{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:12:28Z","timestamp":1792019548574,"version":"4.4.0"},"reference-count":126,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1R01NS121246"],"award-info":[{"award-number":["1R01NS121246"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traumatic brain injury (TBI) survivors face debilitating long-term psychosocial consequences, including social isolation and depression. TBI modifies neurovascular physiology and behavior but the chronic physiological implications of altered brain perfusion on social interactions are unknown. Adult C57\/BL6 male mice received a moderate cortical TBI, and social behaviors were assessed at baseline, 3-, 7-, 14-, 30-, and 60-days post injury (dpi). Magnetic resonance imaging (MRI, 9.4T) using dynamic susceptibility contrast perfusion weighted MRI were acquired. At 60dpi mice underwent histological angioarchitectural mapping. Analysis utilized standardized protocols followed by cross-correlation metrics. Social behavior deficits at 60dpi emerged as reduced interactions with a familiar cage-mate (partner) that mirrored significant reductions in cerebral blood flow (CBF) at 60dpi. CBF perturbations were dynamic temporally and across brain regions including regions known to regulate social behavior such as hippocampus, hypothalamus, and rhinal cortex. Social isolation in TBI-mice emerged with a significant decline in preference to spend time with a cage mate. Cortical vascular density was also reduced corroborating the decline in brain perfusion and social interactions. Thus, the late emergence of social interaction deficits mirrored the reduced vascular density and CBF in regions known to be involved in social behaviors. Vascular morphology and function improved prior to the late decrements in social function and our correlations strongly implicate a linkage between vascular density, cerebral perfusion, and social interactions. Our study provides a clinically relevant timeline of alterations in social deficits alongside functional vascular recovery that can guide future therapeutics.<\/jats:p>","DOI":"10.1186\/s40478-024-01840-w","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T03:32:42Z","timestamp":1723001562000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Social deficits mirror delayed cerebrovascular dysfunction after traumatic brain injury"],"prefix":"10.1186","volume":"12","author":[{"given":"Aditya","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-6950","authenticated-orcid":false,"given":"Andre","family":"Obenaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"1840_CR1","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.3171\/2017.10.JNS17352","volume":"130","author":"MC Dewan","year":"2018","unstructured":"Dewan MC et al (2018) Estimating the global incidence of traumatic brain injury. J Neurosurg 130:1080\u20131097. https:\/\/doi.org\/10.3171\/2017.10.JNS17352","journal-title":"J Neurosurg"},{"key":"1840_CR2","doi-asserted-by":"publisher","first-page":"105613","DOI":"10.1016\/j.nbd.2022.105613","volume":"164","author":"MO Blaya","year":"2022","unstructured":"Blaya MO, Raval AP, Bramlett HM (2022) Traumatic brain injury in women across lifespan. Neurobiol Dis 164:105613. https:\/\/doi.org\/10.1016\/j.nbd.2022.105613","journal-title":"Neurobiol Dis"},{"key":"1840_CR3","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1042\/CS20120259","volume":"124","author":"D M. Bailey","year":"2013","unstructured":"M. Bailey D et al (2013) Impaired cerebral haemodynamic function associated with chronic traumatic brain injury in professional boxers. Clin Sci (Lond) 124:177\u2013189. https:\/\/doi.org\/10.1042\/CS20120259","journal-title":"Clin Sci (Lond)"},{"key":"1840_CR4","doi-asserted-by":"publisher","unstructured":"McKee AC, Robinson ME (2014) Military-related traumatic brain injury and neurodegeneration. Alzheimers Dement 10:S242\u2013253. https:\/\/doi.org\/10.1016\/j.jalz.2014.04.003","DOI":"10.1016\/j.jalz.2014.04.003"},{"key":"1840_CR5","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41582-023-00853-8","volume":"19","author":"LM Li","year":"2023","unstructured":"Li LM, Carson A, Dams-O\u2019Connor K (2023) Psychiatric sequelae of traumatic brain injury - future directions in research. Nat Rev Neurol 19:556\u2013571. https:\/\/doi.org\/10.1038\/s41582-023-00853-8","journal-title":"Nat Rev Neurol"},{"key":"1840_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/B978-0-444-52892-6.00004-0","volume":"127","author":"AC McKee","year":"2015","unstructured":"McKee AC, Daneshvar DH (2015) The neuropathology of traumatic brain injury. Handb Clin Neurol 127:45\u201366. https:\/\/doi.org\/10.1016\/B978-0-444-52892-6.00004-0","journal-title":"Handb Clin Neurol"},{"key":"1840_CR7","doi-asserted-by":"crossref","unstructured":"Obenaus A (2023) in Encyclopedia of Mental Health. pp. 519\u2013534","DOI":"10.1016\/B978-0-323-91497-0.00239-3"},{"key":"1840_CR8","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.jad.2022.01.024","volume":"300","author":"F Chen","year":"2022","unstructured":"Chen F et al (2022) Prevalence of suicidal ideation and suicide attempt among patients with traumatic brain injury: a meta-analysis. J Affect Disord 300:349\u2013357. https:\/\/doi.org\/10.1016\/j.jad.2022.01.024","journal-title":"J Affect Disord"},{"key":"1840_CR9","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1111\/j.1468-1331.2009.02945.x","volume":"17","author":"M