbaf132","volume":"5","author":"V Omoboyede","year":"2025","unstructured":"Omoboyede V, et al. Pharmacological assessment of coffea Arabica compounds as potential therapeutics for cervical cancer, (in eng). Bioinform Adv. 2025;5(1):vbaf132. https:\/\/doi.org\/10.1093\/bioadv\/vbaf132.","journal-title":"Bioinform Adv"},{"key":"1033_CR5","doi-asserted-by":"publisher","unstructured":"Rawla P. Epidemiology of prostate cancer, (in eng). World J Oncol. 2019 Apr;10(2):63\u201389. https:\/\/doi.org\/10.14740\/wjon1191.","DOI":"10.14740\/wjon1191"},{"key":"1033_CR6","doi-asserted-by":"publisher","unstructured":"Singla N, Bagrodia A, Baraban E, Fankhauser CD, Ged YMA. Testicular germ cell tumors: a review, (in eng). JAMA. 2025 Mar 4;333(9);793\u2013803. https:\/\/doi.org\/10.1001\/jama.2024.27122.","DOI":"10.1001\/jama.2024.27122"},{"key":"1033_CR7","doi-asserted-by":"publisher","unstructured":"Fu X, et al. Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches, (in eng). 2025;12:1519095. https:\/\/doi.org\/10.3389\/fmed.2025.1519095.","DOI":"10.3389\/fmed.2025.1519095"},{"key":"1033_CR8","doi-asserted-by":"publisher","unstructured":"An J, Xiang B, Peng J, Li D. Understanding the erectile dysfunction-cardiovascular disease connection: clinical and pathophysiological insights, (in eng). Sex Med Rev. 2025 Mar;28. https:\/\/doi.org\/10.1093\/sxmrev\/qeaf014.","DOI":"10.1093\/sxmrev\/qeaf014"},{"key":"1033_CR9","doi-asserted-by":"publisher","unstructured":"Deng W, Cao H, Sun T, Yuan P. Exploring the role of glycolysis in the pathogenesis of erectile dysfunction in diabetes, (in eng). Transl Androl Urol. 2025 Mar 30;14(3):791\u2013807. https:\/\/doi.org\/10.21037\/tau-2025-6.","DOI":"10.21037\/tau-2025-6"},{"issue":"7","key":"1033_CR10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/jcm14072225","volume":"14","author":"D Tulb\u0103","year":"2025","unstructured":"Tulb\u0103 D, et al. Cardiovascular dysautonomia in patients with parkinson\u2019s disease and hypertension: a cross-sectional pilot study, (in eng). J Clin Med. 2025;14(7):25. https:\/\/doi.org\/10.3390\/jcm14072225.","journal-title":"J Clin Med"},{"key":"1033_CR11","doi-asserted-by":"publisher","unstructured":"Shamloul R, Ghanem H. Erectile dysfunction, (in eng). Lancet. 2013 Jan 12;381(9861):153\u2009\u2013\u200965. https:\/\/doi.org\/10.1016\/s0140-6736(12)60520-0.","DOI":"10.1016\/s0140-6736(12)60520-0"},{"issue":"1","key":"1033_CR12","doi-asserted-by":"publisher","first-page":"vbaf132","DOI":"10.1093\/bioadv\/vbaf132","volume":"5","author":"V Omoboyede","year":"2025","unstructured":"Omoboyede V, et al. Pharmacological assessment of coffea Arabica compounds as potential therapeutics for cervical cancer. Bioinf Adv. 2025;5(1):vbaf132. https:\/\/doi.org\/10.1093\/bioadv\/vbaf132.","journal-title":"Bioinf Adv"},{"key":"1033_CR13","doi-asserted-by":"publisher","unstructured":"Xiao Y, Han D, Currell M, Song X, Zhang Y. Review of endocrine disrupting compounds (EDCs) in China\u2019s water environments: implications for environmental fate, transport and health risks, (in eng). Water Res. 2023 Oct 15;245:120645. https:\/\/doi.org\/10.1016\/j.watres.2023.120645.","DOI":"10.1016\/j.watres.2023.120645"},{"key":"1033_CR14","doi-asserted-by":"publisher","unstructured":"Woodruff TJ. Health effects of fossil fuel-derived endocrine disruptors, (in eng). N Engl J Med. 2024 Mar 