{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:06:41Z","timestamp":1788581201907,"version":"build-2803163510"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Italian Ministry of Health grant","award":["RF-2021-12372337"],"award-info":[{"award-number":["RF-2021-12372337"]}]},{"name":"Alzheimer\u2019s Association Research Fellowship","award":["AARF-22-928286"],"award-info":[{"award-number":["AARF-22-928286"]}]},{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["TCP15011"],"award-info":[{"award-number":["TCP15011"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health grants","doi-asserted-by":"crossref","award":["R01, NS082730"],"award-info":[{"award-number":["R01, NS082730"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"DOI":"10.1186\/s40478-025-01930-3","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T15:19:47Z","timestamp":1737991187000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Tau oligomers impair memory and synaptic plasticity through the cellular prion protein"],"prefix":"10.1186","volume":"13","author":[{"given":"Claudia","family":"Balducci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Orsini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Cerovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marten","family":"Beeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Rocutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Dacomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Masone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Busani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Lavigna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Leva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Zucchelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Musco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Kanaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gobbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Chiesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Fioriti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Forloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"1930_CR1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/B978-0-12-802395-2.00025-0","volume":"145","author":"GG Kovacs","year":"2017","unstructured":"Kovacs GG (2017) Tauopathies. Handb Clin Neurol 145:355\u2013368. https:\/\/doi.org\/10.1016\/B978-0-12-802395-2.00025-0","journal-title":"Handb Clin Neurol"},{"issue":"11","key":"1930_CR2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011585","volume":"2","author":"DM Holtzman","year":"2012","unstructured":"Holtzman DM, Mandelkow E, Selkoe DJ (2012) Alzheimer disease in 2020. Cold Spring Harb Perspect Med 2(11):a011585. https:\/\/doi.org\/10.1101\/cshperspect.a011585","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1930_CR3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3389\/fncel.2015.00464","volume":"9","author":"MJ Guerrero-Mu\u00f1oz","year":"2015","unstructured":"Guerrero-Mu\u00f1oz MJ, Gerson J, Castillo-Carranza DL (2015) Tau oligomers: the toxic player at synapses in Alzheimer\u2019s disease. Front Cell Neurosci 9:464. https:\/\/doi.org\/10.3389\/fncel.2015.00464","journal-title":"Front Cell Neurosci"},{"key":"1930_CR4","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3390\/life11010028","volume":"11","author":"G Niewiadomska","year":"2021","unstructured":"Niewiadomska G, Niewiadomski W, Steczkowska M, Gasiorowska A (2021) Tau oligomers neurotoxicity. Life (Basel) 11:28. https:\/\/doi.org\/10.3390\/life11010028","journal-title":"Life (Basel)"},{"key":"1930_CR5","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1038\/nn.4142","volume":"18","author":"W-S Chung","year":"2015","unstructured":"Chung W-S, Welsh CA, Barres BA, Stevens B (2015) Do glia drive synaptic and cognitive impairment in disease? Nat Neurosci 