{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:21:29Z","timestamp":1783351289096,"version":"3.54.6"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Radioiodine and Tc-99\u00a0m pertechnetate scans are routinely relied upon to detect metastasis in papillary thyroid cancer; false-positive scans are relatively rare. To our knowledge, no published reports exist of sarcoidosis causing such selectively false-positive scans. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We present a case of a 41-year-old woman with known metastatic papillary thyroid cancer (T1bN1aMx) in whom sarcoidosis-affected cervical and mediastinal lymph nodes demonstrated uptake of thyroid-targeting radionuclides. Only the minority of these nodes demonstrated radionuclide uptake, raising the suspicion of adjacent or coexisting sarcoid and metastatic involvement. Selective uptake of thyroid-targeted radionuclides by isolated sarcoidosis is, to our knowledge, a previously undocumented occurrence. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Biopsies of uptake-negative mediastinal nodes revealed sarcoidosis. Pathology from a subsequent neck dissection excising uptake-positive cervical nodes also showed sarcoidosis, with no coinciding malignancy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> We document a case of sarcoidosis causing a selectively false-positive thyroid scintigraphy scan. It is useful for clinicians to be aware of potential false-positives and deceptive patterns on radionuclide scans when managing patients with both well-differentiated thyroid cancer and a co-existing disease affecting the nodal basins draining the thyroid gland. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-015-0069-3","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:24:49Z","timestamp":1431563089000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Selectively false-positive radionuclide scan in a patient with sarcoidosis and papillary thyroid cancer: A case report and review of the literature"],"prefix":"10.1177","volume":"44","author":[{"given":"Nicole L","family":"Lebo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, The Ottawa Hospital, University of Ottawa, Box 216, 501 Smyth Rd., K1H 8L6, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Raymond","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nuclear Medicine, University of Ottawa, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Odell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, The Ottawa Hospital, University of Ottawa, Box 216, 501 Smyth Rd., K1H 8L6, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"bibr1-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.10.016"},{"key":"bibr2-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-011-0173-1"},{"key":"bibr3-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1053\/nm.2000.5414"},{"key":"bibr4-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59259-995-0_20"},{"key":"bibr5-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70188-2"},{"key":"bibr6-s40463-015-0069-3","first-page":"7","volume":"9","author":"Atkins HL","year":"1968","journal-title":"J Nucl Med"},{"key":"bibr7-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59259-995-0_14"},{"key":"bibr8-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0448"},{"key":"bibr9-s40463-015-0069-3","first-page":"871","volume":"5","author":"Smith EM","year":"1964","journal-title":"J Nucl Med"},{"key":"bibr10-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704243361706"},{"key":"bibr11-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-197901000-00009"},{"key":"bibr12-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1089\/105072502761016511"},{"key":"bibr13-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"bibr14-s40463-015-0069-3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00510.x"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-015-0069-3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40463-015-0069-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-015-0069-3","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-015-0069-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40463-015-0069-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:10:11Z","timestamp":1741680611000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-015-0069-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1186\/s40463-015-0069-3"],"URL":"https:\/\/doi.org\/10.1186\/s40463-015-0069-3","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"article-number":"18"}}