7;390(10):922\u201333. https:\/\/doi.org\/10.1056\/NEJMra2300476.","DOI":"10.1056\/NEJMra2300476"},{"key":"1033_CR15","doi-asserted-by":"publisher","unstructured":"Zhang Y, et al. Paternal exposures to endocrine-disrupting chemicals induce intergenerational epigenetic influences on offspring: a review, (in eng). Environ Int. 2024 May:187:108689. https:\/\/doi.org\/10.1016\/j.envint.2024.108689.","DOI":"10.1016\/j.envint.2024.108689"},{"key":"1033_CR16","doi-asserted-by":"publisher","unstructured":"Liu M, Hu C, Li J, Zhou B, Lam PKS, Chen L. Thyroid endocrine disruption and mechanism of the marine antifouling pollutant 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one, (in eng). Environ Sci Technol. 2024 Oct 29;58(43):19189\u201319198. https:\/\/doi.org\/10.1021\/acs.est.4c07614.","DOI":"10.1021\/acs.est.4c07614"},{"key":"1033_CR17","doi-asserted-by":"publisher","first-page":"104702","DOI":"10.1016\/j.etap.2025.104702","volume":"18","author":"R Penalba","year":"2025","unstructured":"Penalba R, Gamez JM, Cardoso N, Bilbao RM, Ponzo OJ, Reynoso R. Effect of bisphenol A on the neuro-immune-endocrine mechanisms controlling the reproductive axis response during an inflammatory event, (in eng). Environ Toxicol Pharmacol. Apr 2025;18:104702. https:\/\/doi.org\/10.1016\/j.etap.2025.104702.","journal-title":"Environ Toxicol Pharmacol"},{"key":"1033_CR18","doi-asserted-by":"publisher","unstructured":"Caporale N, et al. From cohorts to molecules: adverse impacts of endocrine disrupting mixtures. (in eng). Science. 2022 Feb 18;375(6582):eabe8244. https:\/\/doi.org\/10.1126\/science.abe8244.","DOI":"10.1126\/science.abe8244"},{"key":"1033_CR19","doi-asserted-by":"publisher","unstructured":"Chen Y, et al. Association between trimester-specific exposure to thirteen endocrine disrupting chemicals and preterm birth: comparison of three statistical models, (in eng). Sci Total Environ. 2022 Dec 10;851(2):158236. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.158236.","DOI":"10.1016\/j.scitotenv.2022.158236"},{"key":"1033_CR20","doi-asserted-by":"publisher","unstructured":"He W, et al. G protein-coupled estrogen receptor activation by bisphenol-A disrupts lipid metabolism and induces ferroptosis in the liver, (in eng). Environ Pollut. 2023 Oct 1;334:122211. https:\/\/doi.org\/10.1016\/j.envpol.2023.122211.","DOI":"10.1016\/j.envpol.2023.122211"},{"key":"1033_CR21","doi-asserted-by":"publisher","unstructured":"Cripps SM, Mattiske DM, Pask AJ. Erectile dysfunction in men on the rise: is there a link with endocrine disrupting chemicals? (in eng). Sex Dev. 2021;15(1\u20133):187\u2013212. https:\/\/doi.org\/10.1159\/000516600.","DOI":"10.1159\/000516600"},{"key":"1033_CR22","doi-asserted-by":"publisher","unstructured":"Cripps SM, Marshall SA, Mattiske DM, Ingham RY, Pask AJ. Estrogenic endocrine disruptor exposure directly impacts erectile function, (in eng). Commun Biol. 2024 Apr 2;7(1):403. https:\/\/doi.org\/10.1038\/s42003-024-06048-1.","DOI":"10.1038\/s42003-024-06048-1"},{"key":"1033_CR23","doi-asserted-by":"publisher","unstructured":"Zhang Q, et al. A comprehensive evaluation of the endocrine-disrupting effects of emerging organophosphate esters, (in eng). Environ Int. 2024 Nov;193:109120. https:\/\/doi.org\/10.1016\/j.envint.2024.109120.","DOI":"10.1016\/j.envint.2024.109120"},{"key":"1033_CR24","doi-asserted-by":"publisher","unstructured":"Annunzi E, et al. In vitro exposure to the endocrine-disrupting chemical climbazole impairs human sperm motility, hormonal signalling, and mitochondrial activity, (in eng). Cells. 