{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:17:03Z","timestamp":1788243423787,"version":"build-2803163510"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["OZ3544"],"award-info":[{"award-number":["OZ3544"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","award":["A-15040"],"award-info":[{"award-number":["A-15040"]}],"id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomark Res"],"DOI":"10.1186\/s40364-026-00971-7","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:11:21Z","timestamp":1788243081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping brain volume changes in the zQ175DN mouse model of Huntington\u2019s disease: a longitudinal MRI study"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7467-5367","authenticated-orcid":false,"given":"Nicholas","family":"Vidas-Guscic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-3966","authenticated-orcid":false,"given":"Tamara","family":"Vasilkovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Pluym","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6971-7358","authenticated-orcid":false,"given":"Jo\u00eblle","family":"van Rijswijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-4640","authenticated-orcid":false,"given":"Johan","family":"Van Audekerke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Mu\u00f1oz-Sanju\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-7220","authenticated-orcid":false,"given":"Dorian","family":"Pustina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Cachope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2941-6520","authenticated-orcid":false,"given":"Annemie","family":"Van der Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-5432","authenticated-orcid":false,"given":"Daniele","family":"Bertoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6267-0611","authenticated-orcid":false,"given":"Marleen","family":"Verhoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"issue":"April","key":"971_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2015.5","volume":"1","author":"GP Bates","year":"2015","unstructured":"Bates GP, Dorsey R, Gusella JF, Hayden MR, Kay C, Leavitt BR, Nance M, Ross CA, Scahill RI, Wetzel R, Wild EJ, Tabrizi SJ. Huntington disease. Nat Reviews Disease Primers. 2015;1(April):1\u201321. https:\/\/doi.org\/10.1038\/nrdp.2015.5.","journal-title":"Nat Reviews Disease Primers"},{"key":"971_CR2","doi-asserted-by":"publisher","unstructured":"Snowden JS. The neuropsychology of Huntington\u2019s disease. Arch Clin Neuropsychol. 2017;32:876\u201387. https:\/\/doi.org\/10.1093\/arclin\/acx086.","DOI":"10.1093\/arclin\/acx086"},{"key":"971_CR3","doi-asserted-by":"crossref","unstructured":"MacDonald ME, Christine M, Ambrose MP, Duyao RH, Myers C, Lin L, Srinidhi G, Barnes SA, Taylor B, Jenkins MA, Anderson NS, Wexler, James F, Gusella. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell. 1993;72:971\u2013983.","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"971_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.spen.2017.12.005","volume":"25","author":"A Fazl","year":"2018","unstructured":"Fazl A, Fleisher J. Anatomy, Physiology, and Clinical Syndromes of the Basal Ganglia: A Brief Review. Semin Pediatr Neurol. 2018;25:2\u20139. https:\/\/doi.org\/10.1016\/j.spen.2017.12.005.","journal-title":"Semin Pediatr Neurol"},{"key":"971_CR5","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad214","author":"C-F Liu","year":"2023","unstructured":"Liu C-F, Younes L, Tong X, Hinkle JT, Wang M, Phatak S, Xu X, Bu X, Looi V, Bang J, Tabrizi SJ, Scahill RI, Paulsen JS, Georgiou-Karistianis N, Faria AV, Miller MI, Ratnanather JT, Ross CA. Longitudinal imaging highlights preferential basal ganglia circuit atrophy in Huntington\u2019s disease. Brain Commun. 2023. https:\/\/doi.org\/10.1093\/braincomms\/fcad214.","journal-title":"Brain Commun"},{"key":"971_CR6","doi-asserted-by":"crossref","unstructured":"Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr. Neuropathological classification of Huntington\u2019s disease. 1985;44(6):559-77. https:\/\/academic.oup.com\/jnen\/article\/44\/6\/559\/2613653.","DOI":"10.1097\/00005072-198511000-00003"},{"issue":"7","key":"971_CR7","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/mds.22969","volume":"25","author":"EJ Wild","year":"2010","unstructured":"Wild EJ, Henley SMD, Hobbs NZ, Frost C, MacManus DG, Barker RA, Fox NC, Tabrizi SJ. Rate and acceleration of whole-brain atrophy in premanifest and early Huntington\u2019s disease. Mov Disord. 