{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:59:01Z","timestamp":1793836741166,"version":"4.6.1"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Laryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the subjective and objective voice modifications in Laryngopharyngeal reflux (LPR), especially the usefulness of acoustic parameters as treatment outcomes, and to better understand the pathophysiological mechanisms underlying the development of voice disorder. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Forty-one patients with a reflux finding score (RFS)\u2009&gt;\u20097 and a reflux symptom index (RSI)\u2009&gt;\u200913 were enrolled and treated with pantoprazole 20\u00a0mg twice daily for three months. RSI, RFS, Voice Handicap Index (VHI), and Grade, Roughness, Breathiness, Asthenia, Strain and Instability (GRBASI) were assessed at baseline and after three months post-therapy. Acoustic parameters were measured by selecting the most stable interval of the vowel \/a\/. A study of correlations between acoustic measurements and laryngoscopic signs was conducted in patients with roughness. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Significant improvement in RSI, RFS, VHI, jitter, percent jitter, relative average perturbation (RAP), shimmer, percent shimmer, and amplitude perturbation quotient (APQ) was found at 3\u00a0months of treatment ( p\u2009&lt;\u2009.05). A correlation analysis revealed significant correlations between the grade of dysphonia, breathiness, asthenia, instability and jitter, percent jitter, RAP, shimmer, percent shimmer and APQ. In dividing our cohort into two groups of patients according to the presence of roughness, shimmer, percent shimmer and APQ significantly improved in patients with roughness, but no positive correlation was found between acoustic parameters and laryngoscopic signs. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Acoustic parameters can help to better understand voice disorders in LPR and can be used as treatment outcomes in patients with roughness. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-016-0171-1","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T14:01:55Z","timestamp":1478613715000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Impact of laryngopharyngeal reflux on subjective and objective voice assessments: A prospective study"],"prefix":"10.1177","volume":"45","author":[{"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Laboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Avenue du Champ de mars, 6, B7000, Mons, Belgium"},{"name":"Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language Sciences and Technology, University of Mons (UMons), Mons, Belgium"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, RHMS Baudour, EpiCURA Hospital, Baudour, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Huet","sequence":"additional","affiliation":[{"name":"Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language Sciences and Technology, University of Mons (UMons), Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Khalife","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, RHMS Baudour, EpiCURA Hospital, Baudour, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Fran\u00e7oise","family":"Fourneau","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, RHMS Baudour, EpiCURA Hospital, Baudour, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Delvaux","sequence":"additional","affiliation":[{"name":"Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language Sciences and Technology, University of Mons (UMons), Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Piccaluga","sequence":"additional","affiliation":[{"name":"Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language Sciences and Technology, University of Mons (UMons), Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Harmegnies","sequence":"additional","affiliation":[{"name":"Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language Sciences and Technology, University of Mons (UMons), Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Avenue du Champ de mars, 6, B7000, Mons, Belgium"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, RHMS Baudour, EpiCURA Hospital, Baudour, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"bibr1-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.125760"},{"key":"bibr2-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200706-895OC"},{"key":"bibr3-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01134.x"},{"key":"bibr4-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"bibr5-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1475-9"},{"key":"bibr6-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200208000-00014"},{"key":"bibr7-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(96)80001-4"},{"issue":"9","key":"bibr8-s40463-016-0171-1","first-page":"7","volume":"81","author":"Koufman JA","year":"2002","journal-title":"Ear Nose Throat J"},{"issue":"1","key":"bibr9-s40463-016-0171-1","first-page":"38","volume":"85","author":"Katz PO","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"bibr10-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.109935"},{"key":"bibr11-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0097-8"},{"key":"bibr12-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00333-1"},{"key":"bibr13-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2004.12.001"},{"issue":"5","key":"bibr14-s40463-016-0171-1","first-page":"323","volume":"122","author":"Yana M","year":"2001","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"bibr15-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811425142"},{"key":"bibr16-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"issue":"1","key":"bibr17-s40463-016-0171-1","first-page":"CD005054","volume":"25","author":"Hopkins C","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr18-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2010.10.024"},{"key":"bibr19-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199711000-00012"},{"key":"bibr20-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181651c3a"},{"key":"bibr21-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-006-9077-8"},{"key":"bibr22-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480152602357"},{"key":"bibr23-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1067\/S0892-1997(03)00017-1"},{"key":"bibr24-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130608500704"},{"key":"bibr25-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-3984-7"},{"key":"bibr26-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200108000-00001"},{"key":"bibr27-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.08.025"},{"key":"bibr28-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2341-8"},{"key":"bibr29-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215111000120"},{"key":"bibr30-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.01.010"},{"issue":"4","key":"bibr31-s40463-016-0171-1","first-page":"163","volume":"135","author":"Lechien","year":"2014","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"issue":"52","key":"bibr32-s40463-016-0171-1","first-page":"213","volume":"10","author":"Sataloff RT","year":"2010","journal-title":"Discov Med"},{"key":"bibr33-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199802000-00027"},{"key":"bibr34-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(00)80033-8"},{"key":"bibr35-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12358"},{"key":"bibr36-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31802d83cf"},{"key":"bibr37-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(98)80078-7"},{"key":"bibr38-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2009.00992.x"},{"key":"bibr39-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811422014"},{"key":"bibr40-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2016.02.020"},{"key":"bibr41-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1121\/1.3224706"},{"key":"bibr42-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1748-y"},{"key":"bibr43-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2014.08.007"},{"key":"bibr44-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.3109\/14015439.2013.837502"},{"key":"bibr45-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.98362"},{"key":"bibr46-s40463-016-0171-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2014.08.006"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-016-0171-1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-016-0171-1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40463-016-0171-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-016-0171-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T14:19:02Z","timestamp":1741616342000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-016-0171-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1186\/s40463-016-0171-1"],"URL":"https:\/\/doi.org\/10.1186\/s40463-016-0171-1","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"article-number":"59"}}