{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:04:42Z","timestamp":1787619882466,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Prog Orthod."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>This study provides a vital insight in assessing the clinical and biochemical changes in interleukin (IL)-1\u03b2 levels in peri-miniscrew crevicular fluid (PMCF) during the course of orthodontic tooth movement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The study comprised the analysis of IL-1\u03b2 in peri-miniscrew crevicular fluid obtained from crevices around the miniscrews inserted in 11 patients (eight females and three males, mean age 17.3\u2009\u00b1\u20094.64\u00a0years) with all first premolar extraction and maximum anchorage requirement using miniscrew-supported anchorage. Miniscrews were loaded at 3\u00a0weeks after placement by 200-g nitinol closed coil springs of 9-mm length for en masse retraction. Peri-miniscrew crevicular fluid was collected at miniscrew placement (T1), at 3\u00a0weeks (T2\/baseline) and on loading at 0 (T3) and 1\u00a0day (T4), 21 (T5), 72 (T6), 120 (T7), 180 (T8) and 300 (T9) days. IL-1\u03b2 levels were estimated by enzyme-linked immunosorbent assay (ELISA). Peri-miniscrew tissue was examined for signs of inflammation, and also, miniscrew mobility was assessed with Periotest and handles of two mouth mirrors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>IL-1\u03b2 levels in all miniscrews were significantly higher at T1 and peaked again at T4 showing a bimodal peak. However, there was a gradual and statistically significant decrease in IL-1\u03b2 till T5, while further changes till the end of the study were statistically not significant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The changing levels of IL-1\u03b2 levels in PMCF over a duration of 300\u00a0days are suggestive of the underlying inflammatory process. IL-1\u03b2 levels in PMCF show a significant rise during miniscrew insertion and on immediate loading. The trend of gradually reducing IL-1\u03b2 levels around the miniscrew over the period after loading towards baseline is suggestive of adaptive bone response to stimulus.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40510-014-0030-4","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T17:46:52Z","timestamp":1396288012000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A study of interleukin 1\u03b2 levels in peri-miniscrew crevicular fluid (PMCF)"],"prefix":"10.1186","volume":"15","author":[{"given":"Nitika","family":"Monga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Chaurasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Om Prakash","family":"Kharbanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Duggal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moganty Raja","family":"Rajeswari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"30_CR1","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1177\/0022034511409236","volume":"90","author":"MA Papadopoulos","year":"2011","unstructured":"Papadopoulos MA, Papageorgiou SN, Zogakis IP: Clinical effectiveness of orthodontic miniscrew implants: a meta-analysis. J Dent Res 2011, 90: 969\u201376. 10.1177\/0022034511409236","journal-title":"J Dent Res"},{"key":"30_CR2","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1111\/j.1600-0501.2009.01754.x","volume":"20","author":"M Schatzle","year":"2009","unstructured":"Schatzle M, Mannchen R, Zwahlen M, Lang NP: Survival and failure rates of orthodontic temporary anchorage devices: a systematic review. Clin Oral Implants Res 2009, 20: 1351\u20139. 10.1111\/j.1600-0501.2009.01754.x","journal-title":"Clin Oral Implants Res"},{"key":"30_CR3","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0889-5406(03)00565-1","volume":"124","author":"S Miyawaki","year":"2003","unstructured":"Miyawaki S, Koyama I, Inoue M, Mishima K, Sugahara T, Takano-Yamamoto T: Factors associated with the stability of titanium screws placed in the posterior region for orthodontic anchorage. Am J Orthod Dentofacial Orthop 2003, 124: 373\u20138. 