{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:59:41Z","timestamp":1767851981230,"version":"3.49.0"},"reference-count":63,"publisher":"BMJ","issue":"1","funder":[{"name":"Gisela Thier Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["j. immunotherapy cancer"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s40425-019-0500-9","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T13:05:29Z","timestamp":1548939929000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection"],"prefix":"10.1136","volume":"7","author":[{"given":"Elham","family":"Beyranvand Nejad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Ratts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Panagioti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer D.","family":"Oduro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luka","family":"Cicin-Sain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Fr\u00fch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sjoerd H.","family":"van der Burg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-4110","authenticated-orcid":false,"given":"Ramon","family":"Arens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"500_CR1","doi-asserted-by":"crossref","unstructured":"Redeker A, Arens R. Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination. Front Immunol. 2016;7:345.","DOI":"10.3389\/fimmu.2016.00345"},{"issue":"6230","key":"500_CR2","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1126\/science.aaa8172","volume":"348","author":"P Sharma","year":"2015","unstructured":"Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348(6230):56\u201361.","journal-title":"Science"},{"key":"500_CR3","doi-asserted-by":"crossref","unstructured":"van der Burg SH, Arens R, Ossendorp F, van Hall T, Melief CJ. Vaccines for established cancer: overcoming the challenges posed by immune evasion. Nat Rev Cancer. 2016;16(4):219-33.","DOI":"10.1038\/nrc.2016.16"},{"issue":"3","key":"500_CR4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1086\/589862","volume":"47","author":"SA Plotkin","year":"2008","unstructured":"Plotkin SA. Vaccines: correlates of vaccine-induced immunity. Clin Infect Dis. 2008;47(3):401\u20139.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"500_CR5","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.4049\/jimmunol.170.4.2022","volume":"170","author":"U Karrer","year":"2003","unstructured":"Karrer U, Sierro S, Wagner M, Oxenius A, Hengel H, Koszinowski UH, et al. Memory inflation: continuous accumulation of antiviral CD8+ T cells over time. J Immunol. 2003;170(4):2022\u20139.","journal-title":"J Immunol"},{"issue":"2","key":"500_CR6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.it.2011.11.005","volume":"33","author":"GA O'Hara","year":"2012","unstructured":"O'Hara GA, Welten SP, Klenerman P, Arens R. Memory T cell inflation: understanding cause and effect. Trends Immunol. 2012;33(2):84\u201390.","journal-title":"Trends Immunol"},{"issue":"5","key":"500_CR7","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1084\/jem.20050882","volume":"202","author":"AW Sylwester","year":"2005","unstructured":"Sylwester AW, Mitchell BL, Edgar JB, Taormina C, Pelte C, Ruchti F, et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med. 2005;202(5):673\u201385.","journal-title":"J Exp Med"},{"issue":"9","key":"500_CR8","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1128\/JVI.03177-15","volume":"90","author":"SP Welten","year":"2016","unstructured":"Welten SP, Redeker A, Toes RE, Arens R. Viral persistence induces antibody inflation without altering antibody avidity. J Virol. 2016;90(9):4402\u201311.","journal-title":"J Virol"},{"issue":"6","key":"500_CR9","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nri.2016.38","volume":"16","author":"P Klenerman","year":"2016","unstructured":"Klenerman P, Oxenius A. T cell responses to cytomegalovirus. Nat Rev Immunol. 2016;16(6):367\u201377.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"500_CR10","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1086\/649903","volume":"201","author":"SA Ross","year":"2010","unstructured":"Ross SA, Arora N, Novak Z, Fowler KB, Britt WJ, Boppana SB. Cytomegalovirus reinfections in healthy seroimmune women. J Infect Dis. 2010;201(3):386\u20139.","journal-title":"J Infect Dis"},{"key":"500_CR11","doi-asserted-by":"crossref","unstructured":"Trgovcich J, Kincaid M, Thomas A, Griessl M, Zimmerman P, Dwivedi V, et al. Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation. PLoS One. 2016;11(11):e0167097.","DOI":"10.1371\/journal.pone.0167097"},{"issue":"4","key":"500_CR12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/rmv.535","volume":"17","author":"A Kenneson","year":"2007","unstructured":"Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007;17(4):253\u201376.","journal-title":"Rev Med Virol"},{"key":"500_CR13","doi-asserted-by":"crossref","unstructured":"Borst EM, Benkartek C, Messerle M. Use of bacterial artificial chromosomes in generating targeted mutations in human and mouse cytomegaloviruses. Curr Protoc Immunol. 2007; Chapter 10:Unit.","DOI":"10.1002\/0471142735.im1032s77"},{"issue":"7348","key":"500_CR14","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature10003","volume":"473","author":"SG Hansen","year":"2011","unstructured":"Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, et al. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature. 2011;473(7348):523\u20137.","journal-title":"Nature"},{"issue":"8","key":"500_CR15","doi-asserted-by":"publisher","first-page":"e1275","DOI":"10.1371\/journal.pntd.0001275","volume":"5","author":"Y Tsuda","year":"2011","unstructured":"Tsuda Y, Caposio P, Parkins CJ, Botto S, Messaoudi I, Cicin-Sain L, et al. A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. PLoS Negl Trop Dis. 2011;5(8):e1275.","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"500_CR16","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.4049\/jimmunol.1302523","volume":"193","author":"PC Beverley","year":"2014","unstructured":"Beverley PC, Ruzsics Z, Hey A, Hutchings C, Boos S, Bolinger B, et al. A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis. J Immunol. 2014;193(5):2306\u201316.","journal-title":"J Immunol"},{"key":"500_CR17","doi-asserted-by":"publisher","first-page":"21674","DOI":"10.1038\/srep21674","volume":"6","author":"A Marzi","year":"2016","unstructured":"Marzi A, Murphy AA, Feldmann F, Parkins CJ, Haddock E, Hanley PW, et al. Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection. Sci Rep. 2016;6:21674.","journal-title":"Sci Rep"},{"issue":"2","key":"500_CR18","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/nm.4473","volume":"24","author":"SG Hansen","year":"2018","unstructured":"Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, Malouli D, et al. Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine. Nat Med. 2018;24(2):130\u201343.","journal-title":"Nat Med"},{"issue":"8","key":"500_CR19","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1038\/mt.2016.121","volume":"24","author":"DA Erkes","year":"2016","unstructured":"Erkes DA, Xu G, Daskalakis C, Zurbach KA, Wilski NA, Moghbeli T, et al. Intratumoral infection with murine cytomegalovirus synergizes with PD-L1 blockade to clear melanoma lesions and induce long-term immunity. Mol Ther. 2016;24(8):1444\u201355.","journal-title":"Mol Ther"},{"issue":"2","key":"500_CR20","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.bbrc.2013.06.068","volume":"437","author":"G Xu","year":"2013","unstructured":"Xu G, Smith T, Grey F, Hill AB. Cytomegalovirus-based cancer vaccines expressing TRP2 induce rejection of melanoma in mice. Biochem Biophys Res Commun. 2013;437(2):287\u201391.","journal-title":"Biochem Biophys Res Commun"},{"issue":"50","key":"500_CR21","doi-asserted-by":"publisher","first-page":"29392","DOI":"10.18632\/oncotarget.25630","volume":"9","author":"H Benonisson","year":"2018","unstructured":"Benonisson H, Sow HS, Breukel C, Claassens JWC, Brouwers C, Linssen MM, et al. FcgammaRI expression on macrophages is required for antibody-mediated tumor protection by cytomegalovirus-based vaccines. Oncotarget. 