{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:53:37Z","timestamp":1784861617238,"version":"3.55.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Loewe Zentrum Translational Medicine and Pharmacology"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1080 A03"],"award-info":[{"award-number":["CRC1080 A03"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1039 A04"],"award-info":[{"award-number":["CRC1039 A04"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1039 A08"],"award-info":[{"award-number":["CRC1039 A08"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1039 Z01"],"award-info":[{"award-number":["CRC1039 Z01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1080 A03"],"award-info":[{"award-number":["CRC1080 A03"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1080 B05"],"award-info":[{"award-number":["CRC1080 B05"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s40478-017-0446-4","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T08:44:08Z","timestamp":1496393048000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis"],"prefix":"10.1186","volume":"5","author":[{"given":"K.","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Brunkhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"de Bruin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"H\u00e4ussler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ferreiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schiffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Parnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tunaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Offermanns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Foerch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Scholich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"L\u00f6tsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Geisslinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-8025","authenticated-orcid":false,"given":"I.","family":"Tegeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"446_CR1","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1194\/jlr.R046458","volume":"61","author":"B Anliker","year":"2013","unstructured":"Anliker B, Choi JW, Lin ME, Gardell SE, Rivera RR, Kennedy G, Chun J (2013) Lysophosphatidic acid (LPA) and its receptor, LPA1, influence embryonic schwann cell migration, myelination, and cell-to-axon segregation. Glia 61:2009\u20132022. doi: 10.1194\/jlr.R046458","journal-title":"Glia"},{"key":"446_CR2","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.4049\/jimmunol.1202025","volume":"190","author":"Z Bai","year":"2013","unstructured":"Bai Z, Cai L, Umemoto E, Takeda A, Tohya K, Komai Y, Veeraveedu PT, Hata E, Sugiura Y, Kubo A et al (2013) Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin\/lysophosphatidic acid axis. Journal of Immunology 190:2036\u20132048. doi: 10.4049\/jimmunol.1202025","journal-title":"Journal of Immunology"},{"key":"446_CR3","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1073\/pnas.97.13.7260","volume":"97","author":"V Baubet","year":"2000","unstructured":"Baubet V, Le Mouellic H, Campbell AK, Lucas-Meunier E, Fossier P, Brulet P (2000) Chimeric green fluorescent protein-aequorin as bioluminescent Ca2+ reporters at the single-cell level. Proceedings of the National Academy of Sciences of the United States of America 97:7260\u20137265","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"446_CR4","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1189\/jlb.0407221","volume":"82","author":"LC Chan","year":"2007","unstructured":"Chan LC, Peters W, Xu Y, Chun J, Farese RV Jr, Cases S (2007) LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). Journal of Leukocyte Biology 82:1193\u20131200. doi: 10.1189\/jlb.0407221","journal-title":"Journal of Leukocyte Biology"},{"key":"446_CR5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1073\/pnas.1014154108","volume":"108","author":"JW Choi","year":"2011","unstructured":"Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G et al (2011) FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proceedings of the National Academy of Sciences of the United States of America 108:751\u2013756. doi: 