18:1539\u20131545. https:\/\/doi.org\/10.1038\/nn.4142","journal-title":"Nat Neurosci"},{"key":"1930_CR6","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1001\/jamaneurol.2023.3530","volume":"80","author":"RN Taddei","year":"2023","unstructured":"Taddei RN, Perbet R, Mate de Gerando A, Wiedmer AE, Sanchez-Mico M, Connors Stewart T, Gaona A, Melloni A, Amaral AC, Duff K, Frosch MP, G\u00f3mez-Isla T (2023) Tau oligomer-containing synapse elimination by microglia and astrocytes in Alzheimer disease. JAMA Neurol 80:1209\u20131221. https:\/\/doi.org\/10.1001\/jamaneurol.2023.3530","journal-title":"JAMA Neurol"},{"key":"1930_CR7","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1096\/fj.11-199851","volume":"26","author":"CA Lasagna-Reeves","year":"2012","unstructured":"Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Sarmiento J, Troncoso J, Jackson GR, Kayed R (2012) Identification of oligomers at early stages of tau aggregation in Alzheimer\u2019s disease. FASEB J 26:1946\u20131959. https:\/\/doi.org\/10.1096\/fj.11-199851","journal-title":"FASEB J"},{"key":"1930_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.neurobiolaging.2016.07.015","volume":"47","author":"K Cox","year":"2016","unstructured":"Cox K, Combs B, Abdelmesih B, Morfini G, Brady ST, Kanaan NM (2016) Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition. Neurobiol Aging 47:113\u2013126. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.07.015","journal-title":"Neurobiol Aging"},{"key":"1930_CR9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI168553","volume":"133","author":"N Samudra","year":"2023","unstructured":"Samudra N, Lane-Donovan C, VandeVrede L, Boxer AL (2023) Tau pathology in neurodegenerative disease: Disease mechanisms and therapeutic avenues. J Clin Invest 133:e168553. https:\/\/doi.org\/10.1172\/JCI168553","journal-title":"J Clin Invest"},{"key":"1930_CR10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000353687","volume":"13","author":"EJ Mufson","year":"2014","unstructured":"Mufson EJ, Ward S, Binder L (2014) Prefibrillar tau oligomers in mild cognitive impairment and Alzheimer\u2019s disease. Neurodegener Dis 13:151\u2013153. https:\/\/doi.org\/10.1159\/000353687","journal-title":"Neurodegener Dis"},{"key":"1930_CR11","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1016\/j.ajpath.2011.07.044","volume":"179","author":"L Vana","year":"2011","unstructured":"Vana L, Kanaan NM, Ugwu IC, Wuu J, Mufson EJ, Binder LI (2011) Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer\u2019s disease. Am J Pathol 179:2533\u20132550. https:\/\/doi.org\/10.1016\/j.ajpath.2011.07.044","journal-title":"Am J Pathol"},{"key":"1930_CR12","doi-asserted-by":"publisher","first-page":"19393","DOI":"10.1038\/srep19393","volume":"6","author":"M F\u00e1","year":"2016","unstructured":"F\u00e1 M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, Costa JA, Lopez P, Davidowitz E, Yu WH, Haroutunian V, Brown LM, Palmeri A, Sigurdsson EM, Duff KE, Teich AF, Honig LS, Sierks M, Moe JG, D\u2019Adamio L, Grassi C, Kanaan NM, Fraser PE, Arancio O (2016) Extracellular tau oligomers produce an immediate impairment of LTP and memory. Sci Rep 6:19393. https:\/\/doi.org\/10.1038\/srep19393","journal-title":"Sci Rep"},{"key":"1930_CR13","doi-asserted-by":"publisher","first-page":"10300","DOI":"10.1021\/bi2009147","volume":"50","author":"KR Patterson","year":"2011","unstructured":"Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI (2011) Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry 50:10300\u201310310. https:\/\/doi.org\/10.1021\/bi2009147","journal-title":"Biochemistry"},{"key":"1930_CR14","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3233\/JAD-170168","volume":"58","author":"E Swanson","year":"2017","unstructured":"Swanson E, Breckenridge L, McMahon L, Som S, McConnell