Rousseaux","year":"2010","unstructured":"Rousseaux M, Verigneaux C, Kozlowski O (2010) An analysis of communication in conversation after severe traumatic brain injury. Eur J Neurol 17:922\u2013929. https:\/\/doi.org\/10.1111\/j.1468-1331.2009.02945.x","journal-title":"Eur J Neurol"},{"key":"1840_CR10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/026990501300005659","volume":"15","author":"D Hoofien","year":"2001","unstructured":"Hoofien D, Gilboa A, Vakil E, Donovick P.J. (2001) Traumatic brain injury (TBI) 10\u201320 years later: a comprehensive outcome study of psychiatric symptomatology, cognitive abilities and psychosocial functioning. Brain Inj 15:189\u2013209. https:\/\/doi.org\/10.1080\/026990501300005659","journal-title":"Brain Inj"},{"key":"1840_CR11","doi-asserted-by":"publisher","unstructured":"Rigon A, Duff MC, Beadle J (2019) Lonely But Not Alone: Neuroticism Mediates the Relationship Between Social Network Size and Loneliness in Individuals With Traumatic Brain Injury. J Int Neuropsychol Soc 25:285\u2013292. https:\/\/doi.org\/10.1017\/S1355617718001108","DOI":"10.1017\/S1355617718001108"},{"key":"1840_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/026990598122755","volume":"12","author":"TK Andrews","year":"1998","unstructured":"Andrews TK, Rose FD, Johnson DA (1998) Social and behavioural effects of traumatic brain injury in children. Brain Inj 12:133\u2013138. https:\/\/doi.org\/10.1080\/026990598122755","journal-title":"Brain Inj"},{"key":"1840_CR13","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1089\/neu.2022.0420","volume":"40","author":"N Khan","year":"2023","unstructured":"Khan N et al (2023) Associations between peer relationships and Self-Esteem after Childhood Traumatic Brain Injury: exploring the Mediating role of loneliness. J Neurotrauma 40:2100\u20132109. https:\/\/doi.org\/10.1089\/neu.2022.0420","journal-title":"J Neurotrauma"},{"key":"1840_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/HTR.0b013e3182068588","volume":"26","author":"AM Sander","year":"2011","unstructured":"Sander AM, Struchen MA (2011) Interpersonal relationships and traumatic brain injury. J Head Trauma Rehabil 26:1\u20133. https:\/\/doi.org\/10.1097\/HTR.0b013e3182068588","journal-title":"J Head Trauma Rehabil"},{"key":"1840_CR15","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1080\/09602011.2016.1247730","volume":"28","author":"CE Salas","year":"2018","unstructured":"Salas CE, Casassus M, Rowlands L, Pimm S, Flanagan DAJ (2018) Relating through sameness: a qualitative study of friendship and social isolation in chronic traumatic brain injury. Neuropsychol Rehabil 28:1161\u20131178. https:\/\/doi.org\/10.1080\/09602011.2016.1247730","journal-title":"Neuropsychol Rehabil"},{"key":"1840_CR16","doi-asserted-by":"publisher","first-page":"e0151418","DOI":"10.1371\/journal.pone.0151418","volume":"11","author":"A Chou","year":"2016","unstructured":"Chou A, Morganti JM, Rosi S (2016) Frontal lobe contusion in mice chronically impairs prefrontal-dependent behavior. PLoS ONE 11:e0151418. https:\/\/doi.org\/10.1371\/journal.pone.0151418","journal-title":"PLoS ONE"},{"key":"1840_CR17","doi-asserted-by":"publisher","first-page":"104713","DOI":"10.1016\/j.nbd.2019.104713","volume":"136","author":"RM Ritzel","year":"2020","unstructured":"Ritzel RM et al (2020) Sustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injury. Neurobiol Dis 136:104713. https:\/\/doi.org\/10.1016\/j.nbd.2019.104713","journal-title":"Neurobiol Dis"},{"key":"1840_CR18","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1089\/neu.2018.5731","volume":"35","author":"A Nolan","year":"2018","unstructured":"Nolan A et al (2018) Repeated mild Head Injury leads to wide-ranging deficits in higher-Order Cognitive functions Associated with the Prefrontal Cortex. J Neurotrauma 35:2425\u20132434. https:\/\/doi.org\/10.1089\/neu.2018.5731","journal-title":"J Neurotrauma"},{"key":"1840_CR19","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1089\/neu.2018.6314","volume":"36","author":"M Algamal","year":"2019","unstructured":"Algamal M et al (2019) Impact of repetitive mild traumatic brain Injury on behavioral and hippocampal deficits in a mouse model of chronic stress. J Neurotrauma 36:2590\u20132607. https:\/\/doi.org\/10.1089\/neu.2018.6314","journal-title":"J Neurotrauma"},{"key":"1840_CR20","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1089\/neu.2012.2595","volume":"29","author":"BD Semple","year":"2012","unstructured":"Semple BD, Canchola SA, Noble-Haeusslein LJ (2012) Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice. J Neurotrauma 29:2672\u20132683. https:\/\/doi.org\/10.1089\/neu.2012.2595","journal-title":"J Neurotrauma"},{"key":"1840_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbr.2014.09.034","volume":"278","author":"B Khodaie","year":"2015","unstructured":"Khodaie B et al (2015) Structural and functional effects of social isolation on the hippocampus of rats with traumatic brain injury. Behav Brain Res 278:55\u201365. https:\/\/doi.org\/10.1016\/j.bbr.2014.09.034","journal-title":"Behav Brain Res"},{"key":"1840_CR22","doi-asserted-by":"publisher","unstructured":"Doulames VM, Vilcans M, Lee S, Shea TB (2015) Social interaction attenuates the extent of secondary neuronal damage following closed head injury in mice. Front Behav Neurosci 