{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:38:30Z","timestamp":1775043510232,"version":"3.50.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> The purpose of this study was to examine the possible prognostics and clinicopathologic characteristics underlying the BRAFV600E mutation and papillary thyroid carcinoma (PTC) coexisting or in absence of\u00a0chronic lymphocytic thyroiditis (CLT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> This study was conducted on 172 patients who had undergone total thyroidectomy or unilateral total thyroidectomy for PTC; the patients were then examined for the BRAFV600E mutation using specimens obtained after their surgery from January 2013 to August 2015. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> BRAF mutations were found in 130 of 172 patients (75.6%). CLT was present in 27.9% of patients (48\/172). The incidence of the BRAFV600E mutation was significantly increased in the group with no CLT ( P = 0.001). The findings of the multivariate analysis pertaining to the coexistence of CLT and PTC showed no significant correlation other than the BRAFV600E mutation. No significant difference was noted in the clinicopathologic factors between the two groups based on the coexistence of CLT in univariate and multivariate analyses. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> The BRAFV600E mutation is less frequent in PTC coexisting with CLT presumably because CLT and the BRAFV600E mutation\u00a0operate independently\u00a0in the formation and progression of thyroid cancer. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-017-0247-6","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T12:12:30Z","timestamp":1515499950000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Clinical implications of the BRAF mutation in papillary thyroid carcinoma\u00a0and chronic lymphocytic thyroiditis"],"prefix":"10.1177","volume":"47","author":[{"given":"Woon Won","family":"Kim","sequence":"first","affiliation":[{"name":"Department of General Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7980-3700","authenticated-orcid":false,"given":"Tae Kwun","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Busan Paik Hospital, Inje University College of Medicine, 75, Bokji-ro, Busanjin-gu, 614-735, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Kwon","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Medical Management, Kosin University, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"issue":"26","key":"bibr1-s40463-017-0247-6","first-page":"452","volume":"112","author":"Paschke R","year":"2015","journal-title":"Dtsch Arztebl Int."},{"key":"bibr2-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ14-0303"},{"key":"bibr3-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60109-9"},{"key":"bibr4-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.44"},{"key":"bibr5-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-277"},{"key":"bibr6-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1955.01270080137023"},{"key":"bibr7-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099054"},{"key":"bibr8-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21518"},{"key":"bibr9-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23854"},{"key":"bibr10-s40463-017-0247-6","first-page":"733","volume":"79","author":"Marotta V","year":"2013","journal-title":"ClinEndocrinol"},{"key":"bibr11-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03537.x"},{"key":"bibr12-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31826a9c71"},{"key":"bibr13-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.8.883"},{"key":"bibr14-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2978"},{"key":"bibr15-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26500"},{"key":"bibr16-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2872-7"},{"key":"bibr17-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3190"},{"key":"bibr18-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0585"},{"key":"bibr19-s40463-017-0247-6","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0036"}],"container-title":["Journal of Otolaryngology - Head &amp; 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