2018;9(50):29392\u2013402.","journal-title":"Oncotarget"},{"issue":"5","key":"500_CR22","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1158\/2326-6066.CIR-14-0044","volume":"3","author":"Z Qiu","year":"2015","unstructured":"Qiu Z, Huang H, Grenier JM, Perez OA, Smilowitz HM, Adler B, et al. Cytomegalovirus-based vaccine expressing a modified tumor antigen induces potent tumor-specific CD8(+) T-cell response and protects mice from melanoma. Cancer Immunol Res. 2015;3(5):536\u201346.","journal-title":"Cancer Immunol Res"},{"issue":"5","key":"500_CR23","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/CJI.0b013e3182585d50","volume":"35","author":"EN Klyushnenkova","year":"2012","unstructured":"Klyushnenkova EN, Kouiavskaia DV, Parkins CJ, Caposio P, Botto S, Alexander RB, et al. A cytomegalovirus-based vaccine expressing a single tumor-specific CD8+ T-cell epitope delays tumor growth in a murine model of prostate cancer. J Immunother. 2012;35(5):390\u20139.","journal-title":"J Immunother"},{"issue":"8","key":"500_CR24","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1002\/eji.201746964","volume":"47","author":"T Trsan","year":"2017","unstructured":"Trsan T, Vukovic K, Filipovic P, Brizic AL, Lemmermann NAW, Schober K, et al. Cytomegalovirus vector expressing RAE-1gamma induces enhanced anti-tumor capacity of murine CD8(+) T cells. Eur J Immunol. 2017;47(8):1354\u201367.","journal-title":"Eur J Immunol"},{"issue":"12","key":"500_CR25","doi-asserted-by":"publisher","first-page":"6851","DOI":"10.1128\/JVI.03305-12","volume":"87","author":"SP Welten","year":"2013","unstructured":"Welten SP, Redeker A, Franken KL, Benedict CA, Yagita H, Wensveen FM, et al. CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection. J Virol. 2013;87(12):6851\u201365.","journal-title":"J Virol"},{"issue":"12","key":"500_CR26","doi-asserted-by":"publisher","first-page":"e1006072","DOI":"10.1371\/journal.ppat.1006072","volume":"12","author":"I Dekhtiarenko","year":"2016","unstructured":"Dekhtiarenko I, Ratts RB, Blatnik R, Lee LN, Fischer S, Borkner L, et al. Peptide processing is critical for T-cell memory inflation and may be optimized to improve immune protection by CMV-based vaccine vectors. PLoS Pathog. 2016;12(12):e1006072.","journal-title":"PLoS Pathog"},{"issue":"4","key":"500_CR27","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1093\/nar\/gni035","volume":"33","author":"S Warming","year":"2005","unstructured":"Warming S, Costantino N, Court DL, Jenkins NA, Copeland NG. Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res. 2005;33(4):e36.","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"500_CR28","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.4049\/jimmunol.1203173","volume":"190","author":"I Dekhtiarenko","year":"2013","unstructured":"Dekhtiarenko I, Jarvis MA, Ruzsics Z, Cicin-Sain L. The context of gene expression defines the immunodominance hierarchy of cytomegalovirus antigens. J Immunol. 2013;190(7):3399\u2013409.","journal-title":"J Immunol"},{"issue":"10","key":"500_CR29","doi-asserted-by":"publisher","first-page":"4841","DOI":"10.1128\/JVI.02344-10","volume":"85","author":"YC Perng","year":"2011","unstructured":"Perng YC, Qian Z, Fehr AR, Xuan B, Yu D. The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts. J Virol. 2011;85(10):4841\u201352.","journal-title":"J Virol"},{"issue":"1","key":"500_CR30","first-page":"21","volume":"56","author":"KY Lin","year":"1996","unstructured":"Lin KY, Guarnieri FG, Staveley-O'Carroll KF, Levitsky HI, August JT, Pardoll DM, et al. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res. 1996;56(1):21\u20136.","journal-title":"Cancer Res"},{"issue":"7","key":"500_CR31","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.4049\/jimmunol.1201540","volume":"189","author":"S Duikeren van","year":"2012","unstructured":"van Duikeren S, Fransen MF, Redeker A, Wieles B, Platenburg G, Krebber W-J, et al. Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors. J Immunol. 2012;189(7):3397\u2013403.","journal-title":"J Immunol"},{"issue":"9","key":"500_CR32","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1002\/eji.1830230929","volume":"23","author":"MC Feltkamp","year":"1993","unstructured":"Feltkamp MC, Smits HL, Vierboom MP, Minnaar RP, De Jongh BM, Drijfhout JW, et al. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur J Immunol. 1993;23(9):2242\u20139.","journal-title":"Eur J Immunol"},{"issue":"10","key":"500_CR33","doi-asserted-by":"publisher","first-page":"4792","DOI":"10.4049\/jimmunol.1501083","volume":"195","author":"A Redeker","year":"2015","unstructured":"Redeker A, Welten SP, Baert MR, Vloemans SA, Tiemessen MM, Staal FJ, et al. The quantity of autocrine IL-2 governs the expansion potential of CD8+ T cells. J Immunol. 