{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:13:30Z","timestamp":1788398010336,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":73,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pharmacol Toxicol"],"DOI":"10.1186\/s40360-026-01176-2","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:26:23Z","timestamp":1782138383000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregabalin enhances the proliferative potential of pancreatic cancer in vitro but not in mice with pancreatic cancer"],"prefix":"10.1186","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9679-9395","authenticated-orcid":false,"given":"Tomoaki","family":"Itaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichie","family":"Kajiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukino","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Kuramochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsuk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Kitajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Ijichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"1176_CR1","volume-title":"Cancer pain: assessment, diagnosis, and management","author":"DR Fitzgibbon","year":"2010","unstructured":"Fitzgibbon DR, Loese JD. Cancer pain: assessment, diagnosis, and management. Philadelphia: Lippincott Williams & Wilkins\/Wolters Kluwer Health, Inc; 2010."},{"issue":"17","key":"1176_CR2","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1080\/14656566.2021.1958780","volume":"22","author":"J Kato","year":"2021","unstructured":"Kato J, Inoue T, Yokoyama M, Kuroha M. A review of a new voltage-gated Ca 2+ channel \u03b1 2 \u03b4 ligand, mirogabalin, for the treatment of peripheral neuropathic pain. Expert Opin Pharmacother. 2021;22(17):2311\u201322. https:\/\/doi.org\/10.1080\/14656566.2021.1958780.","journal-title":"Expert Opin Pharmacother"},{"issue":"1","key":"1176_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3344\/kjp.2021.34.1.4","volume":"34","author":"JY Kim","year":"2021","unstructured":"Kim JY, Abdi S, Huh B, Kim K-H. Mirogabalin: Could it be the next generation gabapentin or pregabalin? The Korean J Pain. 2021;34(1):4\u201318. https:\/\/doi.org\/10.3344\/kjp.2021.34.1.4.","journal-title":"The Korean J Pain"},{"issue":"1","key":"1176_CR4","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1186\/s12885-021-09069-9","volume":"21","author":"M Sugimoto","year":"2021","unstructured":"Sugimoto M, Takagi T, Suzuki R, Konno N, Asama H, Sato Y, et al. Mirogabalin vs pregabalin for chemotherapy-induced peripheral neuropathy in pancreatic cancer patients. BMC Cancer. 2021;21(1):1319. https:\/\/doi.org\/10.1186\/s12885-021-09069-9.","journal-title":"BMC Cancer"},{"issue":"7","key":"1176_CR5","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1097\/j.pain.0000000000002852","volume":"164","author":"T Itaya","year":"2023","unstructured":"Itaya T, Sano M, Kajiwara I, Oshima Y, Kuramochi T, Kim J, et al. Mirogabalin improves cancer-associated pain but increases the risk of malignancy in mice with pancreatic cancer. Pain. 2023;164(7):1545\u201354. https:\/\/doi.org\/10.1097\/j.pain.0000000000002852.","journal-title":"Pain"},{"issue":"4","key":"1176_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s40265-019-01070-8","volume":"79","author":"ED Deeks","year":"2019","unstructured":"Deeks ED. Mirogabalin: first global approval. Drugs. 2019;79(4):463\u201368. https:\/\/doi.org\/10.1007\/s40265-019-01070-8.","journal-title":"Drugs"},{"issue":"4","key":"1176_CR7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.bja.2021.12.042","volume":"128","author":"Y Oshima","year":"2022","unstructured":"Oshima Y, Sano M, Kajiwara I, Ichimaru Y, Itaya T, Kuramochi T, et al. Midazolam exhibits antitumour and anti-inflammatory effects in a mouse model of pancreatic ductal adenocarcinoma. Br J Anaesth. 