2010;25(7):888\u201395. https:\/\/doi.org\/10.1002\/mds.22969.","journal-title":"Mov Disord"},{"issue":"9","key":"971_CR8","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1176\/appi.ajp.2007.06081266","volume":"164","author":"P Nopoulos","year":"2007","unstructured":"Nopoulos P, Magnotta VA, Mikos A, Paulson H, Andreasen NC, Paulsen JS. Morphology of the cerebral cortex in preclinical Huntington\u2019s disease. Am J Psychiatry. 2007;164(9):1428\u201334. https:\/\/doi.org\/10.1176\/appi.ajp.2007.06081266.","journal-title":"Am J Psychiatry"},{"issue":"5","key":"971_CR9","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1212\/01.wnl.0000174432.87383.87","volume":"65","author":"HD Rosas","year":"2005","unstructured":"Rosas HD, Hevelone ND, Zaleta AK, Greve DN, Salat DH, Fischl B. Regional cortical thinning in preclinical Huntington disease and its relationship to cognition. Neurology. 2005;65(5):745\u20137. https:\/\/doi.org\/10.1212\/01.wnl.0000174432.87383.87.","journal-title":"Neurology"},{"key":"971_CR10","doi-asserted-by":"publisher","unstructured":"Shishegar R, Rajapakse S, Georgiou-Karistianis N. Altered cortical morphometry in pre-manifest Huntington\u2019s disease: cross-sectional data from the IMAGE-HD study. Annu Int Conf IEEE Eng Med Biol Soc. 2019;2019:2844\u20132847. https:\/\/doi.org\/10.1109\/EMBC.2019.8857240.","DOI":"10.1109\/EMBC.2019.8857240"},{"issue":"1","key":"971_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.biopsych.2005.06.003","volume":"59","author":"JS Paulsen","year":"2006","unstructured":"Paulsen JS, Magnotta VA, Mikos AE, Paulson HL, Penziner E, Andreasen NC, Nopoulos PC. Brain structure in preclinical Huntington\u2019s disease. Biol Psychiatry. 2006;59(1):57\u201363. https:\/\/doi.org\/10.1016\/j.biopsych.2005.06.003.","journal-title":"Biol Psychiatry"},{"issue":"9","key":"971_CR12","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","volume":"8","author":"SJ Tabrizi","year":"2009","unstructured":"Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin AJ, Rosas HD, Johnson H, Reilmann R, Landwehrmeyer B, Stout JC. Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol. 2009;8(9):791\u2013801. https:\/\/doi.org\/10.1016\/S1474-4422(09)70170-X. TRACK-HD investigators.","journal-title":"Lancet Neurol"},{"issue":"1","key":"971_CR13","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","volume":"10","author":"SJ Tabrizi","year":"2011","unstructured":"Tabrizi SJ, Scahill RI, Durr A, Roos RAC, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard C, Craufurd D, Frost C, Langbehn DR, Reilmann R, Stout JC. Biological and clinical changes in premanifest and early stage Huntington\u2019s disease in the TRACK-HD study: The 12-month longitudinal analysis. Lancet Neurol. 2011;10(1):31\u201342. https:\/\/doi.org\/10.1016\/S1474-4422(10)70276-3.","journal-title":"Lancet Neurol"},{"key":"971_CR14","doi-asserted-by":"publisher","unstructured":"Tabrizi SJ, Schobel S, Gantman EC, Mansbach A, Borowsky B, Konstantinova P, Mestre TA, Panagoulias J, Ross CA, Zauderer M, Mullin AP, Romero K, Sivakumaran S, Turner EC, Long JD, Sampaio C. A biological classification of Huntington\u2019s disease: the Integrated Staging System. Lancet Neurol. 2022;21(7):632\u2013644. https:\/\/doi.org\/10.1016\/S1474-4422(22)00120-X.","DOI":"10.1016\/S1474-4422(22)00120-X"},{"issue":"8","key":"971_CR15","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1111\/ejn.14617","volume":"51","author":"G Ramirez-Garcia","year":"2020","unstructured":"Ramirez-Garcia G, Galvez V, Diaz R, Bayliss L, Fernandez-Ruiz J, Campos-Romo A. Longitudinal atrophy characterization of cortical and subcortical gray matter in Huntington\u2019s disease patients. Eur J Neurosci. 2020;51(8):1827\u201343. https:\/\/doi.org\/10.1111\/ejn.14617.","journal-title":"Eur J Neurosci"},{"issue":"5","key":"971_CR16","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1002\/acn3.558","volume":"5","author":"PA Wijeratne","year":"2018","unstructured":"Wijeratne PA, Young AL, Oxtoby NP, Marinescu RV, Firth NC, Johnson EB, Mohan A, Sampaio C, Scahill RI, Tabrizi SJ, Alexander DC. An image-based model of brain volume biomarker changes in Huntington\u2019s disease. Ann Clin Transl Neurol. 