{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:44:29Z","timestamp":1784767469658,"version":"3.55.0"},"reference-count":117,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015569","name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015569","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Brains Healthy Lives"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The combination of amyloid beta and tau pathologies leads to tau-mediated neurodegeneration in Alzheimer\u2019s disease. However, the relative contributions of amyloid beta and tau peptide accumulation to the manifestation of the pathological phenotype in the early stages, before the overt deposition of plaques and tangles, are still unclear. We investigated the longitudinal pathological effects of combining human-like amyloidosis and tauopathy in a novel transgenic rat model, coded McGill-R-APPxhTau. We compared the effects of individual and combined amyloidosis and tauopathy in transgenic rats by assessing the spatiotemporal progression of Alzheimer\u2019s-like amyloid and tau pathologies using biochemical and immunohistochemical methods. Extensive behavioral testing for learning and memory was also conducted to evaluate cognitive decline. Additionally, we investigated brain inflammation, neuronal cell loss, as well as synaptic plasticity through acute brain slice electrophysiological recordings and Western blotting. Evaluation of Alzheimer\u2019s-like amyloidosis and tauopathy, at the initial stages, unexpectedly revealed that the combination of amyloid pathology with the initial increment in phosphorylated tau exerted a paradoxical corrective effect on amyloid-induced cognitive impairments and led to a compensatory-like restoration of synaptic plasticity as revealed by electrophysiological evidence, compared to monogenic transgenic rats with amyloidosis or tauopathy. We discovered elevated CREB phosphorylation and increased expression of postsynaptic proteins as a tentative explanation for the improved hippocampal synaptic plasticity. However, this tau-induced protective effect on synaptic function was transient. As anticipated, at more advanced stages, the APPxhTau bigenic rats exhibited aggravated tau and amyloid pathologies, cognitive decline, increased neuroinflammation, and tau-driven neuronal loss compared to monogenic rat models of Alzheimer\u2019s-like amyloid and tau pathologies. The present findings propose that the early accumulation of phosphorylated tau may have a transient protective impact on the evolving amyloid pathology-derived synaptic impairments.<\/jats:p>","DOI":"10.1186\/s40478-024-01901-0","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T16:04:01Z","timestamp":1734710641000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Paradoxical attenuation of early amyloid-induced cognitive impairment and synaptic plasticity in an aged APP\/Tau bigenic rat model"],"prefix":"10.1186","volume":"12","author":[{"given":"Joshua T.","family":"Emmerson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Do Carmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Lavagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak Pan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Martinez-Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Claudio","family":"Cuello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"1901_CR1","doi-asserted-by":"publisher","first-page":"9340","DOI":"10.1523\/JNEUROSCI.22-21-09340.2002","volume":"22","author":"B Allen","year":"2002","unstructured":"Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, Yoshida H, Holzer M, Craxton M, Emson PC, Atzori C, Migheli A, Crowther RA, Ghetti B, Spillantini MG, Goedert M (2002) Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci 22:9340\u20139351. 22\/21\/9340 [pii]","journal-title":"J Neurosci"},{"key":"1901_CR2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.nbd.2017.08.015","volume":"108","author":"SL Angulo","year":"2017","unstructured":"Angulo SL, Orman R, Neymotin SA, Liu L, Buitrago L, Cepeda-Prado E, Stefanov D, Lytton WW, Stewart M, Small SA, Duff KE, Moreno H (2017) Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. Neurobiol Dis 108:261\u2013276. https:\/\/doi.org\/10.1016\/j.nbd.2017.08.015","journal-title":"Neurobiol Dis"},{"key":"1901_CR3","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1038\/s41591-019-0611-3","volume":"25","author":"JF Arboleda-Velasquez","year":"2019","unstructured":"Arboleda-Velasquez JF, Lopera F, O\u2019Hare M, Delgado-Tirado S, Marino C, Chmielewska N, Saez-Torres KL, Amarnani D, Schultz AP, Sperling RA, Leyton-Cifuentes D, Chen K, Baena A, Aguillon D, Rios-Romenets S, Giraldo M, Guzm\u00e1n-V\u00e9lez E, Norton DJ, Pardilla-Delgado E, Artola A, Sanchez JS, Acosta-Uribe J, Lalli M, Kosik KS, Huentelman MJ, Zetterberg H, Blennow K, Reiman RA, Luo J, Chen Y, Thiyyagura P, Su Y, Jun GR, Naymik M, Gai X, Bootwalla M, Ji J, Shen L, Miller JB, Kim LA, Tariot PN, Johnson KA, Reiman EM, Quiroz YT (2019) Resistance to autosomal dominant Alzheimer\u2019s disease in an APOE3 Christchurch homozygote: a case report. Nat Med 25:1680\u20131683. https:\/\/doi.org\/10.1038\/s41591-019-0611-3","journal-title":"Nat Med"},{"key":"1901_CR4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1212\/WNL.42.3.631","volume":"42","author":"PV Arriagada","year":"1992","unstructured":"Arriagada PV, Growdon JH, Hedleywhyte ET, Hyman BT, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of alzheimers-Disease. Neurology 42:631\u2013639. https:\/\/doi.org\/10.1212\/WNL.42.3.631","journal-title":"Neurology"},{"key":"1901_CR5","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/j.1471-4159.2007.04704.x","volume":"103","author":"DN Arvanitis","year":"2007","unstructured":"Arvanitis DN, Ducatenzeiler A, Ou JN, Grodstein E, Andrews SD, Tendulkar SR, Ribeiro-Da-Silva A, Szyf M, Cuello AC (2007) High intracellular concentrations of amyloid-beta block nuclear translocation of phosphorylated CREB. J Neurochem 103:216\u2013228. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.04704.x","journal-title":"J Neurochem"},{"key":"1901_CR6","doi-asserted-by":"publisher","first-page":"e859","DOI":"10.1212\/WNL.0000000000006075","volume":"91","author":"AJ Aschenbrenner","year":"2018","unstructured":"Aschenbrenner AJ, Gordon BA, Benzinger TLS, Morris JC, Hassenstab JJ (2018) Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease. Neurology 91:e859\u2013e866. https:\/\/doi.org\/10.1212\/WNL.0000000000006075","journal-title":"Neurology"},{"key":"1901_CR7","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00401-021-02275-6","volume":"141","author":"NJ Ashton","year":"2021","unstructured":"Ashton NJ, Pascoal TA, Karikari TK, Benedet AL, Lantero-Rodriguez J, Brinkmalm G, Snellman A, Sch\u00f6ll M, Troakes C, Hye A, Gauthier S, Vanmechelen E, Zetterberg H, Rosa-Neto P, Blennow K (2021) Plasma p-tau231: a new biomarker for incipient Alzheimer\u2019s disease pathology. Acta Neuropathol 141:709\u2013724. https:\/\/doi.org\/10.1007\/s00401-021-02275-6","journal-title":"Acta