{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:50:37Z","timestamp":1778698237283,"version":"3.51.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82203280"],"award-info":[{"award-number":["82203280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82273073"],"award-info":[{"award-number":["82273073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82273047"],"award-info":[{"award-number":["82273047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012542","name":"Science and Technology Support Program of Sichuan Province","doi-asserted-by":"crossref","award":["2024YFHZ0054"],"award-info":[{"award-number":["2024YFHZ0054"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"DOI":"10.1186\/s40478-024-01884-y","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T05:04:51Z","timestamp":1731301491000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A primary intracranial neuroepithelial neoplasm with novel TCF3::BEND2 fusion: a case report"],"prefix":"10.1186","volume":"12","author":[{"given":"Linmao","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"1884_CR1","unstructured":"WHO Classification of Tumours Editorial Board (2021) Central nervous system tumoursLyon (France). International Agency for Research on Cancer"},{"issue":"1","key":"1884_CR2","doi-asserted-by":"publisher","first-page":"p2083","DOI":"10.1038\/s41467-022-29302-8","volume":"13","author":"NL Lehman","year":"2022","unstructured":"Lehman NL, Spassky N, Sak M, Webb A, Zumbar CT, Usubalieva A et al (2022) Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes. Nat Commun 13(1):p2083. https:\/\/doi.org\/10.1038\/s41467-022-29302-8","journal-title":"Nat Commun"},{"key":"1884_CR3","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002298","author":"L Fu","year":"2024","unstructured":"Fu L, Lao IW, Huang L, Ou L, Yuan L, Li Z et al (2024) Spinal cord Astroblastoma with EWSR1-BEND2 Fusion in female patients: a report of four cases from China and a Comprehensive Literature Review. Am J Surg Pathol. https:\/\/doi.org\/10.1097\/PAS.0000000000002298","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1884_CR4","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00401-021-02388-y","volume":"143","author":"CG Lucas","year":"2022","unstructured":"Lucas CG, Gupta R, Wu J, Shah K, Ravindranathan A, Barreto J et al (2022) EWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma. Acta Neuropathol 143(1):109\u2013113. https:\/\/doi.org\/10.1007\/s00401-021-02388-y","journal-title":"Acta Neuropathol"},{"issue":"10","key":"1884_CR5","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","volume":"30","author":"MJ Aryee","year":"2014","unstructured":"Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD et al (2014) Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics 30(10):1363\u20131369. https:\/\/doi.org\/10.1093\/bioinformatics\/btu049","journal-title":"Bioinformatics"},{"issue":"1","key":"1884_CR6","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/s41467-019-08823-9","volume":"10","author":"CM Hoeman","year":"2019","unstructured":"Hoeman CM, Cordero FJ, Hu G, Misuraca K, Romero MM, Cardona HJ et al (2019) ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis. Nat Commun 10(1):1023. https:\/\/doi.org\/10.1038\/s41467-019-08823-9","journal-title":"Nat Commun"},{"issue":"6","key":"1884_CR7","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.cell.2020.11.012","volume":"183","author":"CCL Chen","year":"2020","unstructured":"Chen CCL, Deshmukh S, Jessa S, Hadjadj D, Lisi V, Andrade AF et al (2020) Histone H3.3G34-Mutant Interneuron progenitors co-opt PDGFRA for Gliomagenesis. Cell 183(6):1617\u20131633e22. https:\/\/doi.org\/10.1016\/j.cell.2020.11.012","journal-title":"Cell"},{"issue":"11","key":"1884_CR8","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1038\/ng.3688","volume":"48","author":"S Agnihotri","year":"2016","unstructured":"Agnihotri S, Jalali S, Wilson MR, Danesh A, Li M, Klironomos G et al (2016) The genomic landscape of schwannoma. Nat Genet 48(11):1339\u20131348. https:\/\/doi.org\/10.1038\/ng.3688","journal-title":"Nat Genet"},{"issue":"5","key":"1884_CR9","doi-asserted-by":"publisher","first-page":"e313","DOI":"10.1097\/mph.0000000000002885","volume":"46","author":"JA Cuoco","year":"2024","unstructured":"Cuoco JA, Williams S, Klein BJ, Borowicz VM, Ho H, Stump MS et al (2024) Astroblastoma with a Novel YAP1::BEND2 Fusion: a Case Report. J Pediatr Hematol Oncol 46(5):e313\u2013e316. https:\/\/doi.org\/10.1097\/mph.0000000000002885","journal-title":"J Pediatr Hematol