{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:30:07Z","timestamp":1785198607251,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p> Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscript describes a patient with CAD who developed severe ischemia of the nose that resolved completely without sequellae following a medical regimen of aspirin, low molecular weight heparin, nitroglycerin ointment and hyperbaric oxygen therapy (HBOT). To our knowledge, this is the first reported case where nitroglycerin ointment or HBOT was successfully employed in the treatment of this complication. <\/jats:p>","DOI":"10.1186\/s40463-019-0369-0","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T04:28:23Z","timestamp":1571804903000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1814-0776","authenticated-orcid":false,"given":"Scott","family":"Kohlert","sequence":"first","affiliation":[{"name":"ENT Associates of East Texas, 1136 E Grande Blvd, Tyler, TX, USA"},{"name":"CHRISTUS Trinity Mother Frances Health System, 800 E. Dawson, Tyler, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ottawa Hospital, University of Ottawa, 501 Smyth Rd, K1H 8L6, Ottawa, Ontario, Canada"},{"name":"Canada. Hyperbaric Medicine Unit The Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Scarvelis","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Thompson","sequence":"additional","affiliation":[{"name":"Canada. Hyperbaric Medicine Unit The Ottawa Hospital, Ottawa, Ontario, Canada"},{"name":"Department of Anesthesiology and Pain Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"bibr1-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-474437"},{"key":"bibr2-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2905-6"},{"key":"bibr3-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1177\/003591577406700212"},{"issue":"3","key":"bibr4-s40463-019-0369-0","first-page":"261","volume":"132","author":"Poldre P","year":"1985","journal-title":"Can Med Assoc J"},{"key":"bibr5-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03078.x"},{"key":"bibr6-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm1212538"},{"key":"bibr7-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1179\/2046905513Y.0000000065"},{"issue":"2","key":"bibr8-s40463-019-0369-0","first-page":"117","volume":"35","author":"Poredos P","year":"2016","journal-title":"Int Angiol"},{"key":"bibr9-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1983.tb00852.x"},{"key":"bibr10-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.1.1.27"},{"key":"bibr11-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.2147\/BCTT.S81712"},{"key":"bibr12-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210713"},{"key":"bibr13-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjv018"},{"key":"bibr14-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90278-7"},{"key":"bibr15-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002069.pub5."},{"key":"bibr16-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-015-3241-1"},{"key":"bibr17-s40463-019-0369-0","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(05)80446-0"},{"key":"bibr18-s40463-019-0369-0","volume-title":"Hyperbaric oxygen therapy indications","author":"Weaver LE","year":"2014"},{"key":"bibr19-s40463-019-0369-0","volume-title":"Hyperbaric oxygen therapy indications","author":"Weaver L","year":"2014","edition":"13"},{"issue":"2","key":"bibr20-s40463-019-0369-0","first-page":"204","volume":"17","author":"Pou JD","year":"2017","journal-title":"Ochsner J"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-019-0369-0","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40463-019-0369-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-019-0369-0","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40463-019-0369-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-019-0369-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T09:24:01Z","timestamp":1741685041000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-019-0369-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1186\/s40463-019-0369-0"],"URL":"https:\/\/doi.org\/10.1186\/s40463-019-0369-0","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"52"}}