2022;128(4):679\u201390. https:\/\/doi.org\/10.1016\/j.bja.2021.12.042.","journal-title":"Br J Anaesth"},{"issue":"12","key":"1176_CR8","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1097\/j.pain.0000000000001997","volume":"161","author":"I Kajiwara","year":"2020","unstructured":"Kajiwara I, Sano M, Ichimaru Y, Oshima Y, Kitajima O, Hao H, et al. Duloxetine improves cancer-associated pain in a mouse model of pancreatic cancer through stimulation of noradrenaline pathway and its antitumor effects. Pain. 2020;161(12):2909\u201319. https:\/\/doi.org\/10.1097\/j.pain.0000000000001997.","journal-title":"Pain"},{"issue":"3","key":"1176_CR9","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1136\/rapm-2023-104511","volume":"49","author":"T Kuramochi","year":"2024","unstructured":"Kuramochi T, Sano M, Kajiwara I, Oshima Y, Itaya T, Kim J, et al. Effects of tramadol via a \u00b5-opioid receptor on pancreatic ductal adenocarcinoma in vitro and in vivo. Reg Anesth Pain Med. 2024;49(3):200\u201308. https:\/\/doi.org\/10.1136\/rapm-2023-104511.","journal-title":"Reg Anesth Pain Med"},{"issue":"12","key":"1176_CR10","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/j.tranon.2019.08.010","volume":"12","author":"Y Ichimaru","year":"2019","unstructured":"Ichimaru Y, Sano M, Kajiwara I, Tobe T, Yoshioka H, Hayashi K, et al. Indirubin 3\u2032-oxime inhibits migration, invasion, and metastasis in mice bearing spontaneously occurring pancreatic cancer via Blocking the RAF\/ERK, AKT, and SAPK\/JNK pathways. Transl Oncol. 2019;12(12):1574\u201382. https:\/\/doi.org\/10.1016\/j.tranon.2019.08.010.","journal-title":"Transl Oncol"},{"issue":"6","key":"1176_CR11","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s00210-019-01628-z","volume":"392","author":"K Saeki","year":"2019","unstructured":"Saeki K, Yasuda S, Kato M, Kano M, Domon Y, Arakawa N, et al. Analgesic effects of mirogabalin, a novel ligand for \u03b12\u03b4 subunit of voltage-gated calcium channels, in experimental animal models of fibromyalgia. Naunyn-Schmiedeberg\u2019s Arch Pharmacol. 2019;392(6):723\u201328. https:\/\/doi.org\/10.1007\/s00210-019-01628-z.","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"issue":"9","key":"1176_CR12","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1136\/gutjnl-2020-320608","volume":"70","author":"M Sano","year":"2021","unstructured":"Sano M, Takahashi R, Ijichi H, Ishigaki K, Yamada T, Miyabayashi K, et al. Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis\/thromboembolism. Gut. 2021;70(9):1713\u201323. https:\/\/doi.org\/10.1136\/gutjnl-2020-320608.","journal-title":"Gut"},{"issue":"3","key":"1176_CR13","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transpl. 2013;48(3):452\u201358. https:\/\/doi.org\/10.1038\/bmt.2012.244.","journal-title":"Bone Marrow Transpl"},{"key":"1176_CR14","doi-asserted-by":"publisher","unstructured":"G\u00fcl \u015eK, Tepetam H, G\u00fcl HL. Duloxetine and pregabalin in neuropathic pain of lung cancer patients. Brain Behav. 2020;10(3):e01527. https:\/\/doi.org\/10.1002\/brb3.1527.","DOI":"10.1002\/brb3.1527"},{"issue":"19","key":"1176_CR15","doi-asserted-by":"publisher","first-page":"7307","DOI":"10.3390\/ijms21197307","volume":"21","author":"M Huber","year":"2020","unstructured":"Huber M, Brehm CU, Gress TM, Buchholz M, Alashkar Alhamwe B, von Strandmann E, et al. The immune microenvironment in pancreatic cancer. IJMS. 2020;21(19):7307. https:\/\/doi.org\/10.3390\/ijms21197307.","journal-title":"IJMS"},{"key":"1176_CR16","doi-asserted-by":"publisher","first-page":"1140765","DOI":"10.3389\/fcimb.2023.1140765","volume":"13","author":"Q Xiao","year":"2023","unstructured":"Xiao Q, Xia Y. Insights into dendritic cell maturation during infection with application of advanced imaging techniques. Front Cell Infect Microbiol. 