10.1073\/pnas.1014154108","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"446_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","volume":"50","author":"JW Choi","year":"2010","unstructured":"Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN et al (2010) LPA receptors: subtypes and biological actions. Annual Review of Pharmacology and Toxicology 50:157\u2013186. doi: 10.1146\/annurev.pharmtox.010909.105753","journal-title":"Annual Review of Pharmacology and Toxicology"},{"key":"446_CR7","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1016\/j.cell.2015.06.002","volume":"161","author":"JE Chrencik","year":"2015","unstructured":"Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M et al (2015) Crystal structure of antagonist bound human lysophosphatidic acid receptor 1. Cell 161:1633\u20131643. doi: 10.1016\/j.cell.2015.06.002","journal-title":"Cell"},{"key":"446_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/WNF.0b013e3181cbf825","volume":"33","author":"J Chun","year":"2010","unstructured":"Chun J, Hartung HP (2010) Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clinical Neuropharmacology 33:91\u2013101. doi: 10.1097\/WNF.0b013e3181cbf825","journal-title":"Clinical Neuropharmacology"},{"key":"446_CR9","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1056\/NEJMoa0907839","volume":"362","author":"JA Cohen","year":"2010","unstructured":"Cohen JA, Barkhof F, Comi G, Hartung HP, Khatri BO, Montalban X, Pelletier J, Capra R, Gallo P, Izquierdo G et al (2010) Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. New England Journal of Medicine 362:402\u2013415. doi: 10.1056\/NEJMoa0907839","journal-title":"New England Journal of Medicine"},{"key":"446_CR10","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1002\/ana.22426","volume":"69","author":"JA Cohen","year":"2011","unstructured":"Cohen JA, Chun J (2011) Mechanisms of fingolimod\u2019s efficacy and adverse effects in multiple sclerosis. Annals of Neurology 69:759\u2013777. doi: 10.1002\/ana.22426","journal-title":"Annals of Neurology"},{"key":"446_CR11","doi-asserted-by":"publisher","first-page":"5909","DOI":"10.4049\/jimmunol.0803418","volume":"182","author":"C Coisne","year":"2009","unstructured":"Coisne C, Mao W, Engelhardt B (2009) Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis. Journal of Immunology 182:5909\u20135913. doi: 10.4049\/jimmunol.0803418","journal-title":"Journal of Immunology"},{"key":"446_CR12","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1128\/MCB.22.19.6921-6929.2002","volume":"22","author":"JJ Contos","year":"2002","unstructured":"Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J (2002) Characterization of lpa(2) (Edg4) and lpa(1)\/lpa(2) (Edg2\/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Molecular and Cellular Biology 22:6921\u20136929","journal-title":"Molecular and Cellular Biology"},{"key":"446_CR13","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.bbr.2015.1012.1006","volume":"300","author":"NM Bruin de","year":"2015","unstructured":"de Bruin NM, Schmitz K, Schiffmann S, Tafferner N, Schmidt M, Jordan H, Haussler A, Tegeder I, Geisslinger G, Parnham MJ (2015) Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behavioural Brain Research 300:160\u2013174. doi: 10.1016\/j.bbr.2015.1012.1006","journal-title":"Behavioural Brain Research"},{"key":"446_CR14","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.mcn.2007.10.018","volume":"37","author":"J Dennis","year":"2008","unstructured":"Dennis J, White MA, Forrest AD, Yuelling LM, Nogaroli L, Afshari FS, Fox MA, Fuss B (2008) Phosphodiesterase-Ialpha\/autotaxin\u2019s MORFO domain regulates oligodendroglial process network formation and focal adhesion organization. Molecular and Cellular Neurosciences 37:412\u2013424. doi: 10.1016\/j.mcn.2007.10.018","journal-title":"Molecular and Cellular Neurosciences"},{"key":"446_CR15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1126\/science.273.5272.252","volume":"273","author":"TG Diacovo","year":"1996","unstructured":"Diacovo TG, Puri KD, Warnock RA, Springer TA, von Andrian UH (1996) Platelet-mediated lymphocyte delivery to high endothelial venules. Science 273:252\u2013255","journal-title":"Science"},{"key":"446_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00401-016-1606-5","volume":"132","author":"B