2025 Mar 13;14(6). https:\/\/doi.org\/10.3390\/cells14060427.","DOI":"10.3390\/cells14060427"},{"key":"1033_CR25","doi-asserted-by":"publisher","unstructured":"Li X, et al. Association of Di(2-ethylhexyl) phthalate exposure with reproductive hormones in the general population and the susceptible population: a systematic review and meta-analysis, (in eng). Environ Health (Wash). 2024 Nov 15;2(11):750\u2013765. https:\/\/doi.org\/10.1021\/envhealth.4c00046.","DOI":"10.1021\/envhealth.4c00046"},{"key":"1033_CR26","doi-asserted-by":"publisher","unstructured":"Li X, Ye X, Xu L, Chen H. Association between endocrine disrupting chemicals exposure and diabetic kidney disease in adults: a national cross-sectional NHANES study, (in eng). Ecotoxicol Environ Saf. 2025 Mar 15;293:118044. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118044.","DOI":"10.1016\/j.ecoenv.2025.118044"},{"key":"1033_CR27","doi-asserted-by":"publisher","unstructured":"Chen W, et al. Dichloroacetic acid and trichloroacetic acid as disinfection by-products in drinking water are endocrine-disrupting chemicals, (in eng). J Hazard Mater. 2024 Mar 15;466:133035. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.133035.","DOI":"10.1016\/j.jhazmat.2023.133035"},{"key":"1033_CR28","doi-asserted-by":"publisher","unstructured":"Wang Z, Wang J, Fu Q, Zhao H, Wang Z, Gao Y. Efficient evaluation of osteotoxicity and mechanisms of endocrine disrupting chemicals using network toxicology and molecular docking approaches: triclosan as a model compound. (in eng) Ecotoxicol Environ Saf. 2025 Mar 15;293:118030. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118030.","DOI":"10.1016\/j.ecoenv.2025.118030"},{"key":"1033_CR29","doi-asserted-by":"publisher","first-page":"1378444","DOI":"10.3389\/fpubh.2024.1378444","volume":"12","author":"S Han","year":"2024","unstructured":"Han S, Xie M, Cheng S, Han Y, Li P, Guo J. Associations between specific volatile organic chemical exposures and cardiovascular disease risks: insights from NHANES, (in eng). Front Public Health. 2024;12:1378444. https:\/\/doi.org\/10.3389\/fpubh.2024.1378444.","journal-title":"Front Public Health"},{"key":"1033_CR30","doi-asserted-by":"publisher","unstructured":"Ndiaye D, Perceau M, Lorcin M, Denis F, Gat\u00e9 L. Antifungal Climbazole alters androgenic pathways in mammalian cells, (in eng). Toxicol Vitro. Aug 2024;99:105854. https:\/\/doi.org\/10.1016\/j.tiv.2024.105854.","DOI":"10.1016\/j.tiv.2024.105854"},{"key":"1033_CR31","doi-asserted-by":"publisher","unstructured":"Wang Y, Jiang R. Androgens and erectile dysfunction: from androgen deficiency to treatment, (in eng). Sex Med Rev. 2024 Jun 26;12(3):458\u201368. https:\/\/doi.org\/10.1093\/sxmrev\/qeae030.","DOI":"10.1093\/sxmrev\/qeae030"},{"key":"1033_CR32","doi-asserted-by":"publisher","unstructured":"Kataoka T, et al. Effect of high testosterone levels on endothelial function in aorta and erectile function in rats, (in eng). Sex Med. 2022 Oct;10(5):100550. https:\/\/doi.org\/10.1016\/j.esxm.2022.100550.","DOI":"10.1016\/j.esxm.2022.100550"},{"key":"1033_CR33","doi-asserted-by":"publisher","unstructured":"Xi Y, et al. Caveolin-1 scaffolding domain-derived peptide enhances erectile function by regulating oxidative stress, mitochondrial dysfunction, and apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury. (in eng) Life Sci. 2024 Jul 1;348:122694. https:\/\/doi.org\/10.1016\/j.lfs.2024.122694.","DOI":"10.1016\/j.lfs.2024.122694"},{"key":"1033_CR34","doi-asserted-by":"publisher","unstructured":"Deng CJ, Li X, Zeng Y, Jiang J, Jiang R. Icariin inhibits the formation of mitochondria-associated membranes (MAMs) and improves erectile function in rats treated with prostate radiation, (in eng). Andrology. 