{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:54:35Z","timestamp":1787313275702,"version":"build-2736575974"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s40478-015-0221-3","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T08:21:37Z","timestamp":1435566097000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Neuropathology of Beta-propeller protein associated neurodegeneration (BPAN): a new tauopathy"],"prefix":"10.1186","volume":"3","author":[{"given":"R.","family":"Paudel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wiethoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bandopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"de Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Houlden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Holton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"221_CR1","volume-title":"GeneReviews(\u00ae) [Internet]","author":"A Gregory","year":"1993","unstructured":"Gregory A, Hayflick S (1993) Neurodegeneration with Brain Iron Accumulation Disorders Overview. In: Pagon RA, Adam MP, Bird TD, Dolan CR, Fong C-T, Stephens K (eds) GeneReviews(\u00ae) [Internet]. University of Washington, Seattle, Seattle (WA)"},{"key":"221_CR2","doi-asserted-by":"crossref","unstructured":"Arber C, Li A, Houlden H, Wray S (2015) Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories. Neuropathol Appl Neurobiol. doi: 10.1111\/nan.12242.","DOI":"10.1111\/nan.12242"},{"issue":"6","key":"221_CR3","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.ajhg.2012.10.019","volume":"91","author":"TB1 Haack","year":"2012","unstructured":"Haack TB1, Hogarth P, Kruer MC, Gregory A, Wieland T, Schwarzmayr T, Graf E, Sanford L, Meyer E, Kara E, Cuno SM, Harik SI, Dandu VH, Nardocci N, Zorzi G, Dunaway T, Tarnopolsky M, Skinner S, Frucht S, Hanspal E, Schrander-Stumpel C, H\u00e9ron D, Mignot C, Garavaglia B, Bhatia K, Hardy J, Strom TM, Boddaert N, Houlden HH, Kurian MA, Meitinger T, Prokisch H, Hayflick SJ (2012) Exome sequencing reveals de novo WDR45 mutations causing a phenotypically distinct, X-linked dominant form of NBIA. Am J Hum Genet 91(6):1144\u20139","journal-title":"Am J Hum Genet"},{"issue":"4","key":"221_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/ng.2562","volume":"45","author":"H Saitsu","year":"2013","unstructured":"Saitsu H, Nishimura T, Muramatsu K, Kodera H, Kumada S, Sugai K, Kasai-Yoshida E, Sawaura N, Nishida H, Hoshino A, Ryujin F, Yoshioka S, Nishiyama K, Kondo Y, Tsurusaki Y, Nakashima M, Miyake N, Arakawa H, Kato M, Mizushima N, Matsumoto N (2013) De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet 45(4):445\u20139, 449e1","journal-title":"Nat Genet"},{"issue":"Pt 6","key":"221_CR5","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1093\/brain\/awt095","volume":"136","author":"SJ Hayflick","year":"2013","unstructured":"Hayflick SJ, Kruer MC, Gregory A, Haack TB, Kurian MA, Houlden HH, Anderson J, Boddaert N, Sanford L, Harik SI, Dandu VH, Nardocci N, Zorzi G, Dunaway T, Tarnopolsky M, Skinner S, Holden KR, Frucht S, Hanspal E, Schrander-Stumpel C, Mignot C, H\u00e9ron D, Saunders DE, Kaminska M, Lin JP, Lascelles K, Cuno SM, Meyer E, Garavaglia B, Bhatia K, de Silva R, Crisp S, Lunt P, Carey M, Hardy J, Meitinger T, Prokisch H, Hogarth P (2013) \u03b2-Propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation. Brain 136(Pt 6):1708\u201317","journal-title":"Brain"},{"issue":"3","key":"221_CR6","doi-asserted-by":"publisher","first-page":"497","DOI":"10.4161\/auto.27419","volume":"10","author":"S Tsuyuki","year":"2014","unstructured":"Tsuyuki S, Takabayashi M, Kawazu M, Kudo K, Watanabe A, Nagata Y, Kusama Y, Yoshida K (2014) Detection of WIPI1 mRNA as an indicator of autophagosome formation. Autophagy 10(3):497\u2013513","journal-title":"Autophagy"},{"issue":"1","key":"221_CR7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0896-6273(92)90117-V","volume":"8","author":"M Goedert","year":"1992","unstructured":"Goedert M, Spillantini MG, Cairns NJ, Crowther RA (1992) Tau proteins of alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 8(1):159\u201368","journal-title":"Neuron"},{"issue":"6","key":"221_CR8","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1046\/j.1471-4159.1998.71062465.x","volume":"71","author":"DP Hanger","year":"1998","unstructured":"Hanger DP, Betts JC, Loviny TLF, Blackstock