{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:25:12Z","timestamp":1788452712546,"version":"build-2803163510"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pharmacol Toxicol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Arsine poisoning is a rare but life-threatening condition characterized by severe hemolysis. Clinical data on its management remain limited. This study describes the clinical features, diagnostic approach, and treatment experience of 12 patients from a single arsine poisoning incident.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data from the 12 patients were retrospectively collected. Presenting symptoms, diagnostic findings, and treatment strategies were summarized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten of the 12 patients survived. Arsenic was detected in cleaning wastewater and in the red blood cells of four patients, and, together with clinical hemolysis, supported the diagnosis of arsine poisoning. Common symptoms included headache, nausea, vomiting, abdominal pain, dizziness, chest tightness, and hematuria; headache, nausea, and vomiting frequently co-occurred. All patients received high-dose methylprednisolone, vitamin C\u2009+\u2009B6, and chelation therapy. The two non-survivors additionally received mechanical ventilation, therapeutic plasma exchange, dialysis, methylene blue, and transfusions; they died on day 3 from progressive cardiovascular failure secondary to acute hemolysis. Five other patients underwent therapeutic plasma exchange and dialysis and ultimately survived.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case series highlights the clinical presentation, diagnostic workflow, and management of arsine poisoning in a well-characterized patient cluster. Early recognition and timely intervention may facilitate clinical management. The findings are descriptive and limited by the retrospective design and small sample size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40360-026-01199-9","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:43:56Z","timestamp":1787154236000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhalation arsine poisoning: clinical features and treatment experience of 12 cases from a single incident"],"prefix":"10.1186","volume":"27","author":[{"given":"Wei","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"issue":"4","key":"1199_CR1","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1111\/j.1556-4029.2010.01375.x","volume":"55","author":"KF Gensheimer","year":"2010","unstructured":"Gensheimer KF, Rea V, Mills DA, Montagna CP, Simone K. Arsenic poisoning caused by intentional contamination of coffee at a church gathering\u2013an epidemiological approach to a forensic investigation. J Forensic Sci. 2010;55(4):1116\u20139.","journal-title":"J Forensic Sci"},{"key":"1199_CR2","doi-asserted-by":"publisher","first-page":"107152","DOI":"10.1016\/j.envint.2022.107152","volume":"162","author":"SD Griffiths","year":"2022","unstructured":"Griffiths SD, Entwistle JA, Kelly FJ, Deary ME. Characterising the ground level concentrations of harmful organic and inorganic substances released during major industrial fires, and implications for human health. Environ Int. 2022;162:107152.","journal-title":"Environ Int"},{"issue":"22","key":"1199_CR3","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1056\/NEJM197411282912207","volume":"291","author":"BA Fowler","year":"1974","unstructured":"Fowler BA, Weissberg JB. Arsine poisoning. N Engl J Med. 1974;291(22):1171\u20134.","journal-title":"N Engl J Med"},{"issue":"12","key":"1199_CR4","first-page":"1998","volume":"98","author":"S Pullen-James","year":"2006","unstructured":"Pullen-James S, Woods SE. Occupational arsine gas exposure. J Natl Med Assoc. 2006;98(12):1998\u20132001.","journal-title":"J Natl Med Assoc"},{"issue":"6","key":"1199_CR5","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1080\/15563650701502675","volume":"45","author":"Y Song","year":"2007","unstructured":"Song Y, Wang D, Li H, Hao F, Ma J, Xia Y. Severe acute arsine poisoning treated by plasma exchange. Clin Toxicol (Phila). 2007;45(6):721\u20137.","journal-title":"Clin Toxicol (Phila)"},{"issue":"3","key":"1199_CR6","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00134-014-3595-y","volume":"41","author":"C Huang","year":"2015","unstructured":"Huang C, Zhang P, Liu H, Li Y, Yu Y, Du R, et al. Treatment for acute arsine poisoning with blood purification. Intensive Care Med. 2015;41(3):549\u201350.","journal-title":"Intensive Care Med"},{"issue":"4","key":"1199_CR7","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s13181-013-0344-5","volume":"9","author":"MJ Kosnett","year":"2013","unstructured":"Kosnett MJ. The role of chelation in the treatment of arsenic and mercury poisoning. J Med Toxicol. 2013;9(4):347\u201354.","journal-title":"J Med Toxicol"},{"key":"1199_CR8","unstructured":"Kuivenhoven M, Mason K. Arsenic Toxicity. In: StatPearls. edn. Treasure Island (FL) ineligible companies. Disclosure: Kelly Mason declares no relevant financial relationships with ineligible companies; 2025."},{"key":"1199_CR9","doi-asserted-by":"crossref","unstructured":"Nurchi VM, Djordjevic AB, Crisponi G, Alexander J, Bj\u00f8rklund G, Aaseth J. Arsenic toxicity: molecular targets and therapeutic agents. Biomolecules. 2020;10(2):235.","DOI":"10.3390\/biom10020235"},{"issue":"5","key":"1199_CR10","doi-asserted-by":"publisher","first-page":"e04115","DOI":"10.1002\/ccr3.4115","volume":"9","author":"A Ott","year":"2021","unstructured":"Ott A, Venkataraman V, Badran YR, Goldman R, Spasic S, Vyas DA, et al. Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia. Clin Case Rep. 2021;9(5):e04115.","journal-title":"Clin Case Rep"},{"issue":"4","key":"1199_CR11","doi-asserted-by":"publisher","first-page":"e231","DOI":"10.1002\/ski2.231","volume":"3","author":"GT Tang","year":"2023","unstructured":"Tang GT, Elakis J, Scardamaglia L. Cutaneous manifestations and treatment of arsenic toxicity: A systematic review. Skin Health Dis. 2023;3(4):e231.","journal-title":"Skin Health Dis"},{"issue":"1","key":"1199_CR12","first-page":"57","volume":"59","author":"CT Bolliger","year":"1992","unstructured":"Bolliger CT, van Zijl P, Louw JA. Multiple organ failure with the adult respiratory distress syndrome in homicidal arsenic poisoning. Respiration. 1992;59(1):57\u201361.","journal-title":"Respiration"},{"issue":"1","key":"1199_CR13","doi-asserted-by":"publisher","first-page":"e87568","DOI":"10.1371\/journal.pone.0087568","volume":"9","author":"WP Wu","year":"2014","unstructured":"Wu WP, Lai MN, Lin CH, Li YF, Lin CY, Wu MJ. Addition of immunosuppressive treatment to hemoperfusion is associated with improved survival after paraquat poisoning: a nationwide study. 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All the procedures in this study were carried out in accordance with the Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"122"}}