{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:46:44Z","timestamp":1790398004824,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Alliance Biosecure","award":["BoHuToHu"],"award-info":[{"award-number":["BoHuToHu"]}]},{"DOI":"10.13039\/501100003990","name":"Conseil R\u00e9gional, \u00cele-de-France","doi-asserted-by":"publisher","award":["DIM MALINF"],"award-info":[{"award-number":["DIM MALINF"]}],"id":[{"id":"10.13039\/501100003990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["Equipe FRM DEQ20150331689"],"award-info":[{"award-number":["Equipe FRM DEQ20150331689"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s40478-016-0284-9","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T02:02:31Z","timestamp":1454637751000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions"],"prefix":"10.1186","volume":"4","author":[{"given":"J\u00e9r\u00f4me","family":"Chapuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Moudjou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Reine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Jaumain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Chapuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Quadrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Boulliat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Perret-Liaudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Dron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Laude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Human","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"B\u00e9ringue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,5]]},"reference":[{"key":"284_CR1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001285","volume":"7","author":"O Andreoletti","year":"2011","unstructured":"Andreoletti O, Orge L, Benestad SL, Beringue V, Litaise C, Simon S, et al. Atypical\/Nor98 scrapie infectivity in sheep peripheral tissues. PLoS pathogens. 2011;7, e1001285. doi: 10.1371\/journal.ppat.1001285 .","journal-title":"PLoS pathogens"},{"key":"284_CR2","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1126\/science.1187107","volume":"328","author":"RC Angers","year":"2010","unstructured":"Angers RC, Kang HE, Napier D, Browning S, Seward T, Mathiason C, et al. Prion strain mutation determined by prion protein conformational compatibility and primary structure. Science. 2010;328:1154\u20138. doi: 10.1126\/science.1187107 .","journal-title":"Science"},{"key":"284_CR3","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.1074\/jbc.M110.198465","volume":"286","author":"MA Barria","year":"2011","unstructured":"Barria MA, Telling GC, Gambetti P, Mastrianni JA, Soto C. Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prions. The Journal of biological chemistry. 2011;286:7490\u20135. doi: 10.1074\/jbc.M110.198465 .","journal-title":"The Journal of biological chemistry"},{"key":"284_CR4","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1523\/JNEUROSCI.0693-07.2007","volume":"27","author":"V Beringue","year":"2007","unstructured":"Beringue V, Andreoletti O, Le Dur A, Essalmani R, Vilotte JL, Lacroux C, et al. A bovine prion acquires an epidemic bovine spongiform encephalopathy strain-like phenotype on interspecies transmission. J Neurosci. 2007;27:6965\u201371. doi: 10.1523\/JNEUROSCI.0693-07.2007 .","journal-title":"J Neurosci"},{"key":"284_CR5","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.1215659","volume":"335","author":"V Beringue","year":"2012","unstructured":"Beringue V, Herzog L, Jaumain E, Reine F, Sibille P, Le Dur A, et al. Facilitated cross-species transmission of prions in extraneural tissue. Science. 2012;335:472\u20135. doi: 10.1126\/science.1215659 .","journal-title":"Science"},{"key":"284_CR6","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.3201\/eid1412.080941","volume":"14","author":"V Beringue","year":"2008","unstructured":"Beringue V, Herzog L, Reine F, Le Dur A, Casalone C, Vilotte JL, et al. Transmission of atypical bovine prions to mice transgenic for human prion protein. Emerging infectious diseases. 