2018;5(5):570\u201382. https:\/\/doi.org\/10.1002\/acn3.558.","journal-title":"Ann Clin Transl Neurol"},{"issue":"4","key":"971_CR17","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1016\/j.neuroimage.2006.05.057","volume":"32","author":"G Douaud","year":"2006","unstructured":"Douaud G, Gaura V, Ribeiro MJ, Lethimonnier F, Maroy R, Verny C, Krystkowiak P, Damier P, Bachoud-Levi AC, Hantraye P, Remy P. Distribution of grey matter atrophy in Huntington\u2019s disease patients: A combined ROI-based and voxel-based morphometric study. NeuroImage. 2006;32(4):1562\u201375. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.05.057.","journal-title":"NeuroImage"},{"issue":"5","key":"971_CR18","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1136\/jnnp.2004.047993","volume":"76","author":"CM Kipps","year":"2005","unstructured":"Kipps CM, Duggins AJ, Mahant N, Gomes L, Ashburner J, McCusker EA. Progression of structural neuropathology in preclinical Huntington\u2019s disease: A tensor based morphometry study. J Neurol Neurosurg Psychiatry. 2005;76(5):650\u20135. https:\/\/doi.org\/10.1136\/jnnp.2004.047993.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"971_CR19","doi-asserted-by":"publisher","first-page":"117957352210925","DOI":"10.1177\/11795735221092517","volume":"14","author":"MW Ferguson","year":"2022","unstructured":"Ferguson MW, Kennedy CJ, Palpagama TH, Waldvogel HJ, Faull RLM, Kwakowsky A. Current and Possible Future Therapeutic Options for Huntington\u2019s Disease. J Cent Nerv Syst Disease. 2022;14:117957352210925. https:\/\/doi.org\/10.1177\/11795735221092517.","journal-title":"J Cent Nerv Syst Disease"},{"key":"971_CR20","doi-asserted-by":"publisher","unstructured":"Estevez-Fraga C, Flower MD, Tabrizi SJ. Therapeutic strategies for Huntington\u2019s disease. Curr Opin Neurol. 2020;33(4):508-18. https:\/\/doi.org\/10.1097\/WCO.0000000000000835.","DOI":"10.1097\/WCO.0000000000000835"},{"key":"971_CR21","doi-asserted-by":"publisher","unstructured":"Zeun P, Scahill RI, Tabrizi SJ, Wild EJ. Fluid and imaging biomarkers for Huntington\u2019s disease. Mol Cell Neurosci. 2019;97:67\u201380. https:\/\/doi.org\/10.1016\/j.mcn.2019.02.004.","DOI":"10.1016\/j.mcn.2019.02.004"},{"key":"971_CR22","doi-asserted-by":"publisher","unstructured":"Mukherjee, P., Roy, S., Ghosh, D. et al. Role of animal models in biomedical research: a review. Lab Anim Res 38, 18 (2022). https:\/\/doi.org\/10.1186\/s42826-022-00128-1.","DOI":"10.1186\/s42826-022-00128-1"},{"key":"971_CR23","doi-asserted-by":"publisher","unstructured":"Atherton JF, Mciver EL, Mullen MR, Wokosin DL, Surmeier J, Bevan MD. Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington\u2019s disease. Elife. 2016;5:e21616. https:\/\/doi.org\/10.7554\/eLife.21616.001.","DOI":"10.7554\/eLife.21616.001"},{"issue":"10","key":"971_CR24","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1523\/JNEUROSCI.0782-21.2022","volume":"42","author":"JW Callahan","year":"2022","unstructured":"Callahan JW, Wokosin DL, Bevan MD. Dysregulation of the Basal Ganglia Indirect Pathway in Early Symptomatic Q175 Huntington\u2019s Disease Mice. J Neurosci. 2022;42(10):2080\u2013102. https:\/\/doi.org\/10.1523\/JNEUROSCI.0782-21.2022.","journal-title":"J Neurosci"},{"issue":"7","key":"971_CR25","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1002\/cne.25023","volume":"529","author":"Y Deng","year":"2021","unstructured":"Deng Y, Wang H, Joni M, Sekhri R, Reiner A. Progression of basal ganglia pathology in heterozygous Q175 knock-in Huntington\u2019s disease mice. J Comp Neurol. 2021;529(7):1327\u201371. https:\/\/doi.org\/10.1002\/cne.25023.","journal-title":"J Comp Neurol"},{"key":"971_CR26","doi-asserted-by":"publisher","unstructured":"Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI. Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+\/- mouse model of Huntington\u2019s disease. PLoS One. 2019;13(8). https:\/\/doi.org\/10.1371\/journal.pone.0200626.","DOI":"10.1371\/journal.pone.0200626"},{"key":"971_CR27","doi-asserted-by":"publisher","unstructured":"Herrmann F, Hessmann M, Schaertl S, Berg-Rosseburg K, Brown CJ, Bursow G, Chiki A, Ebneth A, Gehrmann M, Hoeschen N, Hotze M, Jahn S, Johnson PD, Khetarpal V, Kiselyov A, Kottig K, Ladewig S, Lashuel H, Letschert S, Bard JA. Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates. Sci Rep. 2021;11(1). https:\/\/doi.org\/10.1038\/s41598-021-97334-z.","DOI":"10.1038\/s41598-021-97334-z"},{"issue":"4","key":"971_CR28","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nn.4256","volume":"19","author":"P Langfelder","year":"2016","unstructured":"Langfelder P, Cantle JP, Chatzopoulou D, Wang N, Gao F, Al-Ramahi I, Lu XH, Ramos EM, El-Zein K, Zhao Y, Deverasetty S, Tebbe A, Schaab C, Lavery DJ, Howland D, Kwak S, Botas J, Aaronson JS, Rosinski J, Yang XW. Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nat Neurosci. 2016;19(4):623\u201333. https:\/\/doi.org\/10.1038\/nn.4256.","journal-title":"Nat Neurosci"},{"issue":"5","key":"971_CR29","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.neuron.2020.06.021","volume":"107","author":"H Lee","year":"2020","unstructured":"Lee H, Fenster RJ, Pineda SS, Gibbs WS, Mohammadi S, Davila-Velderrain J, Garcia FJ, Therrien M, Novis HS, Gao F, Wilkinson H, Vogt T, Kellis M, LaVoie MJ, Heiman M. Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation. Neuron. 2020;107(5):891\u2013e9088. https:\/\/doi.org\/10.1016\/j.neuron.2020.06.021.","journal-title":"Neuron"},{"issue":"17","key":"971_CR30","doi-asserted-by":"publisher","first-page":"4510","DOI":"10.1093\/hmg\/ddu166","volume":"23","author":"GA Smith","year":"2014","unstructured":"Smith GA, Rocha EM, McLean JR, Hayes MA, Izen SC, Isacson O, Hallett PJ. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington\u2019s disease. Hum Mol Genet. 2014;23(17):4510\u201327. https:\/\/doi.org\/10.1093\/hmg\/ddu166.","journal-title":"Hum Mol Genet"},{"key":"971_CR31","doi-asserted-by":"publisher","unstructured":"Carty N, Berson N, Tillack K, Thiede C, Scholz D, Kottig K, Sedaghat Y, Gabrysiak C, Yohrling G, Von Der Kammer H, Ebneth A, Mack V, Munoz-Sanjuan I, Kwak S. Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington\u2019s disease: an in vivo high-content imaging study. PLoS One. 2015;10(4). https:\/\/doi.org\/10.1371\/journal.pone.0123527.","DOI":"10.1371\/journal.pone.0123527"},{"issue":"1","key":"971_CR32","doi-asserted-by":"publisher","first-page":"10194","DOI":"10.1038\/s41598-023-36812-y","volume":"13","author":"MH Adhikari","year":"2023","unstructured":"Adhikari MH, Vasilkovska T, Cachope R, Tang H, Liu L, Keliris GA, Munoz-Sanjuan I, Pustina D, Van der Linden A, Verhoye M. Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington\u2019s disease. Sci Rep. 2023;13(1):10194. https:\/\/doi.org\/10.1038\/s41598-023-36812-y.","journal-title":"Sci Rep"},{"key":"971_CR33","doi-asserted-by":"publisher","unstructured":"Vasilkovska T, Adhikari MH, Van Audekerke J, Salajeghe S, Pustina D, Cachope R, Tang H, Liu L, Mu\u00f1oz-Sanju\u00e1n I, Van der Linden A, Verhoye M. Resting-state fMRI reveals longitudinal alterations in brain network connectivity in the zQ175DN mouse model of Huntington\u2019s disease. Neurobiol Dis. 2023;181. https:\/\/doi.org\/10.1016\/j.nbd.2023.106095.","DOI":"10.1016\/j.nbd.2023.106095"},{"issue":"1","key":"971_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12929-024-01028-3","volume":"31","author":"T Vasilkovska","year":"2024","unstructured":"Vasilkovska T, Salajeghe S, Vanreusel V, Van Audekerke J, Verschuuren M, Hirschler L, Warnking J, Pintelon I, Pustina D, Cachope R, Mrzljak L, Mu\u00f1oz-Sanjuan I, Barbier EL, De Vos WH, Van der Linden A, Verhoye M. Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington\u2019s disease. J Biomed Sci. 2024;31(1):37. https:\/\/doi.org\/10.1186\/s12929-024-01028-3.","journal-title":"J Biomed Sci"},{"key":"971_CR35","doi-asserted-by":"publisher","unstructured":"Vasilkovska T, Verschuuren M, Pustina D, van den Berg M, Van Audekerke J, Pintelon I, Cachope R, De Vos WH, Van der Linden A, Adhikari MH, Verhoye M. Evolution of aberrant brain-wide spatiotemporal dynamics of resting\u2010state networks in a Huntington\u2019s disease mouse model. Clin Translational Med. 2024;14(10). https:\/\/doi.org\/10.1002\/ctm2.70055.","DOI":"10.1002\/ctm2.70055"},{"key":"971_CR36","doi-asserted-by":"publisher","unstructured":"Vidas-Guscic N, van Rijswijk J, Van Audekerke J, Jeurissen B, Nnah I, Tang H, Mu\u00f1oz-Sanjuan I, Pustina D, Cachope R, Van der Linden A, Bertoglio D, Verhoye M. Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington\u2019s disease. Neurobiol Dis. 2024;193. https:\/\/doi.org\/10.1016\/j.nbd.2024.106438.","DOI":"10.1016\/j.nbd.2024.106438"},{"key":"971_CR37","doi-asserted-by":"publisher","unstructured":"Heikkinen T, Lehtim\u00e4ki K, Vartiainen N, Puoliv\u00e4li J, Hendricks SJ, Glaser JR, Bradaia A, Wadel K, Touller C, Kontkanen O, Yrj\u00e4nheikki JM, Buisson B, Howland D, Beaumont V, Munoz-Sanjuan I, Park LC. Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington\u2019s disease. PLoS One. 2012;7(12). https:\/\/doi.org\/10.1371\/journal.pone.0050717.","DOI":"10.1371\/journal.pone.0050717"},{"key":"971_CR38","doi-asserted-by":"publisher","unstructured":"Peng Q, Wu B, Jiang M, Jin J, Hou Z, Zheng J, Zhang J, Duan W. Characterization of behavioral, neuropathological, brain metabolic and key molecular changes in zQ175 knock-in mouse model of Huntington\u2019s disease. PLoS One. 2016;11(2). https:\/\/doi.org\/10.1371\/journal.pone.0148839.","DOI":"10.1371\/journal.pone.0148839"},{"key":"971_CR39","doi-asserted-by":"publisher","unstructured":"Farshim PP, Bates GP. Mouse models of Huntington\u2019s disease. Methods Mol Biol. 2018;1780:97-120. https:\/\/doi.org\/10.1007\/978-1-4939-7825-0_6.","DOI":"10.1007\/978-1-4939-7825-0_6"},{"key":"971_CR40","doi-asserted-by":"publisher","unstructured":"Menalled LB, Kudwa AE, Miller S, Fitzpatrick J, Watson-Johnson J, Keating N, Ruiz M, Mushlin R, Alosio W, McConnell K, Connor D, Murphy C, Oakeshott S, Kwan M, Beltran J, Ghavami A, Brunner D, Park LC, Ramboz S, Howland D. Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington\u2019s disease: ZQ175. PLoS One. 2012;7(12). https:\/\/doi.org\/10.1371\/journal.pone.0049838.","DOI":"10.1371\/journal.pone.0049838"},{"issue":"6","key":"971_CR41","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.neuron.2016.10.064","volume":"92","author":"V Beaumont","year":"2016","unstructured":"Beaumont V, Zhong S, Lin H, Xu WJ, Bradaia A, Steidl E, Gleyzes M, Wadel K, Buisson B, Padovan-Neto FE, Chakroborty S, Ward KM, Harms JF, Beltran J, Kwan M, Ghavami A, H\u00e4ggkvist J, T\u00f3th M, Halldin C, Munoz-Sanjuan I. Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington\u2019s Disease Models. Neuron. 2016;92(6):1220\u201337. https:\/\/doi.org\/10.1016\/j.neuron.2016.10.064.","journal-title":"Neuron"},{"issue":"18","key":"971_CR42","doi-asserted-by":"publisher","first-page":"4993","DOI":"10.1523\/JNEUROSCI.0135-16.2016","volume":"36","author":"DP Covey","year":"2016","unstructured":"Covey DP, Dantrassy HM, Zlebnik NE, Gildish I, Cheer JF. Compromised dopaminergic encoding of reward accompanying suppressed willingness to overcome high effort costs is a prominent prodromal characteristic of the Q175 mouse model of huntington\u2019s disease. J Neurosci. 2016;36(18):4993\u20135002. https:\/\/doi.org\/10.1523\/JNEUROSCI.0135-16.2016.","journal-title":"J Neurosci"},{"issue":"12 December","key":"971_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0243052","volume":"15","author":"T Heikkinen","year":"2020","unstructured":"Heikkinen T, Bragge T, Bhattarai N, Parkkari T, Jukka Puoliv\u00e4li, Kontkanen O, Sweeney P, Park LC, Munoz-Sanjuan I. Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington\u2019s disease. PLoS ONE. 2020;15(12 December):1\u201321. https:\/\/doi.org\/10.1371\/journal.pone.0243052.","journal-title":"PLoS ONE"},{"key":"971_CR44","doi-asserted-by":"publisher","unstructured":"Oakeshott S, Port R, Cummins-Sutphen J, Berger J, Watson-Johnson J, Ramboz S, Paterson N, Kwak S, Howland D, Brunner D. A mixed fixed ratio\/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington\u2019s disease. PLoS Curr. 2012;4:e4f972cffe82c0. https:\/\/doi.org\/10.1371\/4f972cffe82c0.","DOI":"10.1371\/4f972cffe82c0"},{"key":"971_CR45","doi-asserted-by":"publisher","unstructured":"Piiponniemi TO, Parkkari T, Heikkinen T, Puoliv\u00e4li J, Park LC, Cachope R, Kopanitsa MV. Impaired performance of the Q175 mouse model of huntington\u2019s disease in the touch screen paired associates learning task. Front Behav Neurosci. 2018;12. https:\/\/doi.org\/10.3389\/fnbeh.2018.00226.","DOI":"10.3389\/fnbeh.2018.00226"},{"issue":"12","key":"971_CR46","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1002\/jnr.24505","volume":"97","author":"B Smarr","year":"2019","unstructured":"Smarr B, Cutler T, Loh DH, Kudo T, Kuljis D, Kriegsfeld L, Ghiani CA, Colwell CS. Circadian dysfunction in the Q175 model of Huntington\u2019s disease: Network analysis. J Neurosci Res. 2019;97(12):1606\u201323. https:\/\/doi.org\/10.1002\/jnr.24505.","journal-title":"J Neurosci Res"},{"key":"971_CR47","doi-asserted-by":"publisher","unstructured":"Cudalbu C, McLin VA, Lei H, Duarte JMN, Rougemont AL, Oldani G, Terraz S, Toso C, Gruetter R. The C57BL\/6J mouse exhibits sporadic congenital portosystemic shunts. PLoS One. 2013;8(7). https:\/\/doi.org\/10.1371\/journal.pone.0069782.","DOI":"10.1371\/journal.pone.0069782"},{"key":"971_CR48","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/B978-0-12-387003-2.00014-8","volume":"98","author":"A Reiner","year":"2011","unstructured":"Reiner A, Dragatsis I, Dietrich P. Genetics and neuropathology of Huntington's disease. Int Rev Neurobiol. 