{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:41:56Z","timestamp":1791661316976,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":1583,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World Allergy Organization Journal"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1186\/s40413-014-0052-x","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T10:10:38Z","timestamp":1422526238000},"page":"5","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["The care pathway for children with urticaria, angioedema, mastocytosis"],"prefix":"10.1016","volume":"8","author":[{"given":"Giuliana","family":"Ferrante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Scavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concetta","family":"Muscia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Adrignola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Corsello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Passalacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"La Grutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1186\/s40413-014-0052-x_bib0005","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/WOX.0b013e3182758d6c","article-title":"Diagnosis and treatment of urticaria and angioedema: a worldwide perspective","volume":"5","author":"S\u00e1nchez-Borges","year":"2012","journal-title":"World Allergy Organ J"},{"key":"10.1186\/s40413-014-0052-x_bib0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1034\/j.1398-9995.2000.00116.x","article-title":"Chronic urticarial in childhood","volume":"55","author":"Greaves","year":"2000","journal-title":"Allergy"},{"key":"10.1186\/s40413-014-0052-x_bib0015","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2133.2000.03664.x","article-title":"Randomized double-blind study of cyclosporine in chronic \u201cidiopathic\u201d urticarial","volume":"143","author":"Grattan","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1186\/s40413-014-0052-x_bib0020","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1399-3038.2008.00733.x","article-title":"The prevelance of allergic diseases in an unselected group of 6-year-old children. The DARC birth cohort study","volume":"19","author":"Kjaer","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1399-3038.2007.00667.x","article-title":"Clinical features and natural history of physical urticaria in children","volume":"19","author":"Khakoo","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0030","first-page":"41","article-title":"Urticaria in Thai children","volume":"4","author":"Tuchinda","year":"1986","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0035","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1398-9995.2009.02179.x","article-title":"EAACI\/GA(2)LEN\/EDF\/WAO guideline: definition, classification and diagnosis of urticaria","volume":"64","author":"Zuberbier","year":"2009","journal-title":"Allergy"},{"key":"10.1186\/s40413-014-0052-x_bib0040","first-page":"5","article-title":"Urticaria and urticaria related skin condition\/disease in children","volume":"40","author":"Novembre","year":"2008","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-3038.2010.01120.x","article-title":"Chronic spontaneous urticaria in children: itching for insight","volume":"22","author":"Church","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0050","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11882-012-0269-0","article-title":"Physical urticaria","volume":"12","author":"Abajian","year":"2012","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1186\/s40413-014-0052-x_bib0055","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0301-0546(04)79270-8","article-title":"Cold urticaria and infectious mononucleosis in children","volume":"32","author":"Morais-Almeida","year":"2004","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1186\/s40413-014-0052-x_bib0060","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.jaci.2009.09.035","article-title":"Familial atypical cold urticaria: description of a new hereditary disease","volume":"124","author":"Gandhi","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0065","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1111\/j.1398-9995.2009.02177.x","article-title":"The definition and diagnostic testing of physical and cholinergic urticarias \u2013 EAACI\/GA2LEN\/EDF\/UNEV consensus panel recommendations","volume":"64","author":"Magerl","year":"2009","journal-title":"Allergy"},{"key":"10.1186\/s40413-014-0052-x_bib0070","first-page":"38","article-title":"Exercise-induced anaphylaxis: a clinical view","volume":"14","author":"Povesi Dascola","year":"2012","journal-title":"Ital J Pediatr"},{"key":"10.1186\/s40413-014-0052-x_bib0075","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0140-6736(11)60935-5","article-title":"Hereditary angio-oedema","volume":"4","author":"Longhurst","year":"2012","journal-title":"Lancet"},{"key":"10.1186\/s40413-014-0052-x_bib0080","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1001\/archinte.163.10.1229","article-title":"Clinical studies of sudden upper airway obstruction in patients with hereditary angioedema due to C1 esterase inhibitor deficiency","volume":"163","author":"Bork","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1186\/s40413-014-0052-x_bib0085","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jaci.2012.05.055","article-title":"Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency","volume":"130","author":"Bork","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0090","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1067\/mai.2000.110471","article-title":"Frequent de novo mutations and exon deletions in the C1inhibitor gene of patients with angioedema","volume":"106","author":"Pappalardo","year":"2000","journal-title":"J Allergy Clin Immunol."},{"key":"10.1186\/s40413-014-0052-x_bib0095","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/CE.S24743","article-title":"An evidence-based review of the potential role of icatibant in the treatment of acute attacks in hereditary angioedema type I and II","volume":"7","author":"Floccard","year":"2012","journal-title":"Core Evid"},{"key":"10.1186\/s40413-014-0052-x_bib0100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1398-9995.2010.02456.x","article-title":"Mutational spectrum and phenotypes in Danish families with hereditary angioedema because of C1 inhibitor deficiency","volume":"66","author":"Bygum","year":"2011","journal-title":"Allergy"},{"key":"10.1186\/s40413-014-0052-x_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anai.2009.11.006","article-title":"Current approaches to the diagnosis and treatment of systemic mastocytosis","volume":"104","author":"Bains","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0110","first-page":"A4397","article-title":"Systemic mastocytosis - a systematic review","volume":"59","author":"Andersen","year":"2012","journal-title":"Dan Med J"},{"key":"10.1186\/s40413-014-0052-x_bib0115","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1468-3083.2011.04365.x","article-title":"Clinical aspects of paediatric mastocytosis: a review of 101 cases","volume":"27","author":"Lange","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1186\/s40413-014-0052-x_bib0120","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jpeds.2012.08.035","article-title":"Imatinib mesylate in the treatment of diffuse cutaneous mastocytosis","volume":"162","author":"Morren","year":"2013","journal-title":"J Pediatr"},{"key":"10.1186\/s40413-014-0052-x_bib0125","unstructured":"Saini S. Chronic urticaria: clinical manifestations, diagnosis, pathogenesis, and natural history. http:\/\/www.uptodate.com \u00a9 2014 UpToDate \u00ae."