I, Bloom GS (2017) Extracellular tau oligomers induce invasion of endogenous tau into the somatodendritic compartment and axonal transport dysfunction. J Alzheimers Dis 58:803\u2013820. https:\/\/doi.org\/10.3233\/JAD-170168","journal-title":"J Alzheimers Dis"},{"key":"1930_CR15","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1097\/NEN.0b013e3181e85737","volume":"69","author":"A Alzualde","year":"2010","unstructured":"Alzualde A, Indakoetxea B, Ferrer I, Moreno F, Barandiaran M, Gorostidi A, Estanga A, Ruiz I, Calero M, van Leeuwen FW, Atares B, Juste R, Rodriguez-Mart\u00ednez AB, L\u00f3pez de Munain A (2010) A novel PRNP Y218N mutation in Gerstmann-Str\u00e4ussler-Scheinker disease with neurofibrillary degeneration. J Neuropathol Exp Neurol 69:789\u2013800. https:\/\/doi.org\/10.1097\/NEN.0b013e3181e85737","journal-title":"J Neuropathol Exp Neurol"},{"key":"1930_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/ng0492-68","volume":"1","author":"K Hsiao","year":"1992","unstructured":"Hsiao K, Dlouhy SR, Farlow MR, Cass C, Da Costa M, Conneally PM, Hodes ME, Ghetti B, Prusiner SB (1992) Mutant prion proteins in Gerstmann-Str\u00e4ussler-Scheinker disease with neurofibrillary tangles. Nat Genet 1:68\u201371. https:\/\/doi.org\/10.1038\/ng0492-68","journal-title":"Nat Genet"},{"key":"1930_CR17","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s00401-002-0547-3","volume":"104","author":"K Ishizawa","year":"2002","unstructured":"Ishizawa K, Komori T, Shimazu T, Yamamoto T, Kitamoto T, Shimazu K, Hirose T (2002) Hyperphosphorylated tau deposition parallels prion protein burden in a case of Gerstmann-Str\u00e4ussler-Scheinker syndrome P102L mutation complicated with dementia. Acta Neuropathol 104:342\u2013350. https:\/\/doi.org\/10.1007\/s00401-002-0547-3","journal-title":"Acta Neuropathol"},{"key":"1930_CR18","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1136\/jnnp.63.2.240","volume":"63","author":"C Tranchant","year":"1997","unstructured":"Tranchant C, Sergeant N, Wattez A, Mohr M, Warter JM, Delacourte A (1997) Neurofibrillary tangles in Gerstmann-Str\u00e4ussler-Scheinker syndrome with the A117V prion gene mutation. J Neurol Neurosurg Psychiatry 63:240\u2013246. https:\/\/doi.org\/10.1136\/jnnp.63.2.240","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1930_CR19","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/s004010051116","volume":"98","author":"M Yamazaki","year":"1999","unstructured":"Yamazaki M, Oyanagi K, Mori O, Kitamura S, Ohyama M, Terashi A, Kitamoto T, Katayama Y (1999) Variant Gerstmann-Str\u00e4ussler syndrome with the P105L prion gene mutation: an unusual case with nigral degeneration and widespread neurofibrillary tangles. Acta Neuropathol 98:506\u2013511. https:\/\/doi.org\/10.1007\/s004010051116","journal-title":"Acta Neuropathol"},{"key":"1930_CR20","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s00401-019-02053-5","volume":"138","author":"LA Gomes","year":"2019","unstructured":"Gomes LA, Hipp SA, Rijal Upadhaya A, Balakrishnan K, Ospitalieri S, Koper MJ, Largo-Barrientos P, Uytterhoeven V, Reichwald J, Rabe S, Vandenberghe R, von Arnim CAF, Tousseyn T, Feederle R, Giudici C, Willem M, Staufenbiel M, Thal DR (2019) A\u03b2-induced acceleration of Alzheimer-related \u03c4-pathology spreading and its association with prion protein. Acta Neuropathol 138:913\u2013941. https:\/\/doi.org\/10.1007\/s00401-019-02053-5","journal-title":"Acta Neuropathol"},{"key":"1930_CR21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11010-007-9664-6","volume":"310","author":"X-F Wang","year":"2008","unstructured":"Wang X-F, Dong C-F, Zhang J, Wan Y-Z, Li F, Huang Y-X, Han L, Shan B, Gao C, Han J, Dong X-P (2008) Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro. Mol Cell Biochem 