{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:13:35Z","timestamp":1793146415954,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"DOI":"10.1186\/s40478-025-01967-4","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T05:26:14Z","timestamp":1741670774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Targeting NAD\u2009+\u2009biosynthesis suppresses TGF-\u03b21\/Smads\/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis"],"prefix":"10.1186","volume":"13","author":[{"given":"Liyun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Wakimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"1967_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA Cancer J Clin 73:17\u201348. https:\/\/doi.org\/10.3322\/caac.21763","journal-title":"CA Cancer J Clin"},{"key":"1967_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72:7\u201333. https:\/\/doi.org\/10.3322\/caac.21708","journal-title":"CA Cancer J Clin"},{"key":"1967_CR3","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1002\/ijc.26031","volume":"128","author":"RR Langley","year":"2011","unstructured":"Langley RR, Fidler IJ (2011) The seed and soil hypothesis revisited\u2013the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer 128:2527\u20132535. https:\/\/doi.org\/10.1002\/ijc.26031","journal-title":"Int J Cancer"},{"key":"1967_CR4","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.lungcan.2010.01.018","volume":"70","author":"I Olmez","year":"2010","unstructured":"Olmez I, Donahue BR, Butler JS, Huang Y, Rubin P, Xu Y (2010) Clinical outcomes in extracranial tumor sites and unusual toxicities with concurrent whole brain radiation (WBRT) and erlotinib treatment in patients with non-small cell lung cancer (NSCLC) with brain metastasis. Lung Cancer 70:174\u2013179. https:\/\/doi.org\/10.1016\/j.lungcan.2010.01.018","journal-title":"Lung Cancer"},{"key":"1967_CR5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00401-011-0933-9","volume":"123","author":"M Preusser","year":"2012","unstructured":"Preusser M, Capper D, Ilhan-Mutlu A, Berghoff AS, Birner P, Bartsch R et al (2012) Brain metastases: pathobiology and emerging targeted therapies. Acta Neuropathol 123:205\u2013222. https:\/\/doi.org\/10.1007\/s00401-011-0933-9","journal-title":"Acta Neuropathol"},{"key":"1967_CR6","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.3390\/cells11172627","volume":"11","author":"LE Navas","year":"2022","unstructured":"Navas LE, Carnero A (2022) Nicotinamide adenine dinucleotide (NAD) metabolism as a relevant target in Cancer. Cells 11:2627. https:\/\/doi.org\/10.3390\/cells11172627","journal-title":"Cells"},{"key":"1967_CR7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","volume":"5","author":"N Xie","year":"2020","unstructured":"Xie N, Zhang L, Gao W, Huang C, Huber PE, Zhou X et al (2020) NAD\u2009+\u2009metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther 5:227. https:\/\/doi.org\/10.1038\/s41392-020-00311-7","journal-title":"Signal Transduct Target Ther"},{"key":"1967_CR8","doi-asserted-by":"publisher","first-page":"897","DOI":"10.7150\/ijbs.81609","volume":"19","author":"Y Liu","year":"2023","unstructured":"Liu Y, Sun Y, Guo Y, Shi X, Chen X, Feng W et al (2023) An overview: the diversified role of mitochondria in Cancer metabolism. Int J Biol Sci 19:897\u2013915. https:\/\/doi.org\/10.7150\/ijbs.81609","journal-title":"Int J Biol Sci"},{"key":"1967_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/metabo6040033","volume":"6","author":"JD Moreira","year":"2016","unstructured":"Moreira JD, Hamraz M, Abolhassani M, Bigan E, P\u00e9r\u00e8s S, Paulev\u00e9 L et al (2016) The redox status of Cancer cells supports mechanisms behind the Warburg effect. Metabolites 6:33. https:\/\/doi.org\/10.3390\/metabo6040033","journal-title":"Metabolites"},{"key":"1967_CR10","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1172\/JCI90277","volume":"128","author":"M Touat","year":"2018","unstructured":"Touat M, Sourisseau T, Dorvault N, Chabanon RM, Garrido M, Morel D et al (2018) DNA repair deficiency sensitizes lung cancer cells to NAD\u2009+\u2009biosynthesis Blockade. J Clin Invest 128:1671\u20131687. https:\/\/doi.org\/10.1172\/JCI90277","journal-title":"J Clin Invest"},{"key":"1967_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13046-023-02631-2","volume":"42","author":"LE