{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:36:13Z","timestamp":1782549373149,"version":"3.54.5"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009673","name":"Gun och Bertil Stohnes Stiftelse","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100009673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010773","name":"Demensf\u00f6rbundet","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100010773","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation for Geriatric Diseases at Karolinska Institutet","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Kuopio University Hospital VTR Fund","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s40478-018-0605-2","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T09:00:53Z","timestamp":1538384453000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients"],"prefix":"10.1186","volume":"6","author":[{"given":"Nuno Santos","family":"Leal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Dentoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Schreiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli-Pekka","family":"K\u00e4m\u00e4r\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelli","family":"Partanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna-Kaisa","family":"Herukka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hiltunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Rauramaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Leinonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-3694","authenticated-orcid":false,"given":"Maria","family":"Ankarcrona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"key":"605_CR1","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1038\/emboj.2012.202","volume":"31","author":"E Area-Gomez","year":"2012","unstructured":"Area-Gomez E, del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJC, Madra M, Ikenouchi J, Umeda M, Bird TD, Sturley SL, Schon E (2012) Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. EMBO J 31:4106\u20134123. https:\/\/doi.org\/10.1038\/emboj.2012.202","journal-title":"EMBO J"},{"issue":"2","key":"605_CR2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.2174\/1566524011313020008","volume":"13","author":"R. Bravo-Sagua","year":"2012","unstructured":"Bravo-Sagua R, Rodriguez AE, Kuzmicic J, Gutierrez T, Lopez-Crisosto C, Quiroga C, D\u00edaz-Elizondo J, Chiong M, Gillette TG, Rothermel BA, Lavandero S (2013) Cell death and survival through the endoplasmic reticulum-mitochondrial axis. Curr Mol Med. https:\/\/doi.org\/10.2174\/1566524011313020008","journal-title":"Current Molecular Medicine"},{"issue":"10","key":"605_CR3","doi-asserted-by":"publisher","first-page":"3247","DOI":"10.1016\/j.bbadis.2018.07.011","volume":"1864","author":"Domenico Cieri","year":"2018","unstructured":"Cieri D, Vicario M, Vallese F, D\u2019Orsi B, Berto P, Grinzato A, Catoni C, De Stefani D, Rizzuto R, Brini M, Cal\u00ec T (2018) Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular ca 2+ handling. Biochim Biophys Acta - Mol Basis Dis. https:\/\/doi.org\/10.1016\/j.bbadis.2018.07.011","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"605_CR4","doi-asserted-by":"publisher","first-page":"15794","DOI":"10.1074\/jbc.M412694200","volume":"280","author":"NJ Dolman","year":"2005","unstructured":"Dolman NJ, Gerasimenko JV, Gerasimenko OV, Voronina SG, Petersen OH, Tepikin AV (2005) Stable Golgi-mitochondria complexes and formation of Golgi Ca2+ gradients in pancreatic acinar cells. J Biol Chem 280:15794\u201315799. https:\/\/doi.org\/10.1074\/jbc.M412694200","journal-title":"J Biol Chem"},{"key":"605_CR5","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1016\/j.celrep.2016.05.013","volume":"15","author":"R Filadi","year":"2016","unstructured":"Filadi R, Greotti E, Turacchio G, Luini A, Pozzan T, Pizzo P (2016) Presenilin 2 