{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:00:36Z","timestamp":1791216036079,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T00:00:00Z","timestamp":1437782400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["CP-IP 258654"],"award-info":[{"award-number":["CP-IP 258654"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-BSV4-0001-01"],"award-info":[{"award-number":["ANR-12-BSV4-0001-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["LABEX BRAIN ANR-10-LABX-43"],"award-info":[{"award-number":["LABEX BRAIN ANR-10-LABX-43"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s40478-015-0222-2","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T21:26:19Z","timestamp":1437686779000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by \u03b1-synuclein overexpression"],"prefix":"10.1186","volume":"3","author":[{"given":"Mathieu","family":"Bourdenx","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Dovero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Engeln","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Bido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu F.","family":"Bastide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Dutheil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Vollenweider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Baud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Piron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Grouthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Boraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Porras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Baekelandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Scheller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Olivier","family":"Fernagut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Georges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Courtine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Bezard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Dehay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,25]]},"reference":[{"key":"222_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00006-X","author":"B Dehay","year":"2015","unstructured":"Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM, Bezard E, Petsko GA, Meissner WG (2015) Targeting alpha-synuclein for treatment of Parkinson\u2019s disease: mechanistic and therapeutic considerations. Lancet Neurol. doi:10.1016\/S1474-4422(15)00006-X","journal-title":"Lancet Neurol"},{"issue":"4","key":"222_CR2","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nrn1886","volume":"7","author":"MP Mattson","year":"2006","unstructured":"Mattson MP, Magnus T (2006) Ageing and neuronal vulnerability. Nat Rev Neurol 7(4):278\u2013294. doi:10.1038\/nrn1886","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"222_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nrn3039","volume":"12","author":"TJ Collier","year":"2011","unstructured":"Collier TJ, Kanaan NM, Kordower JH (2011) Ageing as a primary risk factor for Parkinson\u2019s disease: evidence from studies of non-human primates. Nat Rev Neurol 12(6):359\u2013366. doi:10.1038\/nrn3039","journal-title":"Nat Rev Neurol"},{"issue":"5","key":"222_CR4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.tins.2007.03.009","volume":"30","author":"D Sulzer","year":"2007","unstructured":"Sulzer D (2007) Multiple hit hypotheses for dopamine neuron loss in Parkinson\u2019s disease. Trends Neurosci 30(5):244\u2013250. doi:10.1016\/j.tins.2007.03.009","journal-title":"Trends Neurosci"},{"issue":"6645","key":"222_CR5","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","volume":"388","author":"MG Spillantini","year":"1997","unstructured":"Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in Lewy bodies. Nature 388(6645):839\u2013840. doi:10.1038\/42166","journal-title":"Nature"},{"issue":"5321","key":"222_CR6","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","volume":"276","author":"MH Polymeropoulos","year":"1997","unstructured":"Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease. Science 276(5321):2045\u20132047","journal-title":"Science"},{"key":"222_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0079-6123(10)84004-X","volume":"184","author":"I Magen","year":"2010","unstructured":"Magen I, Chesselet MF (2010) Genetic mouse models of Parkinson\u2019s disease The state of the art. Prog Brain Res 184:53\u201387. doi:10.1016\/S0079-6123(10)84004-X","journal-title":"Prog Brain Res"},{"issue":"1","key":"222_CR8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/mds.25108","volume":"28","author":"E Bezard","year":"2013","unstructured":"Bezard E, Yue Z, Kirik D, Spillantini MG (2013) Animal models of Parkinson\u2019s disease: limits and relevance to neuroprotection studies. Mov Disord: Off J Mov Dis Soc 28(1):61\u201370. doi:10.1002\/mds.25108","journal-title":"Mov Disord: Off J Mov Dis Soc"},{"key":"222_CR9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1750-1326-8-44","volume":"8","author":"M