WP, Anderton BH (1998) New phosphorylation sites identified in hyperphosphorylated tau (Paired Helical Filament-Tau) from Alzheimer\u2019s disease brain using nanoelectrospray mass spectrometry. J Neurochem 71(6):2465\u201376","journal-title":"J Neurochem"},{"issue":"3","key":"221_CR9","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1046\/j.1365-2990.2003.00463.x","volume":"29","author":"R De Silva","year":"2003","unstructured":"De Silva R, Lashley T, Gibb G, Hanger D, Hope A, Reid A, Bandopadhyay R, Utton M, Strand C, Jowett T, Khan N, Anderton B, Wood N, Holton J, Revesz T, Lees A (2003) Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies. Neuropathol Appl Neurobiol 29(3):288\u2013302","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"3","key":"221_CR10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1212\/WNL.0b013e31827e07be","volume":"80","author":"P Hogarth","year":"2013","unstructured":"Hogarth P, Gregory A, Kruer MC, Sanford L, Wagoner W, Natowicz MR, Egel RT, Subramony SH, Goldman JG, Berry-Kravis E, Foulds NC, Hammans SR, Desguerre I, Rodriguez D, Wilson C, Diedrich A, Green S, Tran H, Reese L, Woltjer RL, Hayflick SJ (2013) New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN. Neurology 80(3):268\u201375","journal-title":"Neurology"},{"issue":"4","key":"221_CR11","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.neurobiolaging.2010.05.009","volume":"33","author":"C Pais\u00e1n-Ruiz","year":"2012","unstructured":"Pais\u00e1n-Ruiz C, Li A, Schneider SA, Holton JL, Johnson R, Kidd D, Chataway J, Bhatia KP, Lees AJ, Hardy J, Revesz T, Houlden H (2012) Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations. Neurobiol Aging 33(4):814\u201323","journal-title":"Neurobiol Aging"},{"key":"221_CR12","doi-asserted-by":"crossref","unstructured":"Li A, Paudel R, Johnson R, Courtney R, Lees AJ, Holton JL, Hardy J, Revesz T, Houlden H (2012) Pantothenate kinase-associated neurodegeneration is not a synucleinopathy. Neuropathol Appl Neurobiol(Mar 15)","DOI":"10.1111\/j.1365-2990.2012.01269.x"},{"issue":"4","key":"221_CR13","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.ajhg.2011.09.007","volume":"89","author":"MB Hartig","year":"2011","unstructured":"Hartig MB, Iuso A, Haack T, Kmiec T, Jurkiewicz E, Heim K, Roeber S, Tarabin V, Dusi S, Krajewska-Walasek M, Jozwiak S, Hempel M, Winkelmann J, Elstner M, Oexle K, Klopstock T, Mueller-Felber W, Gasser T, Trenkwalder C, Tiranti V, Kretzschmar H, Schmitz G, Strom TM, Meitinger T, Prokisch H (2011) Absence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation. Am J Hum Genet 89(4):543\u201350","journal-title":"Am J Hum Genet"},{"issue":"7302","key":"221_CR14","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature09204","volume":"466","author":"C Behrends","year":"2010","unstructured":"Behrends C, Sowa ME, Gygi SP, Harper JW (2010) Network organization of the human autophagy system. Nature 466(7302):68\u201376","journal-title":"Nature"},{"issue":"2","key":"221_CR15","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.devcel.2011.06.024","volume":"21","author":"Q Lu","year":"2011","unstructured":"Lu Q, Yang P, Huang X, Hu W, Guo B, Wu F, Lin L, Kov\u00e1cs AL, Yu L, Zhang H (2011) The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Dev Cell 21(2):343\u201357","journal-title":"Dev Cell"},{"key":"221_CR16","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fneur.2013.00122","volume":"4","author":"AS Chesser","year":"2013","unstructured":"Chesser AS, Pritchard SM, Johnson GVW (2013) Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease. Front Neurol 4:122","journal-title":"Front Neurol"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-015-0221-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40478-015-0221-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-015-0221-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-015-0221-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T15:07:26Z","timestamp":1717945646000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-015-0221-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,30]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["221"],"URL":"https:\/\/doi.org\/10.1186\/s40478-015-0221-3","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,30]]},"assertion":[{"value":"21 May 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"39"}}