10.1016\/S0889-5406(03)00565-1","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"30_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1600-0757.1998.tb00124.x","volume":"17","author":"A Mombelli","year":"1998","unstructured":"Mombelli A, Lang NP: The diagnosis and treatment of peri-implantitis. Periodontol 2000 1998, 17: 63\u201376. 10.1111\/j.1600-0757.1998.tb00124.x","journal-title":"Periodontol 2000"},{"key":"30_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cyto.2010.08.013","volume":"53","author":"F Javed","year":"2011","unstructured":"Javed F, Al-Hezaimi K, Salameh Z, Almas K, Romanos GE: Proinflammatory cytokines in the crevicular fluid of patients with peri-implantitis. Cytokine 2011, 53: 8\u201312. 10.1016\/j.cyto.2010.08.013","journal-title":"Cytokine"},{"issue":"3","key":"30_CR6","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1902\/jop.2003.74.3.391","volume":"74","author":"DT Graves","year":"2003","unstructured":"Graves DT, Cochran D: The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol 2003, 74(3):391\u2013401. 10.1902\/jop.2003.74.3.391","journal-title":"J Periodontol"},{"key":"30_CR7","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.2319\/100506-405.1","volume":"77","author":"E Sari","year":"2007","unstructured":"Sari E, U\u00e7ar C: Interleukin 1beta levels around microscrew implants during orthodontic tooth movement. Angle Orthod 2007, 77: 1073\u20138. 10.2319\/100506-405.1","journal-title":"Angle Orthod"},{"key":"30_CR8","first-page":"215","volume-title":"The Periodontal Ligament in Health and Disease","author":"BJ Moxham","year":"1995","unstructured":"Moxham BJ, Berkovitz BKB: The effects of external forces on the periodontal ligament. In The Periodontal Ligament in Health and Disease. 2nd edition. Edited by: Berkovitz BKB, Moxham BJ, Newman HN. Mosby-Wolfe, London; 1995:215\u201341.","edition":"2"},{"key":"30_CR9","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/j.1600-051X.2004.00568.x","volume":"31","author":"JL Wennstrom","year":"2004","unstructured":"Wennstrom JL, Ekestubbe A, Grondahl K, Karlsson S, Lindhe J: Oral rehabilitation with implant-supported fixed partial dentures in periodontitis susceptible subjects. J Clin Periodontol 2004, 31: 713\u201324. 10.1111\/j.1600-051X.2004.00568.x","journal-title":"J Clin Periodontol"},{"key":"30_CR10","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.archoralbio.2011.01.006","volume":"56","author":"VO Severino","year":"2011","unstructured":"Severino VO, Napimoga MH, de Lima Pereira SA: Expression of IL-6, IL-10, IL-17 and IL-8 in the peri-implant crevicular fluid of patients with peri-implantitis. Arch Oral Biol 2011, 56: 823\u20138. 10.1016\/j.archoralbio.2011.01.006","journal-title":"Arch Oral Biol"},{"key":"30_CR11","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.2319\/100707-484.1","volume":"78","author":"B Wilmes","year":"2008","unstructured":"Wilmes B, Su YY, Drescher D: Insertion angle impact on primary stability of orthodontic mini implant. Angle Orthod 2008, 78: 1065\u201370. 10.2319\/100707-484.1","journal-title":"Angle Orthod"},{"key":"30_CR12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1034\/j.1600-0757.2003.03103.x","volume":"31","author":"GS Griffiths","year":"2003","unstructured":"Griffiths GS: Formation, collection and significance of gingival crevice fluid. Periodontol 2000 2003, 31: 32\u201342. 10.1034\/j.1600-0757.2003.03103.x","journal-title":"Periodontol 2000"},{"key":"30_CR13","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/ejo\/cjn091","volume":"31","author":"PW Woods","year":"2009","unstructured":"Woods PW, Buschang PH, Owens SE, Rossouw PE, Opperman LA: The effect of force, timing, and location on bone-to-implant contact of miniscrews. Eur J Orthod 2009, 31: 232\u201340. 10.1093\/ejo\/cjn091","journal-title":"Eur J Orthod"},{"key":"30_CR14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ajodo.2004.11.032","volume":"130","author":"HS Park","year":"2006","unstructured":"Park HS, Jeong SH, Kwon OW: Factors affecting the clinical success of screw implants used as orthodontic anchorage. Am J Orthod Dentofacial Orthop 2006, 130: 18\u201325. 