2015;195(10):4792\u2013801.","journal-title":"J Immunol"},{"issue":"7","key":"500_CR34","doi-asserted-by":"publisher","first-page":"3874","DOI":"10.4049\/jimmunol.1003231","volume":"186","author":"R Arens","year":"2011","unstructured":"Arens R, Loewendorf A, Redeker A, Sierro S, Boon L, Klenerman P, et al. Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations. J Immunol. 2011;186(7):3874\u201381.","journal-title":"J Immunol"},{"issue":"5284","key":"500_CR35","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1126\/science.274.5284.94","volume":"274","author":"JD Altman","year":"1996","unstructured":"Altman JD, Moss PAH, Goulder PJR, Barouch DH, McHeyzer-Williams MG, Bell JI, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996;274(5284):94\u20136.","journal-title":"Science"},{"key":"500_CR36","doi-asserted-by":"crossref","unstructured":"van Leeuwen EM, Koning JJ, Remmerswaal EB, van BD, van Lier RA, ten Berge IJ. Differential usage of cellular niches by cytomegalovirus versus EBV- and influenza virus-specific CD8+ T cells. J Immunol 2006;177(8):4998\u20135005.","DOI":"10.4049\/jimmunol.177.8.4998"},{"issue":"7226","key":"500_CR37","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/nature07486","volume":"457","author":"V Vezys","year":"2009","unstructured":"Vezys V, Yates A, Casey KA, Lanier G, Ahmed R, Antia R, et al. Memory CD8 T-cell compartment grows in size with immunological experience. Nature. 2009;457(7226):196\u20139.","journal-title":"Nature"},{"issue":"37","key":"500_CR38","doi-asserted-by":"publisher","first-page":"14017","DOI":"10.1073\/pnas.0805452105","volume":"105","author":"NW Schmidt","year":"2008","unstructured":"Schmidt NW, Podyminogin RL, Butler NS, Badovinac VP, Tucker BJ, Bahjat KS, et al. Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria. Proc Natl Acad Sci U S A. 2008;105(37):14017\u201322.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"500_CR39","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.immuni.2016.01.010","volume":"44","author":"S Halle","year":"2016","unstructured":"Halle S, Keyser KA, Stahl FR, Busche A, Marquardt A, Zheng X, et al. In vivo killing capacity of cytotoxic T cells is limited and involves dynamic interactions and T cell cooperativity. Immunity. 2016;44(2):233\u201345.","journal-title":"Immunity"},{"key":"500_CR40","doi-asserted-by":"crossref","unstructured":"Oduro JD, Redeker A, Lemmermann NA, Ebermann L, Marandu TF, Dekhtiarenko I, et al. Murine cytomegalovirus infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection. J Gen Virol. 2016;97(1):185-95.","DOI":"10.1099\/jgv.0.000339"},{"issue":"2","key":"500_CR41","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/mi.2016.48","volume":"10","author":"KM Morabito","year":"2017","unstructured":"Morabito KM, Ruckwardt TR, Redwood AJ, Moin SM, Price DA, Graham BS. Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung. Mucosal Immunol. 2017;10(2):545\u201354.","journal-title":"Mucosal Immunol"},{"issue":"7","key":"500_CR42","doi-asserted-by":"publisher","first-page":"e1442163","DOI":"10.1080\/2162402X.2018.1442163","volume":"7","author":"F Galvez-Cancino","year":"2018","unstructured":"Galvez-Cancino F, Lopez E, Menares E, Diaz X, Flores C, Caceres P, et al. Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma. Oncoimmunology. 2018;7(7):e1442163.","journal-title":"Oncoimmunology"},{"key":"500_CR43","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.3389\/fimmu.2017.01953","volume":"8","author":"A Redeker","year":"2017","unstructured":"Redeker A, Remmerswaal EBM, van der Gracht ETI, Welten SPM, Hollt T, Koning F, et al. The contribution of cytomegalovirus infection to immune senescence is set by the infectious dose. Front Immunol. 2017;8:1953.","journal-title":"Front Immunol"},{"key":"500_CR44","doi-asserted-by":"crossref","unstructured":"Pardieck IN, Beyrend G, Redeker A, Arens R. Cytomegalovirus infection and progressive differentiation of effector-memory T cells. F1000Res. 2018;7:1554.","DOI":"10.12688\/f1000research.15753.1"},{"issue":"4","key":"500_CR45","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nm0402-379","volume":"8","author":"V Appay","year":"2002","unstructured":"Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002;8(4):379\u201385.","journal-title":"Nat Med"},{"issue":"4","key":"500_CR46","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1002\/eji.201343946","volume":"44","author":"A Redeker","year":"2014","unstructured":"Redeker A, Welten SP, Arens R. Viral inoculum dose impacts memory T-cell inflation. Eur J Immunol. 