{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:56:15Z","timestamp":1789005375240,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rotary Club Aalsmeer-Uithoorn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical diagnosis in patients with parkinsonian disorders can be challenging, and a definite diagnosis requires neuropathological confirmation. The aim of this study was to examine whether a clinical diagnosis of Parkinson\u2019s disease (PD) and atypical parkinsonian disorders predict the presence of Lewy pathology (LP) and concomitant neuropathological lesions.<\/jats:p><jats:p>We included 293 donors with a history of parkinsonism without dementia at disease onset, collected by the Netherlands Brain Bank (NBB)\u00a0from 1989 to 2015. We retrospectively categorized donors according the International Parkinson and Movement Disorder Society clinical diagnostic criteria for PD (MDS-PD criteria) as \u2018not PD\u2019, \u2018probable PD\u2019 or \u2018established PD\u2019. We compared the final clinical diagnosis to presence of neuropathological lesions as defined by BrainNet Europe and National\u00a0Institute on\u00a0Aging\u00a0\u2013 Alzheimer's Association guidelines.<\/jats:p><jats:p>LP was present in 150 out of 176 donors (85%) with a clinical diagnosis of PD, in 8 out of 101 donors (8%) with atypical parkinsonian disorders and in 4 out of 16 donors (25%) without a definite clinical diagnosis. Independent from age at death, stages of amyloid-\u03b2, but not neurofibrillary tau or neuritic plaques, were higher in donors with LP compared to other types of pathology (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). The MDS-PD criteria at a certainty level of \u2018probable PD\u2019 predicted presence of LP with a diagnostic accuracy of 89.3%. Among donors with LP, \u2018established PD\u2019 donors showed similar Braak \u03b1-synuclein stages and stages of amyloid-\u03b2, neurofibrillary tau and neuritic plaques compared to \u2018not PD\u2019 or \u2018probable PD\u2019 donors.<\/jats:p><jats:p>In conclusion, both a clinical diagnosis of PD as well as MDS-PD criteria accurately predicted presence of LP in NBB donors. LP was associated with more widespread amyloid-\u03b2 pathology, suggesting a link between amyloid-\u03b2 accumulation and LP formation.<\/jats:p>","DOI":"10.1186\/s40478-020-00914-9","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T09:03:12Z","timestamp":1585213392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series"],"prefix":"10.1186","volume":"8","author":[{"given":"H.","family":"Geut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. H.","family":"Hepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Foncke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. W.","family":"Berendse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Rozemuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Huitinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. D. J.","family":"van de Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,26]]},"reference":[{"key":"914_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s1474-4422(05)70285-4","volume":"5","author":"E Tolosa","year":"2006","unstructured":"Tolosa E, Wenning G, Poewe W (2006) The diagnosis of Parkinson's disease. Lancet Neurol 5:75\u201386. https:\/\/doi.org\/10.1016\/s1474-4422(05)70285-4","journal-title":"Lancet Neurol"},{"key":"914_CR2","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1212\/wnl.0000000000000641","volume":"83","author":"CH Adler","year":"2014","unstructured":"Adler CH, Beach TG, Hentz JG, Shill HA, Caviness JN, Driver-Dunckley E, Sabbagh MN, Sue LI, Jacobson SA, Belden CM et al (2014) Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study. Neurology 83:406\u2013412. https:\/\/doi.org\/10.1212\/wnl.0000000000000641","journal-title":"Neurology"},{"key":"914_CR3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1750-3639.2012.00611.x","volume":"23","author":"J Horvath","year":"2013","unstructured":"Horvath J, Burkhard PR, Bouras C, Kovari E (2013) Etiologies of parkinsonism in a century-long autopsy-based cohort. Brain Pathol 23:28\u201333. https:\/\/doi.org\/10.1111\/j.1750-3639.2012.00611.x","journal-title":"Brain Pathol"},{"key":"914_CR4","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1001\/archneur.1993.00540020018011","volume":"50","author":"AJ Hughes","year":"1993","unstructured":"Hughes AJ, Daniel SE, Blankson S, Lees AJ (1993) A clinicopathologic study of 100 cases of Parkinson's disease. Arch Neurol 50:140\u2013148","journal-title":"Arch Neurol"},{"key":"914_CR5","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1212\/WNL.57.8.1497","volume":"57","author":"AJ Hughes","year":"2001","unstructured":"Hughes AJ, Daniel SE, Lees AJ (2001) Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology 57:1497\u20131499","journal-title":"Neurology"},{"key":"914_CR6","doi-asserted-by":"crossref","unstructured":"Jellinger