10.1016\/j.ajodo.2004.11.032","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"30_CR15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1067\/mod.2001.114300","volume":"119","author":"M Ohmae","year":"2001","unstructured":"Ohmae M, Saito S, Morohashi T, Seki K, Qu H, Kanomi R, Yamasaki KI, Okano T, Yamada S, Shibasaki Y: A clinical and histological evaluation of titanium miniimplants as anchors for orthodontic intrusion in the beagle dog. Am J Orthod Dentofacial Orthop 2001, 119: 489\u201397. 10.1067\/mod.2001.114300","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"30_CR16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ajodo.2006.07.038","volume":"134","author":"SH Kim","year":"2008","unstructured":"Kim SH, Cho JH, Chung KR, Kook YA, Nelson G: Removal torque values of surface-treated mini-implants after loading. Am J Orthod Dentofacial Orthop 2008, 134: 36\u201343. 10.1016\/j.ajodo.2006.07.038","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"30_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00056-010-9933-y","volume":"71","author":"B Florvaag","year":"2010","unstructured":"Florvaag B, Kneuertz P, Lazar F, Koebke J, Zoller JE, Braumann B, Mischkowski RA: Biomechanical properties of orthodontic miniscrews: an in-vitro study. J Orofac Orthop 2010, 71: 53\u201367. 10.1007\/s00056-010-9933-y","journal-title":"J Orofac Orthop"},{"key":"30_CR18","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.ajodo.2010.11.017","volume":"139","author":"EY Suzuki","year":"2011","unstructured":"Suzuki EY, Suzuki B: Placement and removal torque values of orthodontic miniscrews. Am J Orthod Dentofacial Orthop 2011, 139: 669\u201378. 10.1016\/j.ajodo.2010.11.017","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"30_CR19","first-page":"800","volume":"24","author":"X Hou","year":"2009","unstructured":"Hou X, Weiler MA, Winger JN, Morris JR, Borke JL: Rat model for studying tissue changes induced by the mechanical environment surrounding loaded titanium implants. Int J Oral Maxillofac Implants 2009, 24: 800\u20137.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"30_CR20","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1016\/j.joms.2009.04.138","volume":"67","author":"V Dao","year":"2009","unstructured":"Dao V, Renjen R, Prasad HS, Rohrer MD, Maganzini AL, Kraut RA: Cementum, pulp, periodontal ligament, and bone response after direct injury with orthodontic anchorage screws: a histomorphologic study in an animal model. J Oral Maxillofac Surg 2009, 67: 2440\u20135. 10.1016\/j.joms.2009.04.138","journal-title":"J Oral Maxillofac Surg"},{"key":"30_CR21","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1034\/j.1600-0501.2001.012003202.x","volume":"12","author":"B Johansson","year":"2001","unstructured":"Johansson B, Smedberg JI, Langley M, Embery G: Glycosaminoglycans in peri-implant sulcus fluid from implants placed in sinus-inlay bone grafts. Clin Oral Implants Res 2001, 12: 202\u20136. 10.1034\/j.1600-0501.2001.012003202.x","journal-title":"Clin Oral Implants Res"},{"key":"30_CR22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1034\/j.1600-0501.2002.130301.x","volume":"13","author":"D Plagnat","year":"2002","unstructured":"Plagnat D, Giannopoulou C, Carrel A, Bernard JP, Mombelli A, Belser UC: Elastase, alpha2-macroglobulin and alkaline phosphatase in crevicular fluid from implants with and without peri-implantitis. Clin Oral Implants Res 2002, 13: 227\u201333. 10.1034\/j.1600-0501.2002.130301.x","journal-title":"Clin Oral Implants Res"},{"key":"30_CR23","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/j.1600-0501.2004.01061.x","volume":"15","author":"S Liskmann","year":"2004","unstructured":"Liskmann S, Zilmer M, Vihalemm T, Salum O, Fischer K: Correlation of peri-implant health and myeloperoxidase levels: a cross-sectional clinical study. Clin Oral Implants Res 2004, 15: 546\u201352. 