310:49\u201355. https:\/\/doi.org\/10.1007\/s11010-007-9664-6","journal-title":"Mol Cell Biochem"},{"key":"1930_CR22","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1016\/j.celrep.2018.04.040","volume":"23","author":"N-W Hu","year":"2018","unstructured":"Hu N-W, Corbett GT, Moore S, Klyubin I, O\u2019Malley TT, Walsh DM, Livesey FJ, Rowan MJ (2018) Extracellular forms of A\u03b2 and Tau from iPSC models of Alzheimer\u2019s disease disrupt synaptic plasticity. Cell Rep 23:1932\u20131938. https:\/\/doi.org\/10.1016\/j.celrep.2018.04.040","journal-title":"Cell Rep"},{"key":"1930_CR23","doi-asserted-by":"publisher","first-page":"10595","DOI":"10.1523\/JNEUROSCI.1700-18.2018","volume":"38","author":"T Ondrejcak","year":"2018","unstructured":"Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ (2018) Cellular prion protein mediates the disruption of hippocampal synaptic plasticity by soluble tau in vivo. J Neurosci 38:10595\u201310606. https:\/\/doi.org\/10.1523\/JNEUROSCI.1700-18.2018","journal-title":"J Neurosci"},{"key":"1930_CR24","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s00401-019-02114-9","volume":"139","author":"GT Corbett","year":"2020","unstructured":"Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, Young-Pearse TL, Billinton A, Walsh DM (2020) PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta Neuropathol 139:503\u2013526. https:\/\/doi.org\/10.1007\/s00401-019-02114-9","journal-title":"Acta Neuropathol"},{"key":"1930_CR25","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1073\/pnas.0911829107","volume":"107","author":"C Balducci","year":"2010","unstructured":"Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, Tapella L, Colombo L, Manzoni C, Borsello T, Chiesa R, Gobbi M, Salmona M, Forloni G (2010) Synthetic amyloid-\u03b2 oligomers impair long-term memory independently of cellular prion protein. PNAS 107:2295\u20132300. https:\/\/doi.org\/10.1073\/pnas.0911829107","journal-title":"PNAS"},{"key":"1930_CR26","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.neurobiolaging.2018.06.002","volume":"70","author":"C Balducci","year":"2018","unstructured":"Balducci C, Santamaria G, La Vitola P, Brandi E, Grandi F, Viscomi AR, Beeg M, Gobbi M, Salmona M, Ottonello S, Forloni G (2018) Doxycycline counteracts neuroinflammation restoring memory in Alzheimer\u2019s disease mouse models. Neurobiol Aging 70:128\u2013139. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.06.002","journal-title":"Neurobiol Aging"},{"key":"1930_CR27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/bs.mcb.2017.06.005","volume":"141","author":"B Combs","year":"2017","unstructured":"Combs B, Tiernan CT, Hamel C, Kanaan NM (2017) Production of recombinant tau oligomers in vitro. Methods Cell Biol 141:45\u201364. https:\/\/doi.org\/10.1016\/bs.mcb.2017.06.005","journal-title":"Methods Cell Biol"},{"key":"1930_CR28","doi-asserted-by":"publisher","first-page":"107480","DOI":"10.1016\/j.isci.2023.107480","volume":"26","author":"A Masone","year":"2023","unstructured":"Masone A, Zucchelli C, Caruso E, Lavigna G, Era\u00f1a H, Giachin G, Tapella L, Comerio L, Restelli E, Raimondi I, Elezgarai SR, De Leo F, Quilici G, Taiarol L, Oldrati M, Lorenzo NL, Garc\u00eda-Mart\u00ednez S, Cagnotto A, Lucchetti J, Gobbi M, Vanni I, Nonno R, Di Bari MA, Tully MD, Cecatiello V, Ciossani G, Pasqualato S, Van Anken E, Salmona M, Castilla J, Requena JR, Banfi S, Musco G, Chiesa R (2023) A tetracationic porphyrin with dual anti-prion activity. iScience 26:107480. https:\/\/doi.org\/10.1016\/j.isci.2023.107480","journal-title":"iScience"},{"key":"1930_CR29","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ab.2006.08.005","volume":"358","author":"T Bravman","year":"2006","unstructured":"Bravman T, Bronner V, Lavie K, Notcovich A, Papalia GA, Myszka DG (2006) Exploring \u201cone-shot\u201d kinetics and small