KA (2007) Morphological substrates of parkinsonism with and without dementia: a retrospective clinico-pathological study. J Neural Transm Suppl:91\u2013104","DOI":"10.1007\/978-3-211-73574-9_12"},{"key":"914_CR7","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.parkreldis.2014.04.019","volume":"20","author":"J Joutsa","year":"2014","unstructured":"Joutsa J, Gardberg M, Roytta M, Kaasinen V (2014) Diagnostic accuracy of parkinsonism syndromes by general neurologists. Parkinsonism Relat Disord 20:840\u2013844. https:\/\/doi.org\/10.1016\/j.parkreldis.2014.04.019","journal-title":"Parkinsonism Relat Disord"},{"key":"914_CR8","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1212\/wnl.0000000000002350","volume":"86","author":"G Rizzo","year":"2016","unstructured":"Rizzo G, Copetti M, Arcuti S, Martino D, Fontana A, Logroscino G (2016) Accuracy of clinical diagnosis of Parkinson disease: a systematic review and meta-analysis. Neurology 86:566\u2013576. https:\/\/doi.org\/10.1212\/wnl.0000000000002350","journal-title":"Neurology"},{"key":"914_CR9","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1002\/mds.10202","volume":"17","author":"JH Bower","year":"2002","unstructured":"Bower JH, Dickson DW, Taylor L, Maraganore DM, Rocca WA (2002) Clinical correlates of the pathology underlying parkinsonism: a population perspective. Mov Disord 17:910\u2013916. https:\/\/doi.org\/10.1002\/mds.10202","journal-title":"Mov Disord"},{"key":"914_CR10","doi-asserted-by":"publisher","unstructured":"Turcano P, Mielke MM, Josephs KA, Bower JH, Parisi JE, Boeve BF, Savica R (2017) Clinicopathologic discrepancies in a population-based incidence study of parkinsonism in olmsted county: 1991-2010. Mov Disord. https:\/\/doi.org\/10.1002\/mds.27125","DOI":"10.1002\/mds.27125"},{"key":"914_CR11","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1093\/brain\/awx118","volume":"140","author":"SM Fereshtehnejad","year":"2017","unstructured":"Fereshtehnejad SM, Zeighami Y, Dagher A, Postuma RB (2017) Clinical criteria for subtyping Parkinson's disease: biomarkers and longitudinal progression. Brain 140:1959\u20131976. https:\/\/doi.org\/10.1093\/brain\/awx118","journal-title":"Brain"},{"key":"914_CR12","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1093\/brain\/awp234","volume":"132","author":"M Selikhova","year":"2009","unstructured":"Selikhova M, Williams DR, Kempster PA, Holton JL, Revesz T, Lees AJ (2009) A clinico-pathological study of subtypes in Parkinson's disease. Brain 132:2947\u20132957. https:\/\/doi.org\/10.1093\/brain\/awp234","journal-title":"Brain"},{"key":"914_CR13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.parkreldis.2016.12.006","volume":"37","author":"ST Hirschbichler","year":"2017","unstructured":"Hirschbichler ST, Erro R, Ganos C, Stamelou M, Batla A, Balint B, Bhatia KP (2017) \"Atypical\" atypical parkinsonism: critical appraisal of a cohort. Parkinsonism Relat Disord 37:36\u201342. https:\/\/doi.org\/10.1016\/j.parkreldis.2016.12.006","journal-title":"Parkinsonism Relat Disord"},{"key":"914_CR14","doi-asserted-by":"publisher","unstructured":"Jellinger KA, Attems J (2015) Challenges of multimorbidity of the aging brain: a critical update. Journal of neural transmission (Vienna, Austria : 1996) 122: 505-521 Doi https:\/\/doi.org\/10.1007\/s00702-014-1288-x","DOI":"10.1007\/s00702-014-1288-x"},{"key":"914_CR15","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1093\/brain\/awy146","volume":"141","author":"JL Robinson","year":"2018","unstructured":"Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A et al (2018) Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain 141:2181\u20132193. https:\/\/doi.org\/10.1093\/brain\/awy146","journal-title":"Brain"},{"key":"914_CR16","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1159\/000354670","volume":"13","author":"Y Compta","year":"2014","unstructured":"Compta Y, Parkkinen L, Kempster P, Selikhova M, Lashley T, Holton JL, Lees AJ, Revesz T (2014) The significance of alpha-synuclein, amyloid-beta and tau pathologies in Parkinson's disease progression and related dementia. Neurodegener Dis 13:154\u2013156. https:\/\/doi.org\/10.1159\/000354670","journal-title":"Neurodegener Dis"},{"key":"914_CR17","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1002\/ana.23659","volume":"72","author":"DJ Irwin","year":"2012","unstructured":"Irwin DJ, White MT, Toledo JB, Xie SX, Robinson JL, Van Deerlin V, Lee VM, Leverenz JB, Montine TJ, Duda JE et al (2012) Neuropathologic substrates of Parkinson disease dementia. Ann Neurol 72:587\u2013598. https:\/\/doi.org\/10.1002\/ana.23659","journal-title":"Ann Neurol"},{"key":"914_CR18","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1093\/jnen\/nlw070","volume":"75","author":"DH Hepp","year":"2016","unstructured":"Hepp DH, Vergoossen DL, Huisman E, Lemstra