{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:34:08Z","timestamp":1773765248369,"version":"3.50.1"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Giant cell tumors (GCTs) are typically found in the metaphyseal-epiphyseal area of long bones but can also occur in the head and neck region. GCT of the larynx is a rare entity with only 42 reported cases in the international literature. Furthermore, to the best of our knowledge this is the largest laryngeal GCT reported in the literature to date. GCT of the larynx can present with dysphonia, dyspnea, and\/or dysphagia and should be considered in the differential diagnosis of a neck mass. <\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p> This case report describes a giant cell tumor of the left thyroid cartilage in a 30-year-old man who initially presented with dysphonia and dysphagia. Computed tomography (CT) revealed a 5 \u00d7 5.7\u00a0cm mass centered on the left thyroid cartilage, which was further diagnosed by histopathology as giant cell tumour by open biopsy. The patient was counselled on treatment options and it was decided to proceed with a surgical approach. The patient consented to and successfully underwent a total laryngectomy (TL). Currently the patient has no evidence of disease at 13\u00a0months follow-up, has an optimal prosthetic voice, and is able to tolerate all textures of foods. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> GCTs of the larynx have a good prognosis and can be treated successfully through complete resection of the tumor, negating the need for adjunctive therapy such as radiation, chemo or denosumab therapy. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-017-0198-y","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T08:37:37Z","timestamp":1491295057000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["A large giant cell tumor of the larynx: Case report and review of the literature"],"prefix":"10.1177","volume":"46","author":[{"given":"Andrew","family":"Arndt","sequence":"first","affiliation":[{"name":"College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Spafford","sequence":"additional","affiliation":[{"name":"Clinical Professor and Division Head: Otolaryngology - Head & Neck Surgery, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"bibr1-s40463-017-0198-y","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-015-0622-4"},{"key":"bibr2-s40463-017-0198-y","first-page":"80","volume":"4","author":"Federova SS","year":"1951","journal-title":"Vestn Otorinolaringol"},{"key":"bibr3-s40463-017-0198-y","first-page":"92","volume":"3","author":"Wagemann W","year":"1952","journal-title":"HNO"},{"key":"bibr4-s40463-017-0198-y","first-page":"140","volume":"57","author":"Perrino A","year":"1958","journal-title":"Ann Laringol (Torino)"},{"key":"bibr5-s40463-017-0198-y","first-page":"69","volume":"28","author":"Kaliteevskii PF","year":"1966","journal-title":"Vestn Otorinolaringol"},{"key":"bibr6-s40463-017-0198-y","first-page":"727","volume":"47","author":"Pohl W","year":"1968","journal-title":"Z Laryngol Rhinol Otol Ihre Grenzgeb"},{"issue":"10","key":"bibr7-s40463-017-0198-y","first-page":"306","volume":"19","author":"Rudert H","year":"1971","journal-title":"HNO"},{"key":"bibr8-s40463-017-0198-y","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100075393"},{"key":"bibr9-s40463-017-0198-y","first-page":"507","volume":"19","author":"Goto TY","year":"1973","journal-title":"Otol Fukuoka"},{"key":"bibr10-s40463-017-0198-y","first-page":"331","volume":"28","author":"Kotarba E","year":"1974","journal-title":"Otolaryngology Pol"},{"key":"bibr11-s40463-017-0198-y","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100081123"},{"key":"bibr12-s40463-017-0198-y","first-page":"776","volume":"22","author":"Kubo R","year":"1976","journal-title":"Otol Fukuoka"},{"key":"bibr13-s40463-017-0198-y","first-page":"52","volume":"109","author":"Badet JM","year":"1992","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"bibr14-s40463-017-0198-y","doi-asserted-by":"publisher","DOI":"10.1177\/014556139307200512"},{"key":"bibr15-s40463-017-0198-y","first-page":"834","volume":"118","author":"Martin PC","year":"1994","journal-title":"Arch Pathol Lab Med"},{"key":"bibr16-s40463-017-0198-y","first-page":"519","volume":"40","author":"Miyata S","year":"1994","journal-title":"Japanese J Cancer Clinics"},{"key":"bibr17-s40463-017-0198-y","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199703)19:2<153::AID-HED12>3.0.CO;2-E"},{"key":"bibr18-s40463-017-0198-y","first-page":"75","volume":"31","author":"Paik S","year":"1997","journal-title":"Korean J. 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