Neuropathol"},{"key":"1901_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ebiom.2022.103836","volume":"76","author":"NJ Ashton","year":"2022","unstructured":"Ashton NJ, Benedet AL, Pascoal TA, Karikari TK, Lantero-Rodriguez J, Brum WS, Mathotaarachchi S, Therriault J, Savard M, Chamoun M, Stoops E, Francois C, Vanmechelen E, Gauthier S, Zimmer ER, Zetterberg H, Blennow K, Rosa-Neto P (2022) Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer\u2019s disease. EBioMedicine 76:1\u201313. https:\/\/doi.org\/10.1016\/j.ebiom.2022.103836","journal-title":"EBioMedicine"},{"key":"1901_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnagi.2010.00008","volume":"2","author":"TA Bayer","year":"2010","unstructured":"Bayer TA, Wirths O (2010) Intracellular accumulation of amyloid-beta - A predictor for synaptic dysfunction and neuron loss in Alzheimer\u2019s disease. Front Aging Neurosci 2:1\u201310. https:\/\/doi.org\/10.3389\/fnagi.2010.00008","journal-title":"Front Aging Neurosci"},{"key":"1901_CR10","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1093\/brain\/awx243","volume":"140","author":"A Bejanin","year":"2017","unstructured":"Bejanin A, Schonhaut DR, La Joie R, Kramer JH, Baker SL, Sosa N, Ayakta N, Cantwell A, Janabi M, Lauriola M, O\u2019Neil JP, Gorno-Tempini ML, Miller ZA, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD (2017) Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer\u2019s disease. Brain 140:3286\u20133300. https:\/\/doi.org\/10.1093\/brain\/awx243","journal-title":"Brain"},{"key":"1901_CR11","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.neurobiolaging.2005.09.034","volume":"27","author":"KFS Bell","year":"2006","unstructured":"Bell KFS, Ducatenzeiler A, Ribeiro-da-Silva A, Duff K, Bennett DA, Claudio Cuello A (2006) The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiol Aging 27:1644\u20131657. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2005.09.034","journal-title":"Neurobiol Aging"},{"key":"1901_CR12","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/jnc.12176","volume":"126","author":"KFS Bell","year":"2013","unstructured":"Bell KFS, Bent RJ, Meese-Tamuri S, Ali A, Forder JP, Aarts MM (2013) Calmodulin kinase IV-dependent CREB activation is required for neuroprotection via NMDA receptor-PSD95 disruption. J Neurochem 126:274\u2013287. https:\/\/doi.org\/10.1111\/jnc.12176","journal-title":"J Neurochem"},{"key":"1901_CR13","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1001\/archneur.61.3.378","volume":"61","author":"DA Bennett","year":"2004","unstructured":"Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE (2004) Neurofibrillary Tangles Mediate the Association of Amyloid Load with clinical Alzheimer Disease and Level of cognitive function. Arch Neurol 61:378\u2013384. https:\/\/doi.org\/10.1001\/archneur.61.3.378","journal-title":"Arch Neurol"},{"key":"1901_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13195-021-00880-x","volume":"13","author":"D Biel","year":"2021","unstructured":"Biel D, Brendel M, Rubinski A, Buerger K, Janowitz D, Dichgans M, Franzmeier N (2021) Tau-PET and in vivo braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals. Alzheimers Res Ther 13:1\u201313. https:\/\/doi.org\/10.1186\/s13195-021-00880-x","journal-title":"Alzheimers Res Ther"},{"key":"1901_CR15","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","volume":"45","author":"LM Billings","year":"2005","unstructured":"Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal A\u03b2 causes the onset of early Alzheimer\u2019s disease-related cognitive deficits in transgenic mice. Neuron 45:675\u2013688. https:\/\/doi.org\/10.1016\/j.neuron.2005.01.040","journal-title":"Neuron"},{"key":"1901_CR16","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/S0092-8674(00)81816-4","volume":"87","author":"H Bito","year":"1996","unstructured":"Bito H, Deisseroth K, Tsien RW (1996) CREB phosphorylation and dephosphorylation: a Ca2+- and stimulus duration-dependent switch for hippocampal gene expression. Cell 87:1203\u20131214. https:\/\/doi.org\/10.1016\/S0092-8674(00)81816-4","journal-title":"Cell"},{"key":"1901_CR17","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","volume":"71","author":"GS Bloom","year":"2014","unstructured":"Bloom GS (2014) Amyloid-B and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol 71:505\u2013508. https:\/\/doi.org\/10.1001\/jamaneurol.2013.5847","journal-title":"JAMA Neurol"},{"key":"1901_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scitranslmed.aaf2362","volume":"8","author":"MR Brier","year":"2016","unstructured":"Brier MR, Gordon B, Friedrichsen K, McCarthy J, Stern A, Christensen J, Owen C, Aldea P, Su Y, Hassenstab J, Cairns NJ, Holtzman DM, Fagan AM, Morris JC, Benzinger TLS, Ances BM (2016) Tau and ab imaging, CSF measures, and cognition in Alzheimer\u2019s disease. Sci Transl Med 8:1\u20139. https:\/\/doi.org\/10.1126\/scitranslmed.aaf2362","journal-title":"Sci Transl Med"},{"key":"1901_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scitranslmed.aaf2362","volume":"8","author":"MR Brier","year":"2016","unstructured":"Brier MR, Gordon B, Morris JH, Benzinger TLS, Ances BM (2016) Tau and A\u00df imaging, CSF measures, and cognition in Alzheimer\u2019 s disease. Sci Transl Med 8:1\u201310. https:\/\/doi.org\/10.1126\/scitranslmed.aaf2362","journal-title":"Sci Transl Med"},{"key":"1901_CR20","doi-asserted-by":"publisher","unstructured":"Briner A, G\u00f6tz J, Polanco JC (2020) Fyn kinase controls tau aggregation in vivo. Cell Rep 32. https:\/\/doi.org\/10.1016\/j.celrep.2020.108045","DOI":"10.1016\/j.celrep.2020.108045"},{"key":"1901_CR21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41593-018-0289-8","volume":"22","author":"MA Busche","year":"2019","unstructured":"Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT (2019) Tau impairs neural circuits, dominating amyloid-\u03b2 effects, in Alzheimer models in vivo. Nat Neurosci 22:57\u201364. https:\/\/doi.org\/10.1038\/s41593-018-0289-8","journal-title":"Nat Neurosci"},{"key":"1901_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-018-0290-4","volume":"13","author":"W Cao","year":"2018","unstructured":"Cao W, Zheng H (2018) Correction to: peripheral immune system in aging and Alzheimer\u2019s disease. Mol Neurodegener 13:1\u201317. https:\/\/doi.org\/10.1186\/s13024-018-0290-4","journal-title":"Mol Neurodegener"},{"key":"1901_CR23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.nbd.2014.01.007","volume":"64","author":"MA Chabrier","year":"2014","unstructured":"Chabrier MA, Cheng D, Castello NA, Green KN, LaFerla FM (2014) Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer\u2019s disease. Neurobiol Dis 64:107\u2013117. https:\/\/doi.org\/10.1016\/j.nbd.2014.01.007","journal-title":"Neurobiol Dis"},{"key":"1901_CR24","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.cell.2023.11.029","volume":"187","author":"Y Chen","year":"2024","unstructured":"Chen Y, Song S, Parhizkar S, Lord J, Zhu Y, Strickland MR, Wang C, Park J, Tabor GT, Jiang H, Li K, Davis AA, Yuede CM, Colonna M, Ulrich JD, Holtzman DM (2024) APOE3ch alters microglial response and suppresses