modulates endoplasmic reticulum-mitochondria coupling by tuning the antagonistic effect of Mitofusin 2. Cell Rep 15:2226\u20132238. https:\/\/doi.org\/10.1016\/j.celrep.2016.05.013","journal-title":"Cell Rep"},{"key":"605_CR6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.cub.2017.12.047","volume":"28","author":"R Filadi","year":"2018","unstructured":"Filadi R, Leal NS, Schreiner B, Rossi A, Dentoni G, Pinho CM, Wiehager B, Cieri D, Cal\u00ec T, Pizzo P, Ankarcrona M (2018) TOM70 sustains cell bioenergetics by promoting IP3R3-mediated ER to mitochondria Ca2+transfer. Curr Biol 28:369\u2013382.e6. https:\/\/doi.org\/10.1016\/j.cub.2017.12.047","journal-title":"Curr Biol"},{"key":"605_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceca.2017.01.003","volume":"62","author":"R Filadi","year":"2017","unstructured":"Filadi R, Theurey P, Pizzo P (2017) The endoplasmic reticulum-mitochondria coupling in health and disease: molecules, functions and significance. Cell Calcium 62:1\u201315. https:\/\/doi.org\/10.1016\/j.ceca.2017.01.003","journal-title":"Cell Calcium"},{"key":"605_CR8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR (1975) \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189\u2013198. https:\/\/doi.org\/10.1016\/0022-3956(75)90026-6","journal-title":"J Psychiatr Res"},{"key":"605_CR9","doi-asserted-by":"publisher","unstructured":"Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME (2010) Days to criterion as an indicator of toxicity associated with human alzheimer amyloid-\u03b2 oligomers. Ann Neurol. https:\/\/doi.org\/10.1002\/ana.22052","DOI":"10.1002\/ana.22052"},{"key":"605_CR10","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1038\/cdd.2016.52","volume":"23","author":"M Giacomello","year":"2016","unstructured":"Giacomello M, Pellegrini L (2016) The coming of age of the mitochondria\u2013ER contact: a matter of thickness. Cell Death Differ 23:1417\u20131427. https:\/\/doi.org\/10.1038\/cdd.2016.52","journal-title":"Cell Death Differ"},{"key":"605_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnagi.2013.00098","volume":"5","author":"MOW Grimm","year":"2013","unstructured":"Grimm MOW, Mett J, Christoph P, Haupenthal VJ, Zimmer VC (2013) Neprilysin and A\u03b2 clearance\u00a0: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer \u2019 s disease. Front Aging Neurosci 5:1\u201327. https:\/\/doi.org\/10.3389\/fnagi.2013.00098","journal-title":"Front Aging Neurosci"},{"key":"605_CR12","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1038\/s41467-017-01503-6","volume":"8","author":"Y Han","year":"2017","unstructured":"Han Y, Li M, Qiu F, Zhang M, Zhang Y-H (2017) Cell-permeable organic fluorescent probes for live-cell long-term super-resolution imaging reveal lysosome-mitochondrion interactions. Nat Commun 8:1307. https:\/\/doi.org\/10.1038\/s41467-017-01503-6","journal-title":"Nat Commun"},{"key":"605_CR13","doi-asserted-by":"publisher","first-page":"7916","DOI":"10.1073\/pnas.1300677110\/-\/DCSupplemental.www.pnas.org\/cgi\/doi\/10.1073\/pnas.1300677110","volume":"110","author":"L Hedskog","year":"2013","unstructured":"Hedskog L, Moreira C, Filadi R, R\u00f6nnb\u00e4ck A, Hertwig L, Wiehager B (2013) Modulation of the endoplasmic reticulum \u2013 mitochondria interface in Alzheimer\u2019s disease and related models. Proc Natl Acad Sci 110:7916\u20137921. https:\/\/doi.org\/10.1073\/pnas.1300677110\/-\/DCSupplemental.www.pnas.org\/cgi\/doi\/10.1073\/pnas.1300677110","journal-title":"Proc Natl Acad Sci"},{"key":"605_CR14","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1016\/j.bbamcr.2013.01.028","volume":"1833","author":"SCJ Helle","year":"2013","unstructured":"Helle SCJ, Kanfer G, Kolar K, Lang A, Michel AH, Kornmann B (2013) Organization and function of membrane contact sites. Biochim Biophys Acta 