{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:10:14Z","timestamp":1782749414818,"version":"3.54.5"},"reference-count":151,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J of Otolaryngol - Head &amp; Neck Surg"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications include DNA methylation, histone post-translational modifications, small and non-coding RNAs. Alterations in epigenetic profiles cause deregulation of fundamental gene expression pathways associated with carcinogenesis. The role of epigenetics in oropharyngeal squamous cell carcinoma (OPSCC) has recently been recognized, with implications for novel biomarkers, molecular diagnostics and chemotherapeutics. In this review, important epigenetic pathways in human papillomavirus (HPV) positive and negative OPSCC are summarized, as well as the potential clinical utility of this knowledge.<\/jats:p>\n                  <jats:p>This material has never been published and is not currently under evaluation in any other peer-reviewed publication.<\/jats:p>","DOI":"10.1186\/s40463-017-0185-3","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:06:30Z","timestamp":1485821190000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Epigenetics of oropharyngeal squamous cell carcinoma: Opportunities for novel chemotherapeutic targets"],"prefix":"10.1177","volume":"46","author":[{"given":"Cameron","family":"Lindsay","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Dentistry, Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alberta, 1E4.34 WMC, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Seikaly","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry, Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alberta, 1E4.34 WMC, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent L.","family":"Biron","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry, Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alberta, 1E4.34 WMC, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1279"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2011.01809.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/190372a0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/da.22406"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1804-1_1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-5-60"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp220"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.013"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063127"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1787609"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.005"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl046"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.6995"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065497"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Seikaly H Biron VL Zhang H O'Connell DA C\u00f4t\u00e9 DWJ Ansari K et al. The role of primary surgery in the treatment of advanced oropharyngeal cancer. Head Neck. 2015;:n\/a\u2013n\/a.","DOI":"10.1002\/hed.24042"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","unstructured":"Biron VL Kostiuk M Isaac A Puttagunta L O'Connell DA Harris J et al. Detection of human papillomavirus type 16 in oropharyngeal squamous cell carcinoma using droplet digital polymerase chain reaction. Cancer. 2016;:n\/a\u2013n\/a.","DOI":"10.1002\/cncr.29976"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.12.019"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0100-y"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-015-0091-5"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-015-0062-x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0179-6"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0177-8"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc798"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086023"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.1341"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","unstructured":"Marzouki HZ Biron VL Harris J O'Connell D Seikaly H. Human papillomavirus-associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association. Head Neck. 2016;:n\/a\u2013n\/a.","DOI":"10.1002\/hed.24388"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1968"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283484795"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22015"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-30"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000381717"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32835ff48c"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200105000-00009"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.605"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.08.003"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.5.1654"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep12522"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.164806.113"},{"issue":"1","key":"e_1_3_2_43_2","first-page":"S65","article-title":"Epigenetic differences between human papillomavirus-positive and -negative oropharyngeal squamous cell carcinomas","volume":"41","author":"Biron VLV","year":"2012","unstructured":"Biron VLV, Mohamed AA, Hendzel MJM, Underhill DDA, Seikaly HH Epigenetic differences between human papillomavirus-positive and -negative oropharyngeal squamous cell carcinomas J Otolaryngol Head Neck Surg 2012 41 Suppl 1 S65 S70 22569052","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-42-53"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1463"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.09.001"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2008.540"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.6.16216"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204869"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-42-57"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-42-36"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.11.011"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-43-2"},{"key":"e_1_3_2_54_2","first-page":"1017","article-title":"Increased sensitivity of HPV-positive head and neck cancer cell lines to x-irradiation \u00b1 Cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis","volume":"5","author":"Ziemann F","year":"2015","unstructured":"Ziemann F, Arenz A, Preising S, Wittekindt C, Klussmann JP, Engenhart-Cabillic R Increased sensitivity of HPV-positive head and neck cancer cell lines to x-irradiation \u00b1 Cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis Am J Cancer Res 2015 5 1017 31 1:CAS:528:DC%2BC28XhsFWrsrrM 26045983 4449432","journal-title":"Am J Cancer Res"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40463-014-0033-7","article-title":"Metabolic tumour volume as a prognostic factor for oral cavity squamous cell carcinoma treated with primary surgery","volume":"43","author":"Zhang H","year":"2014","unstructured":"Zhang H, Seikaly H, Abele JT, Jeffery DT, HarrisJR, O'Connell DA Metabolic tumour volume as a prognostic factor for oral cavity squamous cell carcinoma treated with primary surgery J Otolaryngol Head Neck Surg 2014 43 33 25312990 4198685","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0163-1"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0142-6"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0120-z"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0168-9"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-015-0082-6"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.5228"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-012-0369-0"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.2217\/epi.15.84"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1551"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2011.557881"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.01.006"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.03.016"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7030842"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.3.461"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.16.2395"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9967-2_2"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81656-6"},{"key":"e_1_3_2_73_2","doi-asserted-by":"crossref","unstructured":"van Kempen PM Noorlag R Braunius WW Stegeman I Willems SM Grolman W. Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma. Epigenetics. 2014;9(2):194\u2013203.http:\/\/doi.org\/10.4161\/epi.26881.","DOI":"10.4161\/epi.26881"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1804-1_39"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.001"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034329"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.184.4139.868"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416074111"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3280"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004941"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.11.023"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.374"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0554-RA"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2157286"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2005.08.003"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209950"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11389"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2013.01.007"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(1998)72:30\/31+<194::AID-JCB24>3.0.CO;2-H"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-4-38"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6364"},{"key":"e_1_3_2_92_2","first-page":"2917","article-title":"DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas","volume":"46","author":"Baylin SB","year":"1986","unstructured":"Baylin SB, H\u00f6ppener JW, de Bustros A, Steenbergh PH, Lips CJ, Nelkin BD DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas Cancer Res 1986 46 2917 22 1:CAS:528:DyaL28XktlKlt7k%3D 3009002","journal-title":"Cancer Res"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2173"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.014"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03677"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06174"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.55.4.805"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.04.020"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2505"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4154"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2012-0054"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.2217\/epi.14.23"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1021\/ml3003346"},{"issue":"1","key":"e_1_3_2_104_2","first-page":"S65","article-title":"Oropharyngeal squamous cell carcinoma and human papillomavirus-associated cancers in women: epidemiologic evaluation of association","volume":"40","author":"Biron VL","year":"2011","unstructured":"Biron VL, C\u00f4t\u00e9 DWJ, Seikaly H Oropharyngeal squamous cell carcinoma and human papillomavirus-associated cancers in women: epidemiologic evaluation of association J Otolaryngol Head Neck Surg 2011 40 Suppl 1 S65 9 21453664","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.08.038"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1531"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1139\/O08-131"},{"key":"e_1_3_2_108_2","first-page":"8094","article-title":"Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone\/protein methyltransferase superfamily","volume":"61","author":"Du Y","year":"2001","unstructured":"Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone\/protein methyltransferase superfamily Cancer Res 2001 61 8094 9 1:CAS:528:DC%2BD3MXovVShsrk%3D 11719434","journal-title":"Cancer Res"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4370"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-013-9434-8"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505323200"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.4161\/epi.4.6.9392"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26100"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1134"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00160-11"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80604-2"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604266113"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-014-1131-8"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.04.006"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.09.005"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/349082a0"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.109"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.07.012"},{"key":"e_1_3_2_124_2","first-page":"668","article-title":"Regulation of cellular miRNA expression by human papillomaviruses","volume":"2011","author":"Zheng Z-M","year":"1809","unstructured":"Zheng Z-M, Wang X Regulation of cellular miRNA expression by human papillomaviruses Biochim Biophys Acta 1809 2011 668 77","journal-title":"Biochim Biophys Acta"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.15.9168"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3114"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.380"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12296"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.05.030"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30414"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.08.003"},{"key":"e_1_3_2_132_2","first-page":"337","article-title":"HDAC inhibitors: a potential new category of anti-tumor agents","volume":"4","author":"Pan LN","year":"2007","unstructured":"Pan LN, Lu J, Huang B HDAC inhibitors: a potential new category of anti-tumor agents Cell Mol Immunol 2007 4 337 43 1:CAS:528:DC%2BD2sXhsVeks7vK 17976313","journal-title":"Cell Mol Immunol"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.594671"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.07.025"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0312"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.05.010"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.04.003"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307708100"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1327"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.01.009"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13022331"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.020"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12436"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000123"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09284"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5260.408"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1804-1_41"},{"key":"e_1_3_2_148_2","first-page":"157","article-title":"The role of epigenetics in kidney malignancies","volume":"68","author":"la Rosa AH-D","year":"2015","unstructured":"la Rosa AH-D, Acker M, Swain S, Manoharan M The role of epigenetics in kidney malignancies Cent European J Urol 2015 68 157 64 26251734 4526599","journal-title":"Cent European J Urol"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0773"},{"key":"e_1_3_2_150_2","unstructured":"Autophagic effect of SAM-competitive EZH2 inhibitors on cancer cells. Can Cell Microenviron [Internet]. 2015;:1\u20134. Available from: http:\/\/www.smartscitech.com\/index.php\/CCM\/article\/view\/551."},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2876"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018200"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-017-0185-3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-017-0185-3","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40463-017-0185-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-017-0185-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:17:10Z","timestamp":1767673030000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-017-0185-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":151,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1186\/s40463-017-0185-3"],"URL":"https:\/\/doi.org\/10.1186\/s40463-017-0185-3","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"article-number":"9"}}