2022 Sep;10(6):1208\u20131216. https:\/\/doi.org\/10.1111\/andr.13218.","DOI":"10.1111\/andr.13218"},{"key":"1033_CR35","doi-asserted-by":"publisher","first-page":"1335239","DOI":"10.3389\/frph.2024.1335239","volume":"6","author":"K Liang","year":"2024","unstructured":"Liang K, Ke Z, Huang J, Fei X, Qi L, Wang J. Analysis of vacuum negative pressure therapy and traditional Chinese medicine lavage in combination with Tadalafil for vascular erectile dysfunction, (in eng). Front Reprod Health. 2024;6:1335239. https:\/\/doi.org\/10.3389\/frph.2024.1335239.","journal-title":"Front Reprod Health"},{"key":"1033_CR36","doi-asserted-by":"publisher","unstructured":"Wei W, Pu S, Yan C, Yang H, Chen H. Exploring the mechanisms of lithium neurotoxicity based on network toxicology and molecular docking, (in eng). Ecotoxicol Environ Saf. 2025 Feb 20;292:117911. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117911.","DOI":"10.1016\/j.ecoenv.2025.117911"},{"key":"1033_CR37","doi-asserted-by":"publisher","unstructured":"Sahoo K, Sundararajan V. IL-1\u03b2 and associated molecules as prognostic biomarkers linked with immune cell infiltration in colorectal cancer: an integrated statistical and machine learning approach, (in eng). Discov Oncol. 2025 Feb 28;16(1):252. https:\/\/doi.org\/10.1007\/s12672-025-01989-3.","DOI":"10.1007\/s12672-025-01989-3"},{"key":"1033_CR38","doi-asserted-by":"publisher","unstructured":"Huang Y, et al. Development and validation of a kinase-related gene signature as a novel diagnostic and prognostic model for prostate cancer, (in eng). Biochim Biophys Acta Mol Basis Dis. 2025 Feb 17;1871(4):167722. https:\/\/doi.org\/10.1016\/j.bbadis.2025.167722.","DOI":"10.1016\/j.bbadis.2025.167722"},{"key":"1033_CR39","doi-asserted-by":"publisher","unstructured":"Kim S, et al. PubChem in 2021: new data content and improved web interfaces, (in eng). Nucleic Acids Res. 2021 Jan 8;49(D1):D1388-d1395. https:\/\/doi.org\/10.1093\/nar\/gkaa971.","DOI":"10.1093\/nar\/gkaa971"},{"key":"1033_CR40","doi-asserted-by":"publisher","unstructured":"Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry, (in eng). Nat Biotechnol. 2007 Feb;25(2):197\u2013206. https:\/\/doi.org\/10.1038\/nbt1284.","DOI":"10.1038\/nbt1284"},{"key":"1033_CR41","doi-asserted-by":"publisher","unstructured":"Wu T, et al. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data, (in eng). Innovation (Camb). 2021 Aug 28;2(3):100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141.","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"1033_CR42","doi-asserted-by":"publisher","unstructured":"Gu Z, Gu L, Eils R, Schlesner M, Brors B. Circlize implements and enhances circular visualization in R, (in eng). Bioinformatics. 2014 Oct;30(19):2811-2. https:\/\/doi.org\/10.1093\/bioinformatics\/btu393.","DOI":"10.1093\/bioinformatics\/btu393"},{"key":"1033_CR43","doi-asserted-by":"publisher","unstructured":"Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks, (in eng). Genome Res. 2003 Nov;13(11):2498\u2009\u2013\u2009504. https:\/\/doi.org\/10.1101\/gr.1239303.","DOI":"10.1101\/gr.1239303"},{"key":"1033_CR44","doi-asserted-by":"publisher","unstructured":"Bader GD, Hogue CW. An automated method for finding molecular complexes in large protein interaction networks. (in eng) BMC Bioinformatics. 