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Research on de-identified postmortem brain tissue is considered exempt from human subjects\u2019 regulations by the Mayo Clinic Institutional Review Board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Mayo Clinic, F.C.F., and W.S. hold a patent related to PRKN activators (Small Molecule Activators of Parkin Enzyme Function, US patent, 11401255B2; August 02, 2022). Z.K.W. serves as PI or Co-PI on projects\/grants from Biohaven Pharmaceuticals, Inc., Vigil Neuroscience, Inc., ONO Pharmaceuticals Co., LTD., and Amylyx Pharmaceuticals, Inc., and he is an external advisory board member for Vigil Neuroscience, Inc., and a consultant on neurodegenerative medical research for Eli Lilly & Company and NovoGlia Inc. All other authors declare they have no competing interests. This research was conducted in compliance with Mayo Clinic conflict of interest policies.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}