molecule analysis using the ProteOn XPR36 array biosensor. Anal Biochem 358:281\u2013288. https:\/\/doi.org\/10.1016\/j.ab.2006.08.005","journal-title":"Anal Biochem"},{"key":"1930_CR30","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1128\/JCM.42.3.972-980.2004","volume":"42","author":"CMA Thuring","year":"2004","unstructured":"Thuring CMA, Erkens JHF, Jacobs JG, Bossers A, Van Keulen LJM, Garssen GJ, Van Zijderveld FG, Ryder SJ, Groschup MH, Sweeney T, Langeveld JPM (2004) Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein. J Clin Microbiol 42:972\u2013980. https:\/\/doi.org\/10.1128\/JCM.42.3.972-980.2004","journal-title":"J Clin Microbiol"},{"key":"1930_CR31","doi-asserted-by":"publisher","first-page":"23063","DOI":"10.1074\/jbc.M111.237974","volume":"286","author":"KR Patterson","year":"2011","unstructured":"Patterson KR, Remmers C, Fu Y, Brooker S, Kanaan NM, Vana L, Ward S, Reyes JF, Philibert K, Glucksman MJ, Binder LI (2011) Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. J Biol Chem 286:23063\u201323076. https:\/\/doi.org\/10.1074\/jbc.M111.237974","journal-title":"J Biol Chem"},{"key":"1930_CR32","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3233\/JAD-131235","volume":"37","author":"SM Ward","year":"2013","unstructured":"Ward SM, Himmelstein DS, Lancia JK, Fu Y, Patterson KR, Binder LI (2013) TOC1: characterization of a selective oligomeric tau antibody. J Alzheimers Dis 37:593\u2013602. https:\/\/doi.org\/10.3233\/JAD-131235","journal-title":"J Alzheimers Dis"},{"key":"1930_CR33","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1042\/BJ20130563","volume":"454","author":"L Tapella","year":"2013","unstructured":"Tapella L, Stravalaci M, Bastone A, Biasini E, Gobbi M, Chiesa R (2013) Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases. Biochem J 454:417\u2013425. https:\/\/doi.org\/10.1042\/BJ20130563","journal-title":"Biochem J"},{"key":"1930_CR34","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0896-6273(00)80653-4","volume":"21","author":"R Chiesa","year":"1998","unstructured":"Chiesa R, Piccardo P, Ghetti B, Harris DA (1998) Neurological illness in transgenic mice expressing a prion protein with an insertional mutation. Neuron 21:1339\u20131351","journal-title":"Neuron"},{"key":"1930_CR35","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/brain\/awy318","volume":"142","author":"P La Vitola","year":"2019","unstructured":"La Vitola P, Beeg M, Balducci C, Santamaria G, Restelli E, Colombo L, Caldinelli L, Pollegioni L, Gobbi M, Chiesa R, Forloni G (2019) Cellular prion protein neither binds to alpha-synuclein oligomers nor mediates their detrimental effects. Brain 142:249\u2013254. https:\/\/doi.org\/10.1093\/brain\/awy318","journal-title":"Brain"},{"key":"1930_CR36","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1042\/BJ20100615","volume":"430","author":"E Biasini","year":"2010","unstructured":"Biasini E, Tapella L, Restelli E, Pozzoli M, Massignan T, Chiesa R (2010) The hydrophobic core region governs mutant prion protein aggregation and intracellular retention. Biochem J 430:477\u2013486. https:\/\/doi.org\/10.1042\/BJ20100615","journal-title":"Biochem J"},{"key":"1930_CR37","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/14728222.2023.2206561","volume":"27","author":"JB Rayman","year":"2023","unstructured":"Rayman JB (2023) Focusing on oligomeric tau as a therapeutic target in Alzheimer\u2019s disease and other tauopathies. Expert Opin Ther Targets 27:269\u2013279. https:\/\/doi.org\/10.1080\/14728222.2023.2206561","journal-title":"Expert Opin Ther Targets"},{"key":"1930_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.822420","volume":"16","author":"G Forloni","year":"2022","unstructured":"Forloni G, La Vitola P, Balducci C (2022) Oligomeropathies, inflammation and prion protein