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Normandin received research funding from NIH National Institute of Neurological Disorders and Stroke (U01NS086659) and NIH National Institute of Mental Health (R01MH100350).Keith A. Johnson received research funding from NIH (grants R01 EB014894, R21 AG038994, R01 AG026484, R01 AG034556, P50 AG00513421, U19 AG10483, P01 AG036694, R13 AG042201174210, R01 AG027435 and R01 AG037497) and the Alzheimer\u2019s Association (ZEN-10-174,210\u2009K). Keith A. Johnson has served as paid consultant for Bayer, GE Healthcare, Janssen Alzheimer\u2019s Immunotherapy, Siemens Medical Solutions, Genzyme, Novartis, Biogen, Roche, ISIS Pharma, AZTherapy, GEHC, Lundberg, and Abbvie. He is a site co-investigator for Lilly\/Avid, Janssen Immunotherapy and Pfizer.Matthew P. Frosch received research funding from the Massachusetts Alzheimer\u2019s Disease Research Center (NIH AG005134).Teresa G\u00f3mez-Isla received research funding from NIH National Institute on Aging (AG005134, AG036694 and AG061206). Teresa G\u00f3mez-Isla participated as speaker in an Eli Lilly and Company sponsored educational symposium and serves in an Eli Lilly Data Monitoring Committee. Eli Lilly and Company owns Avid, the company that created AV-1451, one of the PET compounds used in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"37"}}