{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:52:48Z","timestamp":1762005168378,"version":"3.41.2"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. <\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p> We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-019-0376-1","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T10:03:55Z","timestamp":1571220235000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The infectious thyroid nodule: A case report of mucormycosis associated with ibrutinib therapy"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8880-805X","authenticated-orcid":false,"given":"Marco A.","family":"Mascarella","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, QC H4A 3\u2009J1, Montreal, Canada"},{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorne","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Alreefi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, QC H4A 3\u2009J1, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, QC H4A 3\u2009J1, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derin","family":"Caglar","sequence":"additional","affiliation":[{"name":"Department of Pathology, McGill University Health Centre, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian G.","family":"Loo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. Decarie, D05.5704, QC H4A 3\u2009J1, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Dufresne","sequence":"additional","affiliation":[{"name":"Laboratoire de Sant\u00e9 Publique du Qu\u00e9bec, Sainte-Anne-de-Bellevue, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, McGill University Royal Victoria Hospital, McGill University Health Centre, Glen Site, 1001 Boul. 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