Oncol"},{"issue":"5","key":"1884_CR10","doi-asserted-by":"publisher","first-page":"e12814","DOI":"10.1111\/nan.12814","volume":"48","author":"S Rossi","year":"2022","unstructured":"Rossi S, Barresi S, Colafati GS, Giovannoni I, Miele E, Alesi V et al (2022) Paediatric astroblastoma-like neuroepithelial tumour of the spinal cord with a MAMLD1-BEND2 rearrangement. Neuropathol Appl Neurobiol 48(5):e12814. https:\/\/doi.org\/10.1111\/nan.12814","journal-title":"Neuropathol Appl Neurobiol"},{"key":"1884_CR11","doi-asserted-by":"publisher","unstructured":"Smith-Cohn MA, Abdullaev Z, Aldape KD, Quezado M, Rosenblum MK, Vanderbilt CM et al (2021) Molecular clarification of brainstem astroblastoma with EWSR1-BEND2 fusion in a 38-year-old man. Free Neuropathol 2. https:\/\/doi.org\/10.17879\/freeneuropathology-2021-3334","DOI":"10.17879\/freeneuropathology-2021-3334"},{"key":"1884_CR12","doi-asserted-by":"publisher","unstructured":"Walker EN, Laws MT, Cozzi F, Quezado M, Brown DA, Burton EC (2023) A case of disseminated spinal astroblastoma harboring a MAMLD1::BEND2 fusion. https:\/\/doi.org\/10.1111\/neup.12960. Neuropathology","DOI":"10.1111\/neup.12960"},{"issue":"2","key":"1884_CR13","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/nan.12593","volume":"46","author":"K Yamasaki","year":"2020","unstructured":"Yamasaki K, Nakano Y, Nobusawa S, Okuhiro Y, Fukushima H, Inoue T et al (2020) Spinal cord astroblastoma with an EWSR1-BEND2 fusion classified as a high-grade neuroepithelial tumour with MN1 alteration. Neuropathol Appl Neurobiol 46(2):190\u2013193. https:\/\/doi.org\/10.1111\/nan.12593","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"1","key":"1884_CR14","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1101\/gad.252122.114","volume":"29","author":"Q Dai","year":"2015","unstructured":"Dai Q, Ren A, Westholm JO, Duan H, Patel DJ, Lai EC (2015) Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes Dev 29(1):48\u201362. https:\/\/doi.org\/10.1101\/gad.252122.114","journal-title":"Genes Dev"},{"issue":"2","key":"1884_CR15","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s12105-023-01527-z","volume":"17","author":"DN Palsgrove","year":"2023","unstructured":"Palsgrove DN, Manucha V, Park JY, Bishop JA (2023) A low-grade Sinonasal Sarcoma harboring EWSR1::BEND2: expanding the Differential diagnosis of Sinonasal Spindle Cell Neoplasms. Head Neck Pathol 17(2):571\u2013575. https:\/\/doi.org\/10.1007\/s12105-023-01527-z","journal-title":"Head Neck Pathol"},{"key":"1884_CR16","doi-asserted-by":"publisher","unstructured":"Salguero-Aranda C, Di Blasi E, Galan L, Zaldumbide L, Civantos G, Marcilla D et al (2024) Identification of Novel\/Rare EWSR1 Fusion partners in undifferentiated mesenchymal neoplasms. Int J Mol Sci 25(3). https:\/\/doi.org\/10.3390\/ijms25031735","DOI":"10.3390\/ijms25031735"},{"issue":"7","key":"1884_CR17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/gcc.23028","volume":"61","author":"A Yoshida","year":"2022","unstructured":"Yoshida A, Satomi K, Kobayashi E, Ryo E, Matsushita Y, Narita Y et al (2022) Soft-tissue sarcoma with MN1-BEND2 fusion: a case report and comparison with astroblastoma. Genes Chromosomes Cancer 61(7):427\u2013431. https:\/\/doi.org\/10.1002\/gcc.23028","journal-title":"Genes Chromosomes Cancer"},{"issue":"10","key":"1884_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41408-019-0239-z","volume":"9","author":"RA Rowsey","year":"2019","unstructured":"Rowsey RA, Smoley SA, Williamson CM, Vasmatzis G, Smadbeck JB, Ning Y et al (2019) Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia\/lymphoma by mate-pair sequencing (MPseq) identifies complex genomic rearrangements and a novel TCF3\/TEF gene fusion. Blood Cancer J 9(10):81. https:\/\/doi.org\/10.1038\/s41408-019-0239-z","journal-title":"Blood Cancer J"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-024-01884-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40478-024-01884-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-024-01884-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T17:03:29Z","timestamp":1731344609000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-024-01884-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1884"],"URL":"https:\/\/doi.org\/10.1186\/s40478-024-01884-y","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"15 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by Clinical Ethics Committee of West China Hospital of Sichuan University and patient gave consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"175"}}