{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:08:31Z","timestamp":1793898511133,"version":"4.8.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01-CX001038"],"award-info":[{"award-number":["I01-CX001038"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["NIRG-305779"],"award-info":[{"award-number":["NIRG-305779"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Affairs Biorepository","award":["CSP 501"],"award-info":[{"award-number":["CSP 501"]}]},{"name":"Veterans Affairs Rehabilitation Research and Development Traumatic Brain Injury Center of Excellence","award":["B6796-C"],"award-info":[{"award-number":["B6796-C"]}],"id":[{"id":"https:\/\/ror.org\/01345ed13","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01NS086659-01"],"award-info":[{"award-number":["U01NS086659-01"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1F32NS096803-01"],"award-info":[{"award-number":["1F32NS096803-01"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Defense Peer Reviewed Alzheimer\u2019s Research Program","award":["DoD-PRARP #13267017"],"award-info":[{"award-number":["DoD-PRARP #13267017"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NHLBI\/NIH #N01-HC-25195"],"award-info":[{"award-number":["NHLBI\/NIH #N01-HC-25195"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01AG08122"],"award-info":[{"award-number":["R01AG08122"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1RF1AG054156-01"],"award-info":[{"award-number":["1RF1AG054156-01"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s40478-016-0382-8","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T02:55:38Z","timestamp":1477623338000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":268,"title":["Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy"],"prefix":"10.1186","volume":"4","author":[{"given":"Jonathan D.","family":"Cherry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorghos","family":"Tripodis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Kiernan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Daneshvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip H.","family":"Montenigro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Alosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"McKee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor D.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"382_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00401-013-1230-6","volume":"127","author":"AC McKee","year":"2014","unstructured":"McKee AC, Daneshvar DH, Alvarez VE, Stein TD. The neuropathology of sport. Acta Neuropathol. 2014;127:29\u201351.","journal-title":"Acta Neuropathol"},{"key":"382_CR2","doi-asserted-by":"publisher","first-page":"S242","DOI":"10.1016\/j.jalz.2014.04.003","volume":"10","author":"AC McKee","year":"2014","unstructured":"McKee AC, Robinson ME. Military-related traumatic brain injury and neurodegeneration. Alzheimers Dement. 2014;10:S242\u201353.","journal-title":"Alzheimers Dement"},{"key":"382_CR3","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1212\/WNL.0b013e3182a55f7f","volume":"81","author":"RA Stern","year":"2013","unstructured":"Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, et al. Clinical presentation of chronic traumatic encephalopathy. Neurology. 2013;81:1122\u20139.","journal-title":"Neurology"},{"key":"382_CR4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00401-015-1515-z","volume":"131","author":"AC McKee","year":"2015","unstructured":"McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Dirk Keene C, Litvan I, et al. The first NINDS\/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol. 2015;131:75\u201386.","journal-title":"Acta Neuropathol"},{"key":"382_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/brain\/aws307","volume":"136","author":"AC McKee","year":"2013","unstructured":"McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013;136:43\u201364.","journal-title":"Brain"},{"key":"382_CR6","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","volume":"68","author":"AC McKee","year":"2009","unstructured":"McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 2009;68:709\u201335.","journal-title":"J Neuropathol Exp Neurol"},{"key":"382_CR7","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s00401-015-1502-4","volume":"130","author":"KF Bieniek","year":"2015","unstructured":"Bieniek KF, Ross OA, Cormier KA, Walton RL, Soto-Ortolaza A, Johnston AE, et al. Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank. Acta Neuropathol. 2015;130:877\u201389.","journal-title":"Acta Neuropathol"},{"key":"382_CR8","doi-asserted-by":"crossref","unstructured":"Montenigro PH, Alosco ML, Martin B, Daneshvar DH, Mez J, Chaisson C, et al. Cumulative head impact exposure predicts later-life depression, apathy, executive dysfunction, and cognitive impairment in former high school and college football players. J Neurotrauma. 2016. Epub ahead of print.","DOI":"10.1089\/neu.2016.4413"},{"key":"382_CR9","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s11916-015-0522-z","volume":"19","author":"TD Stein","year":"2015","unstructured":"Stein TD, Alvarez VE, McKee AC. Concussion in chronic traumatic encephalopathy. Curr Pain Headache Rep. 2015;19:522.","journal-title":"Curr Pain Headache Rep"},{"key":"382_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00401-015-1435-y","volume":"130","author":"TD Stein","year":"2015","unstructured":"Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y, et al. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 2015;130:21\u201334.","journal-title":"Acta Neuropathol"},{"key":"382_CR11","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/nan.12008","volume":"39","author":"C Smith","year":"2013","unstructured":"Smith C, Gentleman SM, Leclercq PD, Murray LS, Griffin WS, Graham DI, et al. The neuroinflammatory response in humans after traumatic brain injury. Neuropathol Appl Neurobiol. 2013;39:654\u201366.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"382_CR12","doi-asserted-by":"crossref","unstructured":"Daneshvar DH, Goldstein LE, Kiernan PT, Stein TD, McKee AC. Post-traumatic neurodegeneration and chronic traumatic encephalopathy. Mol Cell Neurosci. 2015;66:81\u201390.","DOI":"10.1016\/j.mcn.2015.03.007"},{"key":"382_CR13","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1750-1326-4-47","volume":"4","author":"TC Frank-Cannon","year":"2009","unstructured":"Frank-Cannon TC, Alto LT, McAlpine FE, Tansey MG. Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener. 2009;4:47.","journal-title":"Mol Neurodegener"},{"key":"382_CR14","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.1523\/JNEUROSCI.4361-12.2013","volume":"33","author":"S Ghosh","year":"2013","unstructured":"Ghosh S, Wu MD, Shaftel SS, Kyrkanides S, LaFerla FM, Olschowka JA, et al. Sustained interleukin-1beta overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer\u2019s mouse model. J Neurosci. 2013;33:5053\u201364.","journal-title":"J Neurosci"},{"key":"382_CR15","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1093\/brain\/awv081","volume":"138","author":"N Maphis","year":"2015","unstructured":"Maphis N, Xu G, Kokiko-Cochran ON, Jiang S, Cardona A, Ransohoff RM, et al. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain. 2015;138:1738\u201355.","journal-title":"Brain"},{"key":"382_CR16","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13195-015-0148-8","volume":"7","author":"J Mez","year":"2015","unstructured":"Mez J, Solomon TM, Daneshvar DH, Murphy L, Kiernan PT, Montenigro PH, et al. Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study. Alzheimers Res Ther. 2015;7:62.","journal-title":"Alzheimers Res Ther"},{"key":"382_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/00005072-199501000-00006","volume":"54","author":"JPG Vonsattel","year":"1995","unstructured":"Vonsattel JPG, Aizawa H, Ge P, DiFiglia M, McKee AC, MacDonald M, et al. An improved approach to prepare human brains for research. J Neuropathol Exp Neurol. 1995;54:42\u201356.","journal-title":"J Neuropathol Exp Neurol"},{"key":"382_CR18","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40478-015-0209-z","volume":"3","author":"AD Bachstetter","year":"2015","unstructured":"Bachstetter AD, Van Eldik LJ, Schmitt FA, Neltner JH, Ighodaro ET, Webster SJ, et al. Disease-related microglia heterogeneity in the hippocampus of Alzheimer\u2019s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. Acta Neuropathol Commun. 2015;3:32.","journal-title":"Acta Neuropathol Commun"},{"key":"382_CR19","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.2353\/ajpath.2010.100265","volume":"177","author":"S Lee","year":"2010","unstructured":"Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, et al. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer\u2019s disease mouse models. Am J Pathol. 2010;177:2549\u201362.","journal-title":"Am J Pathol"},{"key":"382_CR20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/brain\/aws322","volume":"136","author":"VE Johnson","year":"2013","unstructured":"Johnson VE, Stewart JE, Begbie FD, Trojanowski JQ, Smith DH, Stewart W. Inflammation and white matter degeneration persist for years after a single traumatic brain injury. Brain. 2013;136:28\u201342.","journal-title":"Brain"},{"key":"382_CR21","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1089\/neu.2011.1913","volume":"28","author":"KD Browne","year":"2011","unstructured":"Browne KD, Chen XH, Meaney DF, Smith DH. Mild traumatic brain injury and diffuse axonal injury in swine. J Neurotrauma. 2011;28:1747\u201355.","journal-title":"J Neurotrauma"},{"key":"382_CR22","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jmbbm.2011.09.012","volume":"5","author":"RJ Cloots","year":"2012","unstructured":"Cloots RJ, van Dommelen JA, Geers MG. A tissue-level anisotropic criterion for brain injury based on microstructural axonal deformation. J Mech Behav Biomed Mater. 2012;5:41\u201352.","journal-title":"J Mech Behav Biomed Mater"},{"key":"382_CR23","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s10439-008-9510-3","volume":"36","author":"RJ Cloots","year":"2008","unstructured":"Cloots RJ, Gervaise HM, van Dommelen JA, Geers MG. Biomechanics of traumatic brain injury: influences of the morphologic heterogeneities of the cerebral cortex. Ann Biomed Eng. 2008;36:1203\u201315.","journal-title":"Ann Biomed Eng"},{"key":"382_CR24","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1097\/NEN.0b013e31821f891f","volume":"70","author":"Y Shitaka","year":"2011","unstructured":"Shitaka Y, Tran HT, Bennett RE, Sanchez L, Levy MA, Dikranian K, et al. Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity. J Neuropathol Exp Neurol. 2011;70:551\u201367.","journal-title":"J Neuropathol Exp Neurol"},{"key":"382_CR25","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3389\/fimmu.2014.00594","volume":"5","author":"JD Cherry","year":"2014","unstructured":"Cherry JD, Olschowka JA, O\u2019Banion MK. Are \u201cresting\u201d microglia more \u201cm2\u201d? Front Immunol. 2014;5:594.","journal-title":"Front Immunol"},{"key":"382_CR26","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1089\/neu.2012.2399","volume":"30","author":"ML Prins","year":"2013","unstructured":"Prins ML, Alexander D, Giza CC, Hovda DA. Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability. J Neurotrauma. 2013;30:30\u20138.","journal-title":"J Neurotrauma"},{"key":"382_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/672395","volume":"2010","author":"AM Piccinini","year":"2010","unstructured":"Piccinini AM, Midwood KS. DAMPening inflammation by modulating TLR signalling. Mediat Inflamm. 2010;2010:1\u201321.","journal-title":"Mediat Inflamm"},{"key":"382_CR28","first-page":"134ra160","volume":"4","author":"LE Goldstein","year":"2012","unstructured":"Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012;4:134ra160.","journal-title":"Sci Transl Med"},{"key":"382_CR29","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1089\/neu.2014.3715","volume":"32","author":"IK Koerte","year":"2015","unstructured":"Koerte IK, Lin AP, Muehlmann M, Merugumala S, Liao H, Starr T, et al. Altered neurochemistry in former professional soccer players without a history of concussion. J Neurotrauma. 2015;32:1287\u201393.","journal-title":"J Neurotrauma"},{"key":"382_CR30","doi-asserted-by":"publisher","first-page":"6554","DOI":"10.1523\/JNEUROSCI.0291-15.2015","volume":"35","author":"SJ Webster","year":"2015","unstructured":"Webster SJ, Van Eldik LJ, Watterson DM, Bachstetter AD. Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. J Neurosci. 2015;35:6554\u201369.","journal-title":"J Neurosci"},{"key":"382_CR31","doi-asserted-by":"publisher","first-page":"184","DOI":"10.4103\/2152-7806.147566","volume":"5","author":"AL Petraglia","year":"2014","unstructured":"Petraglia AL, Plog BA, Dayawansa S, Dashnaw ML, Czerniecka K, Walker CT, et al. The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy. Surg Neurol Int. 2014;5:184.","journal-title":"Surg Neurol Int"},{"key":"382_CR32","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature14658","volume":"523","author":"A Kondo","year":"2015","unstructured":"Kondo A, Shahpasand K, Mannix R, Qiu J, Moncaster J, Chen CH, et al. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. 2015;523:431\u20136.","journal-title":"Nature"},{"key":"382_CR33","first-page":"391","volume":"1","author":"JA Hausman","year":"1983","unstructured":"Hausman JA. Specification and estimation of simultaneous equation models. Handb Econ. 1983;1:391\u2013448.","journal-title":"Handb Econ"},{"key":"382_CR34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.neuron.2010.08.023","volume":"68","author":"K Bhaskar","year":"2010","unstructured":"Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, Lamb BT. Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 2010;68:19\u201331.","journal-title":"Neuron"},{"key":"382_CR35","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fnins.2015.00196","volume":"9","author":"N Maphis","year":"2015","unstructured":"Maphis N, Xu G, Kokiko-Cochran ON, Cardona AE, Ransohoff RM, Lamb BT, et al. Loss of tau rescues inflammation-mediated neurodegeneration. Front Neurosci. 2015;9:196.","journal-title":"Front Neurosci"},{"key":"382_CR36","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.nbd.2014.10.019","volume":"74","author":"JM Coughlin","year":"2015","unstructured":"Coughlin JM, Wang Y, Munro CA, Ma S, Yue C, Chen S, et al. Neuroinflammation and brain atrophy in former NFL players: an in vivo multimodal imaging pilot study. Neurobiol Dis. 2015;74:58\u201365.","journal-title":"Neurobiol Dis"},{"key":"382_CR37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/15427609.2004.9683330","volume":"1","author":"GJ Duncan","year":"2004","unstructured":"Duncan GJ, Magnuson KA, Ludwig J. The endogeneity problem in developmental studies. Res Hum Dev. 2004;1:59.","journal-title":"Res Hum Dev"},{"key":"382_CR38","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1084\/jem.174.4.827","volume":"174","author":"SS Rabinowitz","year":"1991","unstructured":"Rabinowitz SS, Gordon S. Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. J Exp Med. 1991;174:827\u201336.","journal-title":"J Exp Med"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-016-0382-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40478-016-0382-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-016-0382-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T10:52:27Z","timestamp":1589539947000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-016-0382-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,28]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["382"],"URL":"https:\/\/doi.org\/10.1186\/s40478-016-0382-8","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,28]]},"assertion":[{"value":"15 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"112"}}