binding. Front Neurosci 16:822420. https:\/\/doi.org\/10.3389\/fnins.2022.822420","journal-title":"Front Neurosci"},{"key":"1930_CR39","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3390\/cells9030591","volume":"9","author":"R Gav\u00edn","year":"2020","unstructured":"Gav\u00edn R, Lid\u00f3n L, Ferrer I, Del R\u00edo JA (2020) The quest for cellular prion protein functions in the aged and neurodegenerating brain. Cells 9:591. https:\/\/doi.org\/10.3390\/cells9030591","journal-title":"Cells"},{"key":"1930_CR40","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41572-024-00497-y","volume":"10","author":"I Zerr","year":"2024","unstructured":"Zerr I, Ladogana A, Mead S, Hermann P, Forloni G, Appleby BS (2024) Creutzfeldt-Jakob disease and other prion diseases. Nat Rev Dis Primers 10:14. https:\/\/doi.org\/10.1038\/s41572-024-00497-y","journal-title":"Nat Rev Dis Primers"},{"key":"1930_CR41","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/emmm.201000082","volume":"2","author":"AM Calella","year":"2010","unstructured":"Calella AM, Farinelli M, Nuvolone M, Mirante O, Moos R, Falsig J, Mansuy IM, Aguzzi A (2010) Prion protein and Abeta-related synaptic toxicity impairment. EMBO Mol Med 2:306\u2013314. https:\/\/doi.org\/10.1002\/emmm.201000082","journal-title":"EMBO Mol Med"},{"key":"1930_CR42","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13187","volume":"30","author":"F Del Gallo","year":"2021","unstructured":"Del Gallo F, Bianchi S, Bertani I, Messa M, Colombo L, Balducci C, Salmona M, Imeri L, Chiesa R (2021) Sleep inhibition induced by amyloid-\u03b2 oligomers is mediated by the cellular prion protein. J Sleep Res 30:e13187. https:\/\/doi.org\/10.1111\/jsr.13187","journal-title":"J Sleep Res"},{"key":"1930_CR43","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1038\/nn.4648","volume":"20","author":"DG Ferreira","year":"2017","unstructured":"Ferreira DG, Temido-Ferreira M, Miranda HV, Batalha VL, Coelho JE, Szeg\u00f6 \u00c9M, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF (2017) \u03b1-synuclein interacts with PrPCto induce cognitive impairment through mGluR5 and NMDAR2B. Nat Neurosci 20:1569\u20131579. https:\/\/doi.org\/10.1038\/nn.4648","journal-title":"Nat Neurosci"},{"key":"1930_CR44","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1038\/nature07761","volume":"457","author":"J Lauren","year":"2009","unstructured":"Lauren J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457:1128\u20131132","journal-title":"Nature"},{"key":"1930_CR45","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/bpa.12695","volume":"29","author":"S Baiardi","year":"2019","unstructured":"Baiardi S, Rossi M, Capellari S, Parchi P (2019) Recent advances in the histo-molecular pathology of human prion disease. Brain Pathol 29:278\u2013300. https:\/\/doi.org\/10.1111\/bpa.12695","journal-title":"Brain Pathol"},{"key":"1930_CR46","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/19336896.2021.1946378","volume":"15","author":"K Men\u0161\u00edkov\u00e1","year":"2021","unstructured":"Men\u0161\u00edkov\u00e1 K, Mat\u011bj R, Parobkov\u00e1 E, Sm\u011bt\u00e1kov\u00e1 M, Ka\u0148ovsk\u00fd P (2021) PART and ARTAG tauopathies at a relatively young age as a concomitant finding in sporadic Creutzfeldt-Jakob disease. Prion 15:138\u2013142. https:\/\/doi.org\/10.1080\/19336896.2021.1946378","journal-title":"Prion"},{"key":"1930_CR47","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1097\/NEN.0000000000000228","volume":"74","author":"T Tousseyn","year":"2015","unstructured":"Tousseyn T, Bajsarowicz K, S\u00e1nchez H, Gheyara A, Oehler A, Geschwind M, DeArmond B, DeArmond SJ (2015) Prion disease induces Alzheimer disease-like neuropathologic changes. J Neuropathol Exp Neurol 74:873\u2013888. https:\/\/doi.org\/10.1097\/NEN.0000000000000228","journal-title":"J