2023;13:1140765. https:\/\/doi.org\/10.3389\/fcimb.2023.1140765.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"1176_CR17","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.1038\/s41598-020-61006-1","volume":"10","author":"EY Abu-Rish","year":"2020","unstructured":"Abu-Rish EY, Mansour AT, Mansour HT, Dahabiyeh LA, Aleidi SM, Bustanji Y. Pregabalin inhibits in vivo and in vitro cytokine secretion and attenuates spleen inflammation in lipopolysaccharide\/concanavalin A-induced murine models of inflammation. Sci Rep. 2020;10(1):4007. https:\/\/doi.org\/10.1038\/s41598-020-61006-1.","journal-title":"Sci Rep"},{"issue":"1","key":"1176_CR18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41392-020-00341-1","volume":"5","author":"A Bulle","year":"2020","unstructured":"Bulle A, Lim KH. Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer. Sig Transduct Target Ther. 2020;5(1):249. https:\/\/doi.org\/10.1038\/s41392-020-00341-1.","journal-title":"Sig Transduct Target Ther"},{"issue":"2","key":"1176_CR19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41389-018-0117-8","volume":"8","author":"M Sano","year":"2019","unstructured":"Sano M, Ijichi H, Takahashi R, Miyabayashi K, Fujiwara H, Yamada T, et al. Blocking CXCLs\u2013CXCR2 axis in tumor\u2013stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion\/migration and a shift of immune-inflammatory microenvironment. Oncogenesis. 2019;8(2):8. https:\/\/doi.org\/10.1038\/s41389-018-0117-8.","journal-title":"Oncogenesis"},{"issue":"2","key":"1176_CR20","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/cam4.993","volume":"6","author":"A Zhang","year":"2017","unstructured":"Zhang A, Qian Y, Ye Z, Chen H, Xie H, Zhou L, et al. Cancer-associated fibroblasts promote M2 polarization of macrophages in pancreatic ductal adenocarcinoma. Cancer Med. 2017;6(2):463\u201370. https:\/\/doi.org\/10.1002\/cam4.993.","journal-title":"Cancer Med"},{"issue":"5","key":"1176_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ol.2020.12097","volume":"20","author":"K Zhou","year":"2020","unstructured":"Zhou K, Cheng T, Zhan J, Peng X, Zhang Y, Wen J, et al. Targeting tumor\u2011associated macrophages in the tumor microenvironment (review). Oncol Lett. 2020;20(5):1\u20131. https:\/\/doi.org\/10.3892\/ol.2020.12097.","journal-title":"Oncol Lett"},{"issue":"1","key":"1176_CR22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jphs.2021.01.002","volume":"146","author":"M Oyama","year":"2021","unstructured":"Oyama M, Watanabe S, Iwai T, Tanabe M. Mirogabalin activates the descending noradrenergic system by binding to the \u03b12\u03b4-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects. J Pharmacological Sci. 2021;146(1):33\u201339. https:\/\/doi.org\/10.1016\/j.jphs.2021.01.002.","journal-title":"J Pharmacological Sci"},{"key":"1176_CR23","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuropharm.2014.01.040","volume":"81","author":"T Suto","year":"2014","unstructured":"Suto T, Severino AL, Eisenach JC, Hayashida K-I. Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms. Neuropharmacology. 2014;81:95\u2013100. https:\/\/doi.org\/10.1016\/j.neuropharm.2014.01.040.","journal-title":"Neuropharmacology"},{"issue":"4","key":"1176_CR24","doi-asserted-by":"publisher","first-page":"822","DOI":"10.3390\/ijms20040822","volume":"20","author":"KI Hayashida","year":"2019","unstructured":"Hayashida KI, Obata H. Strategies to treat chronic pain and strengthen impaired descending noradrenergic inhibitory system. IJMS. 2019;20(4):822. https:\/\/doi.org\/10.3390\/ijms20040822.","journal-title":"IJMS"},{"issue":"4","key":"1176_CR25","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/jnc.13927","volume":"141","author":"K Montague","year":"2017","unstructured":"Montague K, Malcangio M. The therapeutic potential of targeting chemokine signalling in the treatment of chronic pain. J Neurochem. 