A\u03b2-induced tau seeding and spread. Cell 187:428\u2013445e20. https:\/\/doi.org\/10.1016\/j.cell.2023.11.029","journal-title":"Cell"},{"key":"1901_CR25","doi-asserted-by":"publisher","first-page":"9694","DOI":"10.1523\/JNEUROSCI.2980-05.2005","volume":"25","author":"J Chin","year":"2005","unstructured":"Chin J, Palop JJ, Puoliv\u00e4li J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L (2005) Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer\u2019s disease. J Neurosci 25:9694\u20139703. https:\/\/doi.org\/10.1523\/JNEUROSCI.2980-05.2005","journal-title":"J Neurosci"},{"key":"1901_CR26","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1046\/j.1471-4159.2003.02155.x","volume":"88","author":"J Cho","year":"2004","unstructured":"Cho J, Johnson GVW (2004) Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3B (GSK3B) plays a critical role in regulating tau\u2019s ability to bind and stabilize microtubules. J Neurochem 88:349\u2013358. https:\/\/doi.org\/10.1046\/j.1471-4159.2003.02155.x","journal-title":"J Neurochem"},{"key":"1901_CR27","doi-asserted-by":"publisher","first-page":"6245","DOI":"10.1523\/JNEUROSCI.3672-12.2013.A","volume":"33","author":"RM Cohen","year":"2013","unstructured":"Cohen RM, Rezai-zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG (2013) A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric A\u03b2 and frank neuronal loss. J Neurosci 33:6245\u20136256. https:\/\/doi.org\/10.1523\/JNEUROSCI.3672-12.2013.A","journal-title":"J Neurosci"},{"key":"1901_CR28","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1159\/000333339","volume":"10","author":"AC Cuello","year":"2012","unstructured":"Cuello AC, Ferretti MT, Iulita MF (2012) Preplaque (\u2018preclinical\u2019) A\u03b2-induced inflammation and nerve growth factor deregulation in transgenic models of Alzheimer\u2019s disease-like amyloid pathology. Neurodegener Dis 10:104\u2013107. https:\/\/doi.org\/10.1159\/000333339","journal-title":"Neurodegener Dis"},{"key":"1901_CR29","doi-asserted-by":"publisher","unstructured":"Cummings J, Lee G, Nahed P, Kambar MEZN, Zhong K, Fonseca J, Taghva K (2022) Alzheimer\u2019s disease drug development pipeline: 2022. Alzheimer\u2019s and Dementia: Translational Research and clinical interventions 8. https:\/\/doi.org\/10.1002\/trc2.12295","DOI":"10.1002\/trc2.12295"},{"key":"1901_CR30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0896-6273(00)80026-4","volume":"16","author":"K Deisseroth","year":"1996","unstructured":"Deisseroth K, Bito H, Tsien RW (1996) Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16:89\u2013101. https:\/\/doi.org\/10.1016\/S0896-6273(00)80026-4","journal-title":"Neuron"},{"key":"1901_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep20833","volume":"6","author":"J Di","year":"2016","unstructured":"Di J, Cohen LS, Corbo CP, Phillips GR, El Idrissi A, Alonso AD (2016) Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss. Sci Rep 6:1\u201312. https:\/\/doi.org\/10.1038\/srep20833","journal-title":"Sci Rep"},{"key":"1901_CR32","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1750-1326-8-37","volume":"8","author":"S Do Carmo","year":"2013","unstructured":"Do Carmo S, Cuello AC (2013) Modeling Alzheimer\u2019s disease in transgenic rats. Mol Neurodegener 8:37. https:\/\/doi.org\/10.1186\/1750-1326-8-37","journal-title":"Mol Neurodegener"},{"key":"1901_CR33","doi-asserted-by":"publisher","first-page":"109194","DOI":"10.1016\/j.celrep.2021.109194","volume":"35","author":"K Dore","year":"2021","unstructured":"Dore K, Carrico Z, Alfonso S, Marino M, Koymans K, Kessels HW, Malinow R (2021) PSD-95 protects synapses from \u03b2-amyloid. Cell Rep 35:109194. https:\/\/doi.org\/10.1016\/j.celrep.2021.109194","journal-title":"Cell Rep"},{"key":"1901_CR34","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.neuroscience.2004.07.036","volume":"129","author":"V Echeverria","year":"2004","unstructured":"Echeverria V, Ducatenzeiler A, Dowd E, J\u00e4nne J, Grant SM, Szyf M, Wandosell F, Avila J, Grimm H, Dunnett SB, Hartmann T, Alhonen L, Cuello AC (2004) Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the \u03b2-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience 129:583\u2013592. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.07.036","journal-title":"Neuroscience"},{"key":"1901_CR35","doi-asserted-by":"publisher","first-page":"106227","DOI":"10.1016\/j.nbd.2023.106227","volume":"184","author":"JT Emmerson","year":"2023","unstructured":"Emmerson JT, Do Carmo S, Liu Y, Shalhoub A, Liu A, Bonomo Q, Malcolm JC, Breuillaud L, Cuello AC (2023) Progressive human-like tauopathy with downstream neurodegeneration and neurovascular compromise in a transgenic rat model. Neurobiol Dis 184:106227. https:\/\/doi.org\/10.1016\/j.nbd.2023.106227","journal-title":"Neurobiol Dis"},{"key":"1901_CR36","doi-asserted-by":"publisher","first-page":"106317","DOI":"10.1016\/j.nbd.2023.106317","volume":"187","author":"JT Emmerson","year":"2023","unstructured":"Emmerson JT, Malcolm JC, Do Carmo S, Nguyen P, Breuillaud L, Martinez-Trujillo JC, Cuello AC (2023) Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathy. Neurobiol Dis 187:106317. https:\/\/doi.org\/10.1016\/j.nbd.2023.106317","journal-title":"Neurobiol Dis"},{"key":"1901_CR37","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.2353\/ajpath.2008.070829","volume":"172","author":"JA Fein","year":"2008","unstructured":"Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH (2008) Co-localization of amyloid beta and tau pathology in Alzheimer\u2019s disease synaptosomes. Am J Pathol 172:1683\u20131692. https:\/\/doi.org\/10.2353\/ajpath.2008.070829","journal-title":"Am J Pathol"},{"key":"1901_CR38","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1006\/mcne.1997.0615","volume":"9","author":"A Ferreira","year":"1997","unstructured":"Ferreira A, Lu Q, Orecchio L, Kosik KS (1997) Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar a\u03b2. Mol Cell Neurosci 9:220\u2013234. https:\/\/doi.org\/10.1006\/mcne.1997.0615","journal-title":"Mol Cell Neurosci"},{"key":"1901_CR39","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad024","author":"H Florian","year":"2023","unstructured":"Florian H, Wang D, Arnold SE, Boada M, Guo Q, Jin Z, Zheng H, Fisseha N, Kalluri HV, Rendenbach-Mueller B, Budur K, Gold M (2023) Tilavonemab in early Alzheimer\u2019s disease: results from a phase 2, randomized, double-blind study. Brain. https:\/\/doi.org\/10.1093\/brain\/awad024","journal-title":"Brain"},{"key":"1901_CR40","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/ana.24186","volume":"76","author":"J Fortea","year":"2014","unstructured":"Fortea J, Vilaplana E, Alcolea D, Carmona-Iragui M, S\u00e1nchez-Saudinos MB, Sala I, Ant\u00f3n-Aguirre S, Gonz\u00e1lez S, Medrano S, Pegueroles J, Morenas E, Clarim\u00f3n J, Blesa R, Lle\u00f3 A (2014) Cerebrospinal fluid \u03b2-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease. Ann Neurol 76:223\u2013230. https:\/\/doi.org\/10.1002\/ana.24186","journal-title":"Ann Neurol"},{"key":"1901_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnbeh.2014.00321","volume":"8","author":"P