2011;98:325-72. https:\/\/doi.org\/10.1016\/B978-0-12-387003-2.00014-8.","journal-title":"Int Rev Neurobiol"},{"issue":"4","key":"971_CR49","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1016\/j.neuroimage.2009.10.015","volume":"49","author":"HD Rosas","year":"2010","unstructured":"Rosas HD, Lee SY, Bender AC, Zaleta AK, Vangel M, Yu P, Fischl B, Pappu V, Onorato C, Cha JH, Salat DH, Hersch SM. Altered white matter microstructure in the corpus callosum in Huntington\u2019s disease: Implications for cortical disconnection. NeuroImage. 2010;49(4):2995\u20133004. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.10.015.","journal-title":"NeuroImage"},{"issue":"3","key":"971_CR50","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1177\/00045632211050531","volume":"59","author":"RM West","year":"2022","unstructured":"West RM. Best practice in statistics: The use of log transformation. Ann Clin Biochem. 2022;59(3):162\u20135. https:\/\/doi.org\/10.1177\/00045632211050531.","journal-title":"Ann Clin Biochem"},{"key":"971_CR51","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","volume":"92","author":"AM Winkler","year":"2014","unstructured":"Winkler AM, Ridgway GR, Webster MA, Smith SM, Nichols TE. Permutation inference for the general linear model. NeuroImage. 2014;92:381\u201397. https:\/\/doi.org\/10.1016\/j.neuroimage.2014.01.060.","journal-title":"NeuroImage"},{"key":"971_CR52","doi-asserted-by":"publisher","unstructured":"Bertoglio D, Verhaeghe J, Kosten L, Thomae D, Van Der Linden A, Stroobants S, Wityak J, Dominguez C, Mrzljak L, Staelens S. MR-based spatial normalization improves [18F]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington\u2019s disease. PLoS One. 2018;13(10). https:\/\/doi.org\/10.1371\/journal.pone.0206613.","DOI":"10.1371\/journal.pone.0206613"},{"key":"971_CR53","doi-asserted-by":"publisher","unstructured":"Heikkinen T, Bragge T, Kuosmanen J, Parkkari T, Gustafsson S, Kwan M, Beltran J, Ghavami A, Subramaniam S, Shahani N, Ram\u00edrez-Jarqu\u00edn UN, Park L, Mu\u00f1oz-Sanju\u00e1n I, Marchionini DM. Global Rhes knockout in the Q175 Huntington\u2019s disease mouse model. PLoS One. 2021;16. https:\/\/doi.org\/10.1371\/journal.pone.0258486.","DOI":"10.1371\/journal.pone.0258486"},{"issue":"17","key":"971_CR54","doi-asserted-by":"publisher","first-page":"E1939","DOI":"10.1212\/WNL.0000000000007355","volume":"92","author":"A Tereshchenko","year":"2019","unstructured":"Tereshchenko A, Magnotta V, Epping E, Mathews K, Espe-Pfeifer P, Martin E, Dawson J, Duan W, Nopoulos P. Brain structure in juvenile-onset Huntington disease. Neurology. 2019;92(17):E1939\u201347. https:\/\/doi.org\/10.1212\/WNL.0000000000007355.","journal-title":"Neurology"},{"key":"971_CR55","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddac036\/6526656","author":"J-B P\u00e9rot","year":"2022","unstructured":"P\u00e9rot J-B, C\u00e9lestine M, Palombo M, Dhenain M, Humbert S, Brouillet E, Flament J. Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington\u2019s disease reveals early grey and white matter alterations. Hum Mol Genet. 2022. https:\/\/doi.org\/10.1093\/hmg\/ddac036\/6526656.","journal-title":"Hum Mol Genet"},{"key":"971_CR56","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.neurobiolaging.2021.02.006","volume":"102","author":"RG Gatto","year":"2021","unstructured":"Gatto RG, Weissmann C, Amin M, Angeles-L\u00f3pez QD, Garc\u00eda-Lara L, Castellanos LCS, Deyoung D, Segovia J, Mareci TH, Uchitel OD, Magin RL. Evaluation of early microstructural changes in the R6\/1 mouse model of Huntington\u2019s disease by ultra-high field diffusion MR imaging. Neurobiol Aging. 2021;102:32\u201349. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.02.006.","journal-title":"Neurobiol Aging"},{"issue":"3","key":"971_CR57","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1016\/j.neuroimage.2009.10.027","volume":"49","author":"J Zhang","year":"2010","unstructured":"Zhang J, Peng Q, Li Q, Jahanshad N, Hou Z, Jiang M, Masuda N, Langbehn DR, Miller MI, Mori S, Ross CA, Duan W. Longitudinal characterization of brain atrophy of a Huntington\u2019s disease mouse model by automated morphological analyses of magnetic resonance images. NeuroImage. 2010;49(3):2340\u201351. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.10.027.","journal-title":"NeuroImage"},{"issue":"7879","key":"971_CR58","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41586-021-03993-3","volume":"598","author":"NN Foster","year":"2021","unstructured":"Foster NN, Barry J, Korobkova L, Garcia L, Gao L, Becerra M, Sherafat Y, Peng B, Li X, Choi JH, Gou L, Zingg B, Azam S, Lo D, Khanjani N, Zhang B, Stanis J, Bowman I, Cotter K, Dong HW. The mouse cortico\u2013basal ganglia\u2013thalamic network. Nature. 2021;598(7879):188\u201394. https:\/\/doi.org\/10.1038\/s41586-021-03993-3.","journal-title":"Nature"},{"issue":"8","key":"971_CR59","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1038\/nn.4332","volume":"19","author":"H Hintiryan","year":"2016","unstructured":"Hintiryan H, Foster NN, Bowman I, Bay M, Song MY, Gou L, Yamashita S, Bienkowski MS, Zingg B, Zhu M, Yang XW, Shih JC, Toga AW, Dong HW. The mouse cortico-striatal projectome. Nat Neurosci. 2016;19(8):1100\u201314. https:\/\/doi.org\/10.1038\/nn.4332.","journal-title":"Nat Neurosci"},{"key":"971_CR60","doi-asserted-by":"publisher","unstructured":"Ehrlich ME. Huntington\u2019s disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics. 2012;9(2):270-84. https:\/\/doi.org\/10.1007\/s13311-012-0112-2.","DOI":"10.1007\/s13311-012-0112-2"},{"key":"971_CR61","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0014-23.2023","author":"KS Ibrahim","year":"2023","unstructured":"Ibrahim KS, Mestikawy E, Abd-Elrahman S, K. S., Ferguson SSG. VGLUT3 deletion rescues motor deficits and neuronal loss in the zQ175 mouse model of Huntington\u2019s disease. J Neuroscience: Official J Soc Neurosci. 2023. https:\/\/doi.org\/10.1523\/JNEUROSCI.0014-23.2023.","journal-title":"J Neuroscience: Official J Soc Neurosci"},{"key":"971_CR62","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1152\/jn.01056.2014.-The","volume":"113","author":"T Indersmitten","year":"2015","unstructured":"Indersmitten T, Tran CH, Cepeda C, Levine MS. Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington\u2019s disease. J Neurophysiol. 2015;113:2953\u201366. https:\/\/doi.org\/10.1152\/jn.01056.2014.-The.","journal-title":"J Neurophysiol"},{"key":"971_CR63","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neuroimage.2016.09.029","volume":"144","author":"DA Raffelt","year":"2017","unstructured":"Raffelt DA, Tournier JD, Smith RE, Vaughan DN, Jackson G, Ridgway GR, Connelly A. Investigating white matter fibre density and morphology using fixel-based analysis. NeuroImage. 2017;144:58\u201373. https:\/\/doi.org\/10.1016\/j.neuroimage.2016.09.029.","journal-title":"NeuroImage"},{"issue":"8","key":"971_CR64","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1002\/mds.28109","volume":"35","author":"C Casella","year":"2020","unstructured":"Casella C, Lipp I, Rosser A, Jones DK, Metzler-Baddeley C. A Critical Review of White Matter Changes in Huntington\u2019s Disease. Mov Disord. 2020;35(8):1302\u201311. https:\/\/doi.org\/10.1002\/mds.28109.","journal-title":"Mov Disord"},{"key":"971_CR65","doi-asserted-by":"publisher","unstructured":"Estevez-Fraga C, Scahill R, Rees G, Tabrizi SJ, Gregory S. (2020). Diffusion imaging in Huntington\u2019s disease: comprehensive review. J Neurol Neurosurg Psychiatry. 2020:92(1):62-9. https:\/\/doi.org\/10.1136\/jnnp-2020-324377.","DOI":"10.1136\/jnnp-2020-324377"},{"issue":"9","key":"971_CR66","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1002\/hbm.24191","volume":"39","author":"S Gregory","year":"2018","unstructured":"Gregory S, Crawford H, Seunarine K, Leavitt B, Durr A, Roos RAC, Scahill RI, Tabrizi SJ, Rees G, Langbehn D, Orth M. Natural biological variation of white matter microstructure is accentuated in Huntington\u2019s disease. Hum Brain Mapp. 2018;39(9):3516\u201327. https:\/\/doi.org\/10.1002\/hbm.24191.","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"971_CR67","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1093\/brain\/awm275","volume":"131","author":"S Kl\u00f6ppel","year":"2008","unstructured":"Kl\u00f6ppel S, Draganski B, Golding CV, Chu C, Nagy Z, Cook PA, Hicks SL, Kennard C, Alexander DC, Parker GJM, Tabrizi SJ, Frackowiak RSJ. White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington\u2019s disease. Brain. 2008;131(1):196\u2013204. https:\/\/doi.org\/10.1093\/brain\/awm275.","journal-title":"Brain"},{"key":"971_CR68","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.nicl.2018.01.029","volume":"20","author":"HD Rosas","year":"2018","unstructured":"Rosas HD, Wilkens P, Salat DH, Mercaldo ND, Vangel M, Yendiki AY, Hersch SM. Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease. NeuroImage: Clin. 2018;20:236\u201342. https:\/\/doi.org\/10.1016\/j.nicl.2018.01.029.","journal-title":"NeuroImage: Clin"},{"issue":"1","key":"971_CR69","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.nbd.2011.03.018","volume":"43","author":"JB Carroll","year":"2011","unstructured":"Carroll JB, Lerch JP, Franciosi S, Spreeuw A, Bissada N, Henkelman RM, Hayden MR. Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease. Neurobiol Dis. 2011;43(1):257\u201365. https:\/\/doi.org\/10.1016\/j.nbd.2011.03.018.","journal-title":"Neurobiol Dis"},{"issue":"3\u20134","key":"971_CR70","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.brainresbull.2010.04.003","volume":"82","author":"JS Paulsen","year":"2010","unstructured":"Paulsen JS, Nopoulos PC, Aylward E, Ross CA, Johnson H, Magnotta VA, Juhl A, Pierson RK, Mills J, Langbehn D, Nance M. Striatal and white matter predictors of estimated diagnosis for Huntington disease. Brain Res Bull. 2010;82(3\u20134):201\u20137. https:\/\/doi.org\/10.1016\/j.brainresbull.2010.04.003.","journal-title":"Brain Res Bull"},{"issue":"2","key":"971_CR71","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1750-3639.2012.00629.x","volume":"23","author":"U R\u00fcb","year":"2013","unstructured":"R\u00fcb U, Hoche F, Brunt ER, Heinsen H, Seidel K, Del Turco D, Paulson HL, Bohl J, von Gall C, Vonsattel J, Korf H, den Dunnen WF. Degeneration of the Cerebellum in Huntington\u2019s Disease (HD): Possible Relevance for the Clinical Picture and Potential Gateway to Pathological Mechanisms of the Disease Process. Brain Pathol. 2013;23(2):165\u201377. https:\/\/doi.org\/10.1111\/j.1750-3639.2012.00629.x.","journal-title":"Brain Pathol"},{"issue":"6","key":"971_CR72","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.3174\/ajnr.A2018","volume":"31","author":"NZ Hobbs","year":"2010","unstructured":"Hobbs NZ, Barnes J, Frost C, Henley SMD, Wild EJ, Macdonald K, Barker RA, Scahill RI, Fox NC, Tabrizi SJ. Onset and progression of pathologic atrophy in Huntington disease: A longitudinal MR imaging study. Am J Neuroradiol. 2010;31(6):1036\u201341. https:\/\/doi.org\/10.3174\/ajnr.A2018.","journal-title":"Am J Neuroradiol"},{"key":"971_CR73","doi-asserted-by":"publisher","unstructured":"Ozturk BO, Monte B, Koundal S, Dai F, Benveniste H, Lee H. Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics. Fluids Barriers CNS. 2021;18(1). https:\/\/doi.org\/10.1186\/s12987-020-00236-x.","DOI":"10.1186\/s12987-020-00236-x"},{"key":"971_CR74","doi-asserted-by":"publisher","unstructured":"Southwell AL, Smith-Dijak A, Kay C, Sepers M, Villanueva EB, Parsons MP, Xie Y, Anderson L, Felczak B, Waltl S, Ko S, Cheung D, Dal Cengio L, Slama R, Petoukhov E, Raymond LA, Hayden MR. An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes. Hum Mol Genet. 2016 Sep 1;25(17):3654-3675. https:\/\/doi.org\/10.1093\/hmg\/ddw212.","DOI":"10.1093\/hmg\/ddw212"},{"key":"971_CR75","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12915-024-01919-9","volume":"22","author":"ET Koch","year":"2024","unstructured":"Koch ET, Cheng J, Ramandi D, Sepers MD, Hsu A, Fong T, Murphy TH, Yttri E, Raymond LA. Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight. BMC Biol. 2024;22:121. https:\/\/doi.org\/10.1186\/s12915-024-01919-9.","journal-title":"BMC Biol"}],"container-title":["Biomarker Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40364-026-00971-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40364-026-00971-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40364-026-00971-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:11:23Z","timestamp":1788243083000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40364-026-00971-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["971"],"URL":"https:\/\/doi.org\/10.1186\/s40364-026-00971-7","relation":{},"ISSN":["2050-7771"],"issn-type":[{"value":"2050-7771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"6 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experimental procedures and animal handling described in this investigation were carried out according to European guidelines for the housing and use of laboratory animals (2010\/63\/EEC). This project was approved by the Ethical Committee on Animal Care and Use at the University of Antwerp, Belgium (ECD 2017-09).","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"100"}}