2008;14:1898\u2013901. doi: 10.3201\/eid1412.080941 .","journal-title":"Emerging infectious diseases"},{"key":"284_CR7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001419","volume":"3","author":"V Beringue","year":"2008","unstructured":"Beringue V, Le Dur A, Tixador P, Reine F, Lepourry L, Perret-Liaudet A, et al. Prominent and persistent extraneural infection in human PrP transgenic mice infected with variant CJD. PloS one. 2008;3, e1419. doi: 10.1371\/journal.pone.0001419 .","journal-title":"PloS one"},{"key":"284_CR8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1051\/vetres:2008024","volume":"39","author":"V Beringue","year":"2008","unstructured":"Beringue V, Vilotte JL, Laude H. Prion agent diversity and species barrier. Veterinary research. 2008;39:47. doi: 10.1051\/vetres:2008024 .","journal-title":"Veterinary research"},{"key":"284_CR9","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1128\/JVI.66.4.2096-2101.1992","volume":"66","author":"RA Bessen","year":"1992","unstructured":"Bessen RA, Marsh RF. Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent. Journal of virology. 1992;66:2096\u2013101.","journal-title":"Journal of virology"},{"key":"284_CR10","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1073\/pnas.1004688107","volume":"107","author":"MT Bishop","year":"2010","unstructured":"Bishop MT, Will RG, Manson JC. Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:12005\u201310. doi: 10.1073\/pnas.1004688107 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"284_CR11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ana.410350504","volume":"35","author":"P Brown","year":"1994","unstructured":"Brown P, Gibbs Jr CJ, Rodgers-Johnson P, Asher DM, Sulima MP, Bacote A, et al. Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease. Annals of neurology. 1994;35:513\u201329. doi: 10.1002\/ana.410350504 .","journal-title":"Annals of neurology"},{"key":"284_CR12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1098\/rstb.1994.0036","volume":"343","author":"M Bruce","year":"1994","unstructured":"Bruce M, Chree A, McConnell I, Foster J, Pearson G, Fraser H. Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier. Philos Trans R Soc Lond B Biol Sci. 1994;343:405\u201311. doi: 10.1098\/rstb.1994.0036 .","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"284_CR13","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/oxfordjournals.bmb.a072649","volume":"49","author":"ME Bruce","year":"1993","unstructured":"Bruce ME. Scrapie strain variation and mutation. Br Med Bull. 1993;49:822\u201338.","journal-title":"Br Med Bull"},{"key":"284_CR14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/bmb\/66.1.99","volume":"66","author":"ME Bruce","year":"2003","unstructured":"Bruce ME. TSE strain variation. Br Med Bull. 2003;66:99\u2013108.","journal-title":"Br Med Bull"},{"key":"284_CR15","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/39057","volume":"389","author":"ME Bruce","year":"1997","unstructured":"Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, Suttie A, et al. Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature. 1997;389:498\u2013501. doi: 10.1038\/39057 .","journal-title":"Nature"},{"key":"284_CR16","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1093\/brain\/awp196","volume":"132","author":"I Cali","year":"2009","unstructured":"Cali I, Castellani R, Alshekhlee A, Cohen Y, Blevins J, Yuan J, et al. Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics. Brain. 2009;132:2643\u201358. doi: 10.1093\/brain\/awp196 .","journal-title":"Brain"},{"key":"284_CR17","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1038\/ncomms6821","volume":"5","author":"H Cassard","year":"2014","unstructured":"Cassard H, Torres JM, Lacroux C, Douet JY, Benestad SL, Lantier F, et al. Evidence for zoonotic potential of ovine scrapie prions. Nature communications. 2014;5:5821. doi: 10.1038\/ncomms6821 .","journal-title":"Nature communications"},{"key":"284_CR18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cell.2008.07.030","volume":"134","author":"J Castilla","year":"2008","unstructured":"Castilla J, Gonzalez-Romero D, Saa P, Morales R, De Castro J, Soto C. Crossing the species barrier by PrP(Sc) replication in vitro generates unique infectious prions. Cell. 2008;134:757\u201368. doi: 10.1016\/j.cell.2008.07.030 .","journal-title":"Cell"},{"key":"284_CR19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.biochem.78.082907.145410","volume":"78","author":"B Caughey","year":"2009","unstructured":"Caughey B, Baron GS, Chesebro B, Jeffrey M. Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annu Rev Biochem. 2009;78:177\u2013204. doi: 10.1146\/annurev.biochem.78.082907.145410 .","journal-title":"Annu Rev Biochem"},{"key":"284_CR20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.neuro.24.1.519","volume":"24","author":"J Collinge","year":"2001","unstructured":"Collinge J. Prion diseases of humans and animals: their causes and molecular basis. Annu Rev Neurosci. 2001;24:519\u201350. doi: 10.1146\/annurev.neuro.24.1.519 .","journal-title":"Annu Rev Neurosci"},{"key":"284_CR21","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1138718","volume":"318","author":"J Collinge","year":"2007","unstructured":"Collinge J, Clarke AR. A general model of prion strains and their pathogenicity. Science. 2007;318:930\u20136. doi: 10.1126\/science.1138718 .","journal-title":"Science"},{"key":"284_CR22","doi-asserted-by":"crossref","first-page":"11573","DOI":"10.1038\/srep11573","volume":"5","author":"EE Comoy","year":"2015","unstructured":"Comoy EE, Mikol J, Luccantoni-Freire S, Correia E, Lescoutra-Etchegaray N, Durand V, et al. Transmission of scrapie prions to primate after an extended silent incubation period. Sci Rep. 2015;5:11573. doi: 10.1038\/srep11573 .","journal-title":"Sci Rep"},{"key":"284_CR23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1099\/vir.0.83344-0","volume":"89","author":"MP Courageot","year":"2008","unstructured":"Courageot MP, Daude N, Nonno R, Paquet S, Di Bari MA, Le Dur A, et al. A cell line infectible by prion strains from different species. J Gen Virol. 2008;89:341\u20137. doi: 10.1099\/vir.0.83344-0 .","journal-title":"J Gen Virol"},{"key":"284_CR24","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1074\/jbc.M407006200","volume":"280","author":"C Feraudet","year":"2005","unstructured":"Feraudet C, Morel N, Simon S, Volland H, Frobert Y, Creminon C, et al. Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells. J Biol Chem. 2005;280:11247\u201358. doi: 10.1074\/jbc.M407006200 .","journal-title":"J Biol Chem"},{"key":"284_CR25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000139","volume":"4","author":"KM Green","year":"2008","unstructured":"Green KM, Castilla J, Seward TS, Napier DL, Jewell JE, Soto C, et al. Accelerated high fidelity prion amplification within and across prion species barriers. PLoS pathogens. 2008;4, e1000139. doi: 10.1371\/journal.ppat.1000139 .","journal-title":"PLoS pathogens"},{"key":"284_CR26","doi-asserted-by":"crossref","first-page":"8678","DOI":"10.1128\/JVI.01118-14","volume":"88","author":"S Halliez","year":"2014","unstructured":"Halliez S, Reine F, Herzog L, Jaumain E, Haik S, Rezaei H, et al. Accelerated, spleen-based titration of variant Creutzfeldt-Jakob disease infectivity in transgenic mice expressing human prion protein with sensitivity comparable to that of survival time bioassay. Journal of virology. 2014;88:8678\u201386. doi: 10.1128\/JVI.01118-14 .","journal-title":"Journal of virology"},{"key":"284_CR27","doi-asserted-by":"crossref","first-page":"10248","DOI":"10.1073\/pnas.97.18.10248","volume":"97","author":"AF Hill","year":"2000","unstructured":"Hill AF, Joiner S, Linehan J, Desbruslais M, Lantos PL, Collinge J. Species-barrier-independent prion replication in apparently resistant species. Proceedings of the National Academy of Sciences of the United States of America. 2000;97:10248\u201353.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"284_CR28","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1093\/brain\/awg125","volume":"126","author":"AF Hill","year":"2003","unstructured":"Hill AF, Joiner S, Wadsworth JD, Sidle KC, Bell JE, Budka H, et al. Molecular classification of sporadic Creutzfeldt-Jakob disease. Brain. 2003;126:1333\u201346.","journal-title":"Brain"},{"issue":"Pt 8","key":"284_CR29","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1099\/0022-1317-70-8-2017","volume":"70","author":"RH Kimberlin","year":"1989","unstructured":"Kimberlin RH, Walker CA, Fraser H. The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice. J Gen Virol. 1989;70(Pt 8):2017\u201325.","journal-title":"J Gen Virol"},{"key":"284_CR30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/2051-5960-1-74","volume":"1","author":"A Kobayashi","year":"2013","unstructured":"Kobayashi A, Iwasaki Y, Otsuka H, Yamada M, Yoshida M, Matsuura Y, et al. Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M\/V and type 2 abnormal prion protein. Acta Neuropathol Commun. 2013;1:74. doi: 10.1186\/2051-5960-1-74 .","journal-title":"Acta Neuropathol Commun"},{"key":"284_CR31","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/BF03401656","volume":"2","author":"S Krasemann","year":"1996","unstructured":"Krasemann S, Groschup MH, Harmeyer S, Hunsmann G, Bodemer W. Generation of monoclonal antibodies against human prion proteins in PrP0\/0 mice. Mol Med. 1996;2:725\u201334.","journal-title":"Mol Med"},{"key":"284_CR32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003702","volume":"9","author":"F Laferriere","year":"2013","unstructured":"Laferriere F, Tixador P, Moudjou M, Chapuis J, Sibille P, Herzog L, et al. Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics. PLoS Pathog. 2013;9, e1003702. doi: 10.1371\/journal.ppat.1003702 .","journal-title":"PLoS Pathog"},{"key":"284_CR33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1746-6148-2-19","volume":"2","author":"JP Langeveld","year":"2006","unstructured":"Langeveld JP, Jacobs JG, Erkens JH, Bossers A, van Zijderveld FG, van Keulen LJ. Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep. BMC Vet Res. 2006;2:19. doi: 10.1186\/1746-6148-2-19 .","journal-title":"BMC Vet Res"},{"key":"284_CR34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2010.09.010","volume":"41","author":"C Langevin","year":"2011","unstructured":"Langevin C, Andreoletti O, Le Dur A, Laude H, Beringue V. Marked influence of the route of infection on prion strain apparent phenotype in a scrapie transgenic mouse model. Neurobiol Dis. 2011;41:219\u201325. doi: 10.1016\/j.nbd.2010.09.010 .","journal-title":"Neurobiol Dis"},{"key":"284_CR35","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1073\/pnas.041490898","volume":"98","author":"CI Lasmezas","year":"2001","unstructured":"Lasmezas CI, Fournier JG, Nouvel V, Boe H, Marce D, Lamoury F, et al. Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health. Proceedings of the National Academy of Sciences of the United States of America. 2001;98:4142\u20137. doi: 10.1073\/pnas.041490898 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"284_CR36","doi-asserted-by":"crossref","first-page":"16031","DOI":"10.1073\/pnas.0502296102","volume":"102","author":"A Dur Le","year":"2005","unstructured":"Le Dur A, Beringue V, Andreoletti O, Reine F, Lai TL, Baron T, et al. A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:16031\u20136. doi: 10.1073\/pnas.0502296102 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"284_CR37","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1126\/science.1183218","volume":"327","author":"J Li","year":"2010","unstructured":"Li J, Browning S, Mahal SP, Oelschlegel AM, Weissmann C. Darwinian evolution of prions in cell culture. Science. 2010;327:869\u201372. doi: 10.1126\/science.1183218 .","journal-title":"Science"},{"key":"284_CR38","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/embor.2011.191","volume":"12","author":"J Li","year":"2011","unstructured":"Li J, Mahal SP, Demczyk CA, Weissmann C. Mutability of prions. EMBO Rep. 2011;12:1243\u201350. doi: 10.1038\/embor.2011.191 .","journal-title":"EMBO Rep"},{"key":"284_CR39","doi-asserted-by":"crossref","first-page":"22653","DOI":"10.1073\/pnas.1013014108","volume":"107","author":"SP Mahal","year":"2010","unstructured":"Mahal SP, Browning S, Li J, Suponitsky-Kroyter I, Weissmann C. Transfer of a prion strain to different hosts leads to emergence of strain variants. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:22653\u20138. doi: 10.1073\/pnas.1013014108 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"284_CR40","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1750-3639.2012.00572.x","volume":"22","author":"F Moda","year":"2012","unstructured":"Moda F, Suardi S, Di Fede G, Indaco A, Limido L, Vimercati C, et al. MM2-thalamic Creutzfeldt-Jakob disease: neuropathological, biochemical and transmission studies identify a distinctive prion strain. Brain Pathol. 