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Prior to treatment commencement, a semi-automatic digital setup simulating the predicted treatment outcome was performed for each patient through Orthoanalyzer software (3Shape\u00ae, Copenhagen, Denmark) to obtain the prediction model. This was compared to the final outcome model through 3D superimposition methods. Metric variables and inspection of color-coded distance maps were used to detect how accurately the digital setup predicts the actual treatment outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean absolute distances (MAD) between the superimposed dental arches of the predicted and the final models were: 0.77\u2009\u00b1\u20090.13 mm following superimposition on the palate, 0.52\u2009\u00b1\u20090.06 mm following superimposition on the maxillary dental arch, and 0.55\u2009\u00b1\u20090.15 mm following superimposition on the mandibular dental arch. The MAD at the palatal reference area was 0.09\u2009\u00b1\u20090.04 mm. Visualization of color-coded distance maps indicated that the digital setup accurately predicted the final teeth position in a few cases. Almost half of the cases had posteriorly wider upper and lower dental arches and palatally\/lingually positioned or inclined anterior teeth, whereas the rest still showed errors within 2\u20133 mm, distributed over the entire dental arches with no distinct pattern.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The accuracy of semi-automatic prediction of the labial fixed appliance treatment outcome in Class I cases with moderate crowding is not yet sufficient. While average measures showed deviations less than 1 mm, examination of individual color-coded distance maps revealed significant disparities between the simulated and the actual results.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40510-024-00513-7","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:27:39Z","timestamp":1712536059000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Digital setup accuracy for moderate crowding correction with fixed orthodontic appliances: a prospective study"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-3743","authenticated-orcid":false,"given":"Abdalrahman Mohieddin","family":"Kusaibati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinda","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Younis","family":"Hajeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-6272","authenticated-orcid":false,"given":"Nikolaos","family":"Gkantidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"issue":"2","key":"513_CR1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2319\/120914-890.1","volume":"86","author":"MS Barreto","year":"2016","unstructured":"Barreto MS, Faber J, Vogel CJ, Araujo TM. 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