{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:28:23Z","timestamp":1792801703407,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DMRF Bergmann-Porter Endowment","award":["\u115f"],"award-info":[{"award-number":["\u115f"]}],"id":[{"id":"https:\/\/ror.org\/0229evh14","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The optimal treatment strategy for oropharyngeal squamous cell carcinoma is highly debated. However, growing evidence supports the use of minimally invasive techniques, such as transoral laser microsurgery (TLM), as a first-line treatment modality for these carcinomas. The purpose of our study was to assess the efficacy and safety of TLM for the treatment of primary and recurrent oropharyngeal carcinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients with oropharyngeal carcinoma undergoing TLM at the QEII Health Sciences Centre in Halifax, Nova Scotia were identified within a prospective database monitoring TLM outcomes. Kaplan-Meier survival analysis was used to evaluate the following end points at 36\u00a0months: local control (LC), disease-specific survival (DSS), and disease-free survival (DFS). Safety endpoints included complications following surgery and long term morbidity related to TLM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 2003 and 2014, 39 patients with oropharyngeal carcinoma underwent TLM resection. Twenty-eight (72\u00a0%) patients had primary carcinoma, nine (23\u00a0%) were radiation\/chemoradiation (RT\/CRT) failures, and two (5\u00a0%) had second primaries following previous RT\/CRT. Three patients had stage I disease, 8 stage II, 5 stage III, and 23 stage IV disease. HPV status was available for 26 patients, of which 23 (88\u00a0%) had HPV positive disease. Kaplan-Meier estimates of 36-month LC, DSS, and DFS for primary oropharyngeal carcinomas were 85.5\u00a0% (SE 10.6\u00a0%), 85.7\u00a0% (SE 13.2\u00a0%) and 77.7\u00a0% (SE 12.5\u00a0%) respectively. Thirty-six-month outcomes for RT\/CRT failures were 66.76\u00a0% (SE 15.7\u00a0%) for LC and 55.6\u00a0% (SE 16.6\u00a0%) for DSS and DFS. Three patients developed complications following surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Observed 36-month efficacy and safety outcomes support the use of TLM for the treatment of primary and recurrent oropharyngeal carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40463-015-0093-3","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T20:40:08Z","timestamp":1443559208000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Transoral laser microsurgery for the treatment of oropharyngeal cancer: The Dalhousie University experience"],"prefix":"10.1177","volume":"44","author":[{"given":"Jonathan C.","family":"Melong","sequence":"first","affiliation":[{"name":"Division of Otolaryngology - Head and Neck Surgery, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew H.","family":"Rigby","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology - Head and Neck Surgery, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bullock","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Hart","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology - Head and Neck Surgery, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.B.","family":"Trites","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology - Head and Neck Surgery, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Mark","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology - Head and Neck Surgery, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"bibr1-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.3747\/co.20.1375"},{"key":"bibr2-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.09.011"},{"key":"bibr3-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.3201\/eid1611.100452"},{"key":"bibr4-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20140005"},{"key":"bibr5-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.6136"},{"key":"bibr6-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-42-9"},{"key":"bibr7-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23622"},{"key":"bibr8-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25023"},{"key":"bibr9-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.03.005"},{"key":"bibr10-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23319"},{"key":"bibr11-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21669"},{"key":"bibr12-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20552"},{"key":"bibr13-s40463-015-0093-3","unstructured":"Hinni ML, Lott DG. 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Oral Oncol. 2014 Oct 30."},{"key":"bibr16-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23293"},{"key":"bibr17-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2501-5"},{"key":"bibr18-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23610"},{"key":"bibr19-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000141"},{"key":"bibr20-s40463-015-0093-3","first-page":"582","volume":"37","author":"Taylor SM","year":"2008","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"bibr21-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2007.0016"},{"key":"bibr22-s40463-015-0093-3","unstructured":"National Comprehensive Cancer Network Practice Guidelines in Oncology\u2013v.2.2013, Head and Neck Cancers, Cancer of the Oropharynx. 2013."},{"key":"bibr23-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.05.008"},{"key":"bibr24-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-42-30"},{"key":"bibr25-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23279"},{"key":"bibr26-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000244159.64179.f0"},{"key":"bibr27-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000143"},{"key":"bibr28-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.04.005"},{"key":"bibr29-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215113001953"},{"key":"bibr30-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.3866"},{"key":"bibr31-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24695"},{"key":"bibr32-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24595"},{"key":"bibr33-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.185"},{"key":"bibr34-s40463-015-0093-3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23909"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-015-0093-3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-015-0093-3","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-015-0093-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:02:46Z","timestamp":1741608166000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-015-0093-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1186\/s40463-015-0093-3"],"URL":"https:\/\/doi.org\/10.1186\/s40463-015-0093-3","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"article-number":"39"}}