2012;22:662\u20139. doi: 10.1111\/j.1750-3639.2012.00572.x .","journal-title":"Brain Pathol"},{"key":"284_CR41","doi-asserted-by":"crossref","first-page":"e00829","DOI":"10.1128\/mBio.00829-13","volume":"5","author":"M Moudjou","year":"2014","unstructured":"Moudjou M, Sibille P, Fichet G, Reine F, Chapuis J, Herzog L, et al. Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification. MBio. 2014;5:e00829\u201300813. doi: 10.1128\/mBio.00829-13 .","journal-title":"MBio"},{"key":"284_CR42","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1128\/JVI.01855-09","volume":"84","author":"MH Neale","year":"2010","unstructured":"Neale MH, Mountjoy SJ, Edwards JC, Vilette D, Laude H, Windl O, et al. Infection of cell lines with experimental and natural ovine scrapie agents. Journal of virology. 2010;84:2444\u201352. doi: 10.1128\/JVI.01855-09 .","journal-title":"Journal of virology"},{"key":"284_CR43","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.3201\/eid1812.120342","volume":"18","author":"S Nicot","year":"2012","unstructured":"Nicot S, Bencsik A, Morignat E, Mestre-Frances N, Perret-Liaudet A, Baron T. Differentiation of prions from L-type BSE versus sporadic Creutzfeldt-Jakob disease. Emerging infectious diseases. 2012;18:2028\u201331. doi: 10.3201\/eid1812.120342 .","journal-title":"Emerging infectious diseases"},{"key":"284_CR44","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.virusres.2011.09.018","volume":"162","author":"S Ojosnegros","year":"2011","unstructured":"Ojosnegros S, Perales C, Mas A, Domingo E. Quasispecies as a matter of fact: viruses and beyond. Virus Res. 2011;162:203\u201315. doi: 10.1016\/j.virusres.2011.09.018 .","journal-title":"Virus Res"},{"key":"284_CR45","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W","volume":"46","author":"P Parchi","year":"1999","unstructured":"Parchi P, Giese A, Capellari S, Brown P, Schulz-Schaeffer W, Windl O, et al. Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects. Annals of neurology. 1999;46:224\u201333.","journal-title":"Annals of neurology"},{"key":"284_CR46","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0034-5288(18)34525-9","volume":"9","author":"IH Pattison","year":"1968","unstructured":"Pattison IH, Jones KM. Modification of a strain of mouse-adapted scrapie by passage through rats. Res Vet Sci. 1968;9:408\u201310.","journal-title":"Res Vet Sci"},{"key":"284_CR47","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0368-1742(61)80013-1","volume":"71","author":"IH Pattison","year":"1961","unstructured":"Pattison IH, Millson GC. Scrapie produced experimentally in goats with special reference to the clinical syndrome. J Comp Pathol. 1961;71:101\u20139.","journal-title":"J Comp Pathol"},{"key":"284_CR48","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(05)70225-8","volume":"4","author":"M Polymenidou","year":"2005","unstructured":"Polymenidou M, Stoeck K, Glatzel M, Vey M, Bellon A, Aguzzi A. Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease. Lancet Neurol. 2005;4:805\u201314. doi: 10.1016\/S1474-4422(05)70225-8 .","journal-title":"Lancet Neurol"},{"key":"284_CR49","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.95.23.13363","volume":"95","author":"SB Prusiner","year":"1998","unstructured":"Prusiner SB. Prions. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:13363\u201383.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"284_CR50","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ana.410110406","volume":"11","author":"SB Prusiner","year":"1982","unstructured":"Prusiner SB, Cochran SP, Groth DF, Downey DE, Bowman KA, Martinez HM. Measurement of the scrapie agent using an incubation time interval assay. Annals of neurology. 1982;11:353\u20138. doi: 10.1002\/ana.410110406 .","journal-title":"Annals of neurology"},{"key":"284_CR51","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1212\/WNL.53.9.2173","volume":"53","author":"G Puoti","year":"1999","unstructured":"Puoti G, Giaccone G, Rossi G, Canciani B, Bugiani O, Tagliavini F. Sporadic Creutzfeldt-Jakob disease: co-occurrence of different types of PrP(Sc) in the same brain. Neurology. 1999;53:2173\u20136.","journal-title":"Neurology"},{"key":"284_CR52","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/35081095","volume":"411","author":"GP Saborio","year":"2001","unstructured":"Saborio GP, Permanne B, Soto C. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature. 2001;411:810\u20133. doi: 10.1038\/35081095 .","journal-title":"Nature"},{"key":"284_CR53","volume":"3","author":"G Schoch","year":"2006","unstructured":"Schoch G, Seeger H, Bogousslavsky J, Tolnay M, Janzer RC, Aguzzi A, et al. Analysis of prion strains by PrPSc profiling in sporadic Creutzfeldt-Jakob disease. PLoS Med. 2006;3, e14. doi: 10.1371\/journal.pmed.0030014 .","journal-title":"PLoS Med"},{"key":"284_CR54","doi-asserted-by":"crossref","first-page":"9032","DOI":"10.1128\/JVI.71.12.9032-9044.1997","volume":"71","author":"MR Scott","year":"1997","unstructured":"Scott MR, Groth D, Tatzelt J, Torchia M, Tremblay P, DeArmond SJ, et al. Propagation of prion strains through specific conformers of the prion protein. Journal of virology. 1997;71:9032\u201344.","journal-title":"Journal of virology"},{"key":"284_CR55","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1128\/JVI.00243-10","volume":"84","author":"RA Shikiya","year":"2010","unstructured":"Shikiya RA, Ayers JI, Schutt CR, Kincaid AE, Bartz JC. Coinfecting prion strains compete for a limiting cellular resource. Journal of virology. 2010;84:5706\u201314. doi: 10.1128\/JVI.00243-10 .","journal-title":"Journal of virology"},{"key":"284_CR56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000859","volume":"6","author":"P Tixador","year":"2010","unstructured":"Tixador P, Herzog L, Reine F, Jaumain E, Chapuis J, Le Dur A, et al. The physical relationship between infectivity and prion protein aggregates is strain-dependent. PLoS Pathog. 2010;6, e1000859. doi: 10.1371\/journal.ppat.1000859 .","journal-title":"PLoS Pathog"},{"key":"284_CR57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000029","volume":"4","author":"E Uro-Coste","year":"2008","unstructured":"Uro-Coste E, Cassard H, Simon S, Lugan S, Bilheude JM, Perret-Liaudet A, et al. Beyond PrP9res) type 1\/type 2 dichotomy in Creutzfeldt-Jakob disease. PLoS pathogens. 2008;4, e1000029. doi: 10.1371\/journal.ppat.1000029 .","journal-title":"PLoS pathogens"},{"key":"284_CR58","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1073\/pnas.061337998","volume":"98","author":"D Vilette","year":"2001","unstructured":"Vilette D, Andreoletti O, Archer F, Madelaine MF, Vilotte JL, Lehmann S, et al. Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein. Proc Natl Acad Sci U S A. 2001;98:4055\u20139. doi: 10.1073\/pnas.061337998 .","journal-title":"Proc Natl Acad Sci U S A"},{"key":"284_CR59","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1128\/JVI.75.13.5977-5984.2001","volume":"75","author":"JL Vilotte","year":"2001","unstructured":"Vilotte JL, Soulier S, Essalmani R, Stinnakre MG, Vaiman D, Lepourry L, et al. Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp. Journal of virology. 2001;75:5977\u201384. doi: 10.1128\/JVI.75.13.5977-5984.2001 .","journal-title":"Journal of virology"},{"key":"284_CR60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002582","volume":"8","author":"C Weissmann","year":"2012","unstructured":"Weissmann C. Mutation and selection of prions. PLoS pathogens. 2012;8, e1002582. doi: 10.1371\/journal.ppat.1002582 .","journal-title":"PLoS pathogens"},{"key":"284_CR61","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/embor.2011.192","volume":"12","author":"C Weissmann","year":"2011","unstructured":"Weissmann C, Li J, Mahal SP, Browning S. Prions on the move. EMBO Rep. 2011;12:1109\u201317. doi: 10.1038\/embor.2011.192 .","journal-title":"EMBO Rep"},{"key":"284_CR62","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/bmb\/66.1.255","volume":"66","author":"RG Will","year":"2003","unstructured":"Will RG. Acquired prion disease: iatrogenic CJD, variant CJD, kuru. Br Med Bull. 2003;66:255\u201365.","journal-title":"Br Med Bull"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-016-0284-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:17:15Z","timestamp":1600129035000},"score":1,"resource":{"primary":{"URL":"http:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-016-0284-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,5]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["284"],"URL":"https:\/\/doi.org\/10.1186\/s40478-016-0284-9","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,5]]},"article-number":"10"}}