Neuropathol Exp Neurol"},{"key":"1930_CR48","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1007\/s12035-014-8793-7","volume":"51","author":"C Vergara","year":"2015","unstructured":"Vergara C, Ord\u00f3\u00f1ez-Guti\u00e9rrez L, Wandosell F, Ferrer I, del R\u00edo JA, Gav\u00edn R (2015) Role of PrPC expression in tau protein levels and phosphorylation in Alzheimer\u2019s disease evolution. Mol Neurobiol 51:1206\u20131220. https:\/\/doi.org\/10.1007\/s12035-014-8793-7","journal-title":"Mol Neurobiol"},{"key":"1930_CR49","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1750-1326-6-39","volume":"6","author":"CA Lasagna-Reeves","year":"2011","unstructured":"Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Clos AL, Jackson GR, Kayed R (2011) Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Mol Neurodegener 6:39. https:\/\/doi.org\/10.1186\/1750-1326-6-39","journal-title":"Mol Neurodegener"},{"key":"1930_CR50","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/19336896.2020.1854034","volume":"14","author":"G Legname","year":"2020","unstructured":"Legname G, Scial\u00f2 C (2020) On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases. Prion 14:257\u2013270. https:\/\/doi.org\/10.1080\/19336896.2020.1854034","journal-title":"Prion"},{"key":"1930_CR51","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26991","volume":"6","author":"D Puzzo","year":"2017","unstructured":"Puzzo D, Piacentini R, F\u00e1 M, Gulisano W, Li Puma DD, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D\u2019Adamio L, Grassi C, Arancio O (2017) LTP and memory impairment caused by extracellular A\u03b2 and tau oligomers is APP-dependent. Elife 6:e26991. https:\/\/doi.org\/10.7554\/eLife.26991","journal-title":"Elife"},{"key":"1930_CR52","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/370295a0","volume":"370","author":"J Collinge","year":"1994","unstructured":"Collinge J, Whittington MA, Sidle KC, Smith CJ, Palmer MS, Clarke AR, Jefferys JG (1994) Prion protein is necessary for normal synaptic function. Nature 370:295\u2013297. https:\/\/doi.org\/10.1038\/370295a0","journal-title":"Nature"},{"key":"1930_CR53","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.nbd.2005.01.001","volume":"19","author":"JR Criado","year":"2005","unstructured":"Criado JR, S\u00e1nchez-Alavez M, Conti B, Giacchino JL, Wills DN, Henriksen SJ, Race R, Manson JC, Chesebro B, Oldstone MBA (2005) Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons. Neurobiol Dis 19:255\u2013265. https:\/\/doi.org\/10.1016\/j.nbd.2005.01.001","journal-title":"Neurobiol Dis"},{"key":"1930_CR54","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.brainres.2006.04.056","volume":"1097","author":"LE Maglio","year":"2006","unstructured":"Maglio LE, Martins VR, Izquierdo I, Ramirez OA (2006) Role of cellular prion protein on LTP expression in aged mice. Brain Res 1097:11\u201318. https:\/\/doi.org\/10.1016\/j.brainres.2006.04.056","journal-title":"Brain Res"},{"key":"1930_CR55","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4161\/pri.1.2.4346","volume":"1","author":"AD Steele","year":"2007","unstructured":"Steele AD, Lindquist S, Aguzzi A (2007) The prion protein knockout mouse: a phenotype under challenge. Prion 1:83\u201393","journal-title":"Prion"},{"key":"1930_CR56","doi-asserted-by":"publisher","first-page":"10278","DOI":"10.1523\/JNEUROSCI.1301-17.2017","volume":"37","author":"I Bertani","year":"2017","unstructured":"Bertani I, Iori V, Trusel M, Maroso M, Foray C, Mantovani S, Tonini R, Vezzani A, Chiesa R (2017) Inhibition of IL-1\u03b2 signaling normalizes NMDA-Dependent neurotransmission and reduces seizure susceptibility in a mouse model of Creutzfeldt-Jakob disease. J Neurosci 37:10278\u201310289. https:\/\/doi.org\/10.1523\/JNEUROSCI.1301-17.2017","journal-title":"J