9(275). https:\/\/doi.org\/10.3389\/fnbeh.2015.00275","DOI":"10.3389\/fnbeh.2015.00275"},{"key":"1840_CR23","doi-asserted-by":"publisher","unstructured":"Obenaus A et al (2017) Traumatic brain injury results in acute rarefication of the vascular network. Sci Rep 7(239). https:\/\/doi.org\/10.1038\/s41598-017-00161-4","DOI":"10.1038\/s41598-017-00161-4"},{"key":"1840_CR24","doi-asserted-by":"publisher","first-page":"3550","DOI":"10.1093\/brain\/awz290","volume":"142","author":"AD Griffin","year":"2019","unstructured":"Griffin AD et al (2019) Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Brain 142:3550\u20133564. https:\/\/doi.org\/10.1093\/brain\/awz290","journal-title":"Brain"},{"key":"1840_CR25","doi-asserted-by":"publisher","unstructured":"Lin X et al (2022) Longitudinal dynamics of microvascular recovery after acquired cortical injury. Acta Neuropathol Commun 10(59). https:\/\/doi.org\/10.1186\/s40478-022-01361-4","DOI":"10.1186\/s40478-022-01361-4"},{"key":"1840_CR26","doi-asserted-by":"publisher","unstructured":"Rodr\u00edguez-Baeza A, Reina-de la Torre F, Poca A, Mart\u00ed M, Garnacho A (2003) Morphological features in human cortical brain microvessels after head injury: a three-dimensional and immunocytochemical study. Anat Rec A Discov Mol Cell Evol Biol 273:583\u2013593. https:\/\/doi.org\/10.1002\/ar.a.10069","DOI":"10.1002\/ar.a.10069"},{"key":"1840_CR27","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1089\/neu.2013.3187","volume":"31","author":"GX Yu","year":"2014","unstructured":"Yu GX et al (2014) Traumatic brain injury in vivo and in vitro contributes to cerebral vascular dysfunction through impaired gap junction communication between vascular smooth muscle cells. J Neurotrauma 31:739\u2013748. https:\/\/doi.org\/10.1089\/neu.2013.3187","journal-title":"J Neurotrauma"},{"key":"1840_CR28","doi-asserted-by":"publisher","first-page":"102086","DOI":"10.1016\/j.nicl.2019.102086","volume":"25","author":"F Amyot","year":"2020","unstructured":"Amyot F et al (2020) Assessment of cerebrovascular dysfunction after traumatic brain injury with fMRI and fNIRS. Neuroimage Clin 25:102086. https:\/\/doi.org\/10.1016\/j.nicl.2019.102086","journal-title":"Neuroimage Clin"},{"key":"1840_CR29","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1089\/neu.2008.0797","volume":"26","author":"EP Wei","year":"2009","unstructured":"Wei EP, Hamm RJ, Baranova AI, Povlishock JT (2009) The long-term microvascular and behavioral consequences of experimental traumatic brain injury after hypothermic intervention. J Neurotrauma 26:527\u2013537. https:\/\/doi.org\/10.1089\/neu.2008.0797","journal-title":"J Neurotrauma"},{"key":"1840_CR30","doi-asserted-by":"publisher","unstructured":"Xu X et al (2021) Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes. Acta Neuropathol Commun 9:60. https:\/\/doi.org\/10.1186\/s40478-021-01161-2","DOI":"10.1186\/s40478-021-01161-2"},{"key":"1840_CR31","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1089\/neu.2010.1448","volume":"27","author":"NM Hayward","year":"2010","unstructured":"Hayward NM et al (2010) Association of chronic vascular changes with functional outcome after traumatic brain injury in rats. J Neurotrauma 27:2203\u20132219. https:\/\/doi.org\/10.1089\/neu.2010.1448","journal-title":"J Neurotrauma"},{"key":"1840_CR32","doi-asserted-by":"publisher","unstructured":"Wang Y, Yu S, Li M (2023) Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders. Front Cell Neurosci 17(1226580). https:\/\/doi.org\/10.3389\/fncel.2023.1226580","DOI":"10.3389\/fncel.2023.1226580"},{"key":"1840_CR33","doi-asserted-by":"publisher","unstructured":"Paloyelis Y et al (2016) A Spatiotemporal Profile of In Vivo Cerebral Blood Flow Changes Following Intranasal Oxytocin in Humans. Biol Psychiatry 79:693\u2013705. https:\/\/doi.org\/10.1016\/j.biopsych.2014.10.005","DOI":"10.1016\/j.biopsych.2014.10.005"},{"key":"1840_CR34","doi-asserted-by":"publisher","unstructured":"Knudsen LV, Sheldrick AJ, Vafaee MS, Michel TM (2023) Diversifying autism neuroimaging research: An arterial spin labeling review. Autism 27:1190\u20131203. https:\/\/doi.org\/10.1177\/13623613221137230","DOI":"10.1177\/13623613221137230"},{"key":"1840_CR35","doi-asserted-by":"publisher","unstructured":"Salehi A et al (2018) A Novel Technique for Visualizing and Analyzing the Cerebral Vasculature in Rodents. Transl Stroke Res. https:\/\/doi.org\/10.1007\/s12975-018-0632-0","DOI":"10.1007\/s12975-018-0632-0"},{"key":"1840_CR36","doi-asserted-by":"publisher","first-page":"e2601","DOI":"10.21769\/BioProtoc.2601","volume":"7","author":"A Singh","year":"2017","unstructured":"Singh A, Balaji J (2017) Sensitive estimation of Flavor preferences in STFP using cumulative time profiles. Bio Protoc 7:e2601. https:\/\/doi.org\/10.21769\/BioProtoc.2601","journal-title":"Bio Protoc"},{"key":"1840_CR37","doi-asserted-by":"publisher","unstructured":"Crawley JN (2023) Twenty years of discoveries emerging from mouse models of autism. Neurosci Biobehav Rev 146:105053. https:\/\/doi.org\/10.1016\/j.neubiorev.2023.105053","DOI":"10.1016\/j.neubiorev.2023.105053"},{"key":"1840_CR38","doi-asserted-by":"publisher","unstructured":"Schindelin J et al (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676\u2013682. https:\/\/doi.org\/10.1038\/nmeth.2019","DOI":"10.1038\/nmeth.2019"},{"key":"1840_CR39","doi-asserted-by":"publisher","unstructured":"Chiara V, Kim SY (2023) AnimalTA: A highly flexible and easy-to\u2010use