1833:2526\u20132541. https:\/\/doi.org\/10.1016\/j.bbamcr.2013.01.028","journal-title":"Biochim Biophys Acta"},{"key":"605_CR15","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.3233\/JAD-170583","volume":"60","author":"J Huovinen","year":"2017","unstructured":"Huovinen J, Helisalmi S, Paananen J, Laiter\u00e4 T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, J\u00e4\u00e4skel\u00e4inen JE, Hiltunen M, Leinonen V (2017) Alzheimer\u2019s disease-related polymorphisms in shunt-responsive idiopathic normal pressure hydrocephalus. J Alzheimers Dis 60:1077\u20131085. https:\/\/doi.org\/10.3233\/JAD-170583","journal-title":"J Alzheimers Dis"},{"key":"605_CR16","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1111\/ene.12755","volume":"22","author":"A Junkkari","year":"2015","unstructured":"Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinam\u00e4ki H, Soininen H, J\u00e4\u00e4skel\u00e4inen JE, Leinonen V (2015) Health-related quality of life in patients with idiopathic normal pressure hydrocephalus. Eur J Neurol 22:1391\u20131399. https:\/\/doi.org\/10.1111\/ene.12755","journal-title":"Eur J Neurol"},{"key":"605_CR17","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3233\/JAD-160554","volume":"55","author":"T Laiter\u00e4","year":"2017","unstructured":"Laiter\u00e4 T, Paananen J, Helisalmi S, Saraj\u00e4rvi T, Huovinen J, Laitinen M, Rauramaa T, Alafuzoff I, Remes AM, Soininen H, Haapasalo A, J\u00e4\u00e4skel\u00e4inen JE, Leinonen V, Hiltunen M (2017) Effects of Alzheimer\u2019s disease-associated risk loci on amyloid-\u03b2 accumulation in the brain of idiopathic normal pressure hydrocephalus patients. J Alzheimers Dis 55:995\u20131003. https:\/\/doi.org\/10.3233\/JAD-160554","journal-title":"J Alzheimers Dis"},{"key":"605_CR18","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1111\/jcmm.12863","volume":"20","author":"NS Leal","year":"2016","unstructured":"Leal NS, Schreiner B, Pinho CM, Filadi R, Wiehager B, Karlstr\u00f6m H, Pizzo P, Ankarcrona M (2016) Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid \u03b2-peptide production. J Cell Mol Med 20:1686\u20131695. https:\/\/doi.org\/10.1111\/jcmm.12863","journal-title":"J Cell Mol Med"},{"issue":"3","key":"605_CR19","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.neuroscience.2007.10.054","volume":"151","author":"S. Lesn\u00e9","year":"2008","unstructured":"Lesn\u00e9 S, Kotilinek L, Ashe KH (2008) Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function. Neuroscience. https:\/\/doi.org\/10.1016\/j.neuroscience.2007.10.054","journal-title":"Neuroscience"},{"key":"605_CR20","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1007\/s00018-008-8112-4","volume":"65","author":"E Malito","year":"2008","unstructured":"Malito E, Hulse RE, Tang WJ (2008) Amyloid \u03b2-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin. Cell Mol Life Sci 65:2574\u20132585","journal-title":"Cell Mol Life Sci"},{"key":"605_CR21","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nrn1886","volume":"7","author":"MP Mattson","year":"2006","unstructured":"Mattson MP, Magnus T (2006) Ageing and neuronal vulnerability. Nat Rev Neurosci 7:278\u2013294. https:\/\/doi.org\/10.1038\/nrn1886","journal-title":"Nat Rev Neurosci"},{"key":"605_CR22","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.tins.2016.01.008","volume":"39","author":"S Paillusson","year":"2016","unstructured":"Paillusson S, Stoica R, Gomez-Suaga P, Lau DHW, Mueller S, Miller T, Miller CCJ (2016) There\u2019s something wrong with my MAM; the ER-mitochondria Axis and neurodegenerative diseases. Trends Neurosci 39:146\u2013157. https:\/\/doi.org\/10.1016\/j.tins.2016.01.008","journal-title":"Trends Neurosci"},{"key":"605_CR23","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/NEN.0b013e3181a1fc49","volume":"68","author":"S Perreault","year":"2009","unstructured":"Perreault S, Bousquet