10.1111\/j.1600-0501.2004.01061.x","journal-title":"Clin Oral Implants Res"},{"key":"30_CR24","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/ejo\/cjp056","volume":"32","author":"I Intachai","year":"2010","unstructured":"Intachai I, Krisanaprakornkit S, Kongtawelert P, Ong-chai S, Buranastidporn B, Suzuki EY, Jotikasthira D: Chondroitin sulphate (WF6 epitope) levels in peri-miniscrew implant crevicular fluid during orthodontic loading. Eur J Orthod 2010, 32: 60\u20135. 10.1093\/ejo\/cjp056","journal-title":"Eur J Orthod"},{"key":"30_CR25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.4041\/kjod.2011.41.1.36","volume":"41","author":"FA Kaya","year":"2011","unstructured":"Kaya FA, Hamamc\u0131 N, Uysal E, Yoku\u015f B: Identification of tumor necrosis factor-\u03b1 levels around miniscrews during canine distalization. Korean J Orthod 2011, 41: 36\u201341. 10.4041\/kjod.2011.41.1.36","journal-title":"Korean J Orthod"},{"key":"30_CR26","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/ejo\/cjr019","volume":"34","author":"N Hamamc\u0131","year":"2012","unstructured":"Hamamc\u0131 N, Acun Kaya F, Uysal E, Yoku\u015f B: Identification of interleukin 2, 6, and 8 levels around miniscrews during orthodontic tooth movement. Eur J Orthod 2012, 34: 357\u201361. 10.1093\/ejo\/cjr019","journal-title":"Eur J Orthod"},{"key":"30_CR27","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/oxfordjournals.bmb.a072187","volume":"43","author":"ME Billingham","year":"1987","unstructured":"Billingham ME: Cytokines as inflammatory mediators. Br Med Bull 1987, 43: 350\u201370.","journal-title":"Br Med Bull"},{"key":"30_CR28","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/S0889-5406(99)70295-7","volume":"115","author":"S Tzannetou","year":"1999","unstructured":"Tzannetou S, Efstratiadis S, Nicolay O, Grbic J, Lamster I: Interleukin-1\u03b2 and \u03b2-glucuronidase in gingival crevicular fluid from molars during rapid palatal expansion. Am J Orthod Dentofacial Orthop 1999, 115: 686\u201396. 10.1016\/S0889-5406(99)70295-7","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"30_CR29","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1067\/mod.2001.110809","volume":"119","author":"N Alhashimi","year":"2001","unstructured":"Alhashimi N, Frithiof L, Brudvik P, Bakhiet M: Orthodontic tooth movement and de novo synthesis of proinflammatory cytokines. Am J Orthod Dentofacial Orthop 2001, 119: 307\u201312. 10.1067\/mod.2001.110809","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"30_CR30","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1093\/ejo\/cjl001","volume":"28","author":"MC Meikle","year":"2006","unstructured":"Meikle MC: The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100\u00a0years after Carl Sandstedt. Eur J Orthod 2006, 28: 221\u201340. 10.1093\/ejo\/cjl001","journal-title":"Eur J Orthod"},{"key":"30_CR31","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1359\/jbmr.2002.17.2.210","volume":"17","author":"H Kanzaki","year":"2002","unstructured":"Kanzaki H, Chiba M, Shimizu Y, Mitani H: Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappa B ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res 2002, 17: 210\u201320. 10.1359\/jbmr.2002.17.2.210","journal-title":"J Bone Miner Res"},{"key":"30_CR32","doi-asserted-by":"publisher","first-page":"558","DOI":"10.2319\/0003-3219(2009)079[0558:BAHCOO]2.0.CO;2","volume":"79","author":"J Wu","year":"2009","unstructured":"Wu J, Bai YX, Wang BK: Biomechanical and histomorphometric characterizations of osseointegration during mini-screw healing in rabbit tibiae. Angle Orthod 2009, 79: 558\u201363. 10.2319\/031108-138.1","journal-title":"Angle Orthod"},{"key":"30_CR33","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/978-4-431-99644-6_20","volume-title":"Interface Oral Health Science 2009","author":"T Deguchi","year":"2010","unstructured":"Deguchi T, Hasegawa M, Seiryu M, Daimaruya T, Yamamoto T: Histomorphometric study of alveolar bone-implant (miniscrew) interface used as an orthodontic anchorage. In Interface Oral Health Science 2009. Edited by: Sasano T, Suzuki O. Springer, Heidelberg; 2010:126. 