Navas","year":"2023","unstructured":"Navas LE, Blanco-Alcaina E, Suarez-Martinez E, Verdugo-Sivianes EM, Espinosa-Sanchez A, Sanchez-Diaz L et al (2023) NAD pool as an antitumor target against cancer stem cells in head and neck cancer. J Exp Clin Cancer Res 42:55. https:\/\/doi.org\/10.1186\/s13046-023-02631-2","journal-title":"J Exp Clin Cancer Res"},{"key":"1967_CR12","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1093\/neuonc\/noab265","volume":"24","author":"J Wu","year":"2022","unstructured":"Wu J (2022) Targeting nicotinamide adenosine dinucleotide (NAD) in diffuse gliomas. Neuro Oncol 24:245\u2013246. https:\/\/doi.org\/10.1093\/neuonc\/noab265","journal-title":"Neuro Oncol"},{"key":"1967_CR13","doi-asserted-by":"publisher","first-page":"5024","DOI":"10.1158\/0008-5472.CAN-20-1094","volume":"80","author":"M Li","year":"2020","unstructured":"Li M, Kirtane AR, Kiyokawa J, Nagashima H, Lopes A, Tirmizi ZA et al (2020) Local targeting of NAD\u2009+\u2009Salvage pathway alters the immune tumor microenvironment and enhances checkpoint immunotherapy in glioblastoma. Cancer Res 80:5024\u20135034. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1094","journal-title":"Cancer Res"},{"key":"1967_CR14","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.ccell.2015.11.006","volume":"28","author":"K Tateishi","year":"2015","unstructured":"Tateishi K, Wakimoto H, Iafrate AJ, Tanaka S, Loebel F, Lelic N et al (2015) Extreme vulnerability of IDH1 mutant cancers to NAD\u2009+\u2009Depletion. Cancer Cell 28:773\u2013784. https:\/\/doi.org\/10.1016\/j.ccell.2015.11.006","journal-title":"Cancer Cell"},{"key":"1967_CR15","doi-asserted-by":"publisher","unstructured":"Audrito V, Manag\u00f2 A, La Vecchia S, Zamporlini F, Vitale N, Baroni G et al (2018) Nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic target in BRAF-Mutated metastatic melanoma. J Natl Cancer Inst 110. https:\/\/doi.org\/10.1093\/jnci\/djx198","DOI":"10.1093\/jnci\/djx198"},{"key":"1967_CR16","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1158\/1078-0432.CCR-20-2400","volume":"27","author":"J Kiyokawa","year":"2021","unstructured":"Kiyokawa J, Kawamura Y, Ghouse SM, Acar S, Bar\u00e7\u0131n E, Mart\u00ednez-Quintanilla J et al (2021) Modification of extracellular matrix enhances oncolytic adenovirus immunotherapy in glioblastoma. Clin Cancer Res 27:889\u2013902. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-2400","journal-title":"Clin Cancer Res"},{"key":"1967_CR17","doi-asserted-by":"publisher","first-page":"8064","DOI":"10.1080\/21655979.2022.2051853","volume":"13","author":"H Ren","year":"2022","unstructured":"Ren H, Yang B, Li M, Lu C, Li X (2022) RAB26 contributes to the progression of non-small cell lung cancer after being transcriptionally activated by SMAD3. Bioengineered 13:8064\u20138075. https:\/\/doi.org\/10.1080\/21655979.2022.2051853","journal-title":"Bioengineered"},{"issue":"9","key":"1967_CR18","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1002\/cbic.201800761","volume":"20","author":"Q Liu","year":"2019","unstructured":"Liu Q, Wang D, Xu Z, Huang C, Zhang C, He B et al (2019) Targeted delivery of Rab26 SiRNA with precisely tailored DNA Prism for lung Cancer therapy. ChemBioChem 20(9):1139\u20131144. https:\/\/doi.org\/10.1002\/cbic.201800761","journal-title":"ChemBioChem"},{"key":"1967_CR19","doi-asserted-by":"publisher","first-page":"109126","DOI":"10.1016\/j.biopha.2019.109126","volume":"117","author":"XY Yang","year":"2019","unstructured":"Yang XY, Liao JJ, Xue WR (2019) FMNL1 down-regulation suppresses bone metastasis through reducing TGF-\u03b21 expression in non-small cell lung cancer (NSCLC). Biomed Pharmacother 117:109126. https:\/\/doi.org\/10.1016\/j.biopha.2019.109126","journal-title":"Biomed Pharmacother"},{"key":"1967_CR20","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1021\/acs.biomac.2c01493","volume":"24","author":"B Wang","year":"2023","unstructured":"Wang B, Zhang R, Wang Y, Qian H, Wu D, He B et al (2023) Targeting Rab26 to conquer Cisplatin-Resistant lung Cancer with Self-Assembled DNA nanomaterials. Biomacromolecules 24:2063\u20132074. https:\/\/doi.org\/10.1021\/acs.biomac.2c01493","journal-title":"Biomacromolecules"},{"key":"1967_CR21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1186\/s13046-021-02188-y","volume":"40","author":"Y