2003 Jan 13;4(2). https:\/\/doi.org\/10.1186\/1471-2105-4-2.","DOI":"10.1186\/1471-2105-4-2"},{"key":"1033_CR45","doi-asserted-by":"publisher","unstructured":"Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY. CytoHubba: identifying hub objects and sub-networks from complex interactome, (in eng). BMC Syst Biol. 2014;8 Suppl 4, no. Suppl 4;S11. https:\/\/doi.org\/10.1186\/1752-0509-8-s4-s11.","DOI":"10.1186\/1752-0509-8-s4-s11"},{"key":"1033_CR46","doi-asserted-by":"publisher","unstructured":"Chen J, Ye W. Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification, (in eng). Pharm Biol. 2024 Dec;62(1):296\u2013313. https:\/\/doi.org\/10.1080\/13880209.2024.2330609.","DOI":"10.1080\/13880209.2024.2330609"},{"key":"1033_CR47","doi-asserted-by":"publisher","unstructured":"Yao Z, S100A. Neutrophil infiltration characterized by upregulation of S100A8, 9, S100A12 and CXCR2 is associated with the co-occurrence of crohn\u2019s disease and peripheral artery disease, (in eng). Front Immunol. 2022;13:896645. https:\/\/doi.org\/10.3389\/fimmu.2022.896645.","DOI":"10.3389\/fimmu.2022.896645"},{"key":"1033_CR48","doi-asserted-by":"publisher","unstructured":"Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species, (in eng). Nat Biotechnol. 2018 Jun;36(5):411\u2013420. https:\/\/doi.org\/10.1038\/nbt.4096.","DOI":"10.1038\/nbt.4096"},{"key":"1033_CR49","doi-asserted-by":"publisher","unstructured":"Chen Z, et al. Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI, (in eng). Cell Death Dis. 2023 May 11;14(5):318. https:\/\/doi.org\/10.1038\/s41419-023-05830-z.","DOI":"10.1038\/s41419-023-05830-z"},{"key":"1033_CR50","doi-asserted-by":"publisher","unstructured":"Liu C, Liu J, Yang Y. Bulk and single-cell transcriptomic reveals shared key genes and patterns of immune dysregulation in both intestinal inflammatory disease and Sepsis, (in eng). J Cell Mol Med. Feb 2025;29(4):e70415. https:\/\/doi.org\/10.1111\/jcmm.70415.","DOI":"10.1111\/jcmm.70415"},{"key":"1033_CR51","doi-asserted-by":"publisher","unstructured":"Yang Y, et al. Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes, (in eng). Cell. 2024 Aug 22;187(17):4790\u20134811.e22. https:\/\/doi.org\/10.1016\/j.cell.2024.06.038.","DOI":"10.1016\/j.cell.2024.06.038"},{"key":"1033_CR52","doi-asserted-by":"publisher","unstructured":"Yang Y, et al. Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma, (in eng). Cell Biosci. 2024 Dec 20;14(1):151. https:\/\/doi.org\/10.1186\/s13578-024-01332-3.","DOI":"10.1186\/s13578-024-01332-3"},{"key":"1033_CR53","doi-asserted-by":"publisher","unstructured":"Tang D, et al. SRplot: A free online platform for data visualization and graphing, (in eng). PLoS One. 2023;18(11):e0294236. https:\/\/doi.org\/10.1371\/journal.pone.0294236.","DOI":"10.1371\/journal.pone.0294236"},{"key":"1033_CR54","doi-asserted-by":"publisher","unstructured":"Keskesiadou GN, et al. Endocrine-disrupting chemicals and the development of diabetes mellitus type 1: a 5-year systematic review, (in eng). Int J Mol Sci. 2024 Sep 20;25(18). https:\/\/doi.org\/10.3390\/ijms251810111.","DOI":"10.3390\/ijms251810111"},{"key":"1033_CR55","doi-asserted-by":"publisher","unstructured":"Avecilla V, et al. Integrative