{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T00:13:50Z","timestamp":1794528830094,"version":"4.9.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Accurate localization of parathyroid adenomas is of critical importance in surgical planning for minimally invasive parathyroidectomy. SPECT\/CT is considered the investigation of choice but has limitations regarding localization of superior versus inferior adenomas. We proposed a novel method for localization using SPECT\/CT by determining the anterior-posterior relationship of the adenoma to a horizontal line in the coronal plane through the tracheoesophageal groove. Our objective was to determine the accuracy, validity, and inter-rater reliability of this method. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p> This was a retrospective review of patients who underwent parathyroidectomy for a single adenoma between 2010-2017. SPECT\/CT images were reviewed by two staff Otolaryngologists, a Radiologist, an Otolaryngology fellow and Otolaryngology resident. Results were compared using intra-operative report as the gold standard. Overall accuracy in determining superior\/inferior and right\/left adenomas was calculated, as well as Cohen's Kappa to determine agreement with operative report and inter-rater reliability. The performance was compared to that of the original radiology report. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> One hundred thirty patients met criteria and were included. Our method correctly identified the location of the adenoma in terms of both side and superior\/inferior position in 80.4% [76 - 84%] of patients, which considerably outperformed the original radiology report at 48.5% [4-78%] accuracy. The agreement level between our method and operative report was high (Kappa=0.717 [0.691-0.743]), as was the inter-rater reliability (Kappa=0.706 [0.674-0.738]). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> We report a novel method for localization of parathyroid adenomas using SPECT\/CT which outperforms standard radiology reporting. This tool can be used by surgeons and radiologists to better inform and plan for minimally invasive parathyroidectomy. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-018-0307-6","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T12:34:52Z","timestamp":1540557292000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Validation of a novel method for localization of parathyroid adenomas using SPECT\/CT"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2656-0917","authenticated-orcid":false,"given":"Rachelle A.","family":"LeBlanc","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Isaac","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Abele","sequence":"additional","affiliation":[{"name":"Department of Radiology & Diagnostic Imaging, Royal Alexandra Hospital, 1046 Royal Alexandra Hospital \u2013 Diagnostic Treatment Center, 2J2.00 WC Mackenzie Health Sciences Centre, 8440 112 Street, T6G 2R7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent L.","family":"Biron","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W. J.","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hearn","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Seikaly","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, T6G 2B7, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"bibr1-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1429-x"},{"key":"bibr2-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3283617d5b"},{"key":"bibr3-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.050237"},{"key":"bibr4-s40463-018-0307-6","first-page":"1012","volume-title":"Atlas of head and neck pathology","author":"Heffess CS","year":"2008","edition":"2"},{"key":"bibr5-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.5858\/2009-0578-CCR.1"},{"issue":"9","key":"bibr6-s40463-018-0307-6","first-page":"621","volume":"42","author":"Gray SW","year":"1976","journal-title":"Am Surg"},{"key":"bibr7-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31823362e5"},{"key":"bibr8-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.01.004"},{"key":"bibr9-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815599372"},{"key":"bibr10-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60507-9"},{"key":"bibr11-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12835"},{"key":"bibr12-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.5.472"},{"key":"bibr13-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31815c3ffd"},{"key":"bibr14-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9894-0"},{"key":"bibr15-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-016-1013-2"},{"key":"bibr16-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1148\/rg.244035718"},{"key":"bibr17-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.4103\/2156-7514.102053"},{"key":"bibr18-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(87)90798-7"},{"key":"bibr19-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnm.0000168407.95508.dc"},{"key":"bibr20-s40463-018-0307-6","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2015.06.002"}],"container-title":["Journal of Otolaryngology - Head &amp; 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