program for tracking and analysing animal movement in different environments. Methods in Ecology and Evolution 14:1699\u20131707. https:\/\/doi.org\/10.1111\/2041-210x.14115","DOI":"10.1111\/2041-210x.14115"},{"key":"1840_CR40","doi-asserted-by":"publisher","unstructured":"Singh A, Kumar S, Singh VP, Das A, Balaji J (2017) Flavor Dependent Retention of Remote Food Preference Memory. Front Behav Neurosci 11:7. https:\/\/doi.org\/10.3389\/fnbeh.2017.00007","DOI":"10.3389\/fnbeh.2017.00007"},{"key":"1840_CR41","doi-asserted-by":"publisher","unstructured":"Friard O, Gamba M, Fitzjohn R (2016) BORIS: a free, versatile open-source event\u2010logging software for video\/audio coding and live observations. Methods in Ecology and Evolution 7:1325\u20131330. https:\/\/doi.org\/10.1111\/2041-210x.12584","DOI":"10.1111\/2041-210x.12584"},{"key":"1840_CR42","doi-asserted-by":"publisher","unstructured":"Salehi A et al (2023) Vascular topology and blood flow are acutely impacted by experimental febrile status epilepticus. J Cereb Blood Flow Metab 43:84\u201398. https:\/\/doi.org\/10.1177\/0271678X221117625","DOI":"10.1177\/0271678X221117625"},{"key":"1840_CR43","doi-asserted-by":"publisher","unstructured":"Parker GJ et al (2006) Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. Magn Reson Med 56:993\u20131000. https:\/\/doi.org\/10.1002\/mrm.21066","DOI":"10.1002\/mrm.21066"},{"key":"1840_CR44","doi-asserted-by":"publisher","first-page":"207","DOI":"10.2214\/ajr.175.1.1750207)","volume":"175","author":"JR Petrella","year":"2000","unstructured":"Petrella JR, Provenzale JM (2000) MR perfusion imaging of the brain: techniques and applications. Am J Roentgenol 175:207\u2013219. https:\/\/doi.org\/10.2214\/ajr.175.1.1750207)","journal-title":"Am J Roentgenol"},{"key":"1840_CR45","doi-asserted-by":"publisher","unstructured":"Zudaire E, Gambardella L, Kurcz C, Vermeren S (2011) A computational tool for quantitative analysis of vascular networks. PLoS One 6:e27385. https:\/\/doi.org\/10.1371\/journal.pone.0027385","DOI":"10.1371\/journal.pone.0027385"},{"key":"1840_CR46","doi-asserted-by":"publisher","unstructured":"Usui N (2024) Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality. Anat Sci Int 99:34\u201347. https:\/\/doi.org\/10.1007\/s12565-023-00747-1","DOI":"10.1007\/s12565-023-00747-1"},{"key":"1840_CR47","doi-asserted-by":"publisher","unstructured":"Morton MV, Wehman P (1995) Psychosocial and emotional sequelae of individuals with traumatic brain injury: a literature review and recommendations. Brain Inj 9:81\u201392. https:\/\/doi.org\/10.3109\/02699059509004574","DOI":"10.3109\/02699059509004574"},{"key":"1840_CR48","doi-asserted-by":"publisher","unstructured":"Lopez DA et al (2022) Association between mild traumatic brain injury, brain structure, and mental health outcomes in the Adolescent Brain Cognitive Development Study. Neuroimage 263:119626. https:\/\/doi.org\/10.1016\/j.neuroimage.2022.119626","DOI":"10.1016\/j.neuroimage.2022.119626"},{"key":"1840_CR49","doi-asserted-by":"publisher","unstructured":"Knox L, Douglas J (2009) Long-term ability to interpret facial expression after traumatic brain injury and its relation to social integration. Brain Cogn 69:442\u2013449. https:\/\/doi.org\/10.1016\/j.bandc.2008.09.009","DOI":"10.1016\/j.bandc.2008.09.009"},{"key":"1840_CR50","doi-asserted-by":"publisher","unstructured":"Rigon A, Voss MW, Turkstra LS, Mutlu B, Duff MC (2018) Different aspects of facial affect recognition impairment following traumatic brain injury: The role of perceptual and interpretative abilities. J Clin Exp Neuropsychol 40:805\u2013819. https:\/\/doi.org\/10.1080\/13803395.2018.1437120","DOI":"10.1080\/13803395.2018.1437120"},{"key":"1840_CR51","doi-asserted-by":"publisher","unstructured":"de Sousa A et al (2011) Understanding deficits in empathy after traumatic brain injury: The role of affective responsivity. Cortex 47:526\u2013535. https:\/\/doi.org\/10.1016\/j.cortex.2010.02.004","DOI":"10.1016\/j.cortex.2010.02.004"},{"key":"1840_CR52","doi-asserted-by":"publisher","unstructured":"Kim Y et al (2015) Mapping social behavior-induced brain activation at cellular resolution in the mouse. Cell Rep 10:292\u2013305. https:\/\/doi.org\/10.1016\/j.celrep.2014.12.014","DOI":"10.1016\/j.celrep.2014.12.014"},{"key":"1840_CR53","doi-asserted-by":"publisher","unstructured":"Miura I et al (2020) Imaging the Neural Circuit Basis of Social Behavior: Insights from Mouse and Human Studies. Neurol Med Chir (Tokyo) 60:429\u2013438. https:\/\/doi.org\/10.2176\/nmc.ra.2020-0088","DOI":"10.2176\/nmc.ra.2020-0088"},{"key":"1840_CR54","doi-asserted-by":"publisher","unstructured":"Vitale EM, Smith AS (2022) Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives. Front Behav Neurosci 16:846315. https:\/\/doi.org\/10.3389\/fnbeh.2022.846315","DOI":"10.3389\/fnbeh.2022.846315"},{"key":"1840_CR55","doi-asserted-by":"publisher","unstructured":"Boyko M et al (2022) Traumatic brain injury-induced submissive behavior in rats: link to depression and anxiety. Transl Psychiatry 12:239. https:\/\/doi.org\/10.1038\/s41398-022-01991-1","DOI":"10.1038\/s41398-022-01991-1"},{"key":"1840_CR56","doi-asserted-by":"publisher","unstructured":"Eyolfson E et al (2020) Repetitive Mild Traumatic Brain Injuries in Mice during Adolescence Cause Sexually Dimorphic Behavioral Deficits and Neuroinflammatory Dynamics. J Neurotrauma 