Bioinformatics-Gene network approach reveals linkage between estrogenic endocrine disruptors and vascular remodeling in peripheral arterial disease, (in eng). Int J Mol Sci. 2024 Apr 19;25(8). https:\/\/doi.org\/10.3390\/ijms25084502.","DOI":"10.3390\/ijms25084502"},{"key":"1033_CR56","doi-asserted-by":"publisher","unstructured":"Xiong Y, et al. Insights into modifiable risk factors of erectile dysfunction, a wide-angled Mendelian randomization study, (in eng). J Adv Res. 2024 Apr;58:149\u201361. https:\/\/doi.org\/10.1016\/j.jare.2023.05.008.","DOI":"10.1016\/j.jare.2023.05.008"},{"key":"1033_CR57","doi-asserted-by":"publisher","unstructured":"Luo Z, et al. Hypoxia signaling in human health and diseases: implications and prospects for therapeutics, (in eng). Signal Transduct Target Ther. 2022 Jul 7;7(1):218. https:\/\/doi.org\/10.1038\/s41392-022-01080-1.","DOI":"10.1038\/s41392-022-01080-1"},{"key":"1033_CR58","doi-asserted-by":"publisher","unstructured":"Xiao M, et al. Yes-associated protein promotes endothelial-mesenchymal transition to mediate diabetes mellitus erectile dysfunction by phosphorylating Smad3, (in eng). World J Mens Health. 2024 Oct;30. https:\/\/doi.org\/10.5534\/wjmh.240126.","DOI":"10.5534\/wjmh.240126"},{"key":"1033_CR59","doi-asserted-by":"publisher","unstructured":"Wang N, Jiang Q, Xie L, Cheng B, Liu QW, Jiang R. Methylation of eNOS in the rat penile corpus cavernosum under different pathological states and its relationship with erectile function, (in eng). Andrology. 2024 Jan;12(1):222\u2013230. https:\/\/doi.org\/10.1111\/andr.13465.","DOI":"10.1111\/andr.13465"},{"key":"1033_CR60","doi-asserted-by":"publisher","unstructured":"Zhou W, Jiang J, Jiang R. A low androgenic state inhibits erectile function by suppressing endothelial glycosides in the penile cavernous tissue of rats, (in eng). Sex Med. 2024 Jun;12(3):qfae039. https:\/\/doi.org\/10.1093\/sexmed\/qfae039.","DOI":"10.1093\/sexmed\/qfae039"},{"key":"1033_CR61","doi-asserted-by":"publisher","unstructured":"Yang HZ, Xiong WJ, Li X, Jiang J, Jiang R. Low androgen status inhibits erectile function by upregulating the expression of proteins of mitochondria-associated membranes in rat corpus cavernosum, (in eng). Andrology. 2022 Jul;10(5):997\u20131007. https:\/\/doi.org\/10.1111\/andr.13188.","DOI":"10.1111\/andr.13188"},{"key":"1033_CR62","doi-asserted-by":"publisher","unstructured":"Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes, (in eng). Lancet. 2017 Jun 3;389(10085):2239\u20132251. https:\/\/doi.org\/10.1016\/s0140-6736(17)30058-2.","DOI":"10.1016\/s0140-6736(17)30058-2"},{"key":"1033_CR63","doi-asserted-by":"publisher","unstructured":"Zhang J, et al. The role of programmed cell death in diabetes mellitus-induced erectile dysfunction: from mechanisms to targeted therapy, (in eng). Reprod Biol Endocrinol. 2025 Mar 3;23(1):32. https:\/\/doi.org\/10.1186\/s12958-025-01368-1.","DOI":"10.1186\/s12958-025-01368-1"},{"key":"1033_CR64","doi-asserted-by":"publisher","unstructured":"Xu W, et al. GPX4 alleviates diabetes mellitus-induced erectile dysfunction by inhibiting ferroptosis, (in eng). Antioxidants (Basel) 2022 Sep 25;11(10). https:\/\/doi.org\/10.3390\/antiox11101896.","DOI":"10.3390\/antiox11101896"},{"key":"1033_CR65","doi-asserted-by":"publisher","unstructured":"Miyata Y, Matsuo T, Nakamura Y, Mitsunari K, Ohba K, Sakai H. Pathological significance of macrophages in erectile dysfunction including peyronie\u2019s disease, (in eng). Biomedicines. 