Engelhardt","year":"2016","unstructured":"Engelhardt B, Carare RO, Bechmann I, Flugel A, Laman JD, Weller RO (2016) Vascular, glial, and lymphatic immune gateways of the central nervous system. Acta Neuropathologica 132:317\u2013338. doi: 10.1007\/s00401-016-1606-5","journal-title":"Acta Neuropathologica"},{"key":"446_CR17","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1093\/cercor\/bhm132","volume":"18","author":"G Estivill-Torrus","year":"2008","unstructured":"Estivill-Torrus G, Llebrez-Zayas P, Matas-Rico E, Santin L, Pedraza C, De Diego I, Del Arco I, Fernandez-Llebrez P, Chun J, De Fonseca FR (2008) Absence of LPA1 signaling results in defective cortical development. Cerebral Cortex 18:938\u2013950. doi: 10.1093\/cercor\/bhm132","journal-title":"Cerebral Cortex"},{"key":"446_CR18","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0092-8674(95)90295-3","volume":"80","author":"O Fourcade","year":"1995","unstructured":"Fourcade O, Simon MF, Viode C, Rugani N, Leballe F, Ragab A, Fournie B, Sarda L, Chap H (1995) Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell 80:919\u2013927","journal-title":"Cell"},{"key":"446_CR19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1044-7431(03)00073-3","volume":"23","author":"MA Fox","year":"2003","unstructured":"Fox MA, Colello RJ, Macklin WB, Fuss B (2003) Phosphodiesterase-Ialpha\/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination. Molecular and Cellular Neurosciences 23:507\u2013519","journal-title":"Molecular and Cellular Neurosciences"},{"key":"446_CR20","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.neuint.2006.09.008","volume":"50","author":"N Fukushima","year":"2007","unstructured":"Fukushima N, Shano S, Moriyama R, Chun J (2007) Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i\/o) pathway. Neurochemistry International 50:302\u2013307. doi: 10.1016\/j.neuint.2006.09.008","journal-title":"Neurochemistry International"},{"key":"446_CR21","doi-asserted-by":"publisher","first-page":"34654","DOI":"10.1074\/jbc.M111.276725","volume":"286","author":"Z Fulkerson","year":"2011","unstructured":"Fulkerson Z, Wu T, Sunkara M, Kooi CV, Morris AJ, Smyth SS (2011) Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. Journal of Biological Chemistry 286:34654\u201334663. doi: 10.1074\/jbc.M111.276725","journal-title":"Journal of Biological Chemistry"},{"key":"446_CR22","doi-asserted-by":"crossref","first-page":"9095","DOI":"10.1523\/JNEUROSCI.17-23-09095.1997","volume":"17","author":"B Fuss","year":"1997","unstructured":"Fuss B, Baba H, Phan T, Tuohy VK, Macklin WB (1997) Phosphodiesterase I, a novel adhesion molecule and\/or cytokine involved in oligodendrocyte function. Journal of Neuroscience 17:9095\u20139103","journal-title":"Journal of Neuroscience"},{"key":"446_CR23","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1007\/s00429-014-0885-7","volume":"220","author":"B Garcia-Diaz","year":"2015","unstructured":"Garcia-Diaz B, Riquelme R, Varela-Nieto I, Jimenez AJ, de Diego I, Gomez-Conde AI, Matas-Rico E, Aguirre JA, Chun J, Pedraza C et al (2015) Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex. Brain Structure & Function 220:3701\u20133720. doi: 10.1007\/s00429-014-0885-7 , 10.1016\/j.yexcr.2014.11.020","journal-title":"Brain Structure & Function"},{"key":"446_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jns.2013.02.011","volume":"328","author":"A Groves","year":"2013","unstructured":"Groves A, Kihara Y, Chun J (2013) Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. Journal of Neurological Sciences 328:9\u201318. doi: 10.1016\/j.jns.2013.02.011","journal-title":"Journal of Neurological Sciences"},{"key":"446_CR25","doi-asserted-by":"publisher","first-page":"17634","DOI":"10.1074\/jbc.M313927200","volume":"279","author":"K Hama","year":"2004","unstructured":"Hama K, Aoki J, Fukaya M, Kishi Y, Sakai T, Suzuki R, Ohta H, Yamori T, Watanabe M, Chun J et al (2004) Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. Journal of Biological Chemistry 279:17634\u201317639. doi: 10.1074\/jbc.M313927200","journal-title":"Journal of Biological Chemistry"},{"key":"446_CR26","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nsmb.1980","volume":"18","author":"J