2014;44(4):1046\u201357.","journal-title":"Eur J Immunol"},{"issue":"3","key":"500_CR47","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0022-3476(96)70279-2","volume":"128","author":"JF Bale Jr","year":"1996","unstructured":"Bale JF Jr, Petheram SJ, Souza IE, Murph JR. Cytomegalovirus reinfection in young children. J Pediatr. 1996;128(3):347\u201352.","journal-title":"J Pediatr"},{"issue":"2","key":"500_CR48","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jcv.2010.03.005","volume":"48","author":"I Gorzer","year":"2010","unstructured":"Gorzer I, Kerschner H, Redlberger-Fritz M, Puchhammer-Stockl E. Human cytomegalovirus (HCMV) genotype populations in immunocompetent individuals during primary HCMV infection. J Clin Virol. 2010;48(2):100\u20133.","journal-title":"J Clin Virol"},{"issue":"5974","key":"500_CR49","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1126\/science.1185350","volume":"328","author":"SG Hansen","year":"2010","unstructured":"Hansen SG, Powers CJ, Richards R, Ventura AB, Ford JC, Siess D, et al. Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science. 2010;328(5974):102\u20136.","journal-title":"Science"},{"issue":"3","key":"500_CR50","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nm.1935","volume":"15","author":"SG Hansen","year":"2009","unstructured":"Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, et al. Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med. 2009;15(3):293\u20139.","journal-title":"Nat Med"},{"issue":"6274","key":"500_CR51","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1126\/science.aac9475","volume":"351","author":"SG Hansen","year":"2016","unstructured":"Hansen SG, Wu HL, Burwitz BJ, Hughes CM, Hammond KB, Ventura AB, et al. Broadly targeted CD8(+) T cell responses restricted by major histocompatibility complex E. Science. 2016;351(6274):714\u201320.","journal-title":"Science"},{"issue":"20161988","key":"500_CR52","first-page":"20161988","volume":"31","author":"SE Murray","year":"2017","unstructured":"Murray SE, Nesterenko PA, Vanarsdall AL, Munks MW, Smart SM, Veziroglu EM, et al. Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans. J Exp Med. 2017;31(20161988):20161988.","journal-title":"J Exp Med"},{"issue":"13","key":"500_CR53","doi-asserted-by":"publisher","first-page":"7182","DOI":"10.1128\/JVI.77.13.7182-7192.2003","volume":"77","author":"X Wang","year":"2003","unstructured":"Wang X, Messerle M, Sapinoro R, Santos K, Hocknell PK, Jin X, et al. Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes. J Virol. 2003;77(13):7182\u201392.","journal-title":"J Virol"},{"issue":"15","key":"500_CR54","doi-asserted-by":"publisher","first-page":"7510","DOI":"10.1128\/JVI.00684-06","volume":"80","author":"Q Tang","year":"2006","unstructured":"Tang Q, Maul GG. Mouse cytomegalovirus crosses the species barrier with help from a few human cytomegalovirus proteins. J Virol. 2006;80(15):7510\u201321.","journal-title":"J Virol"},{"issue":"27","key":"500_CR55","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1016\/S0264-410X(01)00086-X","volume":"19","author":"SH Burg van der","year":"2001","unstructured":"van der Burg SH, Kwappenberg KM, O'Neill T, Brandt RM, Melief CJ, Hickling JK, et al. Pre-clinical safety and efficacy of TA-CIN, a recombinant HPV16 L2E6E7 fusion protein vaccine, in homologous and heterologous prime-boost regimens. Vaccine. 2001;19(27):3652\u201360.","journal-title":"Vaccine"},{"issue":"14","key":"500_CR56","first-page":"5205","volume":"9","author":"PJ Baldwin","year":"2003","unstructured":"Baldwin PJ, van der Burg SH, Boswell CM, Offringa R, Hickling JK, Dobson J, et al. Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia. Clin Cancer Res. 2003;9(14):5205\u201313.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"500_CR57","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s00262-013-1421-y","volume":"62","author":"SY Lee","year":"2013","unstructured":"Lee SY, Kang TH, Knoff J, Huang Z, Soong RS, Alvarez RD, et al. Intratumoral injection of therapeutic HPV vaccinia vaccine following cisplatin enhances HPV-specific antitumor effects. Cancer Immunol Immunother. 