2017;141(4):520\u201331. https:\/\/doi.org\/10.1111\/jnc.13927.","journal-title":"J Neurochem"},{"issue":"5","key":"1176_CR26","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/bcpt.12099","volume":"113","author":"LH Hang","year":"2013","unstructured":"Hang LH, Shao DH, Chen Z, Chen Y-F, Shu W-W, Zhao Z-G. Involvement of spinal CC chemokine ligand 5 in the development of bone cancer pain in rats. Basic Clin Pharma Tox. 2013;113(5):325\u201328. https:\/\/doi.org\/10.1111\/bcpt.12099.","journal-title":"Basic Clin Pharma Tox"},{"issue":"3","key":"1176_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41419-021-03522-0","volume":"12","author":"Y Ma","year":"2021","unstructured":"Ma Y, Yang X, Zhao W, Yang Y, Zhang Z. Calcium channel \u03b12\u03b41 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer. Cell Death Dis. 2021;12(3):257. https:\/\/doi.org\/10.1038\/s41419-021-03522-0.","journal-title":"Cell Death Dis"},{"issue":"1","key":"1176_CR28","doi-asserted-by":"publisher","first-page":"8271","DOI":"10.1038\/ncomms9271","volume":"6","author":"H Han","year":"2015","unstructured":"Han H, Du Y, Zhao W, Li S, Chen D, Zhang J, et al. PBX3 is targeted by multiple miRnas and is essential for liver tumour-initiating cells. Nat Commun. 2015;6(1):8271. https:\/\/doi.org\/10.1038\/ncomms9271.","journal-title":"Nat Commun"},{"issue":"9","key":"1176_CR29","doi-asserted-by":"publisher","first-page":"5400","DOI":"10.1245\/s10434-021-09645-0","volume":"28","author":"A Shiozaki","year":"2021","unstructured":"Shiozaki A, Katsurahara K, Kudou M, Shimizu H, Kosuga T, Ito H, et al. Amlodipine and verapamil, voltage-gated Ca2+ channel inhibitors, suppressed the growth of gastric cancer stem cells. Ann Surg Oncol. 2021;28(9):5400\u201311. https:\/\/doi.org\/10.1245\/s10434-021-09645-0.","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"1176_CR30","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.21037\/tau-21-81","volume":"10","author":"M Huang","year":"2021","unstructured":"Huang M, Long Y, Jin Y, Ya W, Meng D, Qin T, et al. Comprehensive analysis of the lncRNA-miRNA-mRNA regulatory network for bladder cancer. Transl Androl Urol. 2021;10(3):1286\u2013301. https:\/\/doi.org\/10.21037\/tau-21-81.","journal-title":"Transl Androl Urol"},{"issue":"9","key":"1176_CR31","first-page":"2088","volume":"6","author":"D Yu","year":"2016","unstructured":"Yu D, Holm R, Goscinski MA, Trope CG, Nesland JM, Suo Z. Prognostic and clinicopathological significance of Cacna2d1 expression in epithelial ovarian cancers: a retrospective study. Am J Cancer Res. 2016;6(9):2088\u201397.","journal-title":"Am J Cancer Res"},{"issue":"4","key":"1176_CR32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3344\/kjp.2021.34.4.463","volume":"34","author":"A Mercan","year":"2021","unstructured":"Mercan A, Uzun ST, Keles S, Hacibeyoglu G, Yilmaz R, Reisli R. Immunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational study. The Korean J Pain. 2021;34(4):463\u201370. https:\/\/doi.org\/10.3344\/kjp.2021.34.4.463.","journal-title":"The Korean J Pain"},{"key":"1176_CR33","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fimmu.2019.00333","volume":"10","author":"AE Vilgelm","year":"2019","unstructured":"Vilgelm AE, Richmond A. Chemokines modulate immune surveillance in Tumorigenesis, metastasis, and Response to immunotherapy. Front Immunol. 2019;10:333. https:\/\/doi.org\/10.3389\/fimmu.2019.00333.","journal-title":"Front. Immunol"},{"issue":"1","key":"1176_CR34","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1136\/jitc-2020-000599","volume":"8","author":"C Bergamaschi","year":"2020","unstructured":"Bergamaschi C, Pandit H, Nagy BA, Stellas D, Jensen SM, Bear J, et al. Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-\u03b3, CXCL9 and CXCL10. J Immunother Cancer. 2020;8(1):599. https:\/\/doi.org\/10.1136\/jitc-2020-000599.","journal-title":"J Immunother Cancer"},{"issue":"10","key":"1176_CR35","doi-asserted-by":"publisher","first-page":"9830","DOI":"10.1021\/acsnano.8b00967","volume":"12","author":"L Shen","year":"2018","unstructured":"Shen L, Li J, Liu Q, Song W, Zhang X, Tiruthani K, et al. Local blockade of interleukin 10 and C-X-C motif chemokine ligand 12 with Nano-delivery promotes antitumor Response in murine cancers. ACS Nano. 2018;12(10):9830\u201341. https:\/\/doi.org\/10.1021\/acsnano.8b00967.","journal-title":"ACS Nano"},{"issue":"11","key":"1176_CR36","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.trecan.2019.09.010","volume":"5","author":"BA Pereira","year":"2019","unstructured":"Pereira BA, Vennin C, Papanicolaou M, Chambers CR, Herrmann D, Morton JP, et al. CAF subpopulations: a new reservoir of stromal targets in pancreatic cancer. Trends Cancer. 2019;5(11):724\u201341. https:\/\/doi.org\/10.1016\/j.trecan.2019.09.010.","journal-title":"Trends Cancer"},{"key":"1176_CR37","doi-asserted-by":"publisher","first-page":"658","DOI":"10.3389\/fimmu.2018.00658","volume":"9","author":"HH Van Acker","year":"2018","unstructured":"Van Acker HH, Anguille S, Reu HD, Berneman ZN, Smits EL, Van Tendeloo VF. Interleukin-15-cultured dendritic cells enhance anti-tumor Gamma Delta T cell functions through IL-15 secretion. Front Immunol. 2018;9:658. https:\/\/doi.org\/10.3389\/fimmu.2018.00658.","journal-title":"Front. Immunol"},{"key":"1176_CR38","doi-asserted-by":"publisher","unstructured":"Li J, Zhou J, Huang H, Jiang J, Zhang T, Ni C. Mature dendritic cells enriched in immunoregulatory molecules (mregDcs): a novel population in the tumour microenvironment and immunotherapy target. Clin Transl Med. 2023;13(2):e 1199. https:\/\/doi.org\/10.1002\/ctm2.1199.","DOI":"10.1002\/ctm2.1199"},{"issue":"3","key":"1176_CR39","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1158\/2326-6066.CIR-15-0009","volume":"3","author":"TA Waldmann","year":"2015","unstructured":"Waldmann TA. The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy. Cancer Immunol Res. 2015;3(3):219\u201327. https:\/\/doi.org\/10.1158\/2326-6066.CIR-15-0009.","journal-title":"Cancer Immunol Res"},{"issue":"1","key":"1176_CR40","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/toxsci\/kfs147","volume":"128","author":"KA Criswell","year":"2012","unstructured":"Criswell KA, Wojcinski Z, Pegg D, Albassam M, Duddy S, Olsen E, et al. Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats. Toxicological Sci. 2012;128(1):22\u201341. https:\/\/doi.org\/10.1093\/toxsci\/kfs147.","journal-title":"Toxicological Sci"}],"container-title":["BMC Pharmacology and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40360-026-01176-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-026-01176-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40360-026-01176-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:22:07Z","timestamp":1788394927000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40360-026-01176-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1176"],"URL":"https:\/\/doi.org\/10.1186\/s40360-026-01176-2","relation":{},"ISSN":["2050-6511"],"issn-type":[{"value":"2050-6511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"18 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study has obtained the approval of the Animal Care and Use Committee of the School of Medicine, Nihon University (AP21MED012 and AP22MED069) and the Animal Research: Reporting of In Vivo Experiments (ARRIVE).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not Applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"121"}}