Hausmann","year":"2011","unstructured":"Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L et al (2011) Structural basis of substrate discrimination and integrin binding by autotaxin. Nature Structural & Molecular Biology 18:198\u2013204. doi: 10.1038\/nsmb.1980","journal-title":"Nature Structural & Molecular Biology"},{"key":"446_CR27","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S1474-4422(09)70021-3","volume":"8","author":"E Havrdova","year":"2009","unstructured":"Havrdova E, Galetta S, Hutchinson M, Stefoski D, Bates D, Polman CH, O\u2019Connor PW, Giovannoni G, Phillips JT, Lublin FD et al (2009) Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the natalizumab safety and efficacy in relapsing-remitting multiple sclerosis (AFFIRM) study. Lancet Neurology 8:254\u2013260. doi: 10.1016\/S1474-4422(09)70021-3 , S1474-4422(09)70021-3 [pii]","journal-title":"Lancet Neurology"},{"key":"446_CR28","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.135.4.1071","volume":"135","author":"JH Hecht","year":"1996","unstructured":"Hecht JH, Weiner JA, Post SR, Chun J (1996) Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. Journal of Cell Biology 135:1071\u20131083","journal-title":"Journal of Cell Biology"},{"key":"446_CR29","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/labinvest.2013.45","volume":"93","author":"H Hozumi","year":"2013","unstructured":"Hozumi H, Hokari R, Kurihara C, Narimatsu K, Sato H, Sato S, Ueda T, Higashiyama M, Okada Y, Watanabe C et al (2013) Involvement of autotaxin\/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration. Laboratory Investigation 93:508\u2013519. doi: 10.1038\/labinvest.2013.45","journal-title":"Laboratory Investigation"},{"key":"446_CR30","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.4049\/jimmunol.1501613","volume":"196","author":"W Jiang","year":"2016","unstructured":"Jiang W, St-Pierre S, Roy P, Morley BJ, Hao J, Simard AR (2016) Infiltration of CCR2\u2009+\u2009Ly6Chigh proinflammatory monocytes and neutrophils into the central nervous system is modulated by nicotinic acetylcholine receptors in a model of multiple sclerosis. Journal of Immunology 196:2095\u20132108","journal-title":"Journal of Immunology"},{"key":"446_CR31","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1093\/brain\/awp002","volume":"132","author":"A Kalyvas","year":"2009","unstructured":"Kalyvas A, Baskakis C, Magrioti V, Constantinou-Kokotou V, Stephens D, Lopez-Vales R, Lu JQ, Yong VW, Dennis EA, Kokotos G et al (2009) Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. Brain 132:1221\u20131235. doi: 10.1093\/brain\/awp002","journal-title":"Brain"},{"key":"446_CR32","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/ni1573","volume":"9","author":"H Kanda","year":"2008","unstructured":"Kanda H, Newton R, Klein R, Morita Y, Gunn MD, Rosen SD (2008) Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nature Immunology 9:415\u2013423. doi: 10.1038\/ni1573","journal-title":"Nature Immunology"},{"key":"446_CR33","doi-asserted-by":"publisher","first-page":"3575","DOI":"10.1111\/bph.12678","volume":"171","author":"Y Kihara","year":"2014","unstructured":"Kihara Y, Maceyka M, Spiegel S, Chun J (2014) Lysophospholipid receptor nomenclature review: IUPHAR review 8. British Journal of Pharmacology 171:3575\u20133594. doi: 10.1111\/bph.12678","journal-title":"British Journal of Pharmacology"},{"key":"446_CR34","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1038\/nn1157","volume":"6","author":"MA Kingsbury","year":"2003","unstructured":"Kingsbury MA, Rehen SK, Contos JJ, Higgins CM, Chun J (2003) Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nature Neuroscience 6:1292\u20131299. doi: 10.1038\/nn1157","journal-title":"Nature Neuroscience"},{"key":"446_CR35","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.1091\/mbc.E08-03-0316","volume":"19","author":"Z Lee","year":"2008","unstructured":"Lee Z, Cheng CT, Zhang H, Subler MA, Wu J, Mukherjee A, Windle JJ, Chen CK, Fang X (2008) Role of LPA4\/p2y9\/GPR23 in negative regulation of cell motility. Molecular Biology of the Cell 19:5435\u20135445. doi: 10.1091\/mbc.E08-03-0316","journal-title":"Molecular Biology of the Cell"},{"key":"446_CR36","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1186\/1744-8069-4-46","volume":"39","author":"E