Huang","year":"2021","unstructured":"Huang Y, Chen Z, Lu T, Bi G, Li M, Liang J et al (2021) HIF-1\u03b1 switches the functionality of TGF-\u03b2 signaling via changing the partners of Smads to drive glucose metabolic reprogramming in non-small cell lung cancer. J Exp Clin Cancer Res 40:398. https:\/\/doi.org\/10.1186\/s13046-021-02188-y","journal-title":"J Exp Clin Cancer Res"},{"key":"1967_CR22","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2147\/OTT.S282367","volume":"14","author":"X Lv","year":"2021","unstructured":"Lv X, Zhang J, Zhang J, Guan W, Ren W, Liu Y et al (2021) A negative feedback loop between NAMPT and TGF-\u03b2 signaling pathway in colorectal Cancer cells. Onco Targets Ther 14:187\u2013198. https:\/\/doi.org\/10.2147\/OTT.S282367","journal-title":"Onco Targets Ther"},{"key":"1967_CR23","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","volume":"740","author":"S Dasari","year":"2014","unstructured":"Dasari S, Tchounwou PB (2014) Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 740:364\u2013378. https:\/\/doi.org\/10.1016\/j.ejphar.2014.07.025","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"1967_CR24","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1158\/0008-5472.CAN-19-2830","volume":"80","author":"T Nacarelli","year":"2020","unstructured":"Nacarelli T, Fukumoto T, Zundell JA, Fatkhutdinov N, Jean S, Cadungog MG et al (2020) NAMPT Inhibition suppresses Cancer Stem-like cells associated with Therapy-Induced senescence in ovarian Cancer. Cancer Res 80(4):890\u2013900. https:\/\/doi.org\/10.1158\/0008-5472.CAN-19-2830","journal-title":"Cancer Res"},{"key":"1967_CR25","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3390\/cells12050775","volume":"12","author":"K Pant","year":"2023","unstructured":"Pant K, Richard S, Peixoto E, Yin J, Seelig DM, Carotenuto P et al (2023) The NAMPT inhibitor FK866 in combination with cisplatin reduces cholangiocarcinoma cells growth. Cells 12:775. https:\/\/doi.org\/10.3390\/cells12050775","journal-title":"Cells"},{"key":"1967_CR26","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41392-020-00354-w","volume":"6","author":"LE Navas","year":"2021","unstructured":"Navas LE, Carnero A (2021) NAD\u2009+\u2009metabolism, stemness, the immune response, and cancer. Signal Transduct Target Ther 6:2. https:\/\/doi.org\/10.1038\/s41392-020-00354-w","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"1967_CR27","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674. https:\/\/doi.org\/10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"key":"1967_CR28","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1517\/14728222.11.5.695","volume":"11","author":"JA Khan","year":"2007","unstructured":"Khan JA, Forouhar F, Tao X, Tong L (2007) Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets 11:695\u2013705","journal-title":"Expert Opin Ther Targets"},{"key":"1967_CR29","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.3390\/nu14153231","volume":"14","author":"JM Campbell","year":"2022","unstructured":"Campbell JM (2022) Supplementation with NAD\u2009+\u2009and its precursors to prevent cognitive decline across disease contexts. Nutrients 14:3231. https:\/\/doi.org\/10.3390\/nu14153231","journal-title":"Nutrients"},{"key":"1967_CR30","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.3390\/ijms23031328","volume":"23","author":"O Morana","year":"2022","unstructured":"Morana O, Wood W, Gregory CD (2022) The apoptosis paradox in Cancer. Int J Mol Sci 23:1328. https:\/\/doi.org\/10.3390\/ijms23031328","journal-title":"Int J Mol Sci"},{"key":"1967_CR31","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.3390\/pharmaceutics15051472","volume":"15","author":"I Conforti","year":"2023","unstructured":"Conforti I, Benzi A, Caffa I, Bruzzone S, Nencioni A, Marra A (2023) Iminosugar-Based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors as potential Anti-Pancreatic Cancer agents. Pharmaceutics 15:1472. https:\/\/doi.org\/10.3390\/pharmaceutics15051472","journal-title":"Pharmaceutics"},{"key":"1967_CR32","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.3390\/ijms25042092","volume":"25","author":"MS Ghanem","year":"2024","unstructured":"Ghanem MS, Caffa I, Monacelli F, Nencioni A (2024) Inhibitors of NAD\u2009+\u2009Production in Cancer