{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:18:20Z","timestamp":1763705900470,"version":"3.41.2"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> The aim of this study is to assess the feasibility and effectiveness of using peri-operative brachytherapy (BRTx) for positive\/narrow margins present post primary surgical resection of oral tongue squamous cell carcinoma (OTSCC). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Prospective single-centre study of patients with OTSCC (T1\u20133, N0\u20133, M0) treated with resection of primary tumour \u00b1 regional nodal resection and intra-operative insertion of BRTx catheters. BRTx was administered twice daily at 40.8Gy\/12Fr for \u2018Positive\u2019 (\u22642\u2009mm) margins, at 34Gy\/10Fr for \u2018Narrow\u2019 (2.1-5\u2009mm) margins, and not given for \u2018Clear\u2019 (&gt;\u20095\u2009mm) margins over the course of 5\u20136\u2009days, 3\u20135\u2009days post operatively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Out of 55 patients recruited 41 patients (74.6%) were treated with BRTx, as 12 patients had clear margins and 2 patients had unfavourable tumour anatomy for catheter insertion. EBRTx was avoided in 64.3% of patients. Overall Survival (OS) at 3 and 5\u2009years was 75.6 and 59.1% respectively, while Disease Specific Survival (DSS) was 82.3 and 68.6% at 3 and 5\u2009years respectively. Recurrence and survival outcomes were not associated with margin status or the use of or specific dose of BRTx on Cox regression analysis. Acute and late toxicity secondary to BRTx was minimal. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> The use of BRTx after primary OTSCC resection with positive\/narrow margins \u00b1 EBRTx to the neck \u00b1 CTx achieves outcomes comparable to traditional treatment of surgery followed by re-resection or EBRTx \u00b1 CTx. Morbidity associated with oral cavity EBRTx or secondary resection and reconstruction is thus avoided. Both acute and late toxicity rates are low and compare favourably with other BRTx OTSCC studies. <\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p> Retrospectively registered. https:\/\/www.mcgill.ca\/rcr-rcn\/files\/rcr-rcn\/2017.06.05_rcn_hn.pdf . <\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p> 4 <\/jats:p><\/jats:sec><jats:sec><jats:title>Graphical abstract<\/jats:title><jats:p> <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-020-00467-w","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T06:02:41Z","timestamp":1602655361000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The role of brachytherapy for margin control in oral tongue squamous cell carcinoma"],"prefix":"10.1177","volume":"49","author":[{"given":"Ilia","family":"Ianovski","sequence":"first","affiliation":[{"name":"Department of 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