2021 Nov 10;9(11). https:\/\/doi.org\/10.3390\/biomedicines9111658.","DOI":"10.3390\/biomedicines9111658"},{"key":"1033_CR66","doi-asserted-by":"publisher","unstructured":"Xiao W, et al. Branched-chain \u03b1-ketoacids aerobically activate HIF1\u03b1 signalling in vascular cells, (in eng). Nat Metab. 2024 Nov;6(11):2138\u20132156. https:\/\/doi.org\/10.1038\/s42255-024-01150-4.","DOI":"10.1038\/s42255-024-01150-4"},{"key":"1033_CR67","doi-asserted-by":"publisher","unstructured":"Zhu S, et al. Vitamin D3 improved erectile function recovery by regulating autophagy and apoptosis in a rat model of cavernous nerve injury, (in eng). Int J Impot Res. 2024 Jun;36(4):430\u20136. https:\/\/doi.org\/10.1038\/s41443-023-00679-4.","DOI":"10.1038\/s41443-023-00679-4"},{"key":"1033_CR68","doi-asserted-by":"publisher","unstructured":"Lee CH, et al. Chronic administration of udenafil, a selective phosphodiesterase type 5 inhibitor, promotes erectile function recovery in an animal model of bilateral cavernous nerve crush injury, (in eng). J Sex Med. 2011 May;8(5):1330-40. https:\/\/doi.org\/10.1111\/j.1743-6109.2011.02228.x.","DOI":"10.1111\/j.1743-6109.2011.02228.x"},{"key":"1033_CR69","doi-asserted-by":"publisher","unstructured":"Han M, et al. Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis, (in eng). Nat Genet. 2023 Apr;55(4):665\u2013678. https:\/\/doi.org\/10.1038\/s41588-023-01337-7.","DOI":"10.1038\/s41588-023-01337-7"},{"key":"1033_CR70","doi-asserted-by":"publisher","unstructured":"Sun J, et al. LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation, (in eng). Acta Pharm Sin B. 2022 Sep;12(9):3602\u201317. https:\/\/doi.org\/10.1016\/j.apsb.2022.04.006.","DOI":"10.1016\/j.apsb.2022.04.006"},{"key":"1033_CR71","doi-asserted-by":"publisher","unstructured":"Zhang X, Zhao F, Zhao JF, Fu HY, Huang XJ, Lv BD. PDGF-mediated PI3K\/AKT\/\u03b2-catenin signaling regulates gap junctions in corpus cavernosum smooth muscle cells, (in eng). Exp Cell Res. 2018 Jan 15;362(2):252\u20139. https:\/\/doi.org\/10.1016\/j.yexcr.2017.11.025.","DOI":"10.1016\/j.yexcr.2017.11.025"},{"key":"1033_CR72","doi-asserted-by":"publisher","unstructured":"Mitsui Y, et al. Molecular mechanisms and risk factors related to the pathogenesis of peyronie\u2019s disease, (in eng). Int J Mol Sci. 2023 Jun 14;24(12). https:\/\/doi.org\/10.3390\/ijms241210133.","DOI":"10.3390\/ijms241210133"}],"container-title":["BMC Pharmacology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-025-01033-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40360-025-01033-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-025-01033-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:33:22Z","timestamp":1764329602000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpharmacoltoxicol.biomedcentral.com\/articles\/10.1186\/s40360-025-01033-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1033"],"URL":"https:\/\/doi.org\/10.1186\/s40360-025-01033-8","relation":{},"ISSN":["2050-6511"],"issn-type":[{"value":"2050-6511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"12 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study does not involve human or animal subjects. All data used in this study are publicly accessible from authorized datasets, and no ethical approval or consent to participate is required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"203"}}