Matas-Rico","year":"2008","unstructured":"Matas-Rico E, Garcia-Diaz B, Llebrez-Zayas P, Lopez-Barroso D, Santin L, Pedraza C, Smith-Fernandez A, Fernandez-Llebrez P, Tellez T, Redondo M et al (2008) Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. Molecular and Cellular Neurosciences 39:342\u2013355. doi: 10.1186\/1744-8069-4-46","journal-title":"Molecular and Cellular Neurosciences"},{"key":"446_CR37","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nrm3188","volume":"12","author":"WH Moolenaar","year":"2011","unstructured":"Moolenaar WH, Perrakis A (2011) Insights into autotaxin: how to produce and present a lipid mediator. Nature Reviews Molecular Cell Biology 12:674\u2013679. doi: 10.1038\/nrm3188","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"446_CR38","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.2353\/ajpath.2008.071153","volume":"173","author":"T Nakasaki","year":"2008","unstructured":"Nakasaki T, Tanaka T, Okudaira S, Hirosawa M, Umemoto E, Otani K, Jin S, Bai Z, Hayasaka H, Fukui Y et al (2008) Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions. American Journal of Pathology 173:1566\u20131576. doi: 10.2353\/ajpath.2008.071153","journal-title":"American Journal of Pathology"},{"key":"446_CR39","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1084\/jem.20112012","volume":"209","author":"I Nikitopoulou","year":"2012","unstructured":"Nikitopoulou I, Oikonomou N, Karouzakis E, Sevastou I, Nikolaidou-Katsaridou N, Zhao Z, Mersinias V, Armaka M, Xu Y, Masu M et al (2012) Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis. Journal of Experimental Medicine 209:925\u2013933. doi: 10.1084\/jem.20112012","journal-title":"Journal of Experimental Medicine"},{"key":"446_CR40","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.tips.2011.12.004","volume":"33","author":"H Nishimasu","year":"2012","unstructured":"Nishimasu H, Ishitani R, Aoki J, Nureki O (2012) A 3D view of autotaxin. Trends in Pharmacological Sciences 33:138\u2013145. doi: 10.1016\/j.tips.2011.12.004","journal-title":"Trends in Pharmacological Sciences"},{"key":"446_CR41","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.4049\/jimmunol.181.7.5111","volume":"181","author":"H Nochi","year":"2008","unstructured":"Nochi H, Tomura H, Tobo M, Tanaka N, Sato K, Shinozaki T, Kobayashi T, Takagishi K, Ohta H, Okajima F et al (2008) Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells. Journal of Immunology 181:5111\u20135119","journal-title":"Journal of Immunology"},{"key":"446_CR42","doi-asserted-by":"crossref","first-page":"15175","DOI":"10.1074\/jbc.270.25.15175","volume":"270","author":"S Offermanns","year":"1995","unstructured":"Offermanns S, Simon MI (1995) G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. Journal of Biological Chemistry 270:15175\u201315180","journal-title":"Journal of Biological Chemistry"},{"key":"446_CR43","doi-asserted-by":"publisher","first-page":"7385","DOI":"10.1074\/jbc.M807820200","volume":"284","author":"Z Pamuklar","year":"2009","unstructured":"Pamuklar Z, Federico L, Liu S, Umezu-Goto M, Dong A, Panchatcharam M, Fulkerson Z, Berdyshev E, Natarajan V, Fang X et al (2009) Autotaxin\/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. Journal of Biological Chemistry 284:7385\u20137394. doi: 10.1074\/jbc.M807820200","journal-title":"Journal of Biological Chemistry"},{"key":"446_CR44","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.4049\/jimmunol.169.8.4129","volume":"169","author":"E Panther","year":"2002","unstructured":"Panther E, Idzko M, Corinti S, Ferrari D, Herouy Y, Mockenhaupt M, Dichmann S, Gebicke-Haerter P, Di Virgilio F, Girolomoni G et al (2002) The influence of lysophosphatidic acid on the functions of human dendritic cells. Journal of Immunology 169:4129\u20134135","journal-title":"Journal of Immunology"},{"key":"446_CR45","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1084\/jem.20090299","volume":"206","author":"B Pollinger","year":"2009","unstructured":"Pollinger B, Krishnamoorthy G, Berer K, Lassmann H, Bosl MR, Dunn R, Domingues HS, Holz A, Kurschus FC, Wekerle H (2009) Spontaneous relapsing-remitting EAE in the SJL\/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. Journal