},{"key":"10.1186\/s40413-014-0052-x_bib0130","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.jaci.2014.02.036","article-title":"The diagnosis and management of acute and chronic urticaria: 2014 update","volume":"133","author":"Bernstein","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0135","first-page":"89","article-title":"Update on treatment of hereditary angioedema","volume":"30","author":"Buyantseva","year":"2012","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0140","doi-asserted-by":"crossref","unstructured":"Valent P, Escribano L, Broesby-Olsen S, Hartmann K, Grattan C, Brockow K, et al. Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis. Allergy. 2014;69:1267\u201374.","DOI":"10.1111\/all.12436"},{"key":"10.1186\/s40413-014-0052-x_bib0145","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0190-9622(96)90679-9","article-title":"Value of urinary N-methylhistamine measurements in childhood mastocytosis","volume":"35","author":"Van Gysel","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"10.1186\/s40413-014-0052-x_bib0150","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/j.1398-9995.2009.02178.x","article-title":"EAACI\/GA(2)LEN\/EDF\/WAO guideline: management of urticaria","volume":"64","author":"Zuberbier","year":"2009","journal-title":"Allergy"},{"key":"10.1186\/s40413-014-0052-x_bib0155","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11882-012-0270-7","article-title":"Chronic urticaria","volume":"12","author":"Zuberbier","year":"2012","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1186\/s40413-014-0052-x_bib0160","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJMoa1215372","article-title":"Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria","volume":"368","author":"Maurer","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1186\/s40413-014-0052-x_bib0165","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/all.12313","article-title":"The EAACI\/GA(2)LEN\/EDF\/WAO guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update","volume":"69","author":"Zuberbier","year":"2014","journal-title":"Allergy"},{"key":"10.1186\/s40413-014-0052-x_bib0170","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1398-9995.2011.02751.x","article-title":"Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group","volume":"67","author":"Cicardi","year":"2012","journal-title":"Allergy"},{"key":"10.1186\/s40413-014-0052-x_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1710-1492-7-1","article-title":"Hereditary angioedema: beyond international consensus","volume":"10","author":"Bowen","year":"2011","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0180","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1111\/j.1398-9995.2011.02702.x","article-title":"C1 esterase inhibitor concentrate in 1085 Hereditary Angioedema attacks-final results of the I.M.P.A.C.T.2 study","volume":"66","author":"Craig","year":"2011","journal-title":"Allergy"},{"key":"10.1186\/s40413-014-0052-x_bib0185","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s00431-012-1726-4","article-title":"Hereditary angioedema (HAE) in children and adolescents - a consensus on therapeutic strategies","volume":"171","author":"Wahn","year":"2012","journal-title":"Eur J Pediatr"},{"key":"10.1186\/s40413-014-0052-x_bib0190","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1525-1470.2011.01675.x","article-title":"Hereditary angioedema in childhood: a challenging diagnosis you cannot afford to miss","volume":"30","author":"Kj\u00e6r","year":"2013","journal-title":"Pediatr Dermatol"},{"key":"10.1186\/s40413-014-0052-x_bib0195","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/pai.12024","article-title":"C1 INH concentrate for treatment of acute hereditary angioedema: a pediatric cohort from IMPACT studies","volume":"24","author":"Schneider","year":"2013","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1186\/s40413-014-0052-x_bib0200","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jpeds.2012.11.030","article-title":"Nanofiltered C1 Esterase inhibitor for the acute management and prevention of hereditary angioedema attacks due to C1 inhibitor deficiency in children","volume":"162","author":"Lumry","year":"2013","journal-title":"J Pediatr"},{"key":"10.1186\/s40413-014-0052-x_bib0205","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/all.12060","article-title":"Recombinant human C1 inhibitor for the prophylaxis of hereditary angioedema attacks: a pilot study","volume":"68","author":"Reshef","year":"2013","journal-title":"Allergy"},{"key":"10.1186\/s40413-014-0052-x_bib0210","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000100885","article-title":"Efficacy of 25% diluted fluticasone propionate 0.05% cream as wet-wrap treatment in cutaneous mastocytosis","volume":"214","author":"Heide","year":"2007","journal-title":"Dermatology"},{"key":"10.1186\/s40413-014-0052-x_bib0215","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1525-1470.2008.00738.x","article-title":"Mastocytosis in children: a protocol for management","volume":"25","author":"Heide","year":"2008","journal-title":"Pediatr Dermatol"}],"container-title":["World Allergy Organization Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40413-014-0052-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40413-014-0052-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1939455119301991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1939455119301991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40413-014-0052-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40413-014-0052-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T11:59:24Z","timestamp":1556884764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1939455119301991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":43,"alternative-id":["S1939455119301991"],"URL":"https:\/\/doi.org\/10.1186\/s40413-014-0052-x","relation":{},"ISSN":["1939-4551"],"issn-type":[{"value":"1939-4551","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]},"article-number":"5"}}