{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:37:55Z","timestamp":1793407075831,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority","award":["No. XTYB201825"],"award-info":[{"award-number":["No. XTYB201825"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Ossifying fibroma of the paranasal sinuses and skull base in paediatric patients is difficult to operate and can recur easily after surgery. This study aimed to analyse factors associated with recurrence after transnasal endoscopic resection of ossifying fibroma in paediatric patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> This retrospective observational study included 34 patients under 17\u00a0years of age who underwent transnasal endoscopic resection of ossifying fibroma of the paranasal sinuses and skull base from 2005 to 2021 at a single tertiary medical centre. Clinical indicators such as age; surgical history; pathological type; intraoperative bleeding; and orbit, anterior skull base, sphenoid bone, sella turcica, clivus, or frontal sinus involvement were subjected to univariate analysis using the \u03c7<jats:sup>2<\/jats:sup> test, to investigate whether any of these factors affected recurrence. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> All 34 patients underwent transnasal endoscopic resection. The follow-up period was 6\u2013120\u00a0months (mean: 48.0\u00a0months). Five patients experienced local recurrence during the follow-up period (14.7%). Results of \u03c7<jats:sup>2<\/jats:sup> tests indicated that a history of previous surgery, the amount of intraoperative bleeding, and sphenoid and\/or sella turcica and clivus involvement were significantly associated with recurrence ( P\u2009&lt;\u20090.05). Age; pathological stage; and orbit, anterior skull base, and frontal sinus involvement were not associated with recurrence ( P\u2009&gt;\u20090.05). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> The increased risk of recurrence after transnasal endoscopic resection of nasal\u2013skull base ossifying fibroma should be considered during endoscopic surgery in paediatric patients with a history of previous surgery, intraoperative bleeding tendency, and sphenoid and\/or sella turcica and clivus involvement. These patients require careful postoperative follow-up. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s40463-023-00641-w","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T03:23:57Z","timestamp":1690341837000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic factors in transnasal endoscopic surgery for paediatric patients with ossifying fibroma of the paranasal sinuses and skull base"],"prefix":"10.1177","volume":"52","author":[{"given":"Jingying","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology and Head and Neck Surgery, Ministry of Education, 1 Dong Jiao Min Xiang, Dongcheng District, 100730, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology and Head and Neck Surgery, Ministry of Education, 1 Dong Jiao Min Xiang, Dongcheng District, 100730, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology and Head and Neck Surgery, Ministry of Education, 1 Dong Jiao Min Xiang, Dongcheng District, 100730, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunjiu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology and Head and Neck Surgery, Ministry of Education, 1 Dong Jiao Min Xiang, Dongcheng District, 100730, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingfang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,1]]},"reference":[{"key":"bibr1-s40463-023-00641-w","unstructured":"Barnes L, Eveson JW, Reichart P, Sidransky D. 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