Neurosci"},{"key":"1930_CR57","doi-asserted-by":"publisher","first-page":"12845","DOI":"10.1074\/jbc.M808759200","volume":"284","author":"B Frost","year":"2009","unstructured":"Frost B, Jacks RL, Diamond MI (2009) Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem 284:12845\u201312852. https:\/\/doi.org\/10.1074\/jbc.M808759200","journal-title":"J Biol Chem"},{"key":"1930_CR58","doi-asserted-by":"publisher","first-page":"10145","DOI":"10.3390\/ijms221810145","volume":"22","author":"G Siano","year":"2021","unstructured":"Siano G, Falcicchia C, Origlia N, Cattaneo A, Di Primio C (2021) Non-canonical roles of tau and their contribution to synaptic dysfunction. Int J Mol Sci 22:10145. https:\/\/doi.org\/10.3390\/ijms221810145","journal-title":"Int J Mol Sci"},{"key":"1930_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101272","volume":"67","author":"J Zhao","year":"2021","unstructured":"Zhao J, Wu H, Tang X-Q (2021) Tau internalization: a complex step in tau propagation. Ageing Res Rev 67:101272. https:\/\/doi.org\/10.1016\/j.arr.2021.101272","journal-title":"Ageing Res Rev"},{"key":"1930_CR60","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/jnc.15040","volume":"155","author":"E De Cecco","year":"2020","unstructured":"De Cecco E, Celauro L, Vanni S, Grandolfo M, Bistaffa E, Moda F, Aguzzi A, Legname G (2020) The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cells. J Neurochem 155:577\u2013591. https:\/\/doi.org\/10.1111\/jnc.15040","journal-title":"J Neurochem"},{"key":"1930_CR61","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s40035-021-00270-1","volume":"10","author":"M Wu","year":"2021","unstructured":"Wu M, Zhang M, Yin X, Chen K, Hu Z, Zhou Q, Cao X, Chen Z, Liu D (2021) The role of pathological tau in synaptic dysfunction in Alzheimer\u2019s diseases. Transl Neurodegener 10:45. https:\/\/doi.org\/10.1186\/s40035-021-00270-1","journal-title":"Transl Neurodegener"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-025-01930-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40478-025-01930-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-025-01930-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T15:19:53Z","timestamp":1737991193000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-025-01930-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1930"],"URL":"https:\/\/doi.org\/10.1186\/s40478-025-01930-3","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,27]]},"assertion":[{"value":"23 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Mario Negri Institute for Pharmacological Research adheres to the principles set out in the following laws, regulation, and policies governing the Care and Use of Laboratory Animals: Italian Governing Law (D.lgs 26\/2014; Authorization N\u00b019\/2008-A issued March 6, 2008 by Ministry of Health); Mario Negri Institutional Regulations and Policies providing internal authorization for persons conducting animal experiments (Quality Management System Certificate \u2013 UNI EN ISO 9001:2015 \u2013 Reg. N\u00b0 6121); the NIH Guide for the Care and Use of Laboratory Animals (2011 edition) and EU directives and guidelines (EEC Council Directive 2010\/63\/UE). The statement of Compliance (Assurance) with the Public Health Service (PHS) Policy on Human Care and Use of Laboratory Animals was reviewed on 9\/9\/2014 (Animal Welfare Assurance #A5023-01). All animals were managed in accordance with European directive 2010\/63\/UE and with Italian law D.l. 26\/2014. The procedures were approved by the local animal-health and ethical committee and were authorized by the national authority (Istituto Superiore di Sanit\u00e0; authorization numbers 370\/2016-PR and 532\/2021-PR). All efforts were made to reduce the number of animals by following the 3R\u2019s rule.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}