O, Lauzon M, Paiement J, Leclerc N (2009) Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau. J Neuropathol Exp Neurol 68:503\u2013514. https:\/\/doi.org\/10.1097\/NEN.0b013e3181a1fc49","journal-title":"J Neuropathol Exp Neurol"},{"key":"605_CR24","first-page":"525","volume":"22","author":"J Pracha\u0159","year":"2003","unstructured":"Pracha\u0159 J (2003) Intimate contacts of mitochondria with nuclear envelope as a potential energy gateaway for nucleo-cytoplasmic mRNA transport. Gen Physiol Biophys 22:525\u2013534","journal-title":"Gen Physiol Biophys"},{"key":"605_CR25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.bbamcr.2012.04.013","volume":"1833","author":"A Raturi","year":"2013","unstructured":"Raturi A, Simmen T (2013) Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM). Biochim Biophys Acta - Mol Cell Res 1833:213\u2013224. https:\/\/doi.org\/10.1016\/j.bbamcr.2012.04.013","journal-title":"Biochim Biophys Acta - Mol Cell Res"},{"key":"605_CR26","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1159\/000355256","volume":"13","author":"JO Rinne","year":"2014","unstructured":"Rinne JO, Frantzen J, Leinonen V, Lonnrot K, Laakso A, Virtanen KA, Solin O, Kotkansalo A, Koivisto A, Sajanti J, Karppinen A, Lehto H, Rummukainen J, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajarvi M, Grachev ID (2014) Prospective flutemetamol positron emission tomography and histopathology in normal pressure hydrocephalus. Neurodegener Dis 13:237\u2013245. https:\/\/doi.org\/10.1159\/000355256","journal-title":"Neurodegener Dis"},{"key":"605_CR27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.mcn.2012.07.011","volume":"55","author":"E Schon","year":"2013","unstructured":"Schon E, Area-Gomez E (2013) Mitochondria-associated ER membranes in Alzheimer disease. Mol Cell Neurosci 55:26\u201336. https:\/\/doi.org\/10.1016\/j.mcn.2012.07.011","journal-title":"Mol Cell Neurosci"},{"key":"605_CR28","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3233\/JAD-132543","volume":"43","author":"B Schreiner","year":"2015","unstructured":"Schreiner B, Hedskog L, Wiehager B, Ankarcrona M (2015) Amyloid-\u03b2 peptides are generated in mitochondria-associated endoplasmic reticulum membranes. J Alzheimers Dis 43:369\u2013374. https:\/\/doi.org\/10.3233\/JAD-132543","journal-title":"J Alzheimers Dis"},{"key":"605_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/cshperspect.a004457","volume":"3","author":"DJ Selkoe","year":"2011","unstructured":"Selkoe DJ (2011) Alzheimer\u2019s disease. Cold Spring Harb Perspect Biol 3:1\u201316. https:\/\/doi.org\/10.1101\/cshperspect.a004457","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"605_CR30","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ebiom.2016.03.035","volume":"6","author":"U Sengupta","year":"2016","unstructured":"Sengupta U, Nilson AN, Kayed R (2016) The role of amyloid-\u03b2 oligomers in toxicity, propagation, and immunotherapy. EBioMedicine 6:42\u201349. https:\/\/doi.org\/10.1016\/j.ebiom.2016.03.035","journal-title":"EBioMedicine"},{"key":"605_CR31","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1212\/WNL.0b013e3182563bd0","volume":"78","author":"TT Sepp\u00e4l\u00e4","year":"2012","unstructured":"Sepp\u00e4l\u00e4 TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykk\u00f6 OT, Helisalmi S, Alafuzoff I, Hiltunen M, J\u00e4\u00e4skel\u00e4inen JE, Rinne J, Soininen H, Leinonen V, Herukka SK (2012) CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings. Neurology 78:1568\u20131575. https:\/\/doi.org\/10.1212\/WNL.0b013e3182563bd0","journal-title":"Neurology"},{"key":"605_CR32","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s004010050735","volume":"94","author":"JA Sloane","year":"1997","unstructured":"Sloane JA, Pietropaolo MF, Rosene DL, Moss MB, Peters A, Kemper T, Abraham CR (1997) Lack of correlation