treatment: state of the Art and perspectives. Int J Mol Sci 25:2092. https:\/\/doi.org\/10.3390\/ijms25042092","journal-title":"Int J Mol Sci"},{"key":"1967_CR33","doi-asserted-by":"publisher","first-page":"7538071","DOI":"10.1155\/2019\/7538071","volume":"2019","author":"H Chen","year":"2019","unstructured":"Chen H, Yuan M, Huang C, Xu Z, Li M, Zhang C et al (2019) Endothelial cell inflammation and barriers are regulated by the Rab26-Mediated balance between \u03b22-AR and TLR4 in pulmonary microvessel endothelial cells. Mediators Inflamm 2019:7538071. https:\/\/doi.org\/10.1155\/2019\/7538071","journal-title":"Mediators Inflamm"},{"key":"1967_CR34","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1080\/15548627.2018.1476811","volume":"14","author":"W Dong","year":"2018","unstructured":"Dong W, He B, Qian H, Liu Q, Wang D, Li J et al (2018) RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury. Autophagy 14:1677\u20131692. https:\/\/doi.org\/10.1080\/15548627.2018.1476811","journal-title":"Autophagy"},{"key":"1967_CR35","doi-asserted-by":"publisher","first-page":"768435","DOI":"10.3389\/fimmu.2021.768435","volume":"12","author":"W Zhang","year":"2021","unstructured":"Zhang W, Wang Y, Li C, Xu Y, Wang X, Wu D et al (2021) Extracellular CIRP-Impaired Rab26 restrains EPOR-Mediated macrophage polarization in acute lung injury. Front Immunol 12:768435. https:\/\/doi.org\/10.3389\/fimmu.2021.768435","journal-title":"Front Immunol"},{"key":"1967_CR36","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.freeradbiomed.2023.01.001","volume":"195","author":"BF He","year":"2023","unstructured":"He BF, Wu YX, Hu WP, Hua JL, Han Y, Zhang J (2023) ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling. Free Radic Biol Med 195:359\u2013370. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2023.01.001","journal-title":"Free Radic Biol Med"},{"key":"1967_CR37","doi-asserted-by":"publisher","first-page":"e2203958","DOI":"10.1002\/adma.202203958","volume":"34","author":"Y Zou","year":"2022","unstructured":"Zou Y, Wang Y, Xu S, Liu Y, Yin J, Lovejoy DB et al (2022) Brain Co-Delivery of Temozolomide and cisplatin for combinatorial glioblastoma chemotherapy. Adv Mater 34:e2203958. https:\/\/doi.org\/10.1002\/adma.202203958","journal-title":"Adv Mater"},{"key":"1967_CR38","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s00280-009-1125-3","volume":"65","author":"A von Heideman","year":"2010","unstructured":"von Heideman A, Berglund A, Larsson R, Nygren P (2010) Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data. Cancer Chemother Pharmacol 65:1165\u20131172. https:\/\/doi.org\/10.1007\/s00280-009-1125-3","journal-title":"Cancer Chemother Pharmacol"},{"key":"1967_CR39","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s10637-007-9083-2","volume":"26","author":"K Holen","year":"2008","unstructured":"Holen K, Saltz LB, Hollywood E, Burk K, Hanauske AR (2008) The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest New Drugs 26:45\u201351. https:\/\/doi.org\/10.1007\/s10637-007-9083-2","journal-title":"Invest New Drugs"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-025-01967-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40478-025-01967-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40478-025-01967-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:01:41Z","timestamp":1741712501000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/s40478-025-01967-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1967"],"URL":"https:\/\/doi.org\/10.1186\/s40478-025-01967-4","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,11]]},"assertion":[{"value":"14 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Zhengzhou University People\u2019s Hospital, Henan province, China (Approval No.H2023-07-025). The ethics committee of Zhengzhou University People\u2019s Hospital waived the need for informed consent due to the retrospective nature of the study. All procedures were conducted by following the Declaration of Helsinki. All methods were carried out in accordance with relevant guidelines and regulations in the declaration.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and approval and consent to participate"}},{"value":"There are no potential conflicts of interest to be disclosed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"56"}}