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(2) Human subjects: The patients all signed an informed consent form expressing their willingness to allow the use of the excised tumor tissue for scientific research, and the study received approval from the Ethics Committee of Southern Medical University. (3) Clinical Trial: The trial was approved by the Ethics Committee of Nanfang Hospital, Southern Medical University and registered at ClinicalTrial.gov (identifier: NCT00949156). Patients consented to participate in the trial and consented to publication of the outcomes. The work described has been carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"All the authors have read the original manuscript and consented to publish it.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"46"}}