Galeano","year":"2014","unstructured":"Galeano P, Martino Adami PV, Do Carmo S, Blanco E, Rotondaro C, Capani F, Casta\u00f1o EM, Cuello AC, Morelli L (2014) Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer\u2019s disease. Front Behav Neurosci 8:1\u201315. https:\/\/doi.org\/10.3389\/fnbeh.2014.00321","journal-title":"Front Behav Neurosci"},{"key":"1901_CR42","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","volume":"60","author":"P Giannakopoulos","year":"2003","unstructured":"Giannakopoulos P, Herrmann FR, Bussi\u00e8re T, Bouras C, K\u00f6vari E, Perl DP, Morrison JH, Gold G, Hof PR (2003) Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease. Neurology 60:1495\u20131500. https:\/\/doi.org\/10.1212\/01.WNL.0000063311.58879.01","journal-title":"Neurology"},{"key":"1901_CR43","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1016\/j.neurobiolaging.2009.12.026","volume":"32","author":"L Glodzik","year":"2011","unstructured":"Glodzik L, de Santi S, Tsui WH, Mosconi L, Zinkowski R, Pirraglia E, Wang HY, Li Y, Rich KE, Zetterberg H, Blennow K, Mehta P, de Leon MJ (2011) Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders. Neurobiol Aging 32:2131\u20132141. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2009.12.026","journal-title":"Neurobiol Aging"},{"key":"1901_CR44","doi-asserted-by":"publisher","unstructured":"Gotz J, Chen F, van Dorpe J, Nitsch RM (2001) Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Abeta 42 Fibrils. Science (1979) 293:1491\u20131495. https:\/\/doi.org\/10.1126\/science.1062097","DOI":"10.1126\/science.1062097"},{"key":"1901_CR45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0002-9440(10)64700-1","volume":"156","author":"GK Gouras","year":"2000","unstructured":"Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, Greengard P, Relkin NR (2000) Intraneuronal A\u03b242 accumulation in human brain. Am J Pathol 156:15\u201320. https:\/\/doi.org\/10.1016\/S0002-9440(10)64700-1","journal-title":"Am J Pathol"},{"key":"1901_CR46","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.neurobiolaging.2005.05.022","volume":"26","author":"GK Gouras","year":"2005","unstructured":"Gouras GK, Almeida CG, Takahashi RH (2005) Intraneuronal A\u03b2 accumulation and origin of plaques in Alzheimer\u2019s disease. Neurobiol Aging 26:1235\u20131244. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2005.05.022","journal-title":"Neurobiol Aging"},{"key":"1901_CR47","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3233\/JAD-2000-23-403","volume":"2","author":"SM Grant","year":"2000","unstructured":"Grant SM, Ducatenzeiler A, Szyf M, Cuello AC (2000) Abeta immunoreactive material is present in several intracellular compartments in transfected, neuronally differentiated, P19 cells expressing the human amyloid beta-protein precursor. J Alzheimers Dis 2:207\u2013222","journal-title":"J Alzheimers Dis"},{"key":"1901_CR48","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1001\/archneur.60.5.729","volume":"60","author":"AL Guillozet","year":"2003","unstructured":"Guillozet AL, Weintraub S, Mash DC, Marsel Mesulam M (2003) Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch Neurol 60:729\u2013736. https:\/\/doi.org\/10.1001\/archneur.60.5.729","journal-title":"Arch Neurol"},{"key":"1901_CR49","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.jalz.2017.11.009","volume":"14","author":"H Hall","year":"2018","unstructured":"Hall H, Iulita MF, Gubert P, Flores Aguilar L, Ducatenzeiler A, Fisher A, Cuello AC (2018) AF710B, an M1\/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer\u2019s disease. Alzheimer\u2019s Dement 14:811\u2013823. https:\/\/doi.org\/10.1016\/j.jalz.2017.11.009","journal-title":"Alzheimer\u2019s Dement"},{"key":"1901_CR50","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1111\/j.1471-4159.2009.05869.x","volume":"108","author":"J Hanes","year":"2009","unstructured":"Hanes J, Zilka N, Bartkova M, Caletkova M, Dobrota D, Novak M (2009) Rat tau proteome consists of six tau isoforms: implication for animal models of human tauopathies. J Neurochem 108:1167\u20131176. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.05869.x","journal-title":"J Neurochem"},{"key":"1901_CR51","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","volume":"76","author":"BJ Hanseeuw","year":"2019","unstructured":"Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K (2019) Association of Amyloid and tau with cognition in preclinical Alzheimer Disease: a longitudinal study. JAMA Neurol 76:915\u2013924. https:\/\/doi.org\/10.1001\/jamaneurol.2019.1424","journal-title":"JAMA Neurol"},{"key":"1901_CR52","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1016\/j.neurobiolaging.2014.03.026","volume":"35","author":"CE Hanzel","year":"2014","unstructured":"Hanzel CE, Pichet-Binette A, Pimentel LSB, Iulita MF, Allard S, Ducatenzeiler A, Do Carmo S, Cuello AC (2014) Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer\u2019s disease. Neurobiol Aging 35:2249\u20132262. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.03.026","journal-title":"Neurobiol Aging"},{"key":"1901_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/bpa.13119","volume":"33","author":"J Henao-Restrepo","year":"2023","unstructured":"Henao-Restrepo J, L\u00f3pez-Murillo C, Valderrama-Carmona P, Orozco-Santa N, Gomez J, Guti\u00e9rrez-Vargas J, Moraga R, Toledo J, Littau JL, H\u00e4rtel S, Arboleda-Vel\u00e1squez JF, Sepulveda-Falla D, Lopera F, Cardona-G\u00f3mez GP, Villegas A, Posada-Duque R (2023) Gliovascular alterations in sporadic and familial Alzheimer\u2019s disease: APOE3 Christchurch homozygote glioprotection. Brain Pathol 33:1\u201323. https:\/\/doi.org\/10.1111\/bpa.13119","journal-title":"Brain Pathol"},{"key":"1901_CR54","doi-asserted-by":"publisher","first-page":"S141","DOI":"10.3233\/JAD-2012-129025","volume":"33","author":"F Hernandez","year":"2012","unstructured":"Hernandez F, Lucas JJ, Avila J (2012) GSK3 and tau: two convergence points in Alzheimer\u2019s Disease. J Alzheimer\u2019s Disease 33:S141\u2013S144. https:\/\/doi.org\/10.3233\/JAD-2012-129025","journal-title":"J Alzheimer\u2019s Disease"},{"key":"1901_CR55","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.expneurol.2009.09.011","volume":"223","author":"F Hern\u00e1ndez","year":"2010","unstructured":"Hern\u00e1ndez F, G\u00f3mez de Barreda E, Fuster-Matanzo A, Lucas JJ, Avila J (2010) GSK3: a possible link between beta amyloid peptide and tau protein. Exp Neurol 223:322\u2013325. https:\/\/doi.org\/10.1016\/j.expneurol.2009.09.011","journal-title":"Exp Neurol"},{"key":"1901_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/braincomms\/fcac286","volume":"4","author":"Y Hirota","year":"2022","unstructured":"Hirota Y, Sakakibara Y, Ibaraki K, Takei K, Iijima KM, Sekiya M (2022) Distinct brain pathologies associated with Alzheimer\u2019s disease biomarker-related phospho-tau 181 and phospho-tau 217 in app knock-in mouse models of amyloid-\u03b2 amyloidosis. Brain Commun 4:1\u201315. https:\/\/doi.org\/10.1093\/braincomms\/fcac286","journal-title":"Brain Commun"},{"key":"1901_CR57","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1111\/j.1471-4159.2007.05194.x","volume":"104","author":"C Hooper","year":"2008","unstructured":"Hooper C, Killick R, Lovestone S (2008) The GSK3 hypothesis of Alzheimer\u2019s disease. J Neurochem 104:1433\u20131439. