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While Na\n                    <jats:sub>V<\/jats:sub>\n                    1.2 is known to regulate neuronal excitability, its role in oligodendroglial cells is unclear. Here, we show that Na\n                    <jats:sub>V<\/jats:sub>\n                    1.2 is expressed in early oligodendrocyte lineage stages. In mice carrying the gain-of-function\n                    <jats:italic>Scn2a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>p.A263V<\/jats:italic>\n                    <\/jats:sup>\n                    variant, oligodendrocyte precursor cells displayed similar Na\n                    <jats:sub>V<\/jats:sub>\n                    1.2 expression, but altered electrophysiological properties and calcium signaling. Single-cell transcriptomics revealed stage-specific changes in oligodendroglial maturation during early postnatal development, associated with lower variability and slightly faster conduction velocities. In adult mutant mice, gray matter myelination was increased without changes in oligodendrocyte numbers or myelin structure. Since Na\n                    <jats:sub>V<\/jats:sub>\n                    1.2 was absent from mature oligodendrocytes, the enhanced myelination likely reflects an activity-dependent adaptation to altered neuronal network activity rather than a primary myelinopathy. These findings identify a glial contribution to\n                    <jats:italic>SCN2A<\/jats:italic>\n                    -related disease mechanisms and underscore the need to consider neuron\u2013glia interactions when developing targeted therapies for epilepsy.\n                  <\/jats:p>","DOI":"10.1186\/s40478-026-02437-1","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:26:19Z","timestamp":1791354379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered oligodendroglial cell development and increased myelination in SCN2A gain-of-function-linked epilepsy"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6825-0328","authenticated-orcid":false,"given":"Constanza","family":"Bravo-Rossainz Baez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-5978","authenticated-orcid":false,"given":"Xian","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9971-3718","authenticated-orcid":false,"given":"Daniil","family":"Kirianov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Sp\u00e4te","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariapia","family":"Grassia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9104-7194","authenticated-orcid":false,"given":"Birgit","family":"Engeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9009-137X","authenticated-orcid":false,"given":"Malte","family":"Stockebrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-5558","authenticated-orcid":false,"given":"Konstantin","family":"Khodosevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-1306","authenticated-orcid":false,"given":"Ulrike B. 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