{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:41:13Z","timestamp":1781854873037,"version":"3.54.5"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth foundation of Beijing Shijitan Hospital","award":["2018-q13"],"award-info":[{"award-number":["2018-q13"]}]},{"name":"Project of Science and Technology Research and Development of China Railway Corporation","award":["J2017Z602"],"award-info":[{"award-number":["J2017Z602"]}]},{"name":"Project of Science and Technology Research and Development of China Railway Corporation","award":["J2017Z603"],"award-info":[{"award-number":["J2017Z603"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Dysregulated lncRNA score and PVT1 expression may be involved in cancer. However, relationships of lncRNAs with hyperparathyroidism and parathyroid cancer (PC) diagnosis remain mysterious. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Using quantitative real-time polymerase chain reaction (RT-qPCR), expression profile of PVT1 was evaluated in 57 patients with primary hyperparathyroidism, including 11 with parathyroid cancer (PC) and 46 with parathyroid adenoma (PA). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Higher levels of lncRNA score and PVT1 expression were associated with increased serum calcium level after water ingestion and PC risk ( P\u2009&lt;\u20090.05). Accordingly, lncRNA score and PVT1 expression were increased with varying degrees of hypercalcemia in PC. A higher level of lncRNA score (but not PVT1) was an independent risk factor of PC, with an AUC up to 0.872 (95% CI: 0.756\u20130.945, P\u2009&lt;\u20090.001). Moreover, lncRNA score was more valuable (with AUC 0.974, sensitivity of 85.71% and specificity of 100%, respectively) than intact parathyroid hormone (iPTH) in predicting risk of PC among patients with hypercalcemia (especially based on greater AUC, P\u2009=\u20090.010). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Increased lncRNA score is correlated with an elevated level of serum calcium, which may serve as a potential biomarker for PC diagnosis, especially with hypercalcemia. <\/jats:p><\/jats:sec><jats:sec><jats:title>Graphical Abstract<\/jats:title><jats:p> <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-021-00509-x","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T16:09:35Z","timestamp":1619626175000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of LncRNA score and PVT1 in primary hyperparathyroidism-- a preliminary study"],"prefix":"10.1177","volume":"50","author":[{"given":"Dongxue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, 100038, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, 100020, Beijing, China"},{"name":"Department of Otorhinolaryngology, Beijing Shijitan Hospital, Capital Medical University, 100038, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Capital Institute of Pediatrics, 100020, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, 100038, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoai","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, 100038, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Developmental Biology, Capital Medical University, 100069, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, 100038, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,1]]},"reference":[{"key":"bibr1-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.06.051"},{"key":"bibr2-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.104"},{"key":"bibr3-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-011-0171-3"},{"key":"bibr4-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.10.035"},{"key":"bibr5-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1991"},{"key":"bibr6-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0188"},{"key":"bibr7-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2645904"},{"key":"bibr8-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-14-0457"},{"key":"bibr9-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-019-04959-y"},{"key":"bibr10-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-18-0480"},{"key":"bibr11-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S231941"},{"key":"bibr12-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-6598-9"},{"key":"bibr13-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1002\/path.5439"},{"key":"bibr14-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.09.005"},{"key":"bibr15-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3238"},{"key":"bibr16-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1142-z"},{"key":"bibr17-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-018-0582-3"},{"key":"bibr18-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03080-x"},{"issue":"2","key":"bibr19-s40463-021-00509-x","first-page":"1267","volume":"19","author":"Qiu C","year":"2020","journal-title":"Oncol Lett"},{"key":"bibr20-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.02.021"},{"key":"bibr21-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-9881-6"},{"issue":"5","key":"bibr22-s40463-021-00509-x","first-page":"2000","volume":"85","author":"Carling T","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr23-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01081.x"},{"key":"bibr24-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-178"},{"key":"bibr25-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.09.025"},{"key":"bibr26-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.102"},{"key":"bibr27-s40463-021-00509-x","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0997-3"},{"issue":"19","key":"bibr28-s40463-021-00509-x","first-page":"3980","volume":"20","author":"Yang JP","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-021-00509-x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40463-021-00509-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-021-00509-x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40463-021-00509-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-021-00509-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T02:01:30Z","timestamp":1741658490000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-021-00509-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1186\/s40463-021-00509-x"],"URL":"https:\/\/doi.org\/10.1186\/s40463-021-00509-x","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"30"}}