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.05194.x","journal-title":"J Neurochem"},{"key":"1901_CR58","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1093\/brain\/awn174","volume":"131","author":"NW Hu","year":"2008","unstructured":"Hu NW, Smith IM, Walsh DM, Rowan MJ (2008) Soluble amyloid-\u03b2 peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo. Brain 131:2414\u20132424. https:\/\/doi.org\/10.1093\/brain\/awn174","journal-title":"Brain"},{"key":"1901_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells9081807","volume":"9","author":"F Iannuzzi","year":"2020","unstructured":"Iannuzzi F, Sirabella R, Canu N, Maier TJ, Annunziato L, Matrone C (2020) Fyn tyrosine kinase elicits amyloid precursor protein Tyr682 phosphorylation in neurons from Alzheimer\u2019s Disease patients. Cells 9:1\u201321. https:\/\/doi.org\/10.3390\/cells9081807","journal-title":"Cells"},{"key":"1901_CR60","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cell.2010.06.036","volume":"142","author":"LM Ittner","year":"2010","unstructured":"Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, W\u00f6lfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, G\u00f6tz J (2010) Dendritic function of tau mediates amyloid-\u03b2 toxicity in alzheimer\u2019s disease mouse models. Cell 142:387\u2013397. https:\/\/doi.org\/10.1016\/j.cell.2010.06.036","journal-title":"Cell"},{"key":"1901_CR61","doi-asserted-by":"publisher","unstructured":"Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva APG, Mackay JP, Poljak A, Delerue F, Ke YD, Ittner LM (2016) Site-specific phosphorylation of tau inhibits amyloid-\u03b2 toxicity in Alzheimer\u2019s mice. Science (1979) 354:904\u2013908. https:\/\/doi.org\/10.1126\/science.aah6205","DOI":"10.1126\/science.aah6205"},{"key":"1901_CR62","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/2051-5960-2-61","volume":"2","author":"MF Iulita","year":"2014","unstructured":"Iulita MF, Allard S, Richter L, Munter L-M, Ducatenzeiler A, Weise C, Do Carmo S, Klein WL, Multhaup G, Cuello AC (2014) Intracellular A\u03b2 pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study. Acta Neuropathol Commun 2:61. https:\/\/doi.org\/10.1186\/2051-5960-2-61","journal-title":"Acta Neuropathol Commun"},{"key":"1901_CR63","doi-asserted-by":"publisher","first-page":"44594","DOI":"10.1002\/alz.044594","volume":"16","author":"CR Jack","year":"2020","unstructured":"Jack CR (2020) Predicting future rates of tau accumulation on PET. Alzheimer\u2019s Dement 16:44594. https:\/\/doi.org\/10.1002\/alz.044594","journal-title":"Alzheimer\u2019s Dement"},{"key":"1901_CR64","doi-asserted-by":"publisher","first-page":"4761","DOI":"10.1073\/pnas.94.9.4761","volume":"94","author":"N Kojima","year":"1997","unstructured":"Kojima N, Wang J, Mansu IM, Grant SGN, Mayford M, Kandel ER (1997) Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci U S A 94:4761\u20134765. https:\/\/doi.org\/10.1073\/pnas.94.9.4761","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1901_CR65","doi-asserted-by":"publisher","unstructured":"Kornau HC, Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995) Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (1979) 1737:1737\u20131740. https:\/\/doi.org\/10.1126\/science.7569905","DOI":"10.1126\/science.7569905"},{"key":"1901_CR66","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.conb.2015.09.004","volume":"36","author":"L Kr\u00fcger","year":"2016","unstructured":"Kr\u00fcger L, Mandelkow EM (2016) Tau neurotoxicity and rescue in animal models of human tauopathies. Curr Opin Neurobiol 36:52\u201358. https:\/\/doi.org\/10.1016\/j.conb.2015.09.004","journal-title":"Curr Opin Neurobiol"},{"key":"1901_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnbeh.2014.00363","volume":"8","author":"KK Kummer","year":"2014","unstructured":"Kummer KK, Hofhansel L, Barwitz CM, Schardl A, Prast JM, Salti A, El Rawas R, Zernig G (2014) Differences in social interaction- vs. cocaine reward in mouse vs. rat. Front Behav Neurosci 8:1\u20137. https:\/\/doi.org\/10.3389\/fnbeh.2014.00363","journal-title":"Front Behav Neurosci"},{"key":"1901_CR68","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrn2168","volume":"8","author":"FM LaFerla","year":"2007","unstructured":"LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloid-\u03b2 in Alzheimer\u2019s disease. Nat Rev Neurosci 8:499\u2013509. https:\/\/doi.org\/10.1038\/nrn2168","journal-title":"Nat Rev Neurosci"},{"key":"1901_CR69","doi-asserted-by":"publisher","first-page":"118664","DOI":"10.1016\/j.bbamcr.2020.118664","volume":"1867","author":"E Lauretti","year":"2020","unstructured":"Lauretti E, Dincer O, Pratic\u00f2 D (2020) Glycogen synthase kinase-3 signaling in Alzheimer\u2019s disease. Biochim Biophys Acta Mol Cell Res 1867:118664. https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118664","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"1901_CR70","doi-asserted-by":"publisher","first-page":"16243","DOI":"10.1523\/JNEUROSCI.2775-12.2012","volume":"32","author":"I Lauritzen","year":"2012","unstructured":"Lauritzen I, Pardossi-Piquard R, Bauer C, Brigham E, Abraham JD, Ranaldi S, Fraser P, St-George-Hyslop P, Le Thuc O, Espin V, Chami L, Dunys J, Checler F (2012) The \u03b2-secretase-derived C-terminal fragment of \u03b2APP, C99, but not A\u03b2, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus. J Neurosci 32:16243\u201316255. https:\/\/doi.org\/10.1523\/JNEUROSCI.2775-12.2012","journal-title":"J Neurosci"},{"key":"1901_CR71","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3233\/JAD-2010-1349","volume":"20","author":"WC Leon","year":"2010","unstructured":"Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, Dewilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC (2010) A novel transgenic rat model with a full Alzheimer\u2019s-Like amyloid pathology displays pre-plaque intracellular amyloid-B-Associated cognitive impairment. J Alzheimer\u2019s Disease 20:113\u2013126. https:\/\/doi.org\/10.3233\/JAD-2010-1349","journal-title":"J Alzheimer\u2019s Disease"},{"key":"1901_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21769\/bioprotoc.3120","volume":"8","author":"C Leung","year":"2018","unstructured":"Leung C, Kim J, Jia Z (2018) Three-chamber Social Approach Task with Optogenetic Stimulation (mice). Bio Protoc 8:1\u201312. https:\/\/doi.org\/10.21769\/bioprotoc.3120","journal-title":"Bio Protoc"},{"key":"1901_CR73","doi-asserted-by":"crossref","unstructured":"Lewis J, Dickson DW, Lin W, Chisholm L, Corral A, Jones G, Yen S, Sahara N, Skipper L, Yager D, Eckman C, Hutton M, Mcgowan E, Hardy J (2001) Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant tau and APP. Science (1979) 293:1487\u20131491","DOI":"10.1126\/science.1058189"},{"key":"1901_CR74","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.nbd.2019.03.018","volume":"127","author":"JC