{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:41:38Z","timestamp":1784860898197,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> The literature reports various treatment methodologies, such as trans-oral laser microsurgery, radiation therapy, total\/partial laryngectomies, and concurrent radiation chemotherapy for patients with early larynx cancer. However, at the forefront of early glottis treatment is trans-oral laser microsurgery and radiation therapy, likely due to better functional and survival outcomes. Here we conduct the largest Canadian head-to-head comparison of consecutive patients treated with either radiation therapy or trans-oral laser microsurgery. Additionally, we compare these two treatments and their 5-year survival rates post treatment to add to the existing literature. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Charts of patients who were diagnosed with early glottic cancer between 2006 and 2013 were reviewed. Seventy-five patients were identified, and split into 2 groups based on their primary treatment, trans-oral laser microsurgery and radiation therapy. Kaplan\u2013Meier survival curves, life-tables, and the log-rank statistic were reported to determine if there was a difference between the two treatment groups and their disease-specific survival, disease-free survival, and total laryngectomy-free survival. Additionally, each different survival analysis was stratified by potential confounding variables, to help conclude which treatment is more efficacious in this population. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The 5-year disease-specific survival rate is 93.3\u00a0% \u03c3\u2009=\u20090.063 and 90.8\u00a0% \u03c3\u2009=\u20090.056 for patients treated with trans-oral laser microsurgery and radiation therapy, respectively ( \u03c7<jats:sup>2<\/jats:sup>\u2009&lt;\u20090.001, p\u2009=\u20090.983). The disease free survival rate is 60.0\u00a0% (\u03c3 =0.121) for patients treated with trans-oral laser microsurgery, and 67.2\u00a0% (\u03c3\u2009=\u20090.074) for those who received RT ( \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.19, p\u2009=\u20090.663). Additionally, the total laryngectomy-free survival rate is 84.1\u00a0% (\u03c3\u2009=\u20090.1) and 79.1\u00a0% (\u03c3\u2009=\u20090.072) for patients\u2019 early glottic cancer treated by trans-oral laser microsurgery and radiation therapy, respectively ( \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.235, p\u2009=\u20090.628). Chi-square analysis of age-group versus treatment group ( \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20096.455, p\u2009=\u20090.04) and T-stage versus treatment group ( \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200911.3, p\u2009=\u20090.001) revealed a statistically significant relationship, suggesting survival analysis should be stratified by these variables. However, after stratification, there was no statistically significant difference between the trans-oral laser microsurgery and radiation therapy groups in any of the survival analyses. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> No difference was demonstrated in the 5-year disease-specific survival, disease-free survival, and total laryngectomy-free survival, between the RT and TLM treatment groups. Additionally, both groups showed similar 5-year survival after stratifying by confounding variables. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-016-0155-1","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T05:18:16Z","timestamp":1470115096000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of survival between radiation therapy and trans-oral laser microsurgery for early glottic cancer patients; a retrospective cohort study"],"prefix":"10.1177","volume":"45","author":[{"given":"R. J.","family":"De Santis","sequence":"first","affiliation":[{"name":"Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Suite M1 102, M4N 3\u00a0M5, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, M4N 3\u00a0M5, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, M4N 3\u00a0M5, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Karam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, M4N 3\u00a0M5, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Enepekides","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Suite M1 102, M4N 3\u00a0M5, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Suite M1 102, M4N 3\u00a0M5, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"bibr1-s40463-016-0155-1","unstructured":"Canadian Cancer Society: Survival statistics for laryngeal cancer. Canadian Cancer Societys's Advisory Committe on Cancer Statistics. http:\/\/www.cancer.ca\/en\/cancer-information\/cancer-type\/laryngeal\/prognosis-andsurvival\/survival-statistics\/?region=sk (2015). Accessed 1 May 2015."},{"key":"bibr2-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61396-9"},{"key":"bibr3-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0246"},{"key":"bibr4-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2012.06.014"},{"key":"bibr5-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-1947-1"},{"key":"bibr6-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21783"},{"key":"bibr7-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21226"},{"key":"bibr8-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2460-x"},{"issue":"3","key":"bibr9-s40463-016-0155-1","first-page":"110","volume":"26","author":"Qu D","year":"2012","journal-title":"Journal of Clinical Otorhinolaryngology, Head and Neck Surgery"},{"issue":"4","key":"bibr10-s40463-016-0155-1","first-page":"257","volume":"131","author":"Merrot O","year":"2010","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"bibr11-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-013-1025-1"},{"key":"bibr12-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-2-20"},{"key":"bibr13-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21262"},{"key":"bibr14-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e318256f5fd"},{"key":"bibr15-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23728"},{"key":"bibr16-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221511000304X"},{"key":"bibr17-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1135-0"},{"key":"bibr18-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.8"},{"key":"bibr19-s40463-016-0155-1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200301000-00013"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-016-0155-1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-016-0155-1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-016-0155-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T05:57:24Z","timestamp":1741672644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-016-0155-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1186\/s40463-016-0155-1"],"URL":"https:\/\/doi.org\/10.1186\/s40463-016-0155-1","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"article-number":"42"}}