of Experimental Medicine 206:1303\u20131316. doi: 10.1084\/jem.20090299 , jem.20090299 [pii]","journal-title":"Journal of Experimental Medicine"},{"key":"446_CR46","doi-asserted-by":"publisher","first-page":"30130","DOI":"10.1074\/jbc.M111.246884","volume":"286","author":"LP Saunders","year":"2011","unstructured":"Saunders LP, Cao W, Chang WC, Albright RA, Braddock DT, De La Cruz EM (2011) Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution. Journal of Biological Chemistry 286:30130\u201330141. doi: 10.1074\/jbc.M111.246884","journal-title":"Journal of Biological Chemistry"},{"key":"446_CR47","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s00018-006-6412-0","volume":"64","author":"NE Savaskan","year":"2007","unstructured":"Savaskan NE, Rocha L, Kotter MR, Baer A, Lubec G, van Meeteren LA, Kishi Y, Aoki J, Moolenaar WH, Nitsch R et al (2007) Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma. Cellular and Molecular Life Sciences 64:230\u2013243. doi: 10.1007\/s00018-006-6412-0","journal-title":"Cellular and Molecular Life Sciences"},{"key":"446_CR48","doi-asserted-by":"publisher","first-page":"5723","DOI":"10.4049\/jimmunol.1103109","volume":"188","author":"S Schiffmann","year":"2012","unstructured":"Schiffmann S, Ferreiros N, Birod K, Eberle M, Schreiber Y, Pfeilschifter W, Ziemann U, Pierre S, Scholich K, Grosch S et al (2012) Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis. Journal of Immunology 188:5723\u20135733. doi: 10.4049\/jimmunol.1103109","journal-title":"Journal of Immunology"},{"key":"446_CR49","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.15252\/emmm.201404168","volume":"6","author":"K Schmitz","year":"2014","unstructured":"Schmitz K, de Bruin N, Bishay P, Mannich J, Haussler A, Altmann C, Ferreiros N, Lotsch J, Ultsch A, Parnham MJ et al (2014) R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Molecular Medicine 6:1398\u20131422. doi: 10.15252\/emmm.201404168","journal-title":"EMBO Molecular Medicine"},{"key":"446_CR50","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.bbalip.2012.07.019","volume":"1831","author":"I Sevastou","year":"2013","unstructured":"Sevastou I, Kaffe E, Mouratis MA, Aidinis V (2013) Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)\/LPC and ATX\/LPA axes. Biochimica et Biophysica Acta 1831:42\u201360. doi: 10.1016\/j.bbalip.2012.07.019","journal-title":"Biochimica et Biophysica Acta"},{"key":"446_CR51","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1471-4159.2011.07421.x","volume":"119","author":"TCE Spohr","year":"2011","unstructured":"Spohr TCE, Dezonne RS, Rehen SK, Gomes FC (2011) Astrocytes treated by lysophosphatidic acid induce axonal outgrowth of cortical progenitors through extracellular matrix protein and epidermal growth factor signaling pathway. Journal of Neurochemistry 119:113\u2013123. doi: 10.1111\/j.1471-4159.2011.07421.x","journal-title":"Journal of Neurochemistry"},{"key":"446_CR52","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3389\/fncel.2014.00296","volume":"8","author":"TC Spohr","year":"2014","unstructured":"Spohr TC, Dezonne RS, Rehen SK, Gomes FC (2014) LPA-primed astrocytes induce axonal outgrowth of cortical progenitors by activating PKA signaling pathways and modulating extracellular matrix proteins. Frontiers in Cellular Neuroscience 8:296. doi: 10.3389\/fncel.2014.00296","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"446_CR53","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.cca.2012.10.003","volume":"415","author":"H Sumida","year":"2013","unstructured":"Sumida H, Nakamura K, Yanagida K, Ohkawa R, Asano Y, Kadono T, Tamaki K, Igarashi K, Aoki J, Sato S et al (2013) Decrease in circulating autotaxin by oral administration of prednisolone. Clinica Chimica Acta 415:74\u201380. doi: 10.1016\/j.cca.2012.10.003","journal-title":"Clinica Chimica Acta"},{"key":"446_CR54","doi-asserted-by":"crossref","unstructured":"Takeda, A., Kobayashi, D., Aoi, K., Sasaki, N., Sugiura, Y., Igarashi, H., Tohya, K., Inoue, A., Hata, E., Akahoshi, N., et al. (2016) Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. eLife, 5. Doi 10.7554\/eLife.10561.","DOI":"10.7554\/eLife.10561"},{"key":"446_CR55","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1124\/jpet.116.234013","volume":"359","author":"K