{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:46:52Z","timestamp":1768013212205,"version":"3.49.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> We present the first case of a patient with obstructive sleep apnea syndrome (OSA), where drug induced sleep endoscopy was helpful to suspect a non-acid reflux disease and showed an improvement in a swollen epiglottis after treatment. Patient ameliorated significantly his disease only with medical therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p> A 54-year-old man without significant anatomical findings with obstructive sleep apnea syndrome and non-acid gastroesophageal reflux disease (GERD) disease whose Apnea- hypopnea index (AHI) was significantly reduced with the intake of 500\u2009mg of sodium alginate twice a day for 6\u2009months. Conventional digestive tests such as esophagoscopy and simple- and double-channel 24-h pH-metry suggested mild GERD. Conventional proton-pump inhibitor treatment with pantoprazole (40\u2009mg daily) was started without any improvement in his sleep. Multichannel intraluminal 24-h impedanciometry indicated the presence of severe pathological GER of gaseous origin. The patient's AHI decreased from 25.3 at baseline to 8 after treatment with sodium alginate. A drug-induced sleep endoscopy study showed the changes before and after this treatment and was helpful for the diagnosis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Thus, medical treatment can be a therapeutic option in some patients with OSA. Multichannel 24-h impedanciometry should be performed when nonacid GERD is suspected. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-021-00526-w","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T13:02:56Z","timestamp":1625058176000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Non-acid reflux and sleep apnea: The importance of drug induced sleep endoscopy"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-4235","authenticated-orcid":false,"given":"Carlos","family":"O'Connor-Reina","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Quiron Salud Marbella, Marbella, Spain"},{"name":"Otorhinolaryngology Department, Hospital Quiron Salud Campo de Gibraltar, C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8062-335X","authenticated-orcid":false,"given":"Jose Maria Ignacio","family":"Garcia","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Hospital Quiron Salud Marbella, Marbella, Spain"},{"name":"Pulmonology Department, Hospital Quiron Salud Campo de Gibraltar, C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-5331","authenticated-orcid":false,"given":"Peter","family":"Baptista","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Clinica Universitaria de Navarra, Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4066-0137","authenticated-orcid":false,"given":"Maria Teresa","family":"Garcia-Iriarte","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Universitario de Valme, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-6154","authenticated-orcid":false,"given":"Carlos Casado","family":"Alba","sequence":"additional","affiliation":[{"name":"Clinica Universitaria de Navarra, School of Medicine, Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-4348","authenticated-orcid":false,"given":"Monica","family":"Perona","sequence":"additional","affiliation":[{"name":"Digestive Department, Hospital Quironsalud Marbella, Marbella, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9920-5273","authenticated-orcid":false,"given":"Paz Francisca","family":"Borrmann","sequence":"additional","affiliation":[{"name":"Phonoaudiology Unit. Otorhinolaryngology Department Hospital Universitario Italiano Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-5111","authenticated-orcid":false,"given":"Laura Rodriguez","family":"Alcala","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Quiron Salud Marbella, Marbella, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6409-4921","authenticated-orcid":false,"given":"Guillermo","family":"Plaza","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Universitario de Fuenlabrada & Hospital Sanitas la Zarzuela. Universidad Rey Juan Carlos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,1,1]]},"reference":[{"key":"bibr1-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.055418"},{"key":"bibr2-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01920.x"},{"key":"bibr3-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1633-8"},{"key":"bibr4-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.8904"},{"key":"bibr5-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.8640"},{"key":"bibr6-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4812-4"},{"key":"bibr7-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.6.2101"},{"key":"bibr8-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-019-01844-0"},{"key":"bibr9-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000209"},{"issue":"3","key":"bibr10-s40463-021-00526-w","first-page":"220","volume":"26","author":"Herdman C","year":"2013","journal-title":"Ann Gastroenterol"},{"key":"bibr11-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-020-00717-w"},{"key":"bibr12-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1312"},{"key":"bibr13-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12640"},{"key":"bibr14-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.09.006"},{"key":"bibr15-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13745"},{"key":"bibr16-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000162656.05715.57"},{"key":"bibr17-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/626752"},{"key":"bibr18-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819827488"},{"key":"bibr19-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12318"},{"key":"bibr20-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2011.01276.x"},{"key":"bibr21-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/646901"},{"key":"bibr22-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-020-00478-7"},{"key":"bibr23-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-020-00405-w"},{"key":"bibr24-s40463-021-00526-w","doi-asserted-by":"publisher","DOI":"10.1177\/2040622311406464"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-021-00526-w","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40463-021-00526-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-021-00526-w","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40463-021-00526-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-021-00526-w","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T23:07:01Z","timestamp":1741648021000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-021-00526-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1186\/s40463-021-00526-w"],"URL":"https:\/\/doi.org\/10.1186\/s40463-021-00526-w","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"42"}}