Malcolm","year":"2019","unstructured":"Malcolm JC, Breuillaud L, Do Carmo S, Hall H, Welikovitch LA, Macdonald JA, Goedert M, Cuello AC (2019) Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy. Neurobiol Dis 127:323\u2013338. https:\/\/doi.org\/10.1016\/j.nbd.2019.03.018","journal-title":"Neurobiol Dis"},{"key":"1901_CR75","doi-asserted-by":"publisher","first-page":"E1295","DOI":"10.1212\/WNL.0000000000006277","volume":"91","author":"E McDade","year":"2018","unstructured":"McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, Berman SB, Klunk W, Noble J, Ringman J, Ghetti B, Farlow M, Sperling RA, Chhatwal J, Salloway S, Graff-Radford NR, Schofield PR, Masters C, Rossor MN, Fox NC, Levin J, Jucker M, Bateman RJ (2018) Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology 91:E1295\u2013E1306. https:\/\/doi.org\/10.1212\/WNL.0000000000006277","journal-title":"Neurology"},{"key":"1901_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13195-016-0183-0","volume":"8","author":"M Mendioroz","year":"2016","unstructured":"Mendioroz M, Celarain N, Altuna M, S\u00e1nchez-Ruiz De Gordoa J, Zelaya MV, Rold\u00e1n M, Rubio I, Larumbe R, Erro ME, M\u00e9ndez I, Ech\u00e1varri C (2016) CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer\u2019s disease. Alzheimers Res Ther 8:1\u20139. https:\/\/doi.org\/10.1186\/s13195-016-0183-0","journal-title":"Alzheimers Res Ther"},{"key":"1901_CR77","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1056\/NEJMoa2100708","volume":"384","author":"MA Mintun","year":"2021","unstructured":"Mintun MA, Lo AC, Duggan Evans C, Wessels AM, Ardayfio PA, Andersen SW, Shcherbinin S, Sparks J, Sims JR, Brys M, Apostolova LG, Salloway SP, Skovronsky DM (2021) Donanemab in Early Alzheimer\u2019s Disease. N Engl J Med 384:1691\u20131704. https:\/\/doi.org\/10.1056\/NEJMoa2100708","journal-title":"N Engl J Med"},{"key":"1901_CR78","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3233\/978-1-60750-733-8-129","volume":"1","author":"D Morgan","year":"2011","unstructured":"Morgan D, Munireddy S, Alamed J, DeLeon J, Diamond DM, Bickford P, Hutton M, Lewis J, McGowan E, Gordon MN (2011) Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice. Adv Alzheimer Dis 1:129\u2013138. https:\/\/doi.org\/10.3233\/978-1-60750-733-8-129","journal-title":"Adv Alzheimer Dis"},{"key":"1901_CR79","doi-asserted-by":"publisher","first-page":"a006338","DOI":"10.1101\/cshperspect.a006338","volume":"2","author":"L Mucke","year":"2012","unstructured":"Mucke L, Selkoe DJ (2012) Neurotoxicity of amyloid -protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med 2:a006338\u2013a006338. https:\/\/doi.org\/10.1101\/cshperspect.a006338","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1901_CR80","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/s43587-021-00070-2","volume":"1","author":"P Novak","year":"2021","unstructured":"Novak P, Kovacech B, Katina S, Schmidt R, Scheltens P, Kontsekova E, Ropele S, Fialova L, Kramberger M, Paulenka-Ivanovova N, Smisek M, Hanes J, Stevens E, Kovac A, Sutovsky S, Parrak V, Koson P, Prcina M, Galba J, Cente M, Hromadka T, Filipcik P, Piestansky J, Samcova M, Prenn-Gologranc C, Sivak R, Froelich L, Fresser M, Rakusa M, Harrison J, Hort J, Otto M, Tosun D, Ondrus M, Winblad B, Novak M, Zilka N (2021) ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer\u2019s disease. Nat Aging 1:521\u2013534. https:\/\/doi.org\/10.1038\/s43587-021-00070-2","journal-title":"Nat Aging"},{"key":"1901_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/alzrt238","volume":"6","author":"HB Nygaard","year":"2014","unstructured":"Nygaard HB, Dyck CH, Van, Strittmatter SM (2014) Fyn kinase inhibition as a novel therapy for AD. Alzheimers Res Ther 6:1\u20138","journal-title":"Alzheimers Res Ther"},{"key":"1901_CR82","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","volume":"39","author":"S Oddo","year":"2003","unstructured":"Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer\u2019s Disease with plaques and tangles: intracellular A\u03b2 and synaptic dysfunction. Neuron 39:409\u2013421. https:\/\/doi.org\/10.1016\/S0896-6273(03)00434-3","journal-title":"Neuron"},{"key":"1901_CR83","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1007\/s12035-020-02150-7","volume":"58","author":"K Pampuscenko","year":"2021","unstructured":"Pampuscenko K, Morkuniene R, Krasauskas L, Smirnovas V, Tomita T, Borutaite V (2021) Distinct neurotoxic effects of Extracellular Tau species in primary neuronal-glial cultures. Mol Neurobiol 58:658\u2013667. https:\/\/doi.org\/10.1007\/s12035-020-02150-7","journal-title":"Mol Neurobiol"},{"key":"1901_CR84","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1093\/brain\/awz090","volume":"142","author":"MJ Pontecorvo","year":"2019","unstructured":"Pontecorvo MJ, Devous MD, Kennedy I, Navitsky M, Lu M, Galante N, Salloway S, Murali Doraiswamy P, Southekal S, Arora AK, McGeehan A, Lim NC, Xiong H, Truocchio SP, Joshi AD, Shcherbinin S, Teske B, Fleisher AS, Mintun MA (2019) A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer\u2019s disease dementia. Brain 142:1723\u20131735. https:\/\/doi.org\/10.1093\/brain\/awz090","journal-title":"Brain"},{"key":"1901_CR85","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s40478-014-0175-x","volume":"2","author":"Y Qi","year":"2014","unstructured":"Qi Y, Klyubin I, Harney SC, Hu N, Cullen WK, Grant MK, Steffen J, Wilson EN, Do Carmo S, Remy S, Fuhrmann M, Ashe KH, Cuello AC, Rowan MJ (2014) Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human A\u00df-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-A\u00df agents. Acta Neuropathol Commun 2:175. https:\/\/doi.org\/10.1186\/s40478-014-0175-x","journal-title":"Acta Neuropathol Commun"},{"key":"1901_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2019.00861","volume":"13","author":"Y Qi","year":"2019","unstructured":"Qi Y, Klyubin I, Hu NW, Ondrejcak T, Rowan MJ (2019) Pre-plaque A\u00df-Mediated impairment of synaptic depotentiation in a transgenic rat model of Alzheimer\u2019s Disease Amyloidosis. Front Neurosci 13:1\u201313. https:\/\/doi.org\/10.3389\/fnins.2019.00861","journal-title":"Front Neurosci"},{"key":"1901_CR87","doi-asserted-by":"publisher","first-page":"10637","DOI":"10.1523\/JNEUROSCI.3279-05.2005","volume":"25","author":"M Ramsden","year":"2005","unstructured":"Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH (2005) Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci 25:10637\u201310647. https:\/\/doi.org\/10.1523\/JNEUROSCI.3279-05.2005","journal-title":"J Neurosci"},{"key":"1901_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.07080.x","volume":"116","author":"K Sakamoto","year":"2011","unstructured":"Sakamoto K, Karelina K, Obrietan K (2011) CREB: a multifaceted regulator of neuronal plasticity and protection. J Neurochem 116:1\u20139. https:\/\/doi.org\/10.1111\/j.1471-4159.2010.07080.x","journal-title":"J Neurochem"},{"key":"1901_CR89","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.1016\/j.neurobiolaging.2013.05.003","volume":"34","author":"A Saul","year":"2013","unstructured":"Saul A, Sprenger F, Bayer TA, Wirths O (2013) Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer\u2019s disease. Neurobiol Aging 34:2564\u20132573. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2013.05.003","journal-title":"Neurobiol Aging"},{"key":"1901_CR90","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1001\/archneur.65.10.1368","volume":"65","author":"BAJ Schaffer","year":"2008","unstructured":"Schaffer BAJ, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, Bigio EH, Mesulam M, Wiedau-Pazos M, Jackson GR, Cummings JL, Cantor RM, Levey AI, Tanzi RE, Geschwind DH (2008) Association of GSK3B with Alzheimer Disease and Frontotemporal Dementia. Arch Neurol 65:1368\u20131374. https:\/\/doi.org\/10.1001\/archneur.65.10.1368","journal-title":"Arch Neurol"},{"key":"1901_CR91","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","volume":"89","author":"M Sch\u00f6ll","year":"2016","unstructured":"Sch\u00f6ll M, Lockhart SN, Schonhaut DR, O\u2019Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ (2016) PET imaging of tau deposition in the Aging Human Brain. Neuron 89:971\u2013982. https:\/\/doi.org\/10.1016\/j.neuron.2016.01.028","journal-title":"Neuron"},{"key":"1901_CR92","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3390\/ijms19040998","volume":"19","author":"\u00c1 Sebasti\u00e1n-Serrano","year":"2018","unstructured":"Sebasti\u00e1n-Serrano \u00c1, de Diego-Garc\u00eda L, D\u00edaz-Hern\u00e1ndez M (2018) The neurotoxic role of Extracellular tau protein. Int J Mol Sci 19:998. https:\/\/doi.org\/10.3390\/ijms19040998","journal-title":"Int J Mol Sci"},{"key":"1901_CR93","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00401-022-02467-8","volume":"144","author":"D Sepulveda-Falla","year":"2022","unstructured":"Sepulveda-Falla D, Sanchez JS, Almeida MC, Boassa D, Acosta-Uribe J, Vila-Castelar C, Ramirez-Gomez L, Baena A, Aguillon D, Villalba-Moreno ND, Littau JL, Villegas A, Beach TG, White CL, Ellisman M, Krasemann S, Glatzel M, Johnson KA, Sperling RA, Reiman EM, Arboleda-Velasquez JF, Kosik KS, Lopera F, Quiroz YT (2022) Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer\u2019s dementia. Acta Neuropathol 144:589\u2013601. https:\/\/doi.org\/10.1007\/s00401-022-02467-8","journal-title":"Acta Neuropathol"},{"key":"1901_CR94","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature19323","volume":"537","author":"J Sevigny","year":"2016","unstructured":"Sevigny J, Chiao P, Bussi\u00e8re T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O\u2019Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A (2016) The antibody aducanumab reduces A\u03b2 plaques in Alzheimer\u2019s disease. Nature 537:50\u201356. https:\/\/doi.org\/10.1038\/nature19323","journal-title":"Nature"},{"key":"1901_CR95","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature24016","volume":"549","author":"Y Shi","year":"2017","unstructured":"Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C, Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM (2017) ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature 549:523\u2013527. https:\/\/doi.org\/10.1038\/nature24016","journal-title":"Nature"},{"key":"1901_CR96","doi-asserted-by":"publisher","unstructured":"Sosulina L, Mittag M, Geis H-R, Hoffmann K, Klyubin I, Qi Y, Steffen J, Friedrichs D, Henneberg N, Fuhrmann F, Justus D, Keppler K, Cuello AC, Rowan M, Fuhrmann M, Remy S (2020) Hippocampal hyperactivity in a rat model of Alzheimer\u2019s disease. https:\/\/doi.org\/10.1101\/2020.06.09.141598","DOI":"10.1101\/2020.06.09.141598"},{"key":"1901_CR97","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1017\/S1355617702813248","volume":"8","author":"Y Stern","year":"2002","unstructured":"Stern Y (2002) What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 8:448\u2013460","journal-title":"J Int Neuropsychol Soc"},{"key":"1901_CR98","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.jalz.2018.07.219","volume":"16","author":"Y Stern","year":"2020","unstructured":"Stern Y, Arenaza-Urquijo EM, Bartr\u00e9s-Faz D, Belleville S, Cantilon M, Chetelat G, Ewers M, Franzmeier N, Kempermann G, Kremen WS, Okonkwo O, Scarmeas N, Soldan A, Udeh-Momoh C, Valenzuela M, Vemuri P, Vuoksimaa E, Urquiljo EMA, Cantillon M, Clouston SAP, Estanga A, Gold B, Habeck C, Jones R, Kochhann R, Lim YY, Mart\u00ednez-Lage P, Morbelli S, Okonkwo O, Ossenkoppele R, Pettigrew C, Rosen AC, Song X, Van Loenhoud AC (2020) Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance. Alzheimer\u2019s Dement 16:1305\u20131311. https:\/\/doi.org\/10.1016\/j.jalz.2018.07.219","journal-title":"Alzheimer\u2019s Dement"},{"key":"1901_CR99","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1212\/01.WNL.0000046581.81650.D0","volume":"60","author":"D Strozyk","year":"2003","unstructured":"Strozyk D, Blennow K, White LR, Launer LJ (2003) CSF A\u00df 42 levels correlate with amyloid-neuropathology in a population-based autopsy study. Neurology 60:652\u2013656. https:\/\/doi.org\/10.1212\/01.WNL.0000046581.81650.D0","journal-title":"Neurology"},{"key":"1901_CR100","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1523\/JNEUROSCI.5245-10.2011","volume":"31","author":"A Sydow","year":"2011","unstructured":"Sydow A, Van Der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D\u2019Hooge R, Alzheimer C, Mandelkow EM (2011) Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic tau mutant. J Neurosci 31:2511\u20132525. https:\/\/doi.org\/10.1523\/JNEUROSCI.5245-10.2011","journal-title":"J Neurosci"},{"key":"1901_CR101","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.neurobiolaging.2008.07.021","volume":"31","author":"RH Takahashi","year":"2010","unstructured":"Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK (2010) Co-occurrence of Alzheimer\u2019s disease \u03b2-amyloid and tau pathologies at synapses. Neurobiol Aging 31:1145\u20131152. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2008.07.021","journal-title":"Neurobiol Aging"},{"key":"1901_CR102","doi-asserted-by":"publisher","first-page":"14299","DOI":"10.1523\/JNEUROSCI.3383-10.2010","volume":"30","author":"D Tampellini","year":"2010","unstructured":"Tampellini D, Capetillo-Zarate E, Dumont M, Huang Z, Yu F, Lin MT, Gouras GK (2010) Effects of synaptic modulation on \u03b2-amyloid, synaptophysin, and memory performance in Alzheimer\u2019s disease transgenic mice. J Neurosci 30:14299\u201314304. https:\/\/doi.org\/10.1523\/JNEUROSCI.3383-10.2010","journal-title":"J Neurosci"},{"key":"1901_CR103","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.abb.2012.10.007","volume":"529","author":"TN Tran","year":"2013","unstructured":"Tran TN, Kim SH, Gallo C, Amaya M, Kyees J, Narayanaswami V (2013) Biochemical and biophysical characterization of recombinant rat apolipoprotein E: similarities to human apolipoprotein E3. Arch Biochem Biophys 529:18\u201325. https:\/\/doi.org\/10.1016\/j.abb.2012.10.007","journal-title":"Arch Biochem Biophys"},{"key":"1901_CR104","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00401-018-1953-5","volume":"137","author":"C