Thirunavukkarasu","year":"2016","unstructured":"Thirunavukkarasu K, Tan B, Swearingen CA, Rocha G, Bui HH, McCann DJ, Jones SB, Norman BH, Pfeifer LA, Saha JK et al (2016) Pharmacological characterization of a potent inhibitor of autotaxin in animal models of inflammatory bowel disease and multiple sclerosis. Journal of Pharmacology and Experimental Therapeutics 359:207\u2013214. doi: 10.1124\/jpet.116.234013","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"446_CR56","doi-asserted-by":"publisher","first-page":"39436","DOI":"10.1074\/jbc.M205623200","volume":"277","author":"A Tokumura","year":"2002","unstructured":"Tokumura A, Majima E, Kariya Y, Tominaga K, Kogure K, Yasuda K, Fukuzawa K (2002) Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. Journal of Biological Chemistry 277:39436\u201339442. doi: 10.1074\/jbc.M205623200","journal-title":"Journal of Biological Chemistry"},{"key":"446_CR57","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1042\/bj20081888","volume":"419","author":"JL Tomsig","year":"2009","unstructured":"Tomsig JL, Snyder AH, Berdyshev EV, Skobeleva A, Mataya C, Natarajan V, Brindley DN, Lynch KR (2009) Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo. The Biochemical Journal 419:611\u2013618. doi: 10.1042\/bj20081888","journal-title":"The Biochemical Journal"},{"key":"446_CR58","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cellsig.2004.06.003","volume":"17","author":"JS Tou","year":"2005","unstructured":"Tou JS, Gill JS (2005) Lysophosphatidic acid increases phosphatidic acid formation, phospholipase D activity and degranulation by human neutrophils. Cellular Signalling 17:77\u201382. doi: 10.1016\/j.cellsig.2004.06.003","journal-title":"Cellular Signalling"},{"key":"446_CR59","doi-asserted-by":"publisher","first-page":"e8080","DOI":"10.1371\/journal.pone.0008080","volume":"4","author":"A Trousson","year":"2009","unstructured":"Trousson A, Makoukji J, Petit PX, Bernard S, Slomianny C, Schumacher M, Massaad C (2009) Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death. PLoS One 4:e8080. doi: 10.1371\/journal.pone.0008080","journal-title":"PLoS One"},{"key":"446_CR60","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1083\/jcb.200204026","volume":"158","author":"M Umezu-Goto","year":"2002","unstructured":"Umezu-Goto M, Kishi Y, Taira A, Hama K, Dohmae N, Takio K, Yamori T, Mills GB, Inoue K, Aoki J et al (2002) Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. Journal of Cell Biology 158:227\u2013233. doi: 10.1083\/jcb.200204026","journal-title":"Journal of Cell Biology"},{"key":"446_CR61","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00401-012-1014-4","volume":"124","author":"R Doorn van","year":"2012","unstructured":"van Doorn R, Nijland PG, Dekker N, Witte ME, Lopes-Pinheiro MA, van het Hof B, Kooij G, Reijerkerk A, Dijkstra C, van van der Valk P et al (2012) Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes. Acta Neuropathologica 124:397\u2013410. doi: 10.1007\/s00401-012-1014-4","journal-title":"Acta Neuropathologica"},{"key":"446_CR62","doi-asserted-by":"publisher","first-page":"5015","DOI":"10.1128\/mcb.02419-05","volume":"26","author":"LA Meeteren van","year":"2006","unstructured":"van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Pradere JP, Pettit TR, Wakelam MJ, Saulnier-Blache JS, Mummery CL et al (2006) Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Molecular and Cellular Biology 26:5015\u20135022. doi: 10.1128\/mcb.02419-05","journal-title":"Molecular and Cellular Biology"},{"key":"446_CR63","doi-asserted-by":"publisher","first-page":"25","DOI":"10.15252\/emmm.201505677","volume":"8","author":"J Vogt","year":"2015","unstructured":"Vogt J, Yang JW, Mobascher A, Cheng J, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P et al (2015) Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. EMBO Molecular Medicine 8:25\u201338. doi: 10.15252\/emmm.201505677","journal-title":"EMBO Molecular Medicine"},{"key":"446_CR64","doi-asserted-by":"publisher","first-page":"11673","DOI":"10.1073\/pnas.0812569106","volume":"106","author":"CE Allmen von","year":"2009","unstructured":"von Allmen CE, Schmitz N, Bauer M, Hinton HJ, Kurrer MO, Buser RB, Gwerder M, Muntwiler