37:2718\u20132732. https:\/\/doi.org\/10.1089\/neu.2020.7195","DOI":"10.1089\/neu.2020.7195"},{"key":"1840_CR57","doi-asserted-by":"publisher","unstructured":"Bajwa NM et al (2016) Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice. PLoS One 11:e0146886. https:\/\/doi.org\/10.1371\/journal.pone.0146886","DOI":"10.1371\/journal.pone.0146886"},{"key":"1840_CR58","doi-asserted-by":"publisher","unstructured":"Wood RL, Thomas RH (2013) Impulsive and episodic disorders of aggressive behaviour following traumatic brain injury. Brain Inj 27:253\u2013261. https:\/\/doi.org\/10.3109\/02699052.2012.743181","DOI":"10.3109\/02699052.2012.743181"},{"key":"1840_CR59","doi-asserted-by":"publisher","unstructured":"Ozga-Hess JE, Whirtley C, O\u2019Hearn C, Pechacek K, Vonder C, Haar (2020) Unilateral parietal brain injury increases risk-taking on a rat gambling task. Exp Neurol 327:113217. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113217","DOI":"10.1016\/j.expneurol.2020.113217"},{"key":"1840_CR60","doi-asserted-by":"publisher","unstructured":"Bhatti JA, Thiruchelvam D, Redelmeier DA (2019) Traumatic brain injury as an independent risk factor for problem gambling: a matched case-control study. Soc Psychiatry Psychiatr Epidemiol 54:517\u2013523. https:\/\/doi.org\/10.1007\/s00127-018-1583-1","DOI":"10.1007\/s00127-018-1583-1"},{"key":"1840_CR61","doi-asserted-by":"publisher","unstructured":"Rostowsky KA, Irimia A (2021) I. for the Alzheimer\u2019s Disease Neuroimaging, Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer\u2019s disease. GeroScience 43:2015\u20132039. https:\/\/doi.org\/10.1007\/s11357-021-00355-9","DOI":"10.1007\/s11357-021-00355-9"},{"key":"1840_CR62","doi-asserted-by":"publisher","unstructured":"Madsen T et al (2018) Association Between Traumatic Brain Injury and Risk of Suicide. JAMA 320:580\u2013588. https:\/\/doi.org\/10.1001\/jama.2018.10211","DOI":"10.1001\/jama.2018.10211"},{"key":"1840_CR63","doi-asserted-by":"publisher","unstructured":"Engstrom A, Soderberg S (2011) Transition as experienced by close relatives of people with traumatic brain injury. J Neurosci Nurs 43:253\u2013260. https:\/\/doi.org\/10.1097\/JNN.0b013e318227ef9b","DOI":"10.1097\/JNN.0b013e318227ef9b"},{"key":"1840_CR64","doi-asserted-by":"publisher","unstructured":"Gordon WA, Cantor J, Kristen DO, Tsaousides T (2015) Long-term social integration and community support. Handb Clin Neurol 127:423\u2013431. https:\/\/doi.org\/10.1016\/B978-0-444-52892-6.00027-1","DOI":"10.1016\/B978-0-444-52892-6.00027-1"},{"key":"1840_CR65","doi-asserted-by":"publisher","unstructured":"Silverman JL, Yang M, Lord C, Crawley JN (2010) Behavioural phenotyping assays for mouse models of autism. Nat Rev Neurosci 11:490\u2013502. https:\/\/doi.org\/10.1038\/nrn2851","DOI":"10.1038\/nrn2851"},{"key":"1840_CR66","doi-asserted-by":"publisher","unstructured":"Mobbs D, Trimmer PC, Blumstein DT, Dayan P (2018) Foraging for foundations in decision neuroscience: insights from ethology. Nat Rev Neurosci 19:419\u2013427. https:\/\/doi.org\/10.1038\/s41583-018-0010-7","DOI":"10.1038\/s41583-018-0010-7"},{"key":"1840_CR67","doi-asserted-by":"publisher","unstructured":"Leconte C et al (2020) Histological and Behavioral Evaluation after Traumatic Brain Injury in Mice: A Ten Months Follow-Up Study. J Neurotrauma 37:1342\u20131357. https:\/\/doi.org\/10.1089\/neu.2019.6679","DOI":"10.1089\/neu.2019.6679"},{"key":"1840_CR68","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s40141-015-0091-4)","volume":"3","author":"JP Skendelas","year":"2015","unstructured":"Skendelas JP, Muccigrosso M, Eiferman DS, Godbout JP (2015) Chronic inflammation after TBI and Associated behavioral sequelae. Curr Phys Med Rehabilitation Rep 3:115\u2013123. https:\/\/doi.org\/10.1007\/s40141-015-0091-4","journal-title":"Curr Phys Med Rehabilitation Rep"},{"key":"1840_CR69","doi-asserted-by":"publisher","unstructured":"Stoica BA, Faden AI (2010) Cell death mechanisms and modulation in traumatic brain injury. Neurotherapeutics 7:3\u201312. https:\/\/doi.org\/10.1016\/j.nurt.2009.10.023","DOI":"10.1016\/j.nurt.2009.10.023"},{"key":"1840_CR70","doi-asserted-by":"publisher","unstructured":"Papadaki E et al (2021) Cerebral perfusion disturbances in chronic mild traumatic brain injury correlate with psychoemotional outcomes. Brain Imaging Behav 15:1438\u20131449. https:\/\/doi.org\/10.1007\/s11682-020-00343-1","DOI":"10.1007\/s11682-020-00343-1"},{"key":"1840_CR71","doi-asserted-by":"publisher","unstructured":"Kaplan L, Chow BW, Gu C (2020) Neuronal regulation of the blood-brain barrier and neurovascular coupling. Nat Rev Neurosci 21:416\u2013432. https:\/\/doi.org\/10.1038\/s41583-020-0322-2","DOI":"10.1038\/s41583-020-0322-2"},{"key":"1840_CR72","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<47::AID-HIPO5>3.0.CO;2-6","volume":"10","author":"JH Kogan","year":"2000","unstructured":"Kogan JH, Franklandand PW, Silva AJ (2000) Long-term memory underlying hippocampus-dependent social recognition in mice. Hippocampus 10(1):47\u201356. https:\/\/doi.org\/10.1002\/(SICI)1098-1063(2000)10:1%3c47::AID-HIPO5%3e3.0.CO;2-6","journal-title":"Hippocampus"},{"key":"1840_CR73","doi-asserted-by":"publisher","unstructured":"Tanimizu T et al (2017) Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition Memory. J Neurosci 37:4103\u20134116. https:\/\/doi.org\/10.1523\/JNEUROSCI.3451-16.2017","DOI":"10.1523\/JNEUROSCI.3451-16.2017"},{"key":"1840_CR74","doi-asserted-by":"publisher","unstructured":"Kim