AW, Berendse HW, Rozemuller AJ, Foncke EM, van de Berg WD (2016) Distribution and load of amyloid-beta pathology in Parkinson disease and dementia with Lewy bodies. J Neuropathol Exp Neurol 75:936\u2013945. https:\/\/doi.org\/10.1093\/jnen\/nlw070","journal-title":"J Neuropathol Exp Neurol"},{"key":"914_CR19","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE et al (2015) MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord 30:1591\u20131601. https:\/\/doi.org\/10.1002\/mds.26424","journal-title":"Mov Disord"},{"key":"914_CR20","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","volume":"65","author":"IG McKeith","year":"2005","unstructured":"McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK et al (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology 65:1863\u20131872. https:\/\/doi.org\/10.1212\/01.wnl.0000187889.17253.b1","journal-title":"Neurology"},{"key":"914_CR21","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/s1474-4422(09)70238-8","volume":"8","author":"DW Dickson","year":"2009","unstructured":"Dickson DW, Braak H, Duda JE, Duyckaerts C, Gasser T, Halliday GM, Hardy J, Leverenz JB, Del Tredici K, Wszolek ZK et al (2009) Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol 8:1150\u20131157. https:\/\/doi.org\/10.1016\/s1474-4422(09)70238-8","journal-title":"Lancet Neurol"},{"key":"914_CR22","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","volume":"71","author":"S Gilman","year":"2008","unstructured":"Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Durr A, Fowler CJ et al (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670\u2013676","journal-title":"Neurology"},{"key":"914_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1212\/WNL.47.1.1","volume":"47","author":"I Litvan","year":"1996","unstructured":"Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz CG, Golbe LI, Grafman J, Growdon JH et al (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47:1\u20139","journal-title":"Neurology"},{"key":"914_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","volume":"123","author":"TJ Montine","year":"2012","unstructured":"Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS et al (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol 123:1\u201311","journal-title":"Acta Neuropathol"},{"key":"914_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-009-0612-2","volume":"119","author":"IR Mackenzie","year":"2010","unstructured":"Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE et al (2010) Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol 119:1\u20134","journal-title":"Acta Neuropathol"},{"key":"914_CR26","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00401-009-0523-2","volume":"117","author":"I Alafuzoff","year":"2009","unstructured":"Alafuzoff I, Ince PG, Arzberger T, Al-Sarraj S, Bell J, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E et al (2009) Staging\/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe consortium. Acta Neuropathol 117:635\u2013652. https:\/\/doi.org\/10.1007\/s00401-009-0523-2","journal-title":"Acta Neuropathol"},{"key":"914_CR27","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","volume":"55","author":"AJ Hughes","year":"1992","unstructured":"Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181\u2013184","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"914_CR28","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1212\/WNL.42.6.1142","volume":"42","author":"AJ Hughes","year":"1992","unstructured":"Hughes AJ, Ben-Shlomo Y, Daniel SE, Lees AJ (1992) What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. Neurology 42:1142\u20131146","journal-title":"Neurology"},{"key":"914_CR29","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00401-002-0555-3","volume":"104","author":"H Mori","year":"2002","unstructured":"Mori H, Oda M, Komori T, Arai N, Takanashi M, Mizutani T, Hirai S, Mizuno Y (2002) Lewy bodies in progressive supranuclear palsy. Acta Neuropathol 104:273\u2013278. https:\/\/doi.org\/10.1007\/s00401-002-0555-3","journal-title":"Acta Neuropathol"},{"key":"914_CR30","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1093\/brain\/awv114","volume":"138","author":"MD Cykowski","year":"2015","unstructured":"Cykowski MD, Coon EA, Powell SZ, Jenkins SM, Benarroch EE, Low PA, Schmeichel AM, Parisi JE (2015) Expanding the spectrum of neuronal pathology in multiple system atrophy. Brain 138:2293\u20132309. https:\/\/doi.org\/10.1093\/brain\/awv114","journal-title":"Brain"},{"key":"914_CR31","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1046\/j.1365-2990.2003.00432.x","volume":"29","author":"H Braak","year":"2003","unstructured":"Braak H, Rub U, Del Tredici K (2003) Involvement of precerebellar nuclei in multiple system atrophy. Neuropathol Appl Neurobiol 29:60\u201376. https:\/\/doi.org\/10.1046\/j.1365-2990.2003.00432.