{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:54:24Z","timestamp":1763348064462,"version":"3.41.2"},"reference-count":9,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Thyroid metastases to distant sites are uncommon incidents, most often metastasizing to the lungs and bones. Rates of metastasis to the kidney are particularly low, ranging from 2.8\u20133.8% for papillary and 6\u201320% for follicular variants of well-differentiated thyroid cancers (WDTCs). In rare instances, tumor-to-tumor metastasis between two true primary neoplasms can occurs. This medical phenomenon has previously occurred as a clear cell renal cell carcinoma (CCRCC) spreading to a WDTC. To our knowledge, this is the first report of a tumor-to-tumor metastasis of a thyroid cancer metastasizing to a primary renal neoplasm. <\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p> A 72\u00a0year old male presented to the urology clinic with complaints of flank pain. Computed tomography (CT) imaging of the abdomen and pelvis revealed a 5.7\u00a0cm solid enhancing mass from the lateral aspect of the right kidney, suspicious for renal cell carcinoma (RCC). The patient subsequently underwent a right laparoscopic radical nephrectomy, and immunohistochemical staining of the 5.5\u00a0cm lesion revealed a positive RCC marker to establish a diagnosis of a pT1b ISUP Grade 2 CCRCC. The tumor contained a 3\u00a0mm focus of a lesion staining positive for TTF1 and Thyroglobulin, and negative for RCC marker. This finding established a diagnosis of a tumor-to-tumor metastasis of PTC to CCRCC. Subsequent ultrasound and CT of the head and neck revealed a heterogeneously hypodense 3.3\u00a0cm mass in the right thyroid lobe, prompting a total thyroidectomy and level VI neck dissection. Pathology revealed a classic variant multifocal PTC and two ipsilateral lymph nodes positive for metastatic PTC. Ultimately, the thyroid specimen was positive for lymphatic vascular invasion, extrathyroidal extension with invasion of the tracheal cartilage, staging as T4aN1aM1. On follow up examination the patient was recovering well, without signs of dysphagia or dysphonia, and showed bilateral mobile vocal cords on laryngoscope examination. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Tumor-to-tumor metastasis between the thyroid and kidney is an extremely rare occurrence, reports of RCC metastases from a WDTC has not yet been reported in the literature. Corroboration of diagnostic imaging findings with immunohistochemistry staining can consolidate a diagnosis of thyroid neoplasm tumor-to-tumor metastasis to a RCC, thereby prompting surgical excision. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-017-0193-3","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T14:26:05Z","timestamp":1488378365000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Tumor-to-tumor metastases: Papillary thyroid carcinoma into a clear cell renal cell carcinoma"],"prefix":"10.1177","volume":"46","author":[{"given":"Jin Soo Andy","family":"Song","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head & Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Mark","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head & Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Trites","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head & Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew H.","family":"Rigby","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head & Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Joseph","family":"Bullock","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Merrimen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Rendon","sequence":"additional","affiliation":[{"name":"Department of Urology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Hart","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head & Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"bibr1-s40463-017-0193-3","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.894935"},{"key":"bibr2-s40463-017-0193-3","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e32835b5dcc"},{"key":"bibr3-s40463-017-0193-3","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-009-9087-x"},{"key":"bibr4-s40463-017-0193-3","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21117"},{"key":"bibr5-s40463-017-0193-3","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-265"},{"key":"bibr6-s40463-017-0193-3","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0056-RA"},{"key":"bibr7-s40463-017-0193-3","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0147-9"},{"key":"bibr8-s40463-017-0193-3","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410022822"},{"key":"bibr9-s40463-017-0193-3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2002.00537.x"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-017-0193-3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-017-0193-3","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40463-017-0193-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-017-0193-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T07:46:25Z","timestamp":1741679185000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-017-0193-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1186\/s40463-017-0193-3"],"URL":"https:\/\/doi.org\/10.1186\/s40463-017-0193-3","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"type":"print","value":"1916-0216"},{"type":"electronic","value":"1916-0216"}],"subject":[],"published":{"date-parts":[[2017,1]]},"article-number":"17"}}