Vergara","year":"2019","unstructured":"Vergara C, Houben S, Suain V, Yilmaz Z, De Decker R, Vanden Dries V, Boom A, Mansour S, Leroy K, Ando K, Brion J-P (2019) Amyloid-\u03b2 pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo. Acta Neuropathol 137:397\u2013412. https:\/\/doi.org\/10.1007\/s00401-018-1953-5","journal-title":"Acta Neuropathol"},{"key":"1901_CR105","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/416535a","volume":"416","author":"DM Walsh","year":"2002","unstructured":"Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid \u03b2 protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535\u2013539. https:\/\/doi.org\/10.1038\/416535a","journal-title":"Nature"},{"key":"1901_CR106","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1042\/BST20120134","volume":"40","author":"SM Ward","year":"2012","unstructured":"Ward SM, Himmelstein DS, Lancia JK, Binder LI (2012) Tau oligomers and tau toxicity in neurodegenerative disease. Biochem Soc Trans 40:667\u2013671. https:\/\/doi.org\/10.1042\/BST20120134","journal-title":"Biochem Soc Trans"},{"key":"1901_CR107","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/S0031-9384(96)00176-X","volume":"60","author":"IQ Whishaw","year":"1996","unstructured":"Whishaw IQ, Tomie J (1996) Of mice and mazes: similarities between mice and rats on Dry Land but Not Water mazes. Physiol Behav 60:1191\u20131197. https:\/\/doi.org\/10.1016\/S0031-9384(96)00176-X","journal-title":"Physiol Behav"},{"key":"1901_CR108","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3233\/JAD-170560","volume":"61","author":"GK Wilcock","year":"2018","unstructured":"Wilcock GK, Gauthier S, Frisoni GB, Jia J, Hardlund JH, Moebius HJ, Bentham P, Kook KA, Schelter BO, Wischik DJ, Davis CS, Staff RT, Vuksanovic V, Ahearn T, Bracoud L, Shamsi K, Marek K, Seibyl J, Riedel G, Storey JMD, Harrington CR, Wischik CM (2018) Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for treatment of mild Alzheimer\u2019s Disease: Cohort Analysis as Modified Primary Outcome in a phase III clinical trial. J Alzheimer\u2019s Disease 61:435\u2013457. https:\/\/doi.org\/10.3233\/JAD-170560","journal-title":"J Alzheimer\u2019s Disease"},{"key":"1901_CR109","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.imbio.2018.09.002","volume":"224","author":"G Wildner","year":"2019","unstructured":"Wildner G (2019) Are rats more human than mice? Immunobiology 224:172\u2013176. https:\/\/doi.org\/10.1016\/j.imbio.2018.09.002","journal-title":"Immunobiology"},{"key":"1901_CR110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/cercor\/bhv332","volume":"27","author":"EN Wilson","year":"2016","unstructured":"Wilson EN, Abela AR, Do Carmo S, Allard S, Marks AR, Welikovitch LA, Ducatenzeiler A, Chudasama Y, Cuello AC (2016) Intraneuronal amyloid Beta Accumulation disrupts hippocampal CRTC1-Dependent gene expression and cognitive function in a rat model of Alzheimer Disease. Cereb Cortex 27:1\u201311. https:\/\/doi.org\/10.1093\/cercor\/bhv332","journal-title":"Cereb Cortex"},{"key":"1901_CR111","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0304-3940(01)01876-6","volume":"306","author":"O Wirths","year":"2001","unstructured":"Wirths O, Multhaup G, Czech C, Blanchard V, Moussaoui S, Tremp G, Pradier L, Beyreuther K, Bayer TA (2001) Intraneuronal A\u03b2 accumulation precedes plaque formation in \u03b2-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett 306:116\u2013120. https:\/\/doi.org\/10.1016\/S0304-3940(01)01876-6","journal-title":"Neurosci Lett"},{"key":"1901_CR112","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1471-4159.2004.02737.x","volume":"91","author":"O Wirths","year":"2004","unstructured":"Wirths O, Multhaup G, Bayer TA (2004) A modified \u03b2-amyloid hypothesis: Intraneuronal accumulation of the \u03b2-amyloid peptide - the first step of a fatal cascade. J Neurochem 91:513\u2013520. https:\/\/doi.org\/10.1111\/j.1471-4159.2004.02737.x","journal-title":"J Neurochem"},{"key":"1901_CR113","doi-asserted-by":"publisher","first-page":"8596","DOI":"10.1523\/jneurosci.20-22-08596.2000","volume":"20","author":"TP Wong","year":"2000","unstructured":"Wong TP, Marchese G, Casu MA, Ribeiro-Da-Silva A, Caludio Cuello A, De Koninck Y (2000) Loss of presynaptic and postsynaptic structures is accompanied by compensatory increase in action potential-dependent synaptic input to layer V neocortical pyramidal neurons in aged rats. J Neurosci 20:8596\u20138606. https:\/\/doi.org\/10.1523\/jneurosci.20-22-08596.2000","journal-title":"J Neurosci"},{"key":"1901_CR114","doi-asserted-by":"publisher","first-page":"739","DOI":"10.14283\/jpad.2024.54","volume":"3","author":"W Yang","year":"2024","unstructured":"Yang W, Wang J, Guo J, Dove A, Qi X, Bennett DA, Xu W (2024) Association of Cognitive Reserve Indicator with Cognitive decline and structural brain differences in Middle and older age: findings from the UK Biobank. J Prev Alzheimer\u2019s Disease 3:739\u2013748. https:\/\/doi.org\/10.14283\/jpad.2024.54","journal-title":"J Prev Alzheimer\u2019s Disease"},{"key":"1901_CR115","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1126\/science.2218531","volume":"250","author":"BA Yankner","year":"1990","unstructured":"Yankner BA, Duffy LK, Kirschner DA (1990) Neurotrophic and neurotoxic effects of amyloid \u03b2 protein: reversal by Tachykinin Neuropeptides. Sci (1979) 250:279\u2013282. https:\/\/doi.org\/10.1126\/science.2218531","journal-title":"Sci (1979)"},{"key":"1901_CR116","doi-asserted-by":"publisher","unstructured":"Yin Y, Gao D, Wang Y, Wang Z-HH, Wang XCXX-C, Ye J, Wu D, Fang L, Pi G, Yang Y, Wang XCXX-C, Lu C, Ye K, Wang J-ZZ (2016) Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV\/CREB signaling. Proceedings of the National Academy of Sciences 113:E3773\u2013E3781. https:\/\/doi.org\/10.1073\/pnas.1604519113","DOI":"10.1073\/pnas.1604519113"},{"key":"1901_CR117","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","volume":"53","author":"Y Yoshiyama","year":"2007","unstructured":"Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VMY (2007) Synapse loss and Microglial Activation Precede tangles in a P301S Tauopathy Mouse Model. Neuron 53:337\u2013351. https:\/\/doi.org\/10.1016\/j.neuron.2007.01.010","journal-title":"Neuron"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-024-01901-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40478-024-01901-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-024-01901-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T17:07:10Z","timestamp":1734714430000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-024-01901-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":117,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1901"],"URL":"https:\/\/doi.org\/10.1186\/s40478-024-01901-0","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"17 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The use of animals for this study was approved by the McGill Animal Care Committee under the guidelines of the Canadian Council on Animal Care (CCAC).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"193"}}