{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:31:39Z","timestamp":1791207099689,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T00:00:00Z","timestamp":1429920000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s40478-015-0202-6","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T02:25:21Z","timestamp":1429842321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["FUS\/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis"],"prefix":"10.1186","volume":"3","author":[{"given":"Yoshihiro","family":"Kino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Washizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Kurosawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Hashikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Takumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey G","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Shimogori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Nukina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,25]]},"reference":[{"issue":"5918","key":"202_CR1","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1126\/science.1166066","volume":"323","author":"TJ Kwiatkowski Jr","year":"2009","unstructured":"Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr (2009) Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 323(5918):1205\u20131208, doi:10.1126\/science","journal-title":"Science"},{"issue":"5918","key":"202_CR2","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1126\/science.1165942","volume":"323","author":"C Vance","year":"2009","unstructured":"Vance C, Rogelj B, Hortobagyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 323(5918):1208\u20131211, doi:10.1126\/science","journal-title":"Science"},{"key":"202_CR3","doi-asserted-by":"crossref","unstructured":"Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T (2010) FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Ann Neurol 67(6):739\u2013748, doi:10.1002\/ana.22051","DOI":"10.1002\/ana.22051"},{"key":"202_CR4","doi-asserted-by":"crossref","unstructured":"Woulfe J, Gray DA, Mackenzie IR (2010) FUS-immunoreactive intranuclear inclusions in neurodegenerative disease. Brain Pathol 20(3)):589\u2013597, doi:10.1111\/j.1750-3639","DOI":"10.1111\/j.1750-3639.2009.00337.x"},{"issue":"(2","key":"202_CR5","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ajhg.2012.07.002","volume":"91","author":"ND Merner","year":"2012","unstructured":"Merner ND, Girard SL, Catoire H, Bourassa CV, Belzil VV, Riviere JB, Hince P, Levert A, Dionne-Laporte A, Spiegelman D, Noreau A, Diab S, Szuto A, Fournier H, Raelson J, Belouchi M, Panisset M, Cossette P, Dupre N, Bernard G, Chouinard S, Dion PA, Rouleau GA (2012) Exome sequencing identifies FUS mutations as a cause of essential tremor. Am J Hum Genet 91(2):313\u2013319, doi:10.1016\/j.ajhg.2012.07.002","journal-title":"Am J Hum Genet"},{"key":"202_CR6","doi-asserted-by":"crossref","unstructured":"Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C (2010) ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J 29(16):2841\u20132857, doi:10.1038\/emboj.2010.143","DOI":"10.1038\/emboj.2010.143"},{"issue":"7","key":"202_CR7","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1093\/nar\/gkq1162","volume":"39","author":"Y Kino","year":"2011","unstructured":"Kino Y, Washizu C, Aquilanti E, Okuno M, Kurosawa M, Yamada M, Doi H, Nukina N (2011) Intracellular localization and splicing regulation of FUS\/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations. Nucleic Acids Res 39(7):2781\u20132798, doi:10.1093\/nar\/gkq1162","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"202_CR8","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00401-012-1043-z","volume":"125","author":"JC Mitchell","year":"2013","unstructured":"Mitchell JC, McGoldrick P, Vance C, Hortobagyi T, Sreedharan J, Rogelj B, Tudor EL, Smith BN, Klasen C, Miller CC, Cooper JD, Greensmith L, Shaw CE (2013) Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion. Acta Neuropathol 125(2):273\u2013288, doi:10.1007\/s00401-012-1043-z","journal-title":"Acta Neuropathol"},{"issue":"2","key":"202_CR9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/emmm.201202303","volume":"5","author":"H Tsuiji","year":"2013","unstructured":"Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, Yamanaka K (2013) Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. EMBO Mol Med 5(2):221\u2013234, doi:10.1002\/emmm.201202303","journal-title":"EMBO Mol Med"},{"issue":"4","key":"202_CR10","doi-asserted-by":"publisher","first-page":"799-","DOI":"10.1016\/j.celrep.2012.08.025","volume":"2","author":"T Yamazaki","year":"2012","unstructured":"Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, Gygi SP, Shneider NA, Maniatis T, Reed R (2012) FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Rep 2(4):799-\u2013806, doi:10.1016\/j.celrep.2012.08.025","journal-title":"Cell