Oliveras-Salva","year":"2013","unstructured":"Oliveras-Salva M, Van der Perren A, Casadei N, Stroobants S, Nuber S, D\u2019Hooge R, Van den Haute C, Baekelandt V (2013) rAAV2\/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration. Mol Neurodegener 8:44. doi:10.1186\/1750-1326-8-44","journal-title":"Mol Neurodegener"},{"issue":"3","key":"222_CR10","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.neurobiolaging.2014.11.015","volume":"36","author":"A Van der Perren","year":"2015","unstructured":"Van der Perren A, Toelen J, Casteels C, Macchi F, Van Rompuy AS, Sarre S, Casadei N, Nuber S, Himmelreich U, Osorio Garcia MI, Michotte Y, D\u2019Hooge R, Bormans G, Van Laere K, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V (2015) Longitudinal follow-up and characterization of a robust rat model for Parkinson\u2019s disease based on overexpression of alpha-synuclein with adeno-associated viral vectors. Neurobiol Aging 36(3):1543\u20131558. doi:10.1016\/j.neurobiolaging.2014.11.015","journal-title":"Neurobiol Aging"},{"issue":"6","key":"222_CR11","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/sj.gt.3300938","volume":"6","author":"S Zolotukhin","year":"1999","unstructured":"Zolotukhin S, Byrne BJ, Mason E, Zolotukhin I, Potter M, Chesnut K, Summerford C, Samulski RJ, Muzyczka N (1999) Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther 6(6):973\u2013985","journal-title":"Gene Ther"},{"issue":"1","key":"222_CR12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1089\/hgtb.2011.034","volume":"23","author":"C Aurnhammer","year":"2012","unstructured":"Aurnhammer C, Haase M, Muether N, Hausl M, Rauschhuber C, Huber I, Nitschko H, Busch U, Sing A, Ehrhardt A, Baiker A (2012) Universal real-time PCR for the detection and quantification of adeno-associated virus serotype 2-derived inverted terminal repeat sequences. Hum Gene Ther Methods 23(1):18\u201328. doi:10.1089\/hgtb.2011.034","journal-title":"Hum Gene Ther Methods"},{"issue":"1","key":"222_CR13","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/ana.23881","volume":"74","author":"M Engeln","year":"2013","unstructured":"Engeln M, Fasano S, Ahmed SH, Cador M, Baekelandt V, Bezard E, Fernagut PO (2013) Levodopa gains psychostimulant-like properties after nigral dopaminergic loss. Ann Neurol 74(1):140\u2013144. doi:10.1002\/ana.23881","journal-title":"Ann Neurol"},{"issue":"7","key":"222_CR14","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/nm.2845","volume":"18","author":"N Dominici","year":"2012","unstructured":"Dominici N, Keller U, Vallery H, Friedli L, van den Brand R, Starkey ML, Musienko P, Riener R, Courtine G (2012) Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders. Nat Med 18(7):1142\u20131147. doi:10.1038\/nm.2845","journal-title":"Nat Med"},{"key":"222_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.nbd.2012.08.005","volume":"49","author":"M Engeln","year":"2013","unstructured":"Engeln M, Ahmed SH, Vouillac C, Tison F, Bezard E, Fernagut PO (2013) Reinforcing properties of Pramipexole in normal and parkinsonian rats. Neurobiol Dis 49:79\u201386. doi:10.1016\/j.nbd.2012.08.005","journal-title":"Neurobiol Dis"},{"key":"222_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.07.007","author":"M Engeln","year":"2014","unstructured":"Engeln M, Bastide MF, Toulme E, Dehay B, Bourdenx M, Doudnikoff E, Li Q, Gross CE, Boue-Grabot E, Pisani A, Bezard E, Fernagut PO (2014) Selective Inactivation of Striatal FosB\/DeltaFosB-Expressing Neurons Alleviates L-Dopa-Induced Dyskinesia. Biol Psychiatry. doi:10.1016\/j.biopsych.2014.07.007","journal-title":"Biol Psychiatry"},{"issue":"6085","key":"222_CR17","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1126\/science.1217416","volume":"336","author":"R van den Brand","year":"2012","unstructured":"van den Brand R, Heutschi J, Barraud Q, DiGiovanna J, Bartholdi K, Huerlimann M, Friedli L, Vollenweider I, Moraud EM, Duis S, Dominici N, Micera S, Musienko P, Courtine G (2012) Restoring voluntary control of locomotion after paralyzing spinal cord injury. Science 336(6085):1182\u20131185. doi:10.1126\/science.1217416","journal-title":"Science"},{"key":"222_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fncir.2014.00013","volume":"8","author":"C Vitrac","year":"2014","unstructured":"Vitrac C, Peron S, Frappe I, Fernagut PO, Jaber M, Gaillard A, Benoit-Marand M (2014) Dopamine control of pyramidal neuron activity in the primary motor cortex via D2 receptors. Frontiers Neural Circuits 8:13. doi:10.3389\/fncir.2014.00013","journal-title":"Frontiers Neural Circuits"},{"issue":"3","key":"222_CR19","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.nbd.2011.12.013","volume":"45","author":"M Decressac","year":"2012","unstructured":"Decressac M, Mattsson B, Lundblad M, Weikop P, Bjorklund A (2012) Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of alpha-synuclein in midbrain dopamine neurons. Neurobiol Dis 45(3):939\u2013953. doi:10.1016\/j.nbd.2011.12.013","journal-title":"Neurobiol Dis"},{"issue":"7","key":"222_CR20","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1523\/JNEUROSCI.22-07-02780.2002","volume":"22","author":"D Kirik","year":"2002","unstructured":"Kirik D, Rosenblad C, Burger C, Lundberg C, Johansen TE, Muzyczka N, Mandel RJ, Bjorklund A (2002) Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. J Neurosci 22(7):2780\u20132791","journal-title":"J. Neurosci."