S, Sparwasser T, Beerli RR et al (2009) Secretory phospholipase A2-IID is an effector molecule of CD4\u2009+\u2009CD25+ regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America 106:11673\u201311678. doi: 10.1073\/pnas.0812569106","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"446_CR65","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1073\/pnas.96.9.5233","volume":"96","author":"JA Weiner","year":"1999","unstructured":"Weiner JA, Chun J (1999) Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proceedings of the National Academy of Sciences of the United States of America 96:5233\u20135238","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"446_CR66","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/(SICI)1096-9861(19980907)398:4<587::AID-CNE10>3.0.CO;2-5","volume":"398","author":"JA Weiner","year":"1998","unstructured":"Weiner JA, Hecht JH, Chun J (1998) Lysophosphatidic acid receptor gene vzg-1\/lpA1\/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. Journal of Comparative Neurology 398:587\u2013598","journal-title":"Journal of Comparative Neurology"},{"key":"446_CR67","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.cellsig.2004.03.005","volume":"16","author":"Y Xie","year":"2004","unstructured":"Xie Y, Meier KE (2004) Lysophospholipase D and its role in LPA production. Cellular Signalling 16:975\u2013981. doi: 10.1016\/j.cellsig.2004.03.005","journal-title":"Cellular Signalling"},{"key":"446_CR68","doi-asserted-by":"publisher","first-page":"32314","DOI":"10.1074\/jbc.M113.501668","volume":"288","author":"Y Yu","year":"2013","unstructured":"Yu Y, Schurpf T, Springer TA (2013) How natalizumab binds and antagonizes alpha4 integrins. Journal of Biological Chemistry 288:32314\u201332325. doi: 10.1074\/jbc.M113.501668","journal-title":"Journal of Biological Chemistry"},{"key":"446_CR69","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/jnc.13112","volume":"85","author":"YC Yung","year":"2015","unstructured":"Yung YC, Stoddard NC, Mirendil H, Chun J (2015) Lysophosphatidic Acid signaling in the nervous system. Neuron 85:669\u2013682. doi: 10.1111\/jnc.13112","journal-title":"Neuron"},{"key":"446_CR70","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.4049\/jimmunol.1201604","volume":"189","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Chen YC, Krummel MF, Rosen SD (2012) Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. Journal of Immunology 189:3914\u20133924. doi: 10.4049\/jimmunol.1201604","journal-title":"Journal of Immunology"},{"key":"446_CR71","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1042\/bj20110274","volume":"439","author":"J Zhao","year":"2011","unstructured":"Zhao J, He D, Berdyshev E, Zhong M, Salgia R, Morris AJ, Smyth SS, Natarajan V, Zhao Y (2011) Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways. The Biochemical Journal 439:45\u201355. doi: 10.1042\/bj20110274","journal-title":"The Biochemical Journal"},{"key":"446_CR72","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.4049\/jimmunol.166.4.2317","volume":"166","author":"Y Zheng","year":"2001","unstructured":"Zheng Y, Kong Y, Goetzl EJ (2001) Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane. Journal of Immunology 166:2317\u20132322","journal-title":"Journal of Immunology"},{"key":"446_CR73","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1093\/ecco-jcc\/jjw056","volume":"10","author":"K Zschiebsch","year":"2016","unstructured":"Zschiebsch K, Fischer C, Pickert G, Haussler A, Radeke H, Grosch S, Ferreiros N, Geisslinger G, Werner ER, Tegeder I (2016) Tetrahydrobiopterin attenuates DSS-evoked colitis in mice by rebalancing redox and lipid signalling. Journal of Crohn\u2019s & Colitis 10:965\u2013978. doi: 10.1093\/ecco-jcc\/jjw056","journal-title":"Journal of Crohn\u2019s & Colitis"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-017-0446-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T09:07:45Z","timestamp":1569402465000},"score":1,"resource":{"primary":{"URL":"http:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-017-0446-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["446"],"URL":"https:\/\/doi.org\/10.1186\/s40478-017-0446-4","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]},"article-number":"42"}}