J et al (2012) A perfusion fMRI study of the neural correlates of sustained-attention and working-memory deficits in chronic traumatic brain injury. Neurorehabil Neural Repair 26:870\u2013880. https:\/\/doi.org\/10.1177\/1545968311434553","DOI":"10.1177\/1545968311434553"},{"key":"1840_CR75","doi-asserted-by":"publisher","unstructured":"Strange BA, Witter MP, Lein ES, Moser EI (2014) Functional organization of the hippocampal longitudinal axis. Nat Rev Neurosci 15:655\u2013669. https:\/\/doi.org\/10.1038\/nrn3785","DOI":"10.1038\/nrn3785"},{"key":"1840_CR76","doi-asserted-by":"publisher","unstructured":"de Leon Reyes NS et al (2023) Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice. Cell 186:4152\u20134171. https:\/\/doi.org\/10.1016\/j.cell.2023.08.010","DOI":"10.1016\/j.cell.2023.08.010"},{"key":"1840_CR77","doi-asserted-by":"publisher","unstructured":"Nolan AL, Sohal VS, Rosi S (2022) Selective Inhibitory Circuit Dysfunction after Chronic Frontal Lobe Contusion. J Neurosci 42:5361\u20135372. https:\/\/doi.org\/10.1523\/JNEUROSCI.0097-22.2022","DOI":"10.1523\/JNEUROSCI.0097-22.2022"},{"key":"1840_CR78","doi-asserted-by":"publisher","unstructured":"Hall ED, Bryant YD, Cho W, Sullivan PG (2008) Evolution of post-traumatic neurodegeneration after controlled cortical impact traumatic brain injury in mice and rats as assessed by the de Olmos silver and fluorojade staining methods. J Neurotrauma 25:235\u2013247. https:\/\/doi.org\/10.1089\/neu.2007.0383","DOI":"10.1089\/neu.2007.0383"},{"key":"1840_CR79","doi-asserted-by":"publisher","unstructured":"Saatman KE, Feeko KJ, Pape RL, Raghupathi R (2006) Differential behavioral and histopathological responses to graded cortical impact injury in mice. J Neurotrauma 23:1241\u20131253. https:\/\/doi.org\/10.1089\/neu.2006.23.1241","DOI":"10.1089\/neu.2006.23.1241"},{"key":"1840_CR80","doi-asserted-by":"publisher","unstructured":"Bonne O et al (2003) Cerebral blood flow in chronic symptomatic mild traumatic brain injury. Psychiatry Res 124:141\u2013152. https:\/\/doi.org\/10.1016\/s0925-4927(03)00109-4","DOI":"10.1016\/s0925-4927(03)00109-4"},{"key":"1840_CR81","doi-asserted-by":"publisher","unstructured":"Furuya Y, Hlatky R, Valadka AB, Diaz P, Robertson CS (2003) Comparison of cerebral blood flow in computed tomographic hypodense areas of the brain in head-injured patients. Neurosurgery 52:340\u2013345; discussion 345\u2013346. https:\/\/doi.org\/10.1227\/01.neu.0000043931.83041.aa","DOI":"10.1227\/01.neu.0000043931.83041.aa"},{"key":"1840_CR82","doi-asserted-by":"publisher","unstructured":"Engel DC et al (2008) Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14\u00a0C-iodoantipyrine autoradiography in mice using a non-invasive protocol. J Neurotrauma 25:739\u2013753. https:\/\/doi.org\/10.1089\/neu.2007.0480","DOI":"10.1089\/neu.2007.0480"},{"key":"1840_CR83","doi-asserted-by":"publisher","unstructured":"Dixon CE et al (1999) One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats. J Neurotrauma 16:109\u2013122. https:\/\/doi.org\/10.1089\/neu.1999.16.109","DOI":"10.1089\/neu.1999.16.109"},{"key":"1840_CR84","doi-asserted-by":"publisher","unstructured":"To XV, Nasrallah FA (2021) A roadmap of brain recovery in a mouse model of concussion: insights from neuroimaging. Acta Neuropathol Commun 9:2. https:\/\/doi.org\/10.1186\/s40478-020-01098-y","DOI":"10.1186\/s40478-020-01098-y"},{"key":"1840_CR85","doi-asserted-by":"publisher","unstructured":"Sharp DJ, Graham NSN (2023) Clinical outcomes evolve years after traumatic brain injury. Nat Rev Neurol 19:579\u2013580. https:\/\/doi.org\/10.1038\/s41582-023-00868-1","DOI":"10.1038\/s41582-023-00868-1"},{"key":"1840_CR86","doi-asserted-by":"publisher","unstructured":"Inoue Y et al (2005) Changes in cerebral blood flow from the acute to the chronic phase of severe head injury. J Neurotrauma 22:1411\u20131418. https:\/\/doi.org\/10.1089\/neu.2005.22.1411","DOI":"10.1089\/neu.2005.22.1411"},{"key":"1840_CR87","doi-asserted-by":"publisher","unstructured":"Hayward NM et al (2011) Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats. J Cereb Blood Flow Metab 31:166\u2013177. https:\/\/doi.org\/10.1038\/jcbfm.2010.67","DOI":"10.1038\/jcbfm.2010.67"},{"key":"1840_CR88","doi-asserted-by":"publisher","unstructured":"Kochanek PM et al (2002) Cerebral blood flow at one year after controlled cortical impact in rats: assessment by magnetic resonance imaging. J Neurotrauma 19:1029\u20131037. https:\/\/doi.org\/10.1089\/089771502760341947","DOI":"10.1089\/089771502760341947"},{"key":"1840_CR89","doi-asserted-by":"publisher","unstructured":"Paydar A, Harris NG (2023) The pericontused cortex can support function early after TBI but it remains functionally isolated from normal afferent input. Exp Neurol 359:114260. https:\/\/doi.org\/10.1016\/j.expneurol.2022.114260","DOI":"10.1016\/j.expneurol.2022.114260"},{"key":"1840_CR90","doi-asserted-by":"publisher","unstructured":"Hilz MJ et al (2017) Severity of traumatic brain injury correlates with long-term cardiovascular autonomic dysfunction. J Neurol 264:1956\u20131967. https:\/\/doi.org\/10.1007\/s00415-017-8581-1","DOI":"10.1007\/s00415-017-8581-1"},{"key":"1840_CR91","doi-asserted-by":"publisher","unstructured":"Sharp DJ, Scott G, Leech R (2014) Network dysfunction after traumatic brain injury. Nat Rev Neurol 