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In other AD mouse models LTP is unaffected, but other defects in synaptic plasticity may still be present. We recently reported that THY-Tau22 transgenic mice, that overexpress human Tau protein carrying P301S and G272\u2009V mutations and show normal LTP upon high-frequency-stimulation (HFS), develop severe changes in NMDAR mediated long-term-depression (LTD), the physiological counterpart of LTP. In the present study, we focused on putative effects of AD-related pathologies on depotentiation (DP), another form of synaptic plasticity. Using a novel protocol to induce DP in the CA1-region, we found in 11\u201315\u2009months old male THY-Tau22 and APPPS1\u201321 transgenic mice that DP was not deteriorated by A\u00df pathology while significantly compromised by Tau pathology. Our findings advocate DP as a complementary form of synaptic plasticity that may help in elucidating synaptic pathomechanisms associated with different types of dementia.<\/jats:p>","DOI":"10.1186\/s40478-019-0813-4","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T14:03:00Z","timestamp":1575900180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tau- but not A\u00df -pathology enhances NMDAR-dependent depotentiation in AD-mouse models"],"prefix":"10.1186","volume":"7","author":[{"given":"Enrico","family":"Faldini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Bue\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Balschun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"813_CR1","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1126\/science.aat3810","volume":"360","author":"K Abdou","year":"2018","unstructured":"Abdou K, Shehata M, Choko K, Nishizono H, Matsuo M, Muramatsu S-I, Inokuchi K (2018) Synapse-specific representation of the identity of overlapping memory engrams. 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