Rep"},{"issue":"6","key":"202_CR11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.cub.2005.01.058","volume":"15","author":"R Fujii","year":"2005","unstructured":"Fujii R, Okabe S, Urushido T, Inoue K, Yoshimura A, Tachibana T, Nishikawa T, Hicks GG, Takumi T (2005) The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology. Curr Biol 15(6):587\u2013593, doi:10.1016\/j.cub.2005.01.058","journal-title":"Curr Biol"},{"issue":"2","key":"202_CR12","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/72842","volume":"24","author":"GG Hicks","year":"2000","unstructured":"Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, Van Kaer L, Ruley HE (2000) Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat Genet 24(2):175\u2013179. doi:10.1038\/72842","journal-title":"Nat Genet"},{"issue":"Pt 24","key":"202_CR13","doi-asserted-by":"publisher","first-page":"5755","DOI":"10.1242\/jcs.02692","volume":"118","author":"R Fujii","year":"2005","unstructured":"Fujii R, Takumi T (2005) TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines. J Cell Sci 118(Pt 24):5755\u20135765, doi:10.1242\/jcs.02692","journal-title":"J Cell Sci"},{"key":"202_CR14","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/srep00529","volume":"2","author":"S Ishigaki","year":"2012","unstructured":"Ishigaki S, Masuda A, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K (2012) Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Sci Rep 2:529. doi:10.1038\/srep00529","journal-title":"Sci Rep"},{"issue":"11)","key":"202_CR15","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1038\/nn.3230","volume":"15","author":"C Lagier-Tourenne","year":"2012","unstructured":"Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW, Yeo GW (2012) Divergent roles of ALS-linked proteins FUS\/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci 15(11):1488\u20131497, doi:10.1038\/nn.3230","journal-title":"Nat Neurosci"},{"key":"202_CR16","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/srep00603","volume":"2","author":"B Rogelj","year":"2012","unstructured":"Rogelj B, Easton LE, Bogu GK, Stanton LW, Rot G, Curk T, Zupan B, Sugimoto Y, Modic M, Haberman N, Tollervey J, Fujii R, Takumi T, Shaw CE, Ule J (2012) Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain. Sci Rep 2:603, doi:10.1038\/srep00603","journal-title":"Sci Rep"},{"issue":"4","key":"202_CR17","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.cell.2012.04.016","volume":"149","author":"TW Han","year":"2012","unstructured":"Han TW, Kato M, Xie S, Wu LC, Mirzaei H, Pei J, Chen M, Xie Y, Allen J, Xiao G, McKnight SL (2012) Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies. Cell 149(4):768\u2013779, doi:10.1016\/j.cell.2012.04.016","journal-title":"Cell"},{"issue":"4","key":"202_CR18","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.cell.2012.04.017","volume":"149","author":"M Kato","year":"2012","unstructured":"Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, Sawaya MR, Eisenberg D, Tycko R, McKnight SL (2012) Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149(4):753\u2013767, doi:10.1016\/j.cell.2012.04.017","journal-title":"Cell"},{"issue":"Pt 5","key":"202_CR19","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1093\/brain\/awt030","volume":"136","author":"M Thomas","year":"2013","unstructured":"Thomas M, Alegre-Abarrategui J, Wade-Martins R (2013) RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis\/frontotemporal dementia disease continuum. Brain 136(Pt 5):1345\u20131360, doi:10.1093\/brain\/awt030","journal-title":"Brain"},{"issue":"3","key":"202_CR20","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/mds.20331","volume":"20","author":"FC Martin","year":"2005","unstructured":"Martin FC, Le Thu A, Handforth A (2005) Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications. Mov Disord 20(3):298\u2013305. doi:10.1002\/mds.20331","journal-title":"Mov Disord"},{"key":"202_CR21","doi-asserted-by":"crossref","unstructured":"Emig D, Salomonis N, Baumbach J, Lengauer T, Conklin BR, Albrecht M (2010) AltAnalyze and DomainGraph: analyzing and visualizing exon expression data. Nucleic Acids Res 38:W755\u2013762, doi:10.1093\/nar\/gkq405","DOI":"10.1093\/nar\/gkq405"},{"issue":"3","key":"202_CR22","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1093\/emboj\/19.3.453","volume":"19","author":"M Kuroda","year":"2000","unstructured":"Kuroda M, Sok J, Webb L, Baechtold H, Urano F, Yin Y, Chung P, de Rooij DG, Akhmedov A, Ashley T, Ron D (2000) Male sterility and enhanced radiation sensitivity in TLS(-\/-) mice. EMBO J 19(3):453\u2013462, doi:10.1093\/emboj\/19.3.453","journal-title":"EMBO J"},{"issue":"7442","key":"202_CR23","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nature11922","volume":"495","author":"HJ Kim","year":"2013","unstructured":"Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP (2013) Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature 495(7442):467\u2013473, doi:10.1038\/nature11922","journal-title":"Nature"},{"issue":"(6","key":"202_CR24","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/ng1577","volume":"37","author":"W Davies","year":"2005","unstructured":"Davies W, Isles A, Smith R, Karunadasa D, Burrmann D, Humby T, Ojarikre O, Biggin C, Skuse D, Burgoyne P, Wilkinson L (2005) Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nat Genet 37(6):625\u2013629, doi:10.1038\/ng1577","journal-title":"Nat Genet"},{"key":"202_CR25","doi-asserted-by":"crossref","unstructured":"Cubelos B, Sebastian-Serrano A, Beccari L, Calcagnotto ME, Cisneros E, Kim S, Dopazo A, Alvarez-Dolado M, Redondo JM, Bovolenta P, Walsh CA, Nieto M (2010) Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex. Neuron 66(4):523\u2013535, doi:10.1016\/j.neuron.2010.04.038","DOI":"10.1016\/j.neuron.2010.04.038"},{"issue":"8","key":"202_CR26","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/embor.2012.90","volume":"13","author":"D Orozco","year":"2012","unstructured":"Orozco D, Tahirovic S, Rentzsch K, Schwenk BM, Haass C, Edbauer D (2012) Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. EMBO Rep 13(8):759\u2013764, doi:10.1038\/embor.2012.90","journal-title":"EMBO Rep"},{"issue":"3","key":"202_CR27","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s12031-011-9593-4","volume":"45","author":"M Goedert","year":"2011","unstructured":"Goedert M, Spillantini MG (2011) Pathogenesis of the tauopathies. J Mol Neurosci 45(3):425\u2013431. doi:10.1007\/s12031-011-9593-4","journal-title":"J Mol Neurosci"},{"issue":"35","key":"202_CR28","doi-asserted-by":"publisher","first-page":"25266","DOI":"10.1074\/jbc.M113.492017","volume":"288","author":"TA Shelkovnikova","year":"2013","unstructured":"Shelkovnikova TA, Peters OM, Deykin AV, Connor-Robson N, Robinson H, Ustyugov AA, Bachurin SO, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Skvortsova VI, Ling SC, Da Cruz S, Parone PA, Buchman VL, Ninkina NN (2013) Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. J Biol Chem 288(35):25266\u201325274, doi:10.1074\/jbc.M113.492017","journal-title":"J Biol Chem"},{"issue":"11","key":"202_CR29","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.biopsych.2005.02.002","volume":"57","author":"T Sagvolden","year":"2005","unstructured":"Sagvolden T, Russell VA, Aase H, Johansen EB, Farshbaf M (2005) Rodent models of attention-deficit\/hyperactivity disorder. Biol Psychiatry 57(11):1239\u20131247, doi:10.1016\/j.biopsych.2005.02.002","journal-title":"Biol Psychiatry"},{"key":"202_CR30","doi-asserted-by":"crossref","unstructured":"Williams NM, Zaharieva I, Martin A, Langley K, Mantripragada K, Fossdal R, Stefansson H, Stefansson K, Magnusson P, Gudmundsson OO, Gustafsson O, Holmans P, Owen MJ, O'Donovan M, Thapar A (2010) Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet 376(9750):1401\u20131408, doi:10.1016\/S0140-6736(10)61109-9","DOI":"10.1016\/S0140-6736(10)61109-9"},{"issue":"Pt 9","key":"202_CR31","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1093\/brain\/awr201","volume":"134","author":"M Neumann","year":"2011","unstructured":"Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IR (2011) FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain 134(Pt 9):2595\u20132609, doi:10.1093\/brain\/awr201","journal-title":"Brain"},{"issue":"4","key":"202_CR32","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/sj.mp.4001621","volume":"10","author":"X Zhou","year":"2005","unstructured":"Zhou X, Long JM, Geyer MA, Masliah E, Kelsoe JR, Wynshaw-Boris A, Chien KR (2005) Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization. Mol Psychiatry 10(4):393\u2013406, doi:10.1038\/sj.mp.4001621","journal-title":"Mol Psychiatry"},{"key":"202_CR33","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1038\/srep02388","volume":"3","author":"Y Fujioka","year":"2013","unstructured":"Fujioka Y, Ishigaki S, Masuda A, Iguchi Y, Udagawa T, Watanabe H, Katsuno M, Ohno K, Sobue G (2013) FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS\/FTLD. Sci Rep 3:2388, doi:10.1038\/srep02388","journal-title":"Sci Rep"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-015-0202-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40478-015-0202-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-015-0202-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-015-0202-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T11:14:58Z","timestamp":1630581298000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-015-0202-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,25]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["202"],"URL":"https:\/\/doi.org\/10.1186\/s40478-015-0202-6","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,25]]},"assertion":[{"value":"3 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"24"}}