{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:16:55Z","timestamp":1779297415997,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Hypothyroidism following radiation therapy (RT) for treatment of Head and Neck Cancer (HNC) is a common occurrence. Rates of hypothyroidism following RT for Early Stage Laryngeal Squamous Cell Carcinoma (ES-LSCC) are among the highest. Although routine screening for hypothyroidism is recommended; its optimal schedule has not yet been established. We aim to determine the prevalence and optimal timing of testing for hypothyroidism in ES-LSCC treated with RT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p> We conducted a population-based cohort study. Data was extracted from a prospective provincial head and neck cancer database. Demographic, survival data, and pre- and post-treatment thyroid stimulating hormone (TSH) levels were obtained for patients diagnosed with ES-LSCC from 2008\u20132012. Inclusion criteria consisted of patients diagnosed clinically with ES-LSCC (T1 or 2, N0, M0) treated with curative intent. Patients were excluded if there was a history of hypothyroidism before the treatment or any previous history of head and neck cancers. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Ninety-five patients were included in this study. Mean age was 66.1\u00a0years (range: 44.0\u201388.0\u00a0years) and 82.3\u00a0% of patients were male. Glottis was the most common subsite at 77.9\u00a0% and the average follow-up was 40\u00a0months (Range: 12\u201356\u00a0months). Five-year overall survival generated using the Kaplan-Meier method was 79\u00a0%. Incidence of hypothyroidism after RT was found to be 46.9\u00a0%. The greatest frequency of developing hypothyroidism was at 12\u00a0months. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> We found a high prevalence of hypothyroidism for ES-LSCC treated with RT, with the highest rate at 12\u00a0months. Consequently, we recommend possible routine screening for hypothyroidism using TSH level starting at 12\u00a0months. To our knowledge, this is the first study to suggest the optimal timing for the detection of hypothyroidism. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-015-0085-3","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T14:30:55Z","timestamp":1441981855000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Optimal detection of hypothyroidism in early stage laryngeal cancer treated with radiotherapy"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7419-4739","authenticated-orcid":false,"given":"Graeme B.","family":"Mulholland","sequence":"first","affiliation":[{"name":"Division of Otolaryngology-Head and Neck Surgery, University of Alberta Hospital, 1E4.29 WMC, 8440 \u2013 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology-Head and Neck Surgery, University of Alberta Hospital, 1E4.29 WMC, 8440 \u2013 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhu-Tram A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, McMaster University, Hamilton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Tkacyzk","sequence":"additional","affiliation":[{"name":"Northern Ontario School of Medicine, Sudbury, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Seikaly","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology-Head and Neck Surgery, University of Alberta Hospital, 1E4.29 WMC, 8440 \u2013 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology-Head and Neck Surgery, University of Alberta Hospital, 1E4.29 WMC, 8440 \u2013 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent L.","family":"Biron","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology-Head and Neck Surgery, University of Alberta Hospital, 1E4.29 WMC, 8440 \u2013 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology-Head and Neck Surgery, University of Alberta Hospital, 1E4.29 WMC, 8440 \u2013 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"bibr1-s40463-015-0085-3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"bibr2-s40463-015-0085-3","unstructured":"Canadian Cancer Society statistics. 2013. Available at: http:\/\/www.cancer.ca\/en\/cancer-information\/cancer-type\/laryngeal\/statistics\/?region=ab (accessed on February, 2015)."},{"issue":"3","key":"bibr3-s40463-015-0085-3","first-page":"205","volume":"40","author":"Makki FM","year":"2011","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"bibr4-s40463-015-0085-3","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-42-22"},{"key":"bibr5-s40463-015-0085-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.066"},{"key":"bibr6-s40463-015-0085-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.07.001"},{"key":"bibr7-s40463-015-0085-3","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e328325a538"},{"key":"bibr8-s40463-015-0085-3","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00276-0"},{"key":"bibr9-s40463-015-0085-3","doi-asserted-by":"publisher","DOI":"10.4158\/EP12280.GL"},{"key":"bibr10-s40463-015-0085-3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.228"},{"key":"bibr11-s40463-015-0085-3","unstructured":"Pfister DG, Spencer S, Brizel DM, Burtness BA, Busse PM, Caudell JJ\u00a0 et al. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Head and Neck Cancers. 2nd ed. Washington, PA: National Comprehensive Cancer Network; 2014."},{"key":"bibr12-s40463-015-0085-3","volume-title":"AJCC cancer staging handbook: from the AJCC cancer staging manual","author":"Edge SB","year":"2010","edition":"7"},{"key":"bibr13-s40463-015-0085-3","unstructured":"Alberta Heath Services. 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