2013;62(7):1175\u201385.","journal-title":"Cancer Immunol Immunother"},{"issue":"11","key":"500_CR58","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1158\/2326-6066.CIR-18-0166","volume":"6","author":"G Galliverti","year":"2018","unstructured":"Galliverti G, Tichet M, Domingos-Pereira S, Hauert S, Nardelli-Haefliger D, Swartz MA, et al. Nanoparticle conjugation of human papillomavirus 16 E7-long peptides enhances therapeutic vaccine efficacy against solid tumors in mice. Cancer Immunol Res. 2018;6(11):1301\u201313.","journal-title":"Cancer Immunol Res"},{"key":"500_CR59","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13578-016-0080-z","volume":"6","author":"S Peng","year":"2016","unstructured":"Peng S, Qiu J, Yang A, Yang B, Jeang J, Wang JW, et al. Optimization of heterologous DNA-prime, protein boost regimens and site of vaccination to enhance therapeutic immunity against human papillomavirus-associated disease. Cell Bioscience. 2016;6:16.","journal-title":"Cell Bioscience"},{"issue":"3","key":"500_CR60","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.juro.2013.08.009","volume":"191","author":"S Domingos-Pereira","year":"2014","unstructured":"Domingos-Pereira S, Derre L, Warpelin-Decrausaz L, Haefliger JA, Romero P, Jichlinski P, et al. Intravaginal and subcutaneous immunization induced vaccine specific CD8 T cells and tumor regression in the bladder. J Urol. 2014;191(3):814\u201322.","journal-title":"J Urol"},{"issue":"6","key":"500_CR61","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1084\/jem.20091193","volume":"207","author":"DM Andrews","year":"2010","unstructured":"Andrews DM, Estcourt MJ, Andoniou CE, Wikstrom ME, Khong A, Voigt V, et al. Innate immunity defines the capacity of antiviral T cells to limit persistent infection. J Exp Med. 2010;207(6):1333\u201343.","journal-title":"J Exp Med"},{"issue":"19","key":"500_CR62","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1056\/NEJMoa0810097","volume":"361","author":"GG Kenter","year":"2009","unstructured":"Kenter GG, Welters MJ, Valentijn AR, Lowik MJ. Berends-van der Meer DM, Vloon AP, et al. vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med. 2009;361(19):1838\u201347.","journal-title":"N Engl J Med"},{"issue":"10","key":"500_CR63","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1158\/1078-0432.CCR-15-2594","volume":"22","author":"MI Poelgeest van","year":"2016","unstructured":"van Poelgeest MI, Welters MJ, Vermeij R, Stynenbosch LF, Loof NM. Berends-van der Meer DM, et al. vaccination against Oncoproteins of HPV16 for noninvasive vulvar\/vaginal lesions: lesion clearance is related to the strength of the T-cell response. Clin Cancer Res. 2016;22(10):2342\u201350.","journal-title":"Clin Cancer Res"}],"container-title":["Journal for ImmunoTherapy of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40425-019-0500-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T17:45:18Z","timestamp":1601055918000},"score":1,"resource":{"primary":{"URL":"https:\/\/jitc.bmj.com\/lookup\/doi\/10.1186\/s40425-019-0500-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,31]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["500"],"URL":"https:\/\/doi.org\/10.1186\/s40425-019-0500-9","relation":{},"ISSN":["2051-1426"],"issn-type":[{"value":"2051-1426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,31]]},"assertion":[{"value":"18 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were approved by the institutional Animal Experiments Committee and were executed according to the institutional animal experimentation guidelines and were in compliance with the guidelines of the Institutional, European and Federal USA animal care and usage committees.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us.We confirm that we have given due consideration to the protection of intellectual property associated with this work and that there are no impediments to publication, including the timing of publication, with respect to intellectual property. In so doing we confirm that we have followed the regulations of our institutions concerning intellectual property.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"25"}}