10.1007\/978-4-431-99644-6_20"},{"key":"30_CR34","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.ajodo.2003.12.023","volume":"127","author":"SS Huja","year":"2005","unstructured":"Huja SS, Litsky AS, Beck FM, Johnson KA, Larsen PE: Pull-out strength of monocortical screws placed in the maxillae and mandibles of dogs. Am J Orthod Dentofacial Orthop 2005, 127: 307\u201313. 10.1016\/j.ajodo.2003.12.023","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"30_CR35","first-page":"65","volume":"14","author":"CA Dinarello","year":"1992","unstructured":"Dinarello CA: Reduction of inflammation by decreasing production of interleukin-1 or by specific receptor antagonism. Int J Tissue React 1992, 14: 65\u201375.","journal-title":"Int J Tissue React"},{"key":"30_CR36","volume-title":"The Cytokine Handbook","author":"CA Dinarello","year":"1994","unstructured":"Dinarello CA: Interleukin-1. In The Cytokine Handbook. Edited by: Thomson A. Academic Press, San Diego, CA; 1994."},{"key":"30_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ejo\/cjh089","volume":"27","author":"A Jager","year":"2005","unstructured":"Jager A, Zhang D, Kawarizadeh A, Tolba R, Braumann B, Lossdorfer S, Gotz W: Soluble cytokine receptor treatment in experimental orthodontic tooth movement in the rat. Eur J Orthod 2005, 27: 1\u201311. 10.1093\/ejo\/cjh089","journal-title":"Eur J Orthod"},{"key":"30_CR38","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1182\/blood.V85.5.1341.bloodjournal8551341","volume":"85","author":"W Ertel","year":"1995","unstructured":"Ertel W, Kremer JP, Kenney J, Steckholzer U, Jarrar D, Trentz O, Schildberg FW: Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 1995, 85: 1341\u20137.","journal-title":"Blood"},{"key":"30_CR39","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1093\/aje\/kwh325","volume":"160","author":"RB Ness","year":"2004","unstructured":"Ness RB, Haggerty CL, Harger G, Ferrell R: Differential distribution of allelic variants in cytokine genes among African Americans and White Americans. Am J Epidemiol 2004, 160: 1033\u20138. 10.1093\/aje\/kwh325","journal-title":"Am J Epidemiol"},{"issue":"3","key":"30_CR40","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.cden.2005.03.009","volume":"49","author":"M Taba Jr","year":"2005","unstructured":"Taba M Jr, Kinney J, Kim AS, Giannobile WV: Diagnostic biomarkers for oral and periodontal diseases. Dent Clin North Am 2005, 49(3):551\u201371. vi vi 10.1016\/j.cden.2005.03.009","journal-title":"Dent Clin North Am"},{"key":"30_CR41","doi-asserted-by":"publisher","first-page":"704. e1\u20139","DOI":"10.1016\/j.ajodo.2006.09.040","volume":"131","author":"JN Freire","year":"2007","unstructured":"Freire JN, Silva NR, Gil JN, Magini RS, Coelho PG: Histomorphologic and histomorphometric evaluation of immediately and early loaded mini-implants for orthodontic anchorage. Am J Orthod Dentofacial Orthop 2007, 131: 704. e1\u20139.","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"30_CR42","doi-asserted-by":"publisher","first-page":"70","DOI":"10.2319\/012912-78.1","volume":"83","author":"AA Celebi","year":"2013","unstructured":"Celebi AA, Demirer S, Catalbas B, Arikan S: Effect of ovarian activity on orthodontic tooth movement and gingival crevicular fluid levels of interleukin-1\u03b2 and prostaglandin E2 in cats. Angle Orthod 2013, 83: 70\u20135. 10.2319\/012912-78.1","journal-title":"Angle Orthod"}],"container-title":["Progress in Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40510-014-0030-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40510-014-0030-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40510-014-0030-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40510-014-0030-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T03:15:44Z","timestamp":1630552544000},"score":1,"resource":{"primary":{"URL":"https:\/\/progressinorthodontics.springeropen.com\/articles\/10.1186\/s40510-014-0030-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["30"],"URL":"https:\/\/doi.org\/10.1186\/s40510-014-0030-4","relation":{},"ISSN":["2196-1042"],"issn-type":[{"value":"2196-1042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]},"assertion":[{"value":"5 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"30"}}