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Animal studies were approved by the Washington University Institutional Animal Care and Use Committee under protocol #25\u20130218. The protocol of iPSC-generation from a patient was approved by the Ethics Committee of Kyoto University Graduate School and Faculty of Medicine (approval number #G1004) and was conducted according to the guidelines of the Declaration of Helsinki. Written informed consent was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}