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"914_CR32","doi-asserted-by":"crossref","unstructured":"Ozawa T (2004) The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Brain 127(12):2657\u201371.","DOI":"10.1093\/brain\/awh303"},{"key":"914_CR33","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00401-007-0227-4","volume":"114","author":"KA Jellinger","year":"2007","unstructured":"Jellinger KA (2007) More frequent Lewy bodies but less frequent Alzheimer-type lesions in multiple system atrophy as compared to age-matched control brains. Acta Neuropathol 114:299\u2013303. https:\/\/doi.org\/10.1007\/s00401-007-0227-4","journal-title":"Acta Neuropathol"},{"key":"914_CR34","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s13195-014-0077-y","volume":"6","author":"M Swirski","year":"2014","unstructured":"Swirski M, Miners JS, de Silva R, Lashley T, Ling H, Holton J, Revesz T, Love S (2014) Evaluating the relationship between amyloid-beta and alpha-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease. Alzheimers Res Ther 6:77. https:\/\/doi.org\/10.1186\/s13195-014-0077-y","journal-title":"Alzheimers Res Ther"},{"key":"914_CR35","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/j.1471-4159.2012.07847.x","volume":"122","author":"K Ono","year":"2012","unstructured":"Ono K, Takahashi R, Ikeda T, Yamada M (2012) Cross-seeding effects of amyloid \u03b2-protein and \u03b1-synuclein. J Neurochem 122:883\u2013890. https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07847.x","journal-title":"J Neurochem"},{"key":"914_CR36","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00401-017-1709-7","volume":"134","author":"TL Spires-Jones","year":"2017","unstructured":"Spires-Jones TL, Attems J, Thal DR (2017) Interactions of pathological proteins in neurodegenerative diseases. Acta Neuropathol 134:187\u2013205. https:\/\/doi.org\/10.1007\/s00401-017-1709-7","journal-title":"Acta Neuropathol"},{"key":"914_CR37","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000441421","volume":"16","author":"SN Gomperts","year":"2016","unstructured":"Gomperts SN, Marquie M, Locascio JJ, Bayer S, Johnson KA, Growdon JH (2016) PET Radioligands reveal the basis of dementia in Parkinson's disease and dementia with Lewy bodies. Neurodegener Dis 16:118\u2013124. https:\/\/doi.org\/10.1159\/000441421","journal-title":"Neurodegener Dis"},{"key":"914_CR38","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1093\/brain\/awq158","volume":"133","author":"RG Brown","year":"2010","unstructured":"Brown RG, Lacomblez L, Landwehrmeyer BG, Bak T, Uttner I, Dubois B, Agid Y, Ludolph A, Bensimon G, Payan C et al (2010) Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain 133:2382\u20132393. https:\/\/doi.org\/10.1093\/brain\/awq158","journal-title":"Brain"},{"key":"914_CR39","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/mds.21956","volume":"23","author":"MA Hely","year":"2008","unstructured":"Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG (2008) The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov Disord 23:837\u2013844. https:\/\/doi.org\/10.1002\/mds.21956","journal-title":"Mov Disord"},{"key":"914_CR40","doi-asserted-by":"publisher","unstructured":"Postuma RB, Poewe W, Litvan I, Lewis S, Lang AE, Halliday G, Goetz CG, Chan P, Slow E, Seppi K et al (2018) Validation of the MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord: Doi. https:\/\/doi.org\/10.1002\/mds.27362","DOI":"10.1002\/mds.27362"},{"key":"914_CR41","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1046\/j.0305-1846.2001.00342.x","volume":"27","author":"L Parkkinen","year":"2001","unstructured":"Parkkinen L, Soininen H, Laakso M, Alafuzoff I (2001) Alpha-synuclein pathology is highly dependent on the case selection. Neuropathol Appl Neurobiol 27:314\u2013325","journal-title":"Neuropathol Appl Neurobiol"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-020-00914-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40478-020-00914-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-020-00914-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:08:30Z","timestamp":1616717310000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-020-00914-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,26]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["914"],"URL":"https:\/\/doi.org\/10.1186\/s40478-020-00914-9","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,26]]},"assertion":[{"value":"6 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"For all donors, a written informed consent for brain autopsy and the use of the material and clinical information for research purposes has been obtained from the donor or the next of kin. Donation procedures of brain material for scientific research purposes by the NBB have been approved by the Independent Review Board of the VU University Medical Center, IRB number IRB00002991.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"39"}}