{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:13:23Z","timestamp":1789578803254,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate epidemiological, clinical and oncological outcomes of patients with laryngeal verrucous carcinomas (LVC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two independent authors investigated PubMed, Scopus and Cochrane Library for studies dedicated to epidemiological, clinical and oncological outcomes of patients with LVC. The following outcomes were investigated with PRISMA criteria: age; gender; tobacco\/alcohol consumption; HPV infection; anatomical, pathological, therapeutic and survival outcomes. Studies were analyzed for bias through a validated clinical tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 212 identified articles, 15 retrospective studies and one prospective uncontrolled study met our inclusion criteria. Three studies reported findings from national databases. The males\/females ratio is 9\/1. Mean age was 60.3\u00a0years, which was younger compared to other laryngeal malignancies. The alcohol, cigarette overuse and the HPV status of patients were lacking in most studies. Glottis and supraglottis were the most common anatomical locations, corresponding to 78.7% and 12.4% of cases, respectively. The main therapeutic approaches consisted of surgery, radiotherapy, surgery followed by radiotherapy. Treatments reported 5-year overall survival and disease-specific survival of 86.3 and 90.8, respectively. The 5- and 10-year local control rate were 83.6 and 72.6, respectively. The 10-year disease-specific survival was 80.2. Heterogeneity between studies was found for inclusion criteria, comorbidity data, and treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LVC is a rare laryngeal cancer associated with better survival and recurrence outcomes than laryngeal squamous cell carcinoma. The role of radiotherapy in the treatment regimen needs to be investigated in future prospective controlled studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40463-023-00666-1","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T07:02:23Z","timestamp":1702450943000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Epidemiological, Clinical and Oncological Outcomes of Laryngeal Verrucous Carcinomas: A Systematic Review"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France."},{"name":"Department of Otolaryngology, Elsan Hospital, Paris, France."},{"name":"Department of Otolaryngology. Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Universite Versailles Saint-Quentinen- Yvelines (Paris Saclay University), Paris, France."},{"name":"Division of Laryngology, Department of Otolaryngology. Head and Neck Surgery, Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium."},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Universite Versailles Saint- Quentin-en-Yvelines (Paris Saclay University), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Hans","sequence":"additional","affiliation":[{"name":"Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France."},{"name":"Department of Otolaryngology. Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Universite Versailles Saint-Quentinen- Yvelines (Paris Saclay University), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,1]]},"reference":[{"key":"bibr1-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.2996"},{"key":"bibr2-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816662631"},{"key":"bibr3-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815591981"},{"key":"bibr4-s40463-023-00666-1","first-page":"670","volume":"23","author":"Ackerman LV","year":"1948","journal-title":"Surgery"},{"key":"bibr5-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018660"},{"issue":"3","key":"bibr6-s40463-023-00666-1","first-page":"e348","volume":"26","author":"Kompelli AR","year":"2021","journal-title":"Int Arch Otorhinolaryngol"},{"key":"bibr7-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2022.2161626"},{"key":"bibr8-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890090105"},{"key":"bibr9-s40463-023-00666-1","unstructured":"Thompson M, Tiwari A, Fu R, Moe E, Buckley DI. A framework to facilitate the use of systematic reviews and meta-analyses in the design of primary research studies. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK83621\/. Accessed 22 Feb 2020."},{"key":"bibr10-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"bibr11-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04242.x"},{"key":"bibr12-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318219c171"},{"key":"bibr13-s40463-023-00666-1","unstructured":"Viswanathan M, Berkman ND, Dryden DM, Hartling L. Assessing risk of bias and confounding in observational studies of interventions or exposures: further development of the RTI item bank. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK154461\/. Accessed 20 Oct 2019."},{"key":"bibr14-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198404000-00012"},{"key":"bibr15-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00456652"},{"key":"bibr16-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199303000-00003"},{"key":"bibr17-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199402000-00005"},{"issue":"1","key":"bibr18-s40463-023-00666-1","first-page":"49","volume":"46","author":"Longarela Herrero Y","year":"1995","journal-title":"Acta Otorrinolaringol Esp"},{"key":"bibr19-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00615109"},{"key":"bibr20-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1997)21:2<117::AID-LSM2>3.0.CO;2-T"},{"key":"bibr21-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700505"},{"key":"bibr22-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.03.025"},{"key":"bibr23-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510999140X"},{"key":"bibr24-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.05.021"},{"key":"bibr25-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01241"},{"key":"bibr26-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801001)46:7<1617::AID-CNCR2820460722>3.0.CO;2-T"},{"key":"bibr27-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199805)20:3<197::AID-HED3>3.0.CO;2-W"},{"key":"bibr28-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00021-P"},{"key":"bibr29-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489950180531"},{"key":"bibr30-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.09.027"},{"key":"bibr31-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-203308"},{"key":"bibr32-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02968777"},{"key":"bibr33-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000032"},{"key":"bibr34-s40463-023-00666-1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.753908"}],"container-title":["Journal of Otolaryngology - Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-023-00666-1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40463-023-00666-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/s40463-023-00666-1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40463-023-00666-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/s40463-023-00666-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T10:16:30Z","timestamp":1741601790000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/s40463-023-00666-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1186\/s40463-023-00666-1"],"URL":"https:\/\/doi.org\/10.1186\/s40463-023-00666-1","relation":{},"ISSN":["1916-0216","1916-0216"],"issn-type":[{"value":"1916-0216","type":"print"},{"value":"1916-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"s40463-023-00666-1"}}