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Patient compliance was assessed using a 2-point Likert scale. Statistical comparisons between the two groups were performed with independent sample <jats:italic>t<\/jats:italic> tests.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>No statistically significant differences for any of the cephalometric variables describing the baseline dentoskeletal features were found between the two groups except for the mandibular unit length that was significantly greater in the pubertal group (<jats:italic>P<\/jats:italic>\u2009=\u20090.005). The modified SEC III protocol produced favorable sagittal outcomes in both groups, whereas no statistically significant T1-T2 changes were found between the CS1-2 and CS3-4 groups for any of the angular and linear measurements. No significant differences were found in the prevalence rates of the degree of collaboration between the two groups (<jats:italic>P<\/jats:italic>\u2009=\u20091.000).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>No significant differences between prepubertal and pubertal patients were found in the sagittal and vertical dentoskeletal changes with the modified SEC III protocol. Thus, this early Class III treatment produced similar favorable effects in growing subjects regardless of the cervical vertebral maturation stages from CS1 to CS4.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40510-021-00392-2","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:05:42Z","timestamp":1640131542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dentoskeletal effects of early class III treatment protocol based on timing of intervention in children"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7174-7596","authenticated-orcid":false,"given":"Ludovica","family":"Nucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Costanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Carfora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0291-9339","authenticated-orcid":false,"given":"Fabrizia","family":"d\u2019Apuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-460X","authenticated-orcid":false,"given":"Lorenzo","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-7363","authenticated-orcid":false,"given":"Letizia","family":"Perillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"392_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.ajodo.2019.03.026","volume":"157","author":"G Perinetti","year":"2020","unstructured":"Perinetti G, Braga C, Contardo L, Primozic J. 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