10:156\u2013166. https:\/\/doi.org\/10.1038\/nrneurol.2014.15","DOI":"10.1038\/nrneurol.2014.15"},{"key":"1840_CR92","doi-asserted-by":"publisher","unstructured":"Woodrow RE et al (2023) Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury. Brain 146:3484\u20133499. https:\/\/doi.org\/10.1093\/brain\/awad056","DOI":"10.1093\/brain\/awad056"},{"key":"1840_CR93","doi-asserted-by":"publisher","unstructured":"Thomas TC et al (2018) Does time heal all wounds? Experimental diffuse traumatic brain injury results in persisting histopathology in the thalamus. Behav Brain Res 340:137\u2013146. https:\/\/doi.org\/10.1016\/j.bbr.2016.12.038","DOI":"10.1016\/j.bbr.2016.12.038"},{"key":"1840_CR94","doi-asserted-by":"publisher","unstructured":"Salehi A et al (2018) Up-regulation of Wnt\/beta-catenin expression is accompanied with vascular repair after traumatic brain injury. J Cereb Blood Flow Metab 38:274\u2013289. https:\/\/doi.org\/10.1177\/0271678X17744124","DOI":"10.1177\/0271678X17744124"},{"key":"1840_CR95","doi-asserted-by":"publisher","unstructured":"Golding EM (2002) Sequelae following traumatic brain injury. The cerebrovascular perspective. Brain Res Brain Res Rev 38:377\u2013388. https:\/\/doi.org\/10.1016\/s0165-0173(02)00141-8","DOI":"10.1016\/s0165-0173(02)00141-8"},{"key":"1840_CR96","doi-asserted-by":"publisher","unstructured":"Jullienne A et al (2016) Chronic cerebrovascular dysfunction after traumatic brain injury. J Neurosci Res 94:609\u2013622. https:\/\/doi.org\/10.1002\/jnr.23732","DOI":"10.1002\/jnr.23732"},{"key":"1840_CR97","doi-asserted-by":"publisher","unstructured":"Unterberg AW, Stover J, Kress B, Kiening KL (2004) Edema and brain trauma. Neuroscience 129:1021\u20131029. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.06.046","DOI":"10.1016\/j.neuroscience.2004.06.046"},{"key":"1840_CR98","unstructured":"Price L, Wilson C, Grant G (2016) in Translational Research in Traumatic Brain Injury, D. Laskowitz, G. Grant, Eds. (Boca Raton (FL)"},{"key":"1840_CR99","doi-asserted-by":"publisher","unstructured":"Zhou Y et al (2020) Persistent Neurovascular Unit Dysfunction: Pathophysiological Substrate and Trigger for Late-Onset Neurodegeneration After Traumatic Brain Injury. Front Neurosci 14:581. https:\/\/doi.org\/10.3389\/fnins.2020.00581","DOI":"10.3389\/fnins.2020.00581"},{"key":"1840_CR100","doi-asserted-by":"publisher","unstructured":"Kenney K et al (2016) Cerebral Vascular Injury in Traumatic Brain Injury. Exp Neurol 275 Pt 3:353\u2013366. https:\/\/doi.org\/10.1016\/j.expneurol.2015.05.019","DOI":"10.1016\/j.expneurol.2015.05.019"},{"key":"1840_CR101","doi-asserted-by":"publisher","unstructured":"Park E, Bell JD, Siddiq IP, Baker AJ (2009) An analysis of regional microvascular loss and recovery following two grades of fluid percussion trauma: a role for hypoxia-inducible factors in traumatic brain injury. J Cereb Blood Flow Metab 29:575\u2013584. https:\/\/doi.org\/10.1038\/jcbfm.2008.151","DOI":"10.1038\/jcbfm.2008.151"},{"key":"1840_CR102","doi-asserted-by":"publisher","unstructured":"Adams C et al (2018) Neurogliovascular dysfunction in a model of repeated traumatic brain injury. Theranostics 8:4824\u20134836. https:\/\/doi.org\/10.7150\/thno.24747","DOI":"10.7150\/thno.24747"},{"key":"1840_CR103","doi-asserted-by":"publisher","unstructured":"Bartnik-Olson BL et al (2014) Impaired neurovascular unit function contributes to persistent symptoms after concussion: a pilot study. J Neurotrauma 31:1497\u20131506. https:\/\/doi.org\/10.1089\/neu.2013.3213","DOI":"10.1089\/neu.2013.3213"},{"key":"1840_CR104","doi-asserted-by":"publisher","unstructured":"Griffiths DR et al (2022) Chronic Cognitive and Cerebrovascular Function after Mild Traumatic Brain Injury in Rats. J Neurotrauma 39:1429\u20131441. https:\/\/doi.org\/10.1089\/neu.2022.0015","DOI":"10.1089\/neu.2022.0015"},{"key":"1840_CR105","doi-asserted-by":"publisher","unstructured":"Gaggi NL et al (2023) Temporal dynamics of cerebral blood flow during the first year after moderate-severe traumatic brain injury: A longitudinal perfusion MRI study. Neuroimage Clin 37:103344. https:\/\/doi.org\/10.1016\/j.nicl.2023.103344","DOI":"10.1016\/j.nicl.2023.103344"},{"key":"1840_CR106","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.lfs.2015.10.025)","volume":"152","author":"S Dutta","year":"2016","unstructured":"Dutta S, Sengupta P (2016) Men and mice: relating their ages. Life Sci 152:244\u2013248. https:\/\/doi.org\/10.1016\/j.lfs.2015.10.025","journal-title":"Life Sci"},{"key":"1840_CR107","doi-asserted-by":"publisher","unstructured":"Zhang Y et al (2018) Apoptosis of Endothelial Cells Contributes to Brain Vessel Pruning of Zebrafish During Development. Front Mol Neurosci 11:222. https:\/\/doi.org\/10.3389\/fnmol.2018.00222","DOI":"10.3389\/fnmol.2018.00222"},{"key":"1840_CR108","doi-asserted-by":"publisher","unstructured":"Green TRF et al (2024) Blood-Brain Barrier Dysfunction Predicts Microglial Activation After Traumatic Brain Injury in Juvenile Rats. Neurotrauma Rep 5:95\u2013116. https:\/\/doi.org\/10.1089\/neur.2023.0057","DOI":"10.1089\/neur.2023.0057"},{"key":"1840_CR109","doi-asserted-by":"publisher","unstructured":"Haruwaka K et al (2019) Dual microglia effects on blood brain barrier permeability induced by systemic inflammation. Nat Commun 10:5816. https:\/\/doi.org\/10.1038\/s41467-019-13812-z","DOI":"10.1038\/s41467-019-13812-z"},{"key":"1840_CR110","doi-asserted-by":"publisher","unstructured":"Mills