},{"issue":"2","key":"222_CR21","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/ncb748","volume":"4","author":"H Fujiwara","year":"2002","unstructured":"Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T (2002) alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4(2):160\u2013164. doi:10.1038\/ncb748","journal-title":"Nat Cell Biol"},{"issue":"1\u20132","key":"222_CR22","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0006-8993(99)01273-1","volume":"828","author":"K Hamre","year":"1999","unstructured":"Hamre K, Tharp R, Poon K, Xiong X, Smeyne RJ (1999) Differential strain susceptibility following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration acts in an autosomal dominant fashion: quantitative analysis in seven strains of Mus musculus. Brain Res 828(1\u20132):91\u2013103","journal-title":"Brain Res"},{"issue":"7","key":"222_CR23","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1016\/j.cell.2014.11.019","volume":"159","author":"A Takeoka","year":"2014","unstructured":"Takeoka A, Vollenweider I, Courtine G, Arber S (2014) Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury. Cell 159(7):1626\u20131639. doi:10.1016\/j.cell.2014.11.019","journal-title":"Cell"},{"issue":"2","key":"222_CR24","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0167-4943(94)90039-6","volume":"19","author":"T Takeda","year":"1994","unstructured":"Takeda T, Hosokawa M, Higuchi K, Hosono M, Akiguchi I, Katoh H (1994) A novel murine model of aging, Senescence-Accelerated Mouse (SAM). Arch Gerontol Geriatr 19(2):185\u2013192","journal-title":"Arch Gerontol Geriatr"},{"issue":"1","key":"222_CR25","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nprot.2006.342","volume":"2","author":"V Jackson-Lewis","year":"2007","unstructured":"Jackson-Lewis V, Przedborski S (2007) Protocol for the MPTP mouse model of Parkinson\u2019s disease. Nat Protoc 2(1):141\u2013151. doi:10.1038\/nprot.2006.342","journal-title":"Nat Protoc"},{"key":"222_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00006-X","author":"B Dehay","year":"2015","unstructured":"Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM, Bezard E, Petsko GA, Meissner WG (2015) Targeting \u03b1-synuclein for treating Parkinson\u2019s disease: mechanistic and therapeutic considerations. Lancet Neurology. doi:10.1016\/S1474-4422(15)00006-X","journal-title":"Lancet Neurology"},{"issue":"3","key":"222_CR27","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbrc.2009.07.070","volume":"387","author":"K Larsen","year":"2009","unstructured":"Larsen K, Hedegaard C, Bertelsen MF, Bendixen C (2009) Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals. Biochem Biophys Res Commun 387(3):602\u2013605. doi:10.1016\/j.bbrc.2009.07.070","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"222_CR28","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.ygeno.2003.09.016","volume":"83","author":"BA Hamilton","year":"2004","unstructured":"Hamilton BA (2004) alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates. Genomics 83(4):739\u2013742. doi:10.1016\/j.ygeno.2003.09.016","journal-title":"Genomics"},{"issue":"17","key":"222_CR29","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1523\/JNEUROSCI.21-17-06853.2001","volume":"21","author":"E Bezard","year":"2001","unstructured":"Bezard E, Dovero S, Prunier C, Ravenscroft P, Chalon S, Guilloteau D, Crossman AR, Bioulac B, Brotchie JM, Gross CE (2001) Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson\u2019s disease. J Neurosci 21(17):6853\u20136861","journal-title":"J Neurosci"},{"issue":"2","key":"222_CR30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0301-0082(98)00006-9","volume":"55","author":"E Bezard","year":"1998","unstructured":"Bezard E, Gross CE (1998) Compensatory mechanisms in experimental and human parkinsonism: towards a dynamic approach. Prog Neurobiol 55(2):93\u2013116","journal-title":"Prog Neurobiol"},{"issue":"Pt 3","key":"222_CR31","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1093\/brain\/awl382","volume":"130","author":"A Eslamboli","year":"2007","unstructured":"Eslamboli A, Romero-Ramos M, Burger C, Bjorklund T, Muzyczka N, Mandel RJ, Baker H, Ridley RM, Kirik D (2007) Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain :J Neuro 130(Pt 3):799\u2013815. doi:10.1093\/brain\/awl382","journal-title":"Brain :J Neuro"},{"issue":"16","key":"222_CR32","doi-asserted-by":"publisher","first-page":"10813","DOI":"10.1073\/pnas.152339799","volume":"99","author":"C Lo Bianco","year":"2002","unstructured":"Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P (2002) alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson\u2019s disease. Proc Natl Acad Sci U S A 99(16):10813\u201310818. doi:10.1073\/pnas.152339799","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"222_CR33","doi-asserted-by":"publisher","first-page":"16895","DOI":"10.1074\/jbc.M800747200","volume":"283","author":"KE Paleologou","year":"2008","unstructured":"Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT Jr, Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA (2008) Phosphorylation at Ser-129 but not the phosphomimics S129E\/D inhibits the fibrillation of alpha-synuclein. J Biol Chem 283(24):16895\u201316905. doi:10.1074\/jbc.M800747200","journal-title":"J Biol Chem"},{"key":"222_CR34","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.nbd.2015.03.008","volume":"78","author":"K Buck","year":"2015","unstructured":"Buck K, Landeck N, Ulusoy A, Majbour NK, El-Agnaf OM, Kirik D (2015) Ser129 phosphorylation of endogenous alpha-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function. Neurobiol Dis 78:100\u2013114. doi:10.1016\/j.nbd.2015.03.008","journal-title":"Neurobiol Dis"},{"key":"222_CR35","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neuroscience.2011.10.042","volume":"200","author":"G Muntane","year":"2012","unstructured":"Muntane G, Ferrer I, Martinez-Vicente M (2012) alpha-synuclein phosphorylation and truncation are normal events in the adult human brain. Neuroscience 200:106\u2013119. doi:10.1016\/j.neuroscience.2011.10.042","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"222_CR36","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/0006-8993(92)90473-M","volume":"572","author":"I Irwin","year":"1992","unstructured":"Irwin I, Finnegan KT, Delanney LE, Di Monte D, Langston JW (1992) The relationships between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL\/6 mice: a critical reassessment. Brain Res 572(1\u20132):224\u2013231","journal-title":"Brain Res"},{"issue":"2","key":"222_CR37","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0014-2999(93)90800-W","volume":"230","author":"S Rose","year":"1993","unstructured":"Rose S, Nomoto M, Jackson EA, Gibb WR, Jaehnig P, Jenner P, Marsden CD (1993) Age-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets. Eur J Pharmacol 230(2):177\u2013185","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"222_CR38","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/0197-4580(95)02012-8","volume":"16","author":"A Ovadia","year":"1995","unstructured":"Ovadia A, Zhang Z, Gash DM (1995) Increased susceptibility to MPTP toxicity in middle-aged rhesus monkeys. Neurobiol Aging 16(6):931\u2013937","journal-title":"Neurobiol Aging"},{"issue":"3","key":"222_CR39","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s12640-009-9059-4","volume":"16","author":"I Paris","year":"2009","unstructured":"Paris I, Lozano J, Perez-Pastene C, Munoz P, Segura-Aguilar J (2009) Molecular and neurochemical mechanisms in PD pathogenesis. Neurotox Res 16(3):271\u2013279. doi:10.1007\/s12640-009-9059-4","journal-title":"Neurotox Res"},{"issue":"6180","key":"222_CR40","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/334345a0","volume":"334","author":"E Hirsch","year":"1988","unstructured":"Hirsch E, Graybiel AM, Agid YA (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson\u2019s disease. Nature 334(6180):345\u2013348. doi:10.1038\/334345a0","journal-title":"Nature"},{"issue":"2","key":"222_CR41","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/0306-4522(93)90349-K","volume":"56","author":"MT Herrero","year":"1993","unstructured":"Herrero MT, Hirsch EC, Kastner A, Ruberg M, Luquin MR, Laguna J, Javoy-Agid F, Obeso JA, Agid Y (1993) Does neuromelanin contribute to the vulnerability of catecholaminergic neurons in monkeys intoxicated with MPTP? Neuroscience 56(2):499\u2013511","journal-title":"Neuroscience"},{"issue":"3","key":"222_CR42","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3727\/000000006783981990","volume":"15","author":"PM Carvey","year":"2006","unstructured":"Carvey PM, Punati A, Newman MB (2006) Progressive dopamine neuron loss in Parkinson\u2019s disease: the multiple hit hypothesis. Cell Transplant 15(3):239\u2013250","journal-title":"Cell Transplant"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-015-0222-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40478-015-0222-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-015-0222-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-015-0222-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:12:21Z","timestamp":1630591941000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-015-0222-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,25]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["222"],"URL":"https:\/\/doi.org\/10.1186\/s40478-015-0222-2","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,25]]},"assertion":[{"value":"29 June 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"46"}}