between plaque burden and cognition in the aged monkey. Acta Neuropathol 94:471\u2013478. https:\/\/doi.org\/10.1007\/s004010050735","journal-title":"Acta Neuropathol"},{"key":"605_CR33","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.15252\/embr.201541726","volume":"17","author":"R Stoica","year":"2016","unstructured":"Stoica R, Paillusson S, Gomez-Suaga P, Mitchell JC, Lau DH, Gray EH, Sancho RM, Vizcay-Barrena G, De Vos KJ, Shaw CE, Hanger DP, Noble W, Miller CC (2016) ALS\/FTD-associated FUS activates GSK-3\u03b2 to disrupt the VAPB\u2013PTPIP51 interaction and ER\u2013mitochondria associations. EMBO Rep 17:1326\u20131342. https:\/\/doi.org\/10.15252\/embr.201541726","journal-title":"EMBO Rep"},{"issue":"8","key":"605_CR34","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","volume":"11","author":"Jenna M. Tarasoff-Conway","year":"2015","unstructured":"Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, M\u00e9nard J, Zetterberg H, Wisniewski T, de Leon MJ (2015) Clearance systems in the brain\u2014implications for Alzheimer disease. Nat Rev Neurol. https:\/\/doi.org\/10.1038\/nrneurol.2015.119","journal-title":"Nature Reviews Neurology"},{"key":"605_CR35","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1016\/S0021-9258(19)39106-9","volume":"265","author":"JE Vance","year":"1990","unstructured":"Vance JE (1990) Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem 265:7248\u20137256","journal-title":"J Biol Chem"},{"key":"605_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceb.2015.03.001","volume":"35","author":"B Westermann","year":"2015","unstructured":"Westermann B (2015) The mitochondria-plasma membrane contact site. Curr Opin Cell Biol 35:1\u20136. https:\/\/doi.org\/10.1016\/j.ceb.2015.03.001","journal-title":"Curr Opin Cell Biol"},{"key":"605_CR37","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1212\/CPJ.0b013e3182a78f6b","volume":"3","author":"MA Williams","year":"2013","unstructured":"Williams MA, Relkin NR (2013) Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract 3:375\u2013385. https:\/\/doi.org\/10.1212\/CPJ.0b013e3182a78f6b","journal-title":"Neurol Clin Pract"},{"key":"605_CR38","doi-asserted-by":"publisher","first-page":"E4859","DOI":"10.1073\/pnas.1701078114","volume":"114","author":"Y Wu","year":"2017","unstructured":"Wu Y, Whiteus C, Xu CS, Hayworth KJ, Weinberg RJ, Hess HF, De Camilli P (2017) Contacts between the endoplasmic reticulum and other membranes in neurons. Proc Natl Acad Sci 114:E4859\u2013E4867. https:\/\/doi.org\/10.1073\/pnas.1701078114","journal-title":"Proc Natl Acad Sci"},{"key":"605_CR39","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1073\/pnas.1100735108","volume":"108","author":"E Zampese","year":"2011","unstructured":"Zampese E, Fasolato C, Kipanyula MJ, Bortolozzi M, Pozzan T, Pizzo P (2011) Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk. Proc Natl Acad Sci U S A 108:2777\u20132782. https:\/\/doi.org\/10.1073\/pnas.1100735108","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-018-0605-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40478-018-0605-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-018-0605-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T01:59:08Z","timestamp":1662170348000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-018-0605-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["605"],"URL":"https:\/\/doi.org\/10.1186\/s40478-018-0605-2","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,1]]},"assertion":[{"value":"21 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The brain biopsy part was approved by the Kuopio University Hospital Research Ethics Committee (5\/2008, 19.3.2008).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All iNPH patients or their next-of-kin gave their written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"102"}}