SA et al (2021) Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy. Proc Natl Acad Sci USA 118. https:\/\/doi.org\/10.1073\/pnas.2112561118","DOI":"10.1073\/pnas.2112561118"},{"key":"1840_CR111","doi-asserted-by":"publisher","unstructured":"Morris GP et al (2023) Microglia directly associate with pericytes in the central nervous system. Glia 71:1847\u20131869. https:\/\/doi.org\/10.1002\/glia.24371","DOI":"10.1002\/glia.24371"},{"key":"1840_CR112","doi-asserted-by":"publisher","unstructured":"Harris NG et al (2016) Disconnection and hyper-connectivity underlie reorganization after TBI: A rodent functional connectomic analysis. Exp Neurol 277:124\u2013138. https:\/\/doi.org\/10.1016\/j.expneurol.2015.12.020","DOI":"10.1016\/j.expneurol.2015.12.020"},{"key":"1840_CR113","doi-asserted-by":"publisher","unstructured":"Biegon A (2021) Considering Biological Sex in Traumatic Brain Injury. Front Neurol 12:576366. https:\/\/doi.org\/10.3389\/fneur.2021.576366","DOI":"10.3389\/fneur.2021.576366"},{"key":"1840_CR114","unstructured":"A. R. Atlas"},{"key":"1840_CR115","doi-asserted-by":"publisher","unstructured":"Le TT, Im GH, Lee CH, Choi SH, Kim SG (2024) Mapping cerebral perfusion in mice under various anesthesia levels using highly sensitive BOLD MRI with transient hypoxia. Sci Adv 10:eadm7605. https:\/\/doi.org\/10.1126\/sciadv.adm7605","DOI":"10.1126\/sciadv.adm7605"},{"key":"1840_CR116","doi-asserted-by":"publisher","unstructured":"Zhang X (2022) Effects of Anesthesia on Cerebral Blood Flow and Functional Connectivity of Nonhuman Primates. Vet Sci 9. https:\/\/doi.org\/10.3390\/vetsci9100516","DOI":"10.3390\/vetsci9100516"},{"key":"1840_CR117","doi-asserted-by":"publisher","unstructured":"He F et al (2020) Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes. Sci Adv 6:eaba1933. https:\/\/doi.org\/10.1126\/sciadv.aba1933","DOI":"10.1126\/sciadv.aba1933"},{"key":"1840_CR118","doi-asserted-by":"publisher","unstructured":"Tan CO, Meehan WP 3rd, Iverson GL, Taylor JA (2014) Cerebrovascular regulation, exercise, and mild traumatic brain injury. Neurology 83:1665\u20131672. https:\/\/doi.org\/10.1212\/WNL.0000000000000944","DOI":"10.1212\/WNL.0000000000000944"},{"key":"1840_CR119","doi-asserted-by":"publisher","unstructured":"Hamm RJ, Temple MD, O\u2019Dell DM, Pike BR, Lyeth BG (1996) Exposure to environmental complexity promotes recovery of cognitive function after traumatic brain injury. J Neurotrauma 13:41\u201347. https:\/\/doi.org\/10.1089\/neu.1996.13.41","DOI":"10.1089\/neu.1996.13.41"},{"key":"1840_CR120","doi-asserted-by":"publisher","unstructured":"Tapias V et al (2022) Environmental enrichment improves traumatic brain injury-induced behavioral phenotype and associated neurodegenerative process. Exp Neurol 357:114204. https:\/\/doi.org\/10.1016\/j.expneurol.2022.114204","DOI":"10.1016\/j.expneurol.2022.114204"},{"key":"1840_CR121","doi-asserted-by":"publisher","unstructured":"Safaryan K, Mehta MR (2021) Enhanced hippocampal theta rhythmicity and emergence of eta oscillation in virtual reality. Nat Neurosci 24:1065\u20131070. https:\/\/doi.org\/10.1038\/s41593-021-00871-z","DOI":"10.1038\/s41593-021-00871-z"},{"key":"1840_CR122","doi-asserted-by":"publisher","unstructured":"Aida J, Chau B, Dunn J (2018) Immersive virtual reality in traumatic brain injury rehabilitation: A literature review. NeuroRehabilitation 42:441\u2013448. https:\/\/doi.org\/10.3233\/NRE-172361","DOI":"10.3233\/NRE-172361"},{"key":"1840_CR123","doi-asserted-by":"publisher","unstructured":"Aulisio MC, Han DY, Glueck AC (2020) Virtual reality gaming as a neurorehabilitation tool for brain injuries in adults: A systematic review. Brain Inj 34:1322\u20131330. https:\/\/doi.org\/10.1080\/02699052.2020.1802779","DOI":"10.1080\/02699052.2020.1802779"},{"key":"1840_CR124","doi-asserted-by":"publisher","unstructured":"Ahmadi R et al (2022) Facebook Experiences of Users With Traumatic Brain Injury: A Think-Aloud Study. JMIR Rehabil Assist Technol 9:e39984. https:\/\/doi.org\/10.2196\/39984","DOI":"10.2196\/39984"},{"key":"1840_CR125","doi-asserted-by":"publisher","unstructured":"Pearce WJ et al (2016) Imatinib attenuates cerebrovascular injury and phenotypic transformation after intracerebral hemorrhage in rats. Am J Physiol Regul Integr Comp Physiol 311:R1093\u2013R1104. https:\/\/doi.org\/10.1152\/ajpregu.00240.2016","DOI":"10.1152\/ajpregu.00240.2016"},{"key":"1840_CR126","doi-asserted-by":"publisher","unstructured":"Hartmann DA, Coelho-Santos V, Shih AY (2022) Pericyte Control of Blood Flow Across Microvascular Zones in the Central Nervous System. Annu Rev Physiol 84:331\u2013354. https:\/\/doi.org\/10.1146\/annurev-physiol-061121-040127","DOI":"10.1146\/annurev-physiol-061121-040127"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-024-01840-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40478-024-01840-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-024-01840-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T03:34:34Z","timestamp":1723001674000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-024-01840-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,7]]},"references-count":126